Aliases for BTBD17 Gene

Aliases for BTBD17 Gene

  • BTB Domain Containing 17 2 3 5
  • BTB/POZ Domain-Containing Protein 17 3 4
  • BTB (POZ) Domain Containing 17 2 3
  • LGALS3BPL 2 3
  • TANGO10A 2 3
  • BTBD17A 2 3
  • Transport And Golgi Organization 10 Homolog A (Drosophila) 2
  • BTB/POZ And BACK Domain-Containing Protein LOC388419 3
  • Transport And Golgi Organization 10 Homolog A 3
  • Galectin-3-Binding Protein-Like 4
  • BTBD17 5

External Ids for BTBD17 Gene

Previous GeneCards Identifiers for BTBD17 Gene

  • GC17M069865
  • GC17M072352
  • GC17M067762

Summaries for BTBD17 Gene

GeneCards Summary for BTBD17 Gene

BTBD17 (BTB Domain Containing 17) is a Protein Coding gene. An important paralog of this gene is KLHL25.

Additional gene information for BTBD17 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BTBD17 Gene

Genomics for BTBD17 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for BTBD17 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J074360 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 +1.8 1848 2.3 CTCF PRDM10 REST RAD21 CTBP1 ESR1 SMC3 YY1 POLR2A NFIC GPR142 BTBD17 RF00017-2538 KIF19
GH17J074461 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.7 -102.1 -102114 9.3 SP1 ATF7 LEF1 NFRKB POLR2A BACH1 JUND LARP7 STAT3 ZNF143 CD300A NAT9 NUP85 NT5C GGA3 ENSG00000246731 GPR142 CD300LB ARMC7 BTBD17
GH17J074477 Enhancer 1 FANTOM5 ENCODE dbSUPER 9.3 -115.3 -115258 3.7 SP1 BACH1 IKZF2 TRIM22 DPF2 RELB CTBP1 RUNX3 NR2C2 GABPA GPRC5C CD300LB CD300E CD300C BTBD17 CD300LD CD300LF TMEM104 CD300A TTYH2
GH17J074472 Enhancer 0.8 FANTOM5 Ensembl ENCODE dbSUPER 10.2 -110.3 -110310 2.2 ZNF148 GPRC5C GPR142 BTBD17 CD300LD CD300E RAB37 CD300A RF00017-2540 CD300LB RF00017-2539
GH17J074471 Enhancer 0.6 ENCODE dbSUPER 9.9 -108.0 -107954 0.5 SCRT1 ZMYM3 ZFP36 POLR2A GPRC5C GPR142 CD300LD BTBD17 CD300E CD300A RF00017-2540 CD300LB RF00017-2539
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BTBD17 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for BTBD17

Top Transcription factor binding sites by QIAGEN in the BTBD17 gene promoter:
  • AREB6
  • c-Ets-1
  • c-Myc
  • FOXO3
  • Max
  • NF-1
  • NF-1/L
  • NF-kappaB
  • NF-kappaB1
  • RFX1

Genomic Locations for BTBD17 Gene

Genomic Locations for BTBD17 Gene
chr17:74,356,416-74,363,655
(GRCh38/hg38)
Size:
7,240 bases
Orientation:
Minus strand
chr17:72,352,555-72,358,085
(GRCh37/hg19)
Size:
5,531 bases
Orientation:
Minus strand

Genomic View for BTBD17 Gene

Genes around BTBD17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BTBD17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BTBD17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BTBD17 Gene

Proteins for BTBD17 Gene

  • Protein details for BTBD17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NE02-BTBDH_HUMAN
    Recommended name:
    BTB/POZ domain-containing protein 17
    Protein Accession:
    A6NE02

    Protein attributes for BTBD17 Gene

    Size:
    478 amino acids
    Molecular mass:
    52471 Da
    Quaternary structure:
    No Data Available

neXtProt entry for BTBD17 Gene

Post-translational modifications for BTBD17 Gene

  • Glycosylation at Asn61, Asn100, and Asn195
  • Modification sites at PhosphoSitePlus

Other Protein References for BTBD17 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BTBD17 Gene

Domains & Families for BTBD17 Gene

Gene Families for BTBD17 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for BTBD17 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for BTBD17 Gene

GenScript: Design optimal peptide antigens:
  • Galectin-3-binding protein-like (BTBDH_HUMAN)
genes like me logo Genes that share domains with BTBD17: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for BTBD17 Gene

Function for BTBD17 Gene

Phenotypes From GWAS Catalog for BTBD17 Gene

Gene Ontology (GO) - Molecular Function for BTBD17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with BTBD17: view

Phenotypes for BTBD17 Gene

MGI mutant phenotypes for BTBD17:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with BTBD17: view

Animal Model Products

CRISPR Products

miRNA for BTBD17 Gene

miRTarBase miRNAs that target BTBD17

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BTBD17

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BTBD17 Gene

Localization for BTBD17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BTBD17 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BTBD17 gene
Compartment Confidence
plasma membrane 4
extracellular 3
mitochondrion 2
cytoskeleton 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for BTBD17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 colocalizes_with cytoplasm ISS --
GO:0005886 plasma membrane ISS --
genes like me logo Genes that share ontologies with BTBD17: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for BTBD17 Gene

Pathways & Interactions for BTBD17 Gene

PathCards logo

SuperPathways for BTBD17 Gene

No Data Available

Interacting Proteins for BTBD17 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 25)
STRING Interaction Network
Selected Interacting proteins: ENSP00000364515 A6NE02-BTBDH_HUMAN for BTBD17 Gene via STRING IID

Gene Ontology (GO) - Biological Process for BTBD17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009615 response to virus ISS --
GO:0045071 negative regulation of viral genome replication ISS --
genes like me logo Genes that share ontologies with BTBD17: view

No data available for Pathways by source and SIGNOR curated interactions for BTBD17 Gene

Drugs & Compounds for BTBD17 Gene

No Compound Related Data Available

Transcripts for BTBD17 Gene

mRNA/cDNA for BTBD17 Gene

1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BTBD17

Alternative Splicing Database (ASD) splice patterns (SP) for BTBD17 Gene

No ASD Table

Relevant External Links for BTBD17 Gene

GeneLoc Exon Structure for
BTBD17

Expression for BTBD17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for BTBD17 Gene

mRNA differential expression in normal tissues according to GTEx for BTBD17 Gene

This gene is overexpressed in Brain - Cerebellum (x5.3), Brain - Putamen (basal ganglia) (x5.2), Brain - Amygdala (x4.9), Brain - Hypothalamus (x4.9), Brain - Nucleus accumbens (basal ganglia) (x4.4), and Brain - Caudate (basal ganglia) (x4.3).

Protein differential expression in normal tissues from HIPED for BTBD17 Gene

This gene is overexpressed in Fetal Brain (61.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BTBD17 Gene



Protein tissue co-expression partners for BTBD17 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for BTBD17

SOURCE GeneReport for Unigene cluster for BTBD17 Gene:

Hs.211870
genes like me logo Genes that share expression patterns with BTBD17: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for BTBD17 Gene

Orthologs for BTBD17 Gene

This gene was present in the common ancestor of animals.

Orthologs for BTBD17 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia BTBD17 30 31
  • 99.02 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia BTBD17 30 31
  • 91.98 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia BTBD17 30 31
  • 90.79 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Btbd17 30 17 31
  • 87.38 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Btbd17 30
  • 87.31 (n)
Oppossum
(Monodelphis domestica)
Mammalia BTBD17 31
  • 81 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia BTBD17 31
  • 72 (a)
OneToOne
Chicken
(Gallus gallus)
Aves BTBD17 30 31
  • 75.3 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia BTBD17 31
  • 62 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia btbd17 30
  • 60.14 (n)
Str.10709 30
Zebrafish
(Danio rerio)
Actinopterygii btbd17b 30 31
  • 63.88 (n)
OneToMany
btbd17a 31
  • 55 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000791 30
  • 46.81 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta Tango10 30 31
  • 45.19 (n)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea W07A12.4 31
  • 18 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 26 (a)
OneToMany
Species where no ortholog for BTBD17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for BTBD17 Gene

ENSEMBL:
Gene Tree for BTBD17 (if available)
TreeFam:
Gene Tree for BTBD17 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for BTBD17: view image

Paralogs for BTBD17 Gene

Paralogs for BTBD17 Gene

genes like me logo Genes that share paralogs with BTBD17: view

Variants for BTBD17 Gene

Additional dbSNP identifiers (rs#s) for BTBD17 Gene

Structural Variations from Database of Genomic Variants (DGV) for BTBD17 Gene

Variant ID Type Subtype PubMed ID
dgv12e196 CNV duplication 17116639
dgv3282n100 CNV gain 25217958
dgv372n27 CNV gain 19166990
dgv5768n54 CNV gain 21841781
esv2751770 CNV gain 17911159
esv2761978 CNV gain 21179565
esv33995 CNV loss 17666407
esv3573820 CNV gain 25503493
esv3641230 CNV gain 21293372
esv3641237 CNV gain 21293372
nsv509673 CNV insertion 20534489
nsv517569 CNV gain+loss 19592680
nsv833538 CNV gain 17160897
nsv833539 CNV loss 17160897

Variation tolerance for BTBD17 Gene

Gene Damage Index Score: 5.36; 70.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BTBD17 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BTBD17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for BTBD17 Gene

Disorders for BTBD17 Gene

No disorders were found for BTBD17 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BTBD17 Gene

Publications for BTBD17 Gene

  1. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 3 4

Products for BTBD17 Gene

Sources for BTBD17 Gene