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The protein encoded by this gene is a G protein-coupled membrane receptor that binds bombesin-like peptides. This binding results in activation of a phosphatidylinositol-calcium second messenger system, with physiological effects including regulation of metabolic rate, glucose metabolism, and hypertension. [provided by RefSeq, Sep 2011] See more...
Aliases for BRS3 Gene
Aliases for BRS3 Gene
External Ids for BRS3 Gene
- HGNC: 1113
- Entrez Gene: 680
- Ensembl: ENSG00000102239
- OMIM: 300107
- UniProtKB: P32247
Previous GeneCards Identifiers for BRS3 Gene
- GC0XP130142
- GC0XP132415
- GC0XP133514
- GC0XP134275
- GC0XP135295
- GC0XP135397
- GC0XP135570
- GC0XP124840
Summaries for BRS3 Gene
-
The protein encoded by this gene is a G protein-coupled membrane receptor that binds bombesin-like peptides. This binding results in activation of a phosphatidylinositol-calcium second messenger system, with physiological effects including regulation of metabolic rate, glucose metabolism, and hypertension. [provided by RefSeq, Sep 2011]
GeneCards Summary for BRS3 Gene
BRS3 (Bombesin Receptor Subtype 3) is a Protein Coding gene. Diseases associated with BRS3 include Brugada Syndrome 4 and Jejunal Somatostatinoma. Among its related pathways are RET signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and bombesin receptor activity. An important paralog of this gene is GRPR.
UniProtKB/Swiss-Prot Summary for BRS3 Gene
-
Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
-
Bombesin receptors are activated by the endogenous ligands gastrin-releasing peptide (GRP), neuromedin B (NMB) and GRP18-27 (neuromedin C). Three subtypes of bombesin receptor are known: BB1, BB2 and an orphan receptor (bb3).
Additional gene information for BRS3 Gene
- HGNC(1113)
- Entrez Gene(680)
- Ensembl(ENSG00000102239)
- OMIM(300107)
- UniProtKB(P32247)
- Open Targets Platform(ENSG00000102239)
- Search for BRS3 at DataMed
- Search for BRS3 at HumanCyc
No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BRS3 Gene
Genomics for BRS3 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for BRS3 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH0XJ136487 | Promoter | 0.3 | EPDnew | 600.7 | 0.0 | -19 | 0.1 | BRS3 RF00017-8754 ADGRG4 | ||
| GH0XJ136454 | Enhancer | 0.4 | Ensembl | 0.3 | -33.8 | -33846 | 0.2 | FOXA1 GATA3 ZBTB40 | lnc-BRS3-1 HSALNG0140326 BRS3 ADGRG4 | |
| GH0XJ136457 | Enhancer | 0.3 | Ensembl | 0.3 | -30.4 | -30446 | 0.2 | PRDM6 | lnc-BRS3-1 HSALNG0140326 BRS3 ADGRG4 | |
| GH0XJ136352 | Enhancer | 0.7 | Ensembl ENCODE | 0.1 | -134.0 | -133992 | 2.7 | RFX1 CEBPB JUN JUND EP300 CTCF TCF7L2 FOS | STK24P1 ADGRG4 RF00017-8753 BRS3 | |
| GH0XJ136395 | Enhancer | 0.5 | Ensembl | 0.2 | -92.5 | -92546 | 0.8 | CEBPB ZNF316 EP300 MAFK MAFF | MAP7D3 piR-59928-167 RF00017-8753 ADGRG4 BRS3 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around BRS3 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for BRS3
- Top Transcription factor binding sites by QIAGEN in the BRS3 gene promoter:
-
- c-Rel
- Evi-1
- FOXC1
- Gfi-1
- HSF1 (long)
- HSF1short
- Pbx1a
- PPAR-gamma1
- PPAR-gamma2
- STAT5A
Genomic Locations for BRS3 Gene
Genomic Locations for BRS3 Gene
- chrX:136,487,947-136,493,780
- (GRCh38/hg38)
- Size:
- 5,834 bases
- Orientation:
- Plus strand
- chrX:135,570,046-135,575,939
- (GRCh37/hg19)
- Size:
- 5,894 bases
- Orientation:
- Plus strand
Genomic View for BRS3 Gene
Genes around BRS3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- Xq26.3 by HGNC
- Xq26.3 by Entrez Gene
- Xq26.3 by Ensembl
BRS3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for BRS3 Gene
Proteins for BRS3 Gene
-
Protein details for BRS3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P32247-BRS3_HUMAN
- Recommended name:
- Bombesin receptor subtype-3
- Protein Accession:
- P32247
Protein attributes for BRS3 Gene
- Size:
- 399 amino acids
- Molecular mass:
- 44411 Da
- Quaternary structure:
-
- Interacts with C6orf89.
Protein Expression for BRS3 Gene
Post-translational modifications for BRS3 Gene
Other Protein References for BRS3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- HUABIO Anti-Brs3 Antibody
-
Custom Antibody ServicesOriGene Antibodies for BRS3
- Novus Biologicals Antibodies for BRS3
- Invitrogen Antibodies for BRS3 (AFLGC-BRS3)
-
Santa Cruz Biotechnology (SCBT) Antibodies for BRS3
Protein Products
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- Origene Custom Protein Services for BRS3
- Novus Biologicals proteins for BRS3
-
Abcam proteins for BRS3
Assay Products
- antibodies-online: Show 7 available BRS3 Elisa Kits ranked by validation data
- Compare Top BRS3 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for BRS3 Gene
Domains & Families for BRS3 Gene
Gene Families for BRS3 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- G-protein coupled receptors
- Plasma proteins
- Predicted membrane proteins
Protein Domains for BRS3 Gene
- InterPro:
- Blocks:
-
- Bombesin receptor signature
- Type 3 bombesin receptor signature
- ProtoNet:
Suggested Antigen Peptide Sequences for BRS3 Gene
- GenScript: Design optimal peptide antigens:
-
- Bombesin receptor subtype-3 (BRS3_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P32247- Family:
-
- Belongs to the G-protein coupled receptor 1 family.
Function for BRS3 Gene
Molecular function for BRS3 Gene
- UniProtKB/Swiss-Prot Function:
- Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
- GENATLAS Biochemistry:
- releasing peptide receptor,epidermal carcinoma
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004930 | G protein-coupled receptor activity | IBA | 21873635 |
| GO:0004946 | bombesin receptor activity | TAS,IEA | -- |
| GO:0008528 | G protein-coupled peptide receptor activity | IEA | -- |
Phenotypes for BRS3 Gene
- MGI mutant phenotypes for BRS3:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for BRS3:
-
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- no effect
- Decreased viability
- Increased gamma-H2AX phosphorylation
- Decreased Salmonella enterica Typhimurium invasion
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Decreased endosome-nucleus distance (endosomes clustered in the perinuclear region)
Animal Models for BRS3 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for BRS3
CRISPR Products
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-
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-
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miRNA for BRS3 Gene
- miRTarBase miRNAs that target BRS3
miRNA Products
Inhibitory RNA Products
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Clone Products
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- Sino Biological Human cDNA Clone for BRS3
- Addgene plasmids for BRS3
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Cell Line Products
-
Horizon Cell Lines for BRS3
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BRS3 Gene
Localization for BRS3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for BRS3 Gene
- Cell membrane. Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| nucleus | 2 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| cytosol | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | NAS | 9367152 |
| GO:0005887 | integral component of plasma membrane | IBA | 21873635 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | TAS | 9367152 |
| GO:0043005 | neuron projection | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for BRS3 Gene
Pathways & Interactions for BRS3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Peptide ligand-binding receptors |
.34
|
|
| 2 | Signaling by GPCR | ||
| 3 | RET signaling | ||
| 4 | Development Endothelin-1/EDNRA signaling |
Cytoskeleton remodeling FAK signaling
.41
|
|
Pathways by source for BRS3 Gene
2 BioSystems pathways for BRS3 Gene
1 KEGG pathway for BRS3 Gene
1 GeneGo (Thomson Reuters) pathway for BRS3 Gene
- Cytoskeleton remodeling FAK signaling
Interacting Proteins for BRS3 Gene
GPS-Prot Interaction Network for BRS3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006006 | glucose metabolic process | TAS | 9367152 |
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007186 | G protein-coupled receptor signaling pathway | IBA | 21873635 |
| GO:0008217 | regulation of blood pressure | TAS | 9367152 |
| GO:0008343 | adult feeding behavior | TAS | 9367152 |
No data available for SIGNOR curated interactions for BRS3 Gene
Drugs & Compounds for BRS3 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Bombesin | Investigational | Pharma | Agonist, Full agonist | Involved in gastrointestinal tract function | 16 | |
| [<sup>125</sup>I][D-Tyr<sup>6</sup>,β-Ala<sup>11</sup>,Phe<sup>13</sup>,Nle<sup>14</sup>]bombesin-(6-14) | Pharma | Agonist, Full agonist | 0 | |||
| [D-Phe<sup>6</sup>,β-Ala<sup>11</sup>,Phe<sup>13</sup>,Nle<sup>14</sup>]bombesin-(6-14) | Pharma | Agonist, Full agonist | 0 | |||
| [D-Tyr<sup>6</sup>,(R)-APA<sup>11</sup>,Phe<sup>13</sup>,Nle<sup>14</sup>]bombesin-(6-14) | Pharma | Agonist, Full agonist | 0 | |||
| [D-Tyr<sup>6</sup>,Apa-4Cl<sup>11</sup>,Phe<sup>13</sup>,Nle<sup>14</sup>]bombesin-(6-14) | Pharma | Agonist, Full agonist | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| BA 1 |
|
183241-31-8 |
|
|
(5) Tocris Compounds for BRS3 Gene
| Compound | Action | Cas Number |
|---|---|---|
| BA 1 | Potent BRS-3 agonist; also NMBR and GRPR agonist | 183241-31-8 |
| BIM 187 | Bombesin/GRP receptor agonist | 137734-88-4 |
| Bombesin | Involved in gastrointestinal tract function | 31362-50-2 |
| GRP (human) | Endogenous GRP receptor agonist | 93755-85-2 |
| GRP (porcine) | Endogenous GRP receptor agonist | 74815-57-9 |
Transcripts for BRS3 Gene
mRNA/cDNA for BRS3 Gene
- 1 REFSEQ mRNAs :
- 2 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000370648 2773 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for BRS3 - Select products 50% OFF >
- * BRS3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for BRS3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BRS3
-
Santa Cruz Biotechnology (SCBT) CRISPR for BRS3
miRNA Products
Inhibitory RNA Products
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Clone Products
- Applied Biological Materials (abm): Clones for BRS3 - Select products 50% OFF >
- * BRS3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for BRS3
- Addgene plasmids for BRS3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BRS3
Relevant External Links for BRS3 Gene
- GeneLoc Exon Structure for
- BRS3
Expression for BRS3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Neural Tube (Nervous System)
mRNA differential expression in normal tissues according to GTEx for BRS3 Gene
This gene is overexpressed in Fallopian Tube (x9.5), Brain - Hypothalamus (x8.5), Brain - Nucleus accumbens (basal ganglia) (x8.5), and Ovary (x7.1).
This gene is overexpressed in Platelet (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BRS3 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for BRS3
SOURCE GeneReport for Unigene cluster for BRS3 Gene:
Hs.121484mRNA Expression by UniProt/SwissProt for BRS3 Gene:
P32247-BRS3_HUMAN
Tissue specificity:
In germ cells in testis. Lung carcinoma cells.
Evidence on tissue expression from TISSUES for BRS3 Gene
- Nervous system(2.3)
- Pancreas(2.2)
Primer Products
-
OriGene qPCR primer pairs for BRS3
-
OriGene qPCR primer pairs and template standards for BRS3
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for BRS3 Gene
Orthologs for BRS3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | BRS3 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | BRS3 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | BRS3 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Brs3 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Brs3 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | BRS3 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | BRS3 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | BRS3 30 |
|
||
| BRS3.5 31 |
|
OneToOne | |||
| Lizard (Anolis carolinensis) |
Reptilia | BRS3 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100488712 30 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | GPRGRP2 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CCHa2r 30 31 |
|
ManyToMany | |
| CG30106 32 |
|
|
|||
| CCHa1r 31 |
|
ManyToMany |
- Species where no ortholog for BRS3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for BRS3 Gene
- ENSEMBL:
- Gene Tree for BRS3 (if available)
- TreeFam:
- Gene Tree for BRS3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for BRS3: view image
Paralogs for BRS3 Gene
Paralogs for BRS3 Gene
(9) SIMAP similar genes for BRS3 Gene using alignment to 1 proteins:
- BRS3_HUMAN
Variants for BRS3 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3577408 | CNV | gain | 25503493 |
Residual Variation Intolerance Score:
67.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.43;
9.47% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for BRS3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- BRS3
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BRS3 Gene
Disorders for BRS3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| brugada syndrome 4 |
|
|
| jejunal somatostatinoma |
|
|
| lung cancer |
|
|
| small cell cancer of the lung |
|
|
| body mass index quantitative trait locus 11 |
|
Search BRS3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for BRS3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for BRS3 Gene
Publications for BRS3 Gene
- BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells. (PMID: 8383682) Fathi Z … Battey JF (The Journal of biological chemistry 1993) 2 3 4 23
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
- PPARalpha and AP-2alpha regulate bombesin receptor subtype 3 expression in ozone-stressed bronchial epithelial cells. (PMID: 17355223) Tan YR … Weber HC (The Biochemical journal 2007) 3 23
- BRS-3 activation transforms the effect of human bronchial epithelial cells from PGE2 mediated inhibition to TGF-beta1 dependent promotion on proliferation and collagen synthesis of lung fibroblasts. (PMID: 17714959) Wang Y … Qin X (Cell biology international 2007) 3 23
- Activation of bombesin receptor subtype-3 stimulates adhesion of lung cancer cells. (PMID: 16979789) Hou X … Tatamoto K (Lung cancer (Amsterdam, Netherlands) 2006) 3 23
ExternalLinks
Products for BRS3 Gene
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- Humanized Mice
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- antibodies-online: Show 44 available BRS3 Antibodies ranked by validation data
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- antibodies-online: Show 3 available BRS3 Proteins ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for BRS3
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Sources for BRS3 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
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