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Aliases for BTBD11 Gene

Aliases for BTBD11 Gene

  • BTB Domain Containing 11 2 3 5
  • BTB/POZ Domain-Containing Protein 11 3 4
  • BTB (POZ) Domain Containing 11 2 3
  • Ankyrin Repeat And BTB/POZ Domain-Containing Protein BTBD11 3
  • ANK-Repeat BTB Domain Containing Protein 3
  • ABTB2B 3

External Ids for BTBD11 Gene

Previous GeneCards Identifiers for BTBD11 Gene

  • GC12P106531
  • GC12P106216
  • GC12P106513
  • GC12P107712
  • GC12P104772

Summaries for BTBD11 Gene

GeneCards Summary for BTBD11 Gene

BTBD11 (BTB Domain Containing 11) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity. An important paralog of this gene is ABTB2.

Additional gene information for BTBD11 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BTBD11 Gene

Genomics for BTBD11 Gene

GeneHancer (GH) Regulatory Elements for BTBD11 Gene

Promoters and enhancers for BTBD11 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I107317 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 550.8 +3.0 3002 4.9 ARID4B SIN3A ETS1 GLIS2 SP3 REST GLIS1 MXD3 HNF4A PRDM4 BTBD11 GC12P107319 ENSG00000200897 GC12P107333
GH12I107491 Enhancer 0.8 Ensembl ENCODE 27.8 +175.4 175381 1.9 SAP130 FEZF1 THRB ATF2 GABPA GLIS1 ETV4 KLF9 HNF4A NR2F6 BTBD11 ENSG00000200897 RNA5SP371 ENSG00000257579
GH12I107467 Enhancer 0.5 ENCODE 28.8 +151.0 151041 1.2 CTCF FOXA2 ZIC2 RAD21 NFE2L2 BTBD11 GC12M107479 GC12M107425
GH12I108301 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 4.4 +988.5 988458 7.7 ELF3 RAD21 EGR1 RCOR1 FOS RUNX3 EGR2 ELF1 NR2F2 ZNF217 CMKLR1 SART3 LINC01498 FICD ENSG00000257398 BTBD11 UNG CORO1C SELPLG GC12M108289
GH12I107671 Enhancer 0.7 ENCODE 9.2 +354.1 354051 0.2 SOX13 CTCF FOXA2 SAP130 MAX CEBPG ZIC2 RAD21 TEAD3 ZNF143 BTBD11 PWP1 ENSG00000222160
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around BTBD11 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the BTBD11 gene promoter:

Genomic Locations for BTBD11 Gene

Genomic Locations for BTBD11 Gene
342,475 bases
Plus strand

Genomic View for BTBD11 Gene

Genes around BTBD11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BTBD11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BTBD11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BTBD11 Gene

Proteins for BTBD11 Gene

  • Protein details for BTBD11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ankyrin repeat and BTB/POZ domain-containing protein BTBD11
    Protein Accession:
    Secondary Accessions:
    • A4FU41
    • B3KXG3
    • C9J019
    • C9JK80
    • E9PHS4
    • Q3ZTQ4
    • Q52M89
    • Q6ZV99
    • Q8N245

    Protein attributes for BTBD11 Gene

    1104 amino acids
    Molecular mass:
    120884 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAI01562.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI01564.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI46825.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAR21078.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC85963.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=EAW97799.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for BTBD11 Gene


neXtProt entry for BTBD11 Gene

Post-translational modifications for BTBD11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for BTBD11 Gene

Domains & Families for BTBD11 Gene

Gene Families for BTBD11 Gene

Suggested Antigen Peptide Sequences for BTBD11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with BTBD11: view

No data available for UniProtKB/Swiss-Prot for BTBD11 Gene

Function for BTBD11 Gene

Molecular function for BTBD11 Gene

UniProtKB/Swiss-Prot Induction:
By all-trans retinoic acid (ATRA).

Phenotypes From GWAS Catalog for BTBD11 Gene

Gene Ontology (GO) - Molecular Function for BTBD11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031625 ubiquitin protein ligase binding IBA --
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with BTBD11: view
genes like me logo Genes that share phenotypes with BTBD11: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BTBD11 Gene

Localization for BTBD11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BTBD11 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BTBD11 gene
Compartment Confidence
nucleus 3
cytosol 3
mitochondrion 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for BTBD11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0019005 SCF ubiquitin ligase complex IBA --
genes like me logo Genes that share ontologies with BTBD11: view

Pathways & Interactions for BTBD11 Gene

SuperPathways for BTBD11 Gene

No Data Available

Interacting Proteins for BTBD11 Gene

Gene Ontology (GO) - Biological Process for BTBD11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030162 regulation of proteolysis IBA --
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process IBA --
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA --
GO:0060395 SMAD protein signal transduction IBA --
genes like me logo Genes that share ontologies with BTBD11: view

No data available for Pathways by source and SIGNOR curated interactions for BTBD11 Gene

Drugs & Compounds for BTBD11 Gene

No Compound Related Data Available

Transcripts for BTBD11 Gene

Unigene Clusters for BTBD11 Gene

BTB (POZ) domain containing 11:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for BTBD11 Gene

No ASD Table

Relevant External Links for BTBD11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BTBD11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BTBD11 Gene

mRNA differential expression in normal tissues according to GTEx for BTBD11 Gene

This gene is overexpressed in Esophagus - Mucosa (x8.8).

Protein differential expression in normal tissues from HIPED for BTBD11 Gene

This gene is overexpressed in Bone marrow stromal cell (55.6) and Cerebrospinal fluid (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for BTBD11 Gene

NURSA nuclear receptor signaling pathways regulating expression of BTBD11 Gene:


SOURCE GeneReport for Unigene cluster for BTBD11 Gene:


Evidence on tissue expression from TISSUES for BTBD11 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with BTBD11: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for BTBD11 Gene

Orthologs for BTBD11 Gene

This gene was present in the common ancestor of animals.

Orthologs for BTBD11 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BTBD11 33 34
  • 98.91 (n)
(Canis familiaris)
Mammalia BTBD11 33 34
  • 94.81 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 94 (a)
-- 34
  • 93 (a)
-- 34
  • 78 (a)
(Bos Taurus)
Mammalia BTBD11 33 34
  • 93.12 (n)
(Rattus norvegicus)
Mammalia Btbd11 33
  • 91.57 (n)
(Mus musculus)
Mammalia Btbd11 33 16 34
  • 89.86 (n)
(Monodelphis domestica)
Mammalia BTBD11 34
  • 81 (a)
(Gallus gallus)
Aves BTBD11 33 34
  • 83.36 (n)
(Anolis carolinensis)
Reptilia BTBD11 34
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia btbd11 33
  • 76.86 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15727 33
(Danio rerio)
Actinopterygii btbd11a 34
  • 73 (a)
btbd11b 33 34
  • 71.31 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG43980 34
  • 23 (a)
Species where no ortholog for BTBD11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BTBD11 Gene

Gene Tree for BTBD11 (if available)
Gene Tree for BTBD11 (if available)

Paralogs for BTBD11 Gene

Paralogs for BTBD11 Gene

(1) SIMAP similar genes for BTBD11 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with BTBD11: view

Variants for BTBD11 Gene

Sequence variations from dbSNP and Humsavar for BTBD11 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs200629571 uncertain-significance, Malignant tumor of prostate 107,319,088(+) A/G/T coding_sequence_variant, genic_upstream_transcript_variant, missense_variant, upstream_transcript_variant
rs1000013886 -- 107,655,602(+) T/C intron_variant
rs1000020949 -- 107,372,099(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000024997 -- 107,583,841(+) CCC/CC intron_variant
rs1000046037 -- 107,563,627(+) A/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for BTBD11 Gene

Variant ID Type Subtype PubMed ID
dgv910e59 CNV duplication 20981092
esv1000854 CNV deletion 20482838
esv1332246 CNV deletion 17803354
esv2025373 CNV deletion 18987734
esv2746337 CNV deletion 23290073
esv2746338 CNV deletion 23290073
esv2746339 CNV deletion 23290073
esv32768 CNV gain 17666407
esv3630690 CNV loss 21293372
esv3630691 CNV loss 21293372
esv3630692 CNV gain 21293372
nsv1038935 CNV gain 25217958
nsv455705 CNV loss 19166990
nsv524699 CNV loss 19592680
nsv524835 CNV loss 19592680
nsv528273 CNV gain 19592680
nsv560091 CNV gain 21841781
nsv560092 CNV loss 21841781
nsv872 CNV insertion 18451855
nsv873 CNV deletion 18451855
nsv874 CNV insertion 18451855
nsv875 CNV deletion 18451855
nsv876 CNV insertion 18451855

Variation tolerance for BTBD11 Gene

Residual Variation Intolerance Score: 6.29% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 18.46; 98.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BTBD11 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BTBD11 Gene

Disorders for BTBD11 Gene

Additional Disease Information for BTBD11

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for BTBD11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BTBD11 Gene

Publications for BTBD11 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta GD … Pelletier L (Cell 2015) 3 58
  5. Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. (PMID: 24927181) Navarini AA … Barker JN (Nature communications 2014) 3 58

Products for BTBD11 Gene

Sources for BTBD11 Gene

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