Aliases for BRWD1 Gene
External Ids for BRWD1 Gene
Previous HGNC Symbols for BRWD1 Gene
Previous GeneCards Identifiers for BRWD1 Gene
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD) residues which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 2 bromodomains and multiple WD repeats. This gene is located within the Down syndrome region-2 on chromosome 21. Alternative splicing of this gene generates multiple transcript variants encoding distinct isoforms. In mouse, this gene encodes a nuclear protein that has a polyglutamine-containing region that functions as a transcriptional activation domain which may regulate chromatin remodelling and associates with a component of the SWI/SNF chromatin remodelling complex.[provided by RefSeq, Jun 2011]
GeneCards Summary for BRWD1 Gene
BRWD1 (Bromodomain And WD Repeat Domain Containing 1) is a Protein Coding gene. Diseases associated with BRWD1 include Down Syndrome. Among its related pathways are Cytokine Signaling in Immune system and Innate Immune System. An important paralog of this gene is BRWD3.
UniProtKB/Swiss-Prot for BRWD1 Gene
May be a transcriptional activator. May be involved in chromatin remodeling (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.