Aliases for BTBD16 Gene
Aliases for BTBD16 Gene
External Ids for BTBD16 Gene
- HGNC: 26340
- Entrez Gene: 118663
- Ensembl: ENSG00000138152
- UniProtKB: Q32M84
Previous HGNC Symbols for BTBD16 Gene
- C10orf87
Previous GeneCards Identifiers for BTBD16 Gene
- GC10P124022
- GC10P117661
Summaries for BTBD16 Gene
-
This gene encodes a protein that contains a BTB/POZ domain. This domain mediates protein-protein interactions. A mutation in this gene may be associated with bipolar disorder. [provided by RefSeq, Sep 2016]
GeneCards Summary for BTBD16 Gene
BTBD16 (BTB Domain Containing 16) is a Protein Coding gene. Diseases associated with BTBD16 include Bipolar Disorder. An important paralog of this gene is GMCL1.
Additional gene information for BTBD16 Gene
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BTBD16 Gene
Genomics for BTBD16 Gene
GeneHancer (GH) Regulatory Elements for BTBD16 Gene
Promoters and enhancers for BTBD16 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH10J122301 | Enhancer | 1 | ENCODE dbSUPER | 35 | +30.5 | 30493 | 0.2 | SOX13 FOXA2 KLF17 MAX CEBPG ZNF644 RAD21 RARA YY1 EGR1 | BTBD16 GC10P122346 | |
| GH10J122306 | Enhancer | 1.7 | FANTOM5 Ensembl ENCODE dbSUPER | 19.7 | +38.6 | 38576 | 6.5 | FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 IRF4 YY1 FOS REST | BTBD16 IKZF5 BUB3 NSMCE4A GC10P122346 | |
| GH10J122284 | Enhancer | 0.8 | ENCODE dbSUPER | 37.5 | +15.9 | 15852 | 4.5 | ZBTB6 BACH1 ZIC2 ZKSCAN1 RAD51 JUND GLIS2 ZNF23 POLR2A PATZ1 | BTBD16 C10orf88 HTRA1 GC10P122346 | |
| GH10J122258 | Enhancer | 0.7 | ENCODE dbSUPER | 42.1 | -11.9 | -11939 | 1.2 | ZFP69B POLR2A GLIS1 BACH1 MAFK | BTBD16 GC10M122162 | |
| GH10J122263 | Enhancer | 0.7 | ENCODE dbSUPER | 41.3 | -6.3 | -6296 | 1.6 | NFIA NFIB CEBPB RCOR1 | BTBD16 GC10M122162 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around BTBD16 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the BTBD16 gene promoter:
-
- HNF-1A
- HNF-1
- Brachyury
- SRY
- En-1
- PPAR-alpha
- C/EBPbeta
- Nkx2-2
- Cart-1
Regulatory Element Products
Genomic Locations for BTBD16 Gene
Genomic Locations for BTBD16 Gene
- chr10:122,270,828-122,338,162
- (GRCh38/hg38)
- Size:
- 67,335 bases
- Orientation:
- Plus strand
- chr10:124,030,821-124,097,677
- (GRCh37/hg19)
- Size:
- 66,857 bases
- Orientation:
- Plus strand
Genomic View for BTBD16 Gene
Genes around BTBD16 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10q26.13 by Entrez Gene
- 10q26.13 by HGNC
- 10q26.13 by Ensembl
BTBD16 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for BTBD16 Gene
Proteins for BTBD16 Gene
-
Protein details for BTBD16 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q32M84-BTBDG_HUMAN
- Recommended name:
- BTB/POZ domain-containing protein 16
- Protein Accession:
- Q32M84
- A6NM63
- Q4VXL1
- Q96LN0
Protein attributes for BTBD16 Gene
- Size:
- 506 amino acids
- Molecular mass:
- 58481 Da
- Quaternary structure:
- No Data Available
Protein Expression for BTBD16 Gene
Post-translational modifications for BTBD16 Gene
Other Protein References for BTBD16 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
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-
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Protein Products
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Assay Products
No data available for DME Specific Peptides for BTBD16 Gene
Domains & Families for BTBD16 Gene
Gene Families for BTBD16 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for BTBD16 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for BTBD16 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for BTBD16 Gene
Function for BTBD16 Gene
Phenotypes From GWAS Catalog for BTBD16 Gene
Phenotypes for BTBD16 Gene
- MGI mutant phenotypes for BTBD16:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for BTBD16:
Animal Models for BTBD16 Gene
- MGI Knock Outs for BTBD16:
-
- Btbd16 Btbd16<tm2b(EUCOMM)Hmgu>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for BTBD16
-
CRISPR Products
-
OriGene CRISPR knockouts for BTBD16
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-
Vectors and viruses for KO, Activation, Repression, and more
-
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miRNA for BTBD16 Gene
- miRTarBase miRNAs that target BTBD16
miRNA Products
Inhibitory RNA Products
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Clone Products
- Sino Biological Human cDNA Clone for BTBD16
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BTBD16
- genomics-online: cdna clones - Search results for available BTBD16 gene related products
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- Applied Biological Materials Clones for BTBD16
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for BTBD16
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BTBD16 Gene
Localization for BTBD16 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 4 |
| mitochondrion | 1 |
| peroxisome | 1 |
| cytosol | 1 |
- Cytosol (1)
- Nucleoli (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000151 | ubiquitin ligase complex | IBA | -- |
| GO:0005634 | nucleus | IBA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for BTBD16 Gene
Pathways & Interactions for BTBD16 Gene
No Data Available
Interacting Proteins for BTBD16 Gene
No data available for Pathways by source and SIGNOR curated interactions for BTBD16 Gene
Transcripts for BTBD16 Gene
mRNA/cDNA for BTBD16 Gene
- (8) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (11) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000260723 1849 bps (uc001lgc.2)
- ENST00000507495 379 bps (uc057wne.1)
- ENST00000495370 598 bps (uc057wnf.1)
Unigene Clusters for BTBD16 Gene
CRISPR Products
-
OriGene CRISPR knockouts for BTBD16
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- genomics-online: gRNA clones - Search results for available BTBD16 gene related products
- Applied Biological Materials CRISPR for BTBD16
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for BTBD16
- GenScript: Design CRISPR guide RNA sequences for BTBD16
miRNA Products
Inhibitory RNA Products
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Clone Products
- Sino Biological Human cDNA Clone for BTBD16
- VectorBuilder custom plasmid, inducible vectors for BTBD16
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for BTBD16
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BTBD16
- genomics-online: cdna clones - Search results for available BTBD16 gene related products
- orf clones - Search results for available BTBD16 gene related products
- Applied Biological Materials Clones for BTBD16
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||||||||||||
| SP2: |
Expression for BTBD16 Gene
mRNA differential expression in normal tissues according to GTEx for BTBD16 Gene
This gene is overexpressed in Bladder (x13.7), Skin - Sun Exposed (Lower leg) (x6.1), and Testis (x5.9).
This gene is overexpressed in Stomach (27.1), Prostate (20.0), Ovary (9.8), and Testis (6.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BTBD16 Gene
NURSA nuclear receptor signaling pathways regulating expression of BTBD16 Gene:
BTBD16SOURCE GeneReport for Unigene cluster for BTBD16 Gene:
Hs.422466Primer Products
-
OriGene qPCR primer pairs for BTBD16
- genomics-online: primer clones - Search results for available BTBD16 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for BTBD16 Gene
Orthologs for BTBD16 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | BTBD16 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | BTBD16 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | BTBD16 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Btbd16 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Btbd16 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | BTBD16 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | BTBD16 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | BTBD16 34 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | btbd16 34 33 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | gcl 34 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | gcl-1 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for BTBD16 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Evolution for BTBD16 Gene
- ENSEMBL:
- Gene Tree for BTBD16 (if available)
- TreeFam:
- Gene Tree for BTBD16 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for BTBD16: view image
Paralogs for BTBD16 Gene
Variants for BTBD16 Gene
| SNP ID | Clin | Chr 10 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs193920863 | uncertain-significance, Malignant tumor of prostate | 122,276,854(+) | C/T | coding_sequence_variant, intron_variant, missense_variant | |
| rs1000038018 | -- | 122,309,739(+) | C/T | intron_variant | |
| rs1000087639 | -- | 122,270,044(+) | C/G | upstream_transcript_variant | |
| rs1000119579 | -- | 122,287,167(+) | T/G | intron_variant | |
| rs1000184541 | -- | 122,276,851(+) | C/G | coding_sequence_variant, intron_variant, missense_variant |
Residual Variation Intolerance Score:
78.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.07;
80.36% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for BTBD16 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- BTBD16
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for BTBD16 Gene
Disorders for BTBD16 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| bipolar disorder |
|
|
Search BTBD16 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for BTBD16
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for BTBD16 Gene
Publications for BTBD16 Gene
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
- Genome-wide association study of bipolar disorder in European American and African American individuals. (PMID: 19488044) Smith EN … Kelsoe JR (Molecular psychiatry 2009) 3 44 58
- Molecular genetics of successful smoking cessation: convergent genome-wide association study results. (PMID: 18519826) Uhl GR … Lerman C (Archives of general psychiatry 2008) 3 44 58
- A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 44 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
Products for BTBD16 Gene
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for available BTBD16 related products ranked by validation data
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- antibodies-online: Search results for available BTBD16 related products ranked by validation data
- GeneTex BTBD16 Antibody for BTBD16
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Sources for BTBD16 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
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