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Aliases for BTBD10 Gene

Aliases for BTBD10 Gene

  • BTB Domain Containing 10 2 3 5
  • Glucose Metabolism-Related Protein 1 3 4
  • BTB (POZ) Domain Containing 10 2 3
  • GMRP1 3 4
  • BTB (Broad-Complex Tramtrack And Bric-A-Brac/Pox Virus And Zinc Finger) Domain-Containing Protein 10 3
  • BTB/POZ Domain-Containing Protein 10 3
  • K+ Channel Tetramerization Protein 3
  • GMRP-1 3

External Ids for BTBD10 Gene

Previous GeneCards Identifiers for BTBD10 Gene

  • GC11M013367
  • GC11M013089

Summaries for BTBD10 Gene

GeneCards Summary for BTBD10 Gene

BTBD10 (BTB Domain Containing 10) is a Protein Coding gene. Diseases associated with BTBD10 include Amyotrophic Lateral Sclerosis 1. An important paralog of this gene is KCTD20.

UniProtKB/Swiss-Prot for BTBD10 Gene

  • Plays a major role as an activator of AKT family members by inhibiting PPP2CA-mediated dephosphorylation, thereby keeping AKTs activated. Plays a role in preventing motor neuronal death and accelerating the growth of pancreatic beta cells.

Additional gene information for BTBD10 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BTBD10 Gene

Genomics for BTBD10 Gene

GeneHancer (GH) Regulatory Elements for BTBD10 Gene

Promoters and enhancers for BTBD10 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I013461 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 555.4 +0.5 474 2.9 HDGF PKNOX1 CLOCK SMAD1 ZFP64 ARID4B SIN3A DMAP1 YY1 POLR2B BTBD10 GC11P013405
GH11I013439 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 555 +22.8 22811 1.7 PKNOX1 NFYA DDX20 SP2 SP1 GATA3 POLR2A NFYB CREB1 ZNF350 BTBD10 GC11P013405
GH11I013487 Enhancer 0.9 Ensembl ENCODE 10.6 -24.2 -24240 0.7 CTCF TFAP4 ZNF792 SAP130 ARID4B DMAP1 ZNF644 KMT2B ZNF48 RAD21 ENSG00000255401 BTBD10 PIR60789
GH11I013434 Enhancer 0.4 ENCODE 21.5 +28.7 28702 0.9 ZNF623 PRDM1 ATF2 BTBD10 GC11P013405
GH11I013448 Enhancer 0.8 Ensembl ENCODE 10.3 +14.3 14296 0.4 CEBPB MZF1 CEBPG ATF2 ZBTB40 ZNF148 ATF4 ATF3 ATF7 TRIM24 BTBD10 PTH GC11P013405
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around BTBD10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the BTBD10 gene promoter:

Genomic Locations for BTBD10 Gene

Genomic Locations for BTBD10 Gene
75,302 bases
Minus strand

Genomic View for BTBD10 Gene

Genes around BTBD10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BTBD10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BTBD10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BTBD10 Gene

Proteins for BTBD10 Gene

  • Protein details for BTBD10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    BTB/POZ domain-containing protein 10
    Protein Accession:
    Secondary Accessions:
    • B7Z228
    • Q86WG1

    Protein attributes for BTBD10 Gene

    475 amino acids
    Molecular mass:
    53779 Da
    Quaternary structure:
    • Interacts (via C-terminal 330-amino-acid region) with AKT1; AKT2 and AKT3. Interacts with PPP2CA and PPP1CA.

    Alternative splice isoforms for BTBD10 Gene


neXtProt entry for BTBD10 Gene

Post-translational modifications for BTBD10 Gene

  • Ubiquitination at Lys157 and Lys211
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for BTBD10 Gene

Domains & Families for BTBD10 Gene

Gene Families for BTBD10 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for BTBD10 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with BTBD10: view

No data available for UniProtKB/Swiss-Prot for BTBD10 Gene

Function for BTBD10 Gene

Molecular function for BTBD10 Gene

UniProtKB/Swiss-Prot Function:
Plays a major role as an activator of AKT family members by inhibiting PPP2CA-mediated dephosphorylation, thereby keeping AKTs activated. Plays a role in preventing motor neuronal death and accelerating the growth of pancreatic beta cells.

Phenotypes From GWAS Catalog for BTBD10 Gene

genes like me logo Genes that share phenotypes with BTBD10: view

Animal Model Products

CRISPR Products

miRNA for BTBD10 Gene

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BTBD10 Gene

Localization for BTBD10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BTBD10 Gene

Nucleus. Cytoplasm. Note=Colocalizes with KCTD20 in filamentous structures. {ECO:0000250 UniProtKB:Q80X66}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BTBD10 gene
Compartment Confidence
nucleus 5
cytosol 3
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (3)
  • Nucleus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for BTBD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001650 fibrillar center IDA --
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with BTBD10: view

Pathways & Interactions for BTBD10 Gene

SuperPathways for BTBD10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for BTBD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042327 positive regulation of phosphorylation IEA,ISS --
GO:0044342 type B pancreatic cell proliferation ISS --
GO:1901215 negative regulation of neuron death ISS,IEA --
genes like me logo Genes that share ontologies with BTBD10: view

No data available for Pathways by source and SIGNOR curated interactions for BTBD10 Gene

Drugs & Compounds for BTBD10 Gene

(3) Drugs for BTBD10 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with BTBD10: view

Transcripts for BTBD10 Gene

Unigene Clusters for BTBD10 Gene

BTB (POZ) domain containing 10:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for BTBD10 Gene

No ASD Table

Relevant External Links for BTBD10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BTBD10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BTBD10 Gene

Protein differential expression in normal tissues from HIPED for BTBD10 Gene

This gene is overexpressed in Heart (68.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for BTBD10 Gene

Protein tissue co-expression partners for BTBD10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of BTBD10 Gene:


SOURCE GeneReport for Unigene cluster for BTBD10 Gene:


mRNA Expression by UniProt/SwissProt for BTBD10 Gene:

Tissue specificity: Ubiquitously expressed. Highly expressed in adult brain, testis, aorta and small intestine and weakly expressed in the heart, lung, liver, kidney, pancreas, spleen, thymus, prostate, ovary and colon. Down-regulated in glioma.

Evidence on tissue expression from TISSUES for BTBD10 Gene

  • Nervous system(4.9)
  • Muscle(4.2)
  • Stomach(4.2)
genes like me logo Genes that share expression patterns with BTBD10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for BTBD10 Gene

Orthologs for BTBD10 Gene

This gene was present in the common ancestor of animals.

Orthologs for BTBD10 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BTBD10 33 34
  • 99.86 (n)
(Canis familiaris)
Mammalia BTBD10 33 34
  • 95.02 (n)
(Monodelphis domestica)
Mammalia BTBD10 34
  • 95 (a)
(Ornithorhynchus anatinus)
Mammalia BTBD10 34
  • 95 (a)
(Bos Taurus)
Mammalia BTBD10 33 34
  • 92.6 (n)
(Mus musculus)
Mammalia Btbd10 33 16 34
  • 92.07 (n)
(Rattus norvegicus)
Mammalia Btbd10 33
  • 91.26 (n)
(Gallus gallus)
Aves BTBD10 33 34
  • 83.07 (n)
(Anolis carolinensis)
Reptilia BTBD10 34
  • 88 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia btbd10 33
  • 78.44 (n)
Str.11032 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.4191 33
(Danio rerio)
Actinopterygii btbd10b 33 34
  • 74.98 (n)
wufa12a08 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6042 33
fruit fly
(Drosophila melanogaster)
Insecta mri 34
  • 47 (a)
(Caenorhabditis elegans)
Secernentea snpc-1.4 34
  • 35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5266 34
  • 47 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2024 33
Species where no ortholog for BTBD10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BTBD10 Gene

Gene Tree for BTBD10 (if available)
Gene Tree for BTBD10 (if available)

Paralogs for BTBD10 Gene

Paralogs for BTBD10 Gene

(1) SIMAP similar genes for BTBD10 Gene using alignment to 10 proteins: Pseudogenes for BTBD10 Gene

genes like me logo Genes that share paralogs with BTBD10: view

Variants for BTBD10 Gene

Sequence variations from dbSNP and Humsavar for BTBD10 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000001638 -- 13,464,337(-) G/C upstream_transcript_variant
rs1000010380 -- 13,418,796(-) T/G intron_variant
rs1000022253 -- 13,458,512(-) A/C genic_upstream_transcript_variant, intron_variant
rs1000063888 -- 13,413,871(-) T/C intron_variant
rs1000090330 -- 13,407,229(-) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for BTBD10 Gene

Variant ID Type Subtype PubMed ID
nsv1053021 CNV gain 25217958

Variation tolerance for BTBD10 Gene

Residual Variation Intolerance Score: 29.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.66; 31.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BTBD10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BTBD10 Gene

Disorders for BTBD10 Gene

MalaCards: The human disease database

(1) MalaCards diseases for BTBD10 Gene - From: DISEASES

Disorder Aliases PubMed IDs
amyotrophic lateral sclerosis 1
  • als1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for BTBD10

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with BTBD10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BTBD10 Gene

Publications for BTBD10 Gene

  1. Molecular cloning and characterization of a novel human BTB domain-containing gene, BTBD10, which is down-regulated in glioma. (PMID: 15556295) Chen J … Lu Y (Gene 2004) 2 3 4 22 58
  2. Glucose metabolism-related protein 1 (GMRP1) regulates pancreatic beta cell proliferation and apoptosis via activation of Akt signalling pathway in rats and mice. (PMID: 21267538) Wang X … Hu R (Diabetologia 2011) 3 4 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for BTBD10 Gene

Sources for BTBD10 Gene

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