Aliases for BST1 Gene
External Ids for BST1 Gene
Previous GeneCards Identifiers for BST1 Gene
Bone marrow stromal cell antigen-1 is a stromal cell line-derived glycosylphosphatidylinositol-anchored molecule that facilitates pre-B-cell growth. The deduced amino acid sequence exhibits 33% similarity with CD38. BST1 expression is enhanced in bone marrow stromal cell lines derived from patients with rheumatoid arthritis. The polyclonal B-cell abnormalities in rheumatoid arthritis may be, at least in part, attributed to BST1 overexpression in the stromal cell population. [provided by RefSeq, Jul 2008]
GeneCards Summary for BST1 Gene
BST1 (Bone Marrow Stromal Cell Antigen 1) is a Protein Coding gene. Diseases associated with BST1 include Paroxysmal Nocturnal Hemoglobinuria and Rheumatoid Arthritis. Among its related pathways are Metabolism of water-soluble vitamins and cofactors and NAD metabolism. Gene Ontology (GO) annotations related to this gene include transferase activity and NAD+ nucleosidase activity. An important paralog of this gene is CD38.
UniProtKB/Swiss-Prot Summary for BST1 Gene
Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth.