Aliases for BRSK1 Gene
- BR Serine/Threonine Kinase 1 2 3 5
- Brain-Specific Serine/Threonine-Protein Kinase 1 3 4
- Synapses Of Amphids Defective Homolog 1 3 4
- Serine/Threonine-Protein Kinase BRSK1 3 4
- Serine/Threonine-Protein Kinase SAD-B 3 4
- BR Serine/Threonine-Protein Kinase 1 3 4
- Brain-Selective Kinase 1 3 4
- SAD1 Homolog 3 4
- EC 220.127.116.11 4 54
External Ids for BRSK1 Gene
Previous GeneCards Identifiers for BRSK1 Gene
GeneCards Summary for BRSK1 Gene
BRSK1 (BR Serine/Threonine Kinase 1) is a Protein Coding gene. Diseases associated with BRSK1 include Lung Large Cell Carcinoma. Among its related pathways are Neuroscience and DNA Damage. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is BRSK2.
UniProtKB/Swiss-Prot Summary for BRSK1 Gene
Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C.