Aliases for BSG Gene
External Ids for BSG Gene
Previous HGNC Symbols for BSG Gene
Previous GeneCards Identifiers for BSG Gene
The protein encoded by this gene, basigin, is a plasma membrane protein that is important in spermatogenesis, embryo implantation, neural network formation, and tumor progression. Basigin is also a member of the immunoglobulin superfamily, ubiquitously expressed in various tissues. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2020]
GeneCards Summary for BSG Gene
BSG (Basigin (Ok Blood Group)) is a Protein Coding gene. Diseases associated with BSG include Ameloblastoma and Alveolar Soft Part Sarcoma. Among its related pathways are Pyruvate metabolism and Citric Acid (TCA) cycle and Degradation of the extracellular matrix. Gene Ontology (GO) annotations related to this gene include mannose binding. An important paralog of this gene is NPTN.
UniProtKB/Swiss-Prot Summary for BSG Gene
Plays an important role in targeting the monocarboxylate transporters SLC16A1, SLC16A3, SLC16A8, SLC16A11 and SLC16A12 to the plasma membrane (PubMed:21778275). Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes.
[Isoform 1]: May induce the production of pro-inflammatory cytokines such as IL6 in monocytes.
(Microbial infection) Erythrocyte receptor for P.falciparum RH5 which is essential for erythrocyte invasion by the merozoite stage of P.falciparum isolates 3D7, Dd2, 7G8 and HB3 (PubMed:22080952, PubMed:26195724). Binding of P.falciparum RH5 results in BSG dimerization which triggers an increase in intracellular Ca(2+) in the erythrocyte (PubMed:28409866). This essential step leads to a rearrangement of the erythrocyte cytoskeleton required for the merozoite invasion (PubMed:28409866).