Aliases for BST1 Gene
External Ids for BST1 Gene
Previous GeneCards Identifiers for BST1 Gene
Bone marrow stromal cell antigen-1 is a stromal cell line-derived glycosylphosphatidylinositol-anchored molecule that facilitates pre-B-cell growth. The deduced amino acid sequence exhibits 33% similarity with CD38. BST1 expression is enhanced in bone marrow stromal cell lines derived from patients with rheumatoid arthritis. The polyclonal B-cell abnormalities in rheumatoid arthritis may be, at least in part, attributed to BST1 overexpression in the stromal cell population. [provided by RefSeq, Jul 2008]
GeneCards Summary for BST1 Gene
BST1 (Bone Marrow Stromal Cell Antigen 1) is a Protein Coding gene. Diseases associated with BST1 include Paroxysmal Nocturnal Hemoglobinuria and Rheumatoid Arthritis. Among its related pathways are Metabolism of proteins and Innate Immune System. Gene Ontology (GO) annotations related to this gene include transferase activity and NAD+ nucleosidase activity. An important paralog of this gene is CD38.
UniProtKB/Swiss-Prot Summary for BST1 Gene
Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth.