The protein encoded by this gene is a G protein-coupled membrane receptor that binds bombesin-like peptides. This binding results in activation of a phosphatidylinositol-calcium second messenger system, with physiological effects including regulation of metabolic rate, glucose metabolism, and hypertension. [provided by RefSeq, Sep 2011] See more...

Aliases for BRS3 Gene

Aliases for BRS3 Gene

  • Bombesin Receptor Subtype 3 2 3 5
  • Bombesin Receptor Subtype-3 3 4
  • Bombesin Like Receptor 3 2 3
  • BRS-3 3 4
  • BB3R 2 3
  • BBR3 2 3
  • BB3 2 3
  • G-Protein Coupled Receptor 3
  • BRS3 5

External Ids for BRS3 Gene

Previous GeneCards Identifiers for BRS3 Gene

  • GC0XP130142
  • GC0XP132415
  • GC0XP133514
  • GC0XP134275
  • GC0XP135295
  • GC0XP135397
  • GC0XP135570
  • GC0XP124840

Summaries for BRS3 Gene

Entrez Gene Summary for BRS3 Gene

  • The protein encoded by this gene is a G protein-coupled membrane receptor that binds bombesin-like peptides. This binding results in activation of a phosphatidylinositol-calcium second messenger system, with physiological effects including regulation of metabolic rate, glucose metabolism, and hypertension. [provided by RefSeq, Sep 2011]

GeneCards Summary for BRS3 Gene

BRS3 (Bombesin Receptor Subtype 3) is a Protein Coding gene. Diseases associated with BRS3 include Brugada Syndrome 4 and Jejunal Somatostatinoma. Among its related pathways are RET signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and bombesin receptor activity. An important paralog of this gene is GRPR.

UniProtKB/Swiss-Prot Summary for BRS3 Gene

  • Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Tocris Summary for BRS3 Gene

  • Bombesin receptors are activated by the endogenous ligands gastrin-releasing peptide (GRP), neuromedin B (NMB) and GRP18-27 (neuromedin C). Three subtypes of bombesin receptor are known: BB1, BB2 and an orphan receptor (bb3).

Gene Wiki entry for BRS3 Gene

Additional gene information for BRS3 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BRS3 Gene

Genomics for BRS3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for BRS3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ136487 Promoter 0.3 EPDnew 600.7 0.0 -19 0.1 BRS3 RF00017-8754 ADGRG4
GH0XJ136454 Enhancer 0.4 Ensembl 0.3 -33.8 -33846 0.2 FOXA1 GATA3 ZBTB40 lnc-BRS3-1 HSALNG0140326 BRS3 ADGRG4
GH0XJ136457 Enhancer 0.3 Ensembl 0.3 -30.4 -30446 0.2 PRDM6 lnc-BRS3-1 HSALNG0140326 BRS3 ADGRG4
GH0XJ136352 Enhancer 0.7 Ensembl ENCODE 0.1 -134.0 -133992 2.7 RFX1 CEBPB JUN JUND EP300 CTCF TCF7L2 FOS STK24P1 ADGRG4 RF00017-8753 BRS3
GH0XJ136395 Enhancer 0.5 Ensembl 0.2 -92.5 -92546 0.8 CEBPB ZNF316 EP300 MAFK MAFF MAP7D3 piR-59928-167 RF00017-8753 ADGRG4 BRS3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BRS3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for BRS3

Top Transcription factor binding sites by QIAGEN in the BRS3 gene promoter:
  • c-Rel
  • Evi-1
  • FOXC1
  • Gfi-1
  • HSF1 (long)
  • HSF1short
  • Pbx1a
  • PPAR-gamma1
  • PPAR-gamma2
  • STAT5A

Genomic Locations for BRS3 Gene

Genomic Locations for BRS3 Gene
chrX:136,487,947-136,493,780
(GRCh38/hg38)
Size:
5,834 bases
Orientation:
Plus strand
chrX:135,570,046-135,575,939
(GRCh37/hg19)
Size:
5,894 bases
Orientation:
Plus strand

Genomic View for BRS3 Gene

Genes around BRS3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BRS3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BRS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BRS3 Gene

Proteins for BRS3 Gene

  • Protein details for BRS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P32247-BRS3_HUMAN
    Recommended name:
    Bombesin receptor subtype-3
    Protein Accession:
    P32247

    Protein attributes for BRS3 Gene

    Size:
    399 amino acids
    Molecular mass:
    44411 Da
    Quaternary structure:
    • Interacts with C6orf89.

neXtProt entry for BRS3 Gene

Post-translational modifications for BRS3 Gene

  • Glycosylation at Asn10 and Asn18
  • Modification sites at PhosphoSitePlus

Other Protein References for BRS3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BRS3 Gene

Domains & Families for BRS3 Gene

Gene Families for BRS3 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Plasma proteins
  • Predicted membrane proteins

Protein Domains for BRS3 Gene

InterPro:
Blocks:
  • Bombesin receptor signature
  • Type 3 bombesin receptor signature
ProtoNet:

Suggested Antigen Peptide Sequences for BRS3 Gene

GenScript: Design optimal peptide antigens:
  • Bombesin receptor subtype-3 (BRS3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P32247

UniProtKB/Swiss-Prot:

BRS3_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with BRS3: view

Function for BRS3 Gene

Molecular function for BRS3 Gene

UniProtKB/Swiss-Prot Function:
Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
GENATLAS Biochemistry:
releasing peptide receptor,epidermal carcinoma

Gene Ontology (GO) - Molecular Function for BRS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IBA 21873635
GO:0004946 bombesin receptor activity TAS,IEA --
GO:0008528 G protein-coupled peptide receptor activity IEA --
genes like me logo Genes that share ontologies with BRS3: view
genes like me logo Genes that share phenotypes with BRS3: view

Animal Models for BRS3 Gene

MGI Knock Outs for BRS3:

Animal Model Products

  • Taconic Biosciences Mouse Models for BRS3

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BRS3

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BRS3 Gene

Localization for BRS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BRS3 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BRS3 gene
Compartment Confidence
plasma membrane 5
nucleus 2
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for BRS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane NAS 9367152
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane TAS 9367152
GO:0043005 neuron projection IEA --
genes like me logo Genes that share ontologies with BRS3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for BRS3 Gene

Pathways & Interactions for BRS3 Gene

genes like me logo Genes that share pathways with BRS3: view

Pathways by source for BRS3 Gene

1 KEGG pathway for BRS3 Gene
1 GeneGo (Thomson Reuters) pathway for BRS3 Gene
  • Cytoskeleton remodeling FAK signaling

Gene Ontology (GO) - Biological Process for BRS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006006 glucose metabolic process TAS 9367152
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IBA 21873635
GO:0008217 regulation of blood pressure TAS 9367152
GO:0008343 adult feeding behavior TAS 9367152
genes like me logo Genes that share ontologies with BRS3: view

No data available for SIGNOR curated interactions for BRS3 Gene

Drugs & Compounds for BRS3 Gene

(19) Drugs for BRS3 Gene - From: DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bombesin Investigational Pharma Agonist, Full agonist Involved in gastrointestinal tract function 16
[<sup>125</sup>I][D-Tyr<sup>6</sup>,&beta;-Ala<sup>11</sup>,Phe<sup>13</sup>,Nle<sup>14</sup>]bombesin-(6-14) Pharma Agonist, Full agonist 0
[D-Phe<sup>6</sup>,&beta;-Ala<sup>11</sup>,Phe<sup>13</sup>,Nle<sup>14</sup>]bombesin-(6-14) Pharma Agonist, Full agonist 0
[D-Tyr<sup>6</sup>,(R)-APA<sup>11</sup>,Phe<sup>13</sup>,Nle<sup>14</sup>]bombesin-(6-14) Pharma Agonist, Full agonist 0
[D-Tyr<sup>6</sup>,Apa-4Cl<sup>11</sup>,Phe<sup>13</sup>,Nle<sup>14</sup>]bombesin-(6-14) Pharma Agonist, Full agonist 0

(2) Additional Compounds for BRS3 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
BA 1
183241-31-8

(5) Tocris Compounds for BRS3 Gene

Compound Action Cas Number
BA 1 Potent BRS-3 agonist; also NMBR and GRPR agonist 183241-31-8
BIM 187 Bombesin/GRP receptor agonist 137734-88-4
Bombesin Involved in gastrointestinal tract function 31362-50-2
GRP (human) Endogenous GRP receptor agonist 93755-85-2
GRP (porcine) Endogenous GRP receptor agonist 74815-57-9
genes like me logo Genes that share compounds with BRS3: view

Transcripts for BRS3 Gene

mRNA/cDNA for BRS3 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BRS3

Alternative Splicing Database (ASD) splice patterns (SP) for BRS3 Gene

No ASD Table

Relevant External Links for BRS3 Gene

GeneLoc Exon Structure for
BRS3

Expression for BRS3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for BRS3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BRS3 Gene

This gene is overexpressed in Fallopian Tube (x9.5), Brain - Hypothalamus (x8.5), Brain - Nucleus accumbens (basal ganglia) (x8.5), and Ovary (x7.1).

Protein differential expression in normal tissues from HIPED for BRS3 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BRS3 Gene



Protein tissue co-expression partners for BRS3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for BRS3

SOURCE GeneReport for Unigene cluster for BRS3 Gene:

Hs.121484

mRNA Expression by UniProt/SwissProt for BRS3 Gene:

P32247-BRS3_HUMAN
Tissue specificity: In germ cells in testis. Lung carcinoma cells.

Evidence on tissue expression from TISSUES for BRS3 Gene

  • Nervous system(2.3)
  • Pancreas(2.2)
genes like me logo Genes that share expression patterns with BRS3: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for BRS3 Gene

Orthologs for BRS3 Gene

This gene was present in the common ancestor of animals.

Orthologs for BRS3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia BRS3 30 31
  • 99.92 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia BRS3 30 31
  • 90.87 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia BRS3 30 31
  • 88.27 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Brs3 30 17 31
  • 87.35 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Brs3 30
  • 86.52 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia BRS3 31
  • 66 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia BRS3 31
  • 61 (a)
OneToOne
Chicken
(Gallus gallus)
Aves BRS3 30
  • 71.2 (n)
BRS3.5 31
  • 68 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia BRS3 31
  • 66 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100488712 30
  • 66.58 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta GPRGRP2 30
  • 47.95 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CCHa2r 30 31
  • 47.73 (n)
ManyToMany
CG30106 32
  • 37 (a)
CCHa1r 31
  • 26 (a)
ManyToMany
Species where no ortholog for BRS3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for BRS3 Gene

ENSEMBL:
Gene Tree for BRS3 (if available)
TreeFam:
Gene Tree for BRS3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for BRS3: view image

Paralogs for BRS3 Gene

(9) SIMAP similar genes for BRS3 Gene using alignment to 1 proteins:

  • BRS3_HUMAN
genes like me logo Genes that share paralogs with BRS3: view

Variants for BRS3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for BRS3 Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
rs5232 - p.Thr53Pro
rs5234 - p.Leu162Gln

Additional dbSNP identifiers (rs#s) for BRS3 Gene

Structural Variations from Database of Genomic Variants (DGV) for BRS3 Gene

Variant ID Type Subtype PubMed ID
esv3577408 CNV gain 25503493

Variation tolerance for BRS3 Gene

Residual Variation Intolerance Score: 67.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.43; 9.47% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BRS3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BRS3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BRS3 Gene

Disorders for BRS3 Gene

MalaCards: The human disease database

(6) MalaCards diseases for BRS3 Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
brugada syndrome 4
  • brgda4
jejunal somatostatinoma
  • jejunal delta cell somatostatin producing tumor
lung cancer
  • adenocarcinoma of lung
small cell cancer of the lung
  • sclc1
body mass index quantitative trait locus 11
  • bmiq11
- elite association - COSMIC cancer census association via MalaCards
Search BRS3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for BRS3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with BRS3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BRS3 Gene

Publications for BRS3 Gene

  1. BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells. (PMID: 8383682) Fathi Z … Battey JF (The Journal of biological chemistry 1993) 2 3 4 23
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
  3. PPARalpha and AP-2alpha regulate bombesin receptor subtype 3 expression in ozone-stressed bronchial epithelial cells. (PMID: 17355223) Tan YR … Weber HC (The Biochemical journal 2007) 3 23
  4. BRS-3 activation transforms the effect of human bronchial epithelial cells from PGE2 mediated inhibition to TGF-beta1 dependent promotion on proliferation and collagen synthesis of lung fibroblasts. (PMID: 17714959) Wang Y … Qin X (Cell biology international 2007) 3 23
  5. Activation of bombesin receptor subtype-3 stimulates adhesion of lung cancer cells. (PMID: 16979789) Hou X … Tatamoto K (Lung cancer (Amsterdam, Netherlands) 2006) 3 23

Products for BRS3 Gene

Sources for BRS3 Gene