Aliases for BRSK1 Gene
- BR Serine/Threonine Kinase 1 2 3 5
- Brain-Specific Serine/Threonine-Protein Kinase 1 3 4
- Synapses Of Amphids Defective Homolog 1 3 4
- Serine/Threonine-Protein Kinase BRSK1 3 4
- Serine/Threonine-Protein Kinase SAD-B 3 4
- BR Serine/Threonine-Protein Kinase 1 3 4
- Brain-Selective Kinase 1 3 4
- SAD1 Homolog 3 4
- EC 18.104.22.168 4 50
External Ids for BRSK1 Gene
Previous GeneCards Identifiers for BRSK1 Gene
GeneCards Summary for BRSK1 Gene
BRSK1 (BR Serine/Threonine Kinase 1) is a Protein Coding gene. Diseases associated with BRSK1 include Large Cell Carcinoma and Lung Large Cell Carcinoma. Among its related pathways are DNA Damage and Glucose / Energy Metabolism. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is BRSK2.
UniProtKB/Swiss-Prot Summary for BRSK1 Gene
Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C.