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The protein encoded by this gene is a G protein-coupled membrane receptor that binds bombesin-like peptides. This binding results in activation of a phosphatidylinositol-calcium second messenger system, with physiological effects including regulation of metabolic rate, glucose metabolism, and hypertension. [provided by RefSeq, Sep 2011]
BRS3 (Bombesin Receptor Subtype 3) is a Protein Coding gene. Diseases associated with BRS3 include Brugada Syndrome 4 and Jejunal Somatostatinoma. Among its related pathways are RET signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and bombesin receptor activity. An important paralog of this gene is GRPR.
Bombesin receptors are activated by the endogenous ligands gastrin-releasing peptide (GRP), neuromedin B (NMB) and GRP18-27 (neuromedin C). Three subtypes of bombesin receptor are known: BB1, BB2 and an orphan receptor (bb3).
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH0XJ136487 | Promoter | 0.3 | EPDnew | 600.7 | 0.0 | -19 | 0.1 | BRS3 RF00017-8754 ADGRG4 | ||
GH0XJ136454 | Enhancer | 0.4 | Ensembl | 0.3 | -33.8 | -33846 | 0.2 | FOXA1 GATA3 ZBTB40 | lnc-BRS3-1 HSALNG0140326 BRS3 ADGRG4 | |
GH0XJ136457 | Enhancer | 0.3 | Ensembl | 0.3 | -30.4 | -30446 | 0.2 | PRDM6 | lnc-BRS3-1 HSALNG0140326 BRS3 ADGRG4 | |
GH0XJ136352 | Enhancer | 0.7 | Ensembl ENCODE | 0.1 | -134.0 | -133992 | 2.7 | RFX1 CEBPB JUN JUND EP300 CTCF TCF7L2 FOS | STK24P1 ADGRG4 RF00017-8753 BRS3 | |
GH0XJ136395 | Enhancer | 0.5 | Ensembl | 0.2 | -92.5 | -92546 | 0.8 | CEBPB ZNF316 EP300 MAFK MAFF | MAP7D3 piR-59928-167 RF00017-8753 ADGRG4 BRS3 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004930 | G protein-coupled receptor activity | IBA | 21873635 |
GO:0004946 | bombesin receptor activity | TAS,IEA | -- |
GO:0008528 | G protein-coupled peptide receptor activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | NAS | 9367152 |
GO:0005887 | integral component of plasma membrane | IBA | 21873635 |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | TAS | 9367152 |
GO:0043005 | neuron projection | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Peptide ligand-binding receptors |
.34
|
|
2 | Signaling by GPCR | ||
3 | RET signaling | ||
4 | Development Endothelin-1/EDNRA signaling |
Cytoskeleton remodeling FAK signaling
.41
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006006 | glucose metabolic process | TAS | 9367152 |
GO:0007165 | signal transduction | IEA | -- |
GO:0007186 | G protein-coupled receptor signaling pathway | IBA | 21873635 |
GO:0008217 | regulation of blood pressure | TAS | 9367152 |
GO:0008343 | adult feeding behavior | TAS | 9367152 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Bombesin | Investigational | Pharma | Agonist, Full agonist | Involved in gastrointestinal tract function | 16 | |
[<sup>125</sup>I][D-Tyr<sup>6</sup>,β-Ala<sup>11</sup>,Phe<sup>13</sup>,Nle<sup>14</sup>]bombesin-(6-14) | Pharma | Agonist, Full agonist | 0 | |||
[D-Phe<sup>6</sup>,β-Ala<sup>11</sup>,Phe<sup>13</sup>,Nle<sup>14</sup>]bombesin-(6-14) | Pharma | Agonist, Full agonist | 0 | |||
[D-Tyr<sup>6</sup>,(R)-APA<sup>11</sup>,Phe<sup>13</sup>,Nle<sup>14</sup>]bombesin-(6-14) | Pharma | Agonist, Full agonist | 0 | |||
[D-Tyr<sup>6</sup>,Apa-4Cl<sup>11</sup>,Phe<sup>13</sup>,Nle<sup>14</sup>]bombesin-(6-14) | Pharma | Agonist, Full agonist | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
BA 1 |
|
183241-31-8 |
|
|
Compound | Action | Cas Number |
---|---|---|
BA 1 | Potent BRS-3 agonist; also NMBR and GRPR agonist | 183241-31-8 |
BIM 187 | Bombesin/GRP receptor agonist | 137734-88-4 |
Bombesin | Involved in gastrointestinal tract function | 31362-50-2 |
GRP (human) | Endogenous GRP receptor agonist | 93755-85-2 |
GRP (porcine) | Endogenous GRP receptor agonist | 74815-57-9 |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | BRS3 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | BRS3 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | BRS3 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Brs3 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Brs3 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | BRS3 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | BRS3 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | BRS3 30 |
|
||
BRS3.5 31 |
|
OneToOne | |||
Lizard (Anolis carolinensis) |
Reptilia | BRS3 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100488712 30 |
|
||
African malaria mosquito (Anopheles gambiae) |
Insecta | GPRGRP2 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | CCHa2r 30 31 |
|
ManyToMany | |
CG30106 32 |
|
|
|||
CCHa1r 31 |
|
ManyToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3577408 | CNV | gain | 25503493 |
Disorder | Aliases | PubMed IDs |
---|---|---|
brugada syndrome 4 |
|
|
jejunal somatostatinoma |
|
|
lung cancer |
|
|
small cell cancer of the lung |
|
|
body mass index quantitative trait locus 11 |
|