Aliases for BRS3 Gene
External Ids for BRS3 Gene
Previous GeneCards Identifiers for BRS3 Gene
The protein encoded by this gene is a G protein-coupled membrane receptor that binds bombesin-like peptides. This binding results in activation of a phosphatidylinositol-calcium second messenger system, with physiological effects including regulation of metabolic rate, glucose metabolism, and hypertension. [provided by RefSeq, Sep 2011]
GeneCards Summary for BRS3 Gene
BRS3 (Bombesin Receptor Subtype 3) is a Protein Coding gene. Diseases associated with BRS3 include Lung Cancer and Body Mass Index Quantitative Trait Locus 11. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and bombesin receptor activity. An important paralog of this gene is GRPR.
UniProtKB/Swiss-Prot for BRS3 Gene
Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Bombesin receptors are activated by the endogenous ligands gastrin-releasing peptide (GRP), neuromedin B (NMB) and GRP18-27 (neuromedin C). Three subtypes of bombesin receptor are known: BB1, BB2 and an orphan receptor (bb3).