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This gene encodes a protein that contains a BTB/POZ domain. This domain mediates protein-protein interactions. A mutation in this gene may be associated with bipolar disorder. [provided by RefSeq, Sep 2016]
BTBD16 (BTB Domain Containing 16) is a Protein Coding gene. Diseases associated with BTBD16 include Bipolar Disorder. An important paralog of this gene is GMCL2.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH10J122258 | Enhancer | 0.9 | Ensembl ENCODE dbSUPER | 42.1 | -11.8 | -11794 | 1.3 | MAFF RBM22 POLR2A BHLHE40 ZFP69B MAFK GLIS1 BACH1 | BTBD16 HSALNG0081194 piR-43583-062 TACC2 | |
GH10J122301 | Enhancer | 1 | Ensembl ENCODE dbSUPER | 35.3 | +30.7 | 30656 | 1.2 | CEBPG GATAD2A CEBPA SOX13 CEBPB FOXA2 YY1 ZBTB33 JUND KLF17 | BTBD16 HTRA1 HSALNG0081195 HSALNG0081198 PLEKHA1 | |
GH10J122284 | Enhancer | 1 | Ensembl ENCODE dbSUPER | 37.5 | +16.1 | 16061 | 4.8 | PRDM1 ZIC2 PATZ1 ZNF600 ZNF341 ESR1 ZNF23 RAD51 POLR2A ZKSCAN1 | HSALNG0081195 BTBD16 C10orf88 HTRA1 PLEKHA1 | |
GH10J122279 | Enhancer | 0.9 | Ensembl ENCODE dbSUPER | 36.8 | +9.2 | 9217 | 0.9 | CTCF PRDM10 ZSCAN4 RAD21 IRF2 TRIM22 ZBTB26 SMC3 ZNF654 ZFP64 | BTBD16 HSALNG0081195 PLEKHA1 | |
GH10J122263 | Enhancer | 0.8 | Ensembl ENCODE dbSUPER | 41.3 | -5.8 | -5840 | 2.6 | CEBPB ESR1 RCOR1 NFIB NFIA NR3C1 | BTBD16 HSALNG0081194 piR-43583-062 TACC2 |
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||||||||||||||||||||||||||
SP2: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | BTBD16 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | BTBD16 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | BTBD16 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Btbd16 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Btbd16 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | BTBD16 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | BTBD16 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | BTBD16 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | btbd16 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | gcl 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | gcl-1 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 10 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs193920863 | Uncertain Significance: Malignant tumor of prostate | 122,276,854(+) | C/T | MISSENSE_VARIANT | |
rs1048347 | - | p.His439Pro | |||
rs10510108 | - | p.Gln472Arg | |||
rs2421013 | - | p.Arg318Gln | |||
rs986178 | - | p.Gly331Asp |
Disorder | Aliases | PubMed IDs |
---|---|---|
bipolar disorder |
|
|