Aliases for BRS3 Gene
Aliases for BRS3 Gene
External Ids for BRS3 Gene
- HGNC: 1113
- Entrez Gene: 680
- Ensembl: ENSG00000102239
- OMIM: 300107
- UniProtKB: P32247
Previous GeneCards Identifiers for BRS3 Gene
- GC0XP130142
- GC0XP132415
- GC0XP133514
- GC0XP134275
- GC0XP135295
- GC0XP135397
- GC0XP135570
- GC0XP124840
Summaries for BRS3 Gene
-
The protein encoded by this gene is a G protein-coupled membrane receptor that binds bombesin-like peptides. This binding results in activation of a phosphatidylinositol-calcium second messenger system, with physiological effects including regulation of metabolic rate, glucose metabolism, and hypertension. [provided by RefSeq, Sep 2011]
GeneCards Summary for BRS3 Gene
BRS3 (Bombesin Receptor Subtype 3) is a Protein Coding gene. Diseases associated with BRS3 include Lung Cancer and Body Mass Index Quantitative Trait Locus 11. Among its related pathways are Development Endothelin-1/EDNRA signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and bombesin receptor activity. An important paralog of this gene is GRPR.
UniProtKB/Swiss-Prot for BRS3 Gene
-
Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
-
Bombesin receptors are activated by the endogenous ligands gastrin-releasing peptide (GRP), neuromedin B (NMB) and GRP18-27 (neuromedin C). Three subtypes of bombesin receptor are known: BB1, BB2 and an orphan receptor (bb3).
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BRS3 Gene
Genomics for BRS3 Gene
GeneHancer (GH) Regulatory Elements for BRS3 Gene
Promoters and enhancers for BRS3 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH0XJ136487 | Promoter | 0.5 | EPDnew | 650.3 | +24.1 | 24113 | 0.1 | BRS3 HTATSF1 GC0XM136460 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around BRS3 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the BRS3 gene promoter:
-
- Gfi-1
- STAT5A
- FOXC1
- HSF1short
- HSF1 (long)
- c-Rel
- Pbx1a
- Evi-1
- PPAR-gamma1
- PPAR-gamma2
Regulatory Element Products
Genomic Locations for BRS3 Gene
Genomic Locations for BRS3 Gene
- chrX:136,463,815-136,493,780
- (GRCh38/hg38)
- Size:
- 29,966 bases
- Orientation:
- Plus strand
- chrX:135,570,046-135,575,939
- (GRCh37/hg19)
- Size:
- 5,894 bases
- Orientation:
- Plus strand
Genomic View for BRS3 Gene
Genes around BRS3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- Xq26.3 by Entrez Gene
- Xq26.3 by HGNC
- Xq26.3 by Ensembl
BRS3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for BRS3 Gene
Proteins for BRS3 Gene
-
Protein details for BRS3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P32247-BRS3_HUMAN
- Recommended name:
- Bombesin receptor subtype-3
- Protein Accession:
- P32247
Protein attributes for BRS3 Gene
- Size:
- 399 amino acids
- Molecular mass:
- 44411 Da
- Quaternary structure:
-
- Interacts with C6orf89.
Protein Expression for BRS3 Gene
Post-translational modifications for BRS3 Gene
Other Protein References for BRS3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for BRS3
- Novus Biologicals Antibodies for BRS3
- Invitrogen Antibodies for BRS3 (AFLGC-BRS3)
- antibodies-online: Search results for 115 available BRS3 Antibodies ranked by validation data
- Compare Top BRS3 Antibodies
-
Recommended
- 45 WB Antibodies (anti-human)
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- 7 IHC Antibodies (anti-human)
- 13 WB Antibodies (anti-mouse)
- 8 IHC (p) Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 8 IHC (p) Antibodies (anti-rat)
- 2 WB Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
- 45 WB Antibodies (anti-human)
- 42 IHC (p) Antibodies (anti-human)
- 7 IHC Antibodies (anti-human)
- 13 WB Antibodies (anti-mouse)
- 8 IHC (p) Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 8 IHC (p) Antibodies (anti-rat)
- 2 WB Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
- GeneTex BRS3 Antibody for BRS3
-
Boster Bio Antibodies for BRS3
-
Santa Cruz Biotechnology (SCBT) Antibodies for BRS3
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for BRS3
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- Search GeneTex for Proteins for BRS3
-
Abcam proteins for BRS3
Assay Products
No data available for DME Specific Peptides for BRS3 Gene
Domains & Families for BRS3 Gene
Gene Families for BRS3 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- G-protein coupled receptors
- Plasma proteins
- Predicted membrane proteins
Protein Domains for BRS3 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for BRS3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P32247- Family:
-
- Belongs to the G-protein coupled receptor 1 family.
Function for BRS3 Gene
Molecular function for BRS3 Gene
- UniProtKB/Swiss-Prot Function:
- Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
- GENATLAS Biochemistry:
- releasing peptide receptor,epidermal carcinoma
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004930 | G-protein coupled receptor activity | IEA | -- |
| GO:0004946 | bombesin receptor activity | IEA,TAS | -- |
| GO:0008528 | G-protein coupled peptide receptor activity | IEA | -- |
Phenotypes for BRS3 Gene
- MGI mutant phenotypes for BRS3:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for BRS3:
-
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Decreased Salmonella enterica Typhimurium invasion
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- Mildly decreased CFP-tsO45G cell surface transport
- Increased transferrin (TF) endocytosis
Animal Models for BRS3 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for BRS3
- Cyagen custom Knockout/knockin (KOKI) mouse models for BRS3
-
CRISPR Products
-
OriGene CRISPR knockouts for BRS3
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- genomics-online: gRNA clones - Search results for 71 available BRS3 gene related products
- Overview of 71 available BRS3 gene related products
-
Recommended
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- pPB-N-His
- pRFP-C-RS
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- Applied Biological Materials CRISPR for BRS3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for BRS3
- GenScript: Design CRISPR guide RNA sequences for BRS3
miRNA for BRS3 Gene
- miRTarBase miRNAs that target BRS3
miRNA Products
Inhibitory RNA Products
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- Overview of 71 available BRS3 gene related products
-
Recommended
- pCMV6-Entry
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- pPB-C-His
- pPB-N-His
- pRFP-C-RS
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- pCMV6-Entry
- pCMV6-XL4
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- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-C-His
- pPB-N-His
- pRFP-C-RS
- pGFP-V-RS
Clone Products
- Sino Biological Human cDNA Clone for BRS3
- Addgene plasmids for BRS3
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- genomics-online: cdna clones - Search results for 71 available BRS3 gene related products
- Overview of 71 available BRS3 gene related products
-
Recommended
- pCMV6-Entry
- pCMV6-XL4
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-C-His
- pPB-N-His
- pRFP-C-RS
- pGFP-V-RS
- pCMV6-Entry
- pCMV6-XL4
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-C-His
- pPB-N-His
- pRFP-C-RS
- pGFP-V-RS
- orf clones - Search results for 71 available BRS3 gene related products
- Overview of 71 available BRS3 gene related products
-
Recommended
- pCMV6-Entry
- pCMV6-XL4
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-C-His
- pPB-N-His
- pRFP-C-RS
- pGFP-V-RS
- pCMV6-Entry
- pCMV6-XL4
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-C-His
- pPB-N-His
- pRFP-C-RS
- pGFP-V-RS
- Applied Biological Materials Clones for BRS3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for BRS3
Cell Line Products
-
Horizon Cell Lines for BRS3
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BRS3 Gene
Localization for BRS3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for BRS3 Gene
- Cell membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | IEA,NAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA,TAS | -- |
| GO:0043005 | neuron projection | IEA | -- |
| GO:0043025 | neuronal cell body | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for BRS3 Gene
Pathways & Interactions for BRS3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Peptide ligand-binding receptors |
.34
|
|
| 2 | Signaling by GPCR | ||
| 3 | RET signaling | ||
| 4 | Development Endothelin-1/EDNRA signaling | ||
Pathways by source for BRS3 Gene
2 BioSystems pathways for BRS3 Gene
1 KEGG pathway for BRS3 Gene
1 GeneGo (Thomson Reuters) pathway for BRS3 Gene
Interacting Proteins for BRS3 Gene
GPS-Prot Interaction Network for BRS3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006006 | glucose metabolic process | TAS | 9367152 |
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007186 | G-protein coupled receptor signaling pathway | IEA | -- |
| GO:0008217 | regulation of blood pressure | TAS | 9367152 |
| GO:0008343 | adult feeding behavior | TAS | 9367152 |
No data available for SIGNOR curated interactions for BRS3 Gene
Drugs & Compounds for BRS3 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| calcium | Approved | Nutra | 0 | |||
| Bombesin | Investigational | Pharma | Full agonist, Agonist | Involved in gastrointestinal tract function | 9 | |
| [D-Tyr<sup>6</sup>,(R)-APA<sup>11</sup>,Phe<sup>13</sup>,Nle<sup>14</sup>]bombesin-(6-14) | Pharma | Full agonist, Agonist | 0 | |||
| [D-Tyr<sup>6</sup>,Apa-4Cl<sup>11</sup>,Phe<sup>13</sup>,Nle<sup>14</sup>]bombesin-(6-14) | Pharma | Full agonist, Agonist | 0 | |||
| Bag-1 | Pharma | Full agonist, Agonist | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| [<sup>125</sup>I][D-Tyr<sup>6</sup>,beta-Ala<sup>11</sup>,Phe<sup>13</sup>,Nle<sup>14</sup>]bombesin-(6-14) |
|
Full agonist, Agonist |
|
|||
| [D-Phe<sup>6</sup>,beta-Ala<sup>11</sup>,Phe<sup>13</sup>,Nle<sup>14</sup>]bombesin-(6-14) |
|
Full agonist, Agonist |
|
|||
| Ac-Phe-Trp-Ala-His(tauBZL)-Nip-Gly-Arg-NH<sub>2</sub> |
|
Full agonist, Agonist |
|
|||
| BA 1 |
|
183241-31-8 |
|
|
(5) Tocris Compounds for BRS3 Gene
| Compound | Action | Cas Number |
|---|---|---|
| BA 1 | Potent BRS-3 agonist; also NMBR and GRPR agonist | 183241-31-8 |
| BIM 187 | Bombesin/GRP receptor agonist | 137734-88-4 |
| Bombesin | Involved in gastrointestinal tract function | 31362-50-2 |
| GRP (human) | Endogenous GRP receptor agonist | 93755-85-2 |
| GRP (porcine) | Endogenous GRP receptor agonist | 74815-57-9 |
Drug Products
Transcripts for BRS3 Gene
mRNA/cDNA for BRS3 Gene
- (1) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (8) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000370648 2833 bps (uc004ezv.2)
Unigene Clusters for BRS3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for BRS3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BRS3
- genomics-online: gRNA clones - Search results for 71 available BRS3 gene related products
- Overview of 71 available BRS3 gene related products
-
Recommended
- pCMV6-Entry
- pCMV6-XL4
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-C-His
- pPB-N-His
- pRFP-C-RS
- pGFP-V-RS
- pCMV6-Entry
- pCMV6-XL4
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-C-His
- pPB-N-His
- pRFP-C-RS
- pGFP-V-RS
- Applied Biological Materials CRISPR for BRS3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for BRS3
- GenScript: Design CRISPR guide RNA sequences for BRS3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BRS3
- Browse OriGene Inhibitory RNA Products For BRS3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BRS3
- genomics-online: shRNA clones - Search results for 71 available BRS3 gene related products
- Overview of 71 available BRS3 gene related products
-
Recommended
- pCMV6-Entry
- pCMV6-XL4
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-C-His
- pPB-N-His
- pRFP-C-RS
- pGFP-V-RS
- pCMV6-Entry
- pCMV6-XL4
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-C-His
- pPB-N-His
- pRFP-C-RS
- pGFP-V-RS
Clone Products
- Sino Biological Human cDNA Clone for BRS3
- Addgene plasmids for BRS3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BRS3
- genomics-online: cdna clones - Search results for 71 available BRS3 gene related products
- Overview of 71 available BRS3 gene related products
-
Recommended
- pCMV6-Entry
- pCMV6-XL4
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-C-His
- pPB-N-His
- pRFP-C-RS
- pGFP-V-RS
- pCMV6-Entry
- pCMV6-XL4
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-C-His
- pPB-N-His
- pRFP-C-RS
- pGFP-V-RS
- orf clones - Search results for 71 available BRS3 gene related products
- Overview of 71 available BRS3 gene related products
-
Recommended
- pCMV6-Entry
- pCMV6-XL4
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-C-His
- pPB-N-His
- pRFP-C-RS
- pGFP-V-RS
- pCMV6-Entry
- pCMV6-XL4
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-C-His
- pPB-N-His
- pRFP-C-RS
- pGFP-V-RS
- Applied Biological Materials Clones for BRS3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for BRS3
Expression for BRS3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Neural Tube (Nervous System)
mRNA differential expression in normal tissues according to GTEx for BRS3 Gene
This gene is overexpressed in Fallopian Tube (x9.5), Brain - Hypothalamus (x8.5), Brain - Nucleus accumbens (basal ganglia) (x8.5), and Ovary (x7.1).
This gene is overexpressed in Platelet (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BRS3 Gene
NURSA nuclear receptor signaling pathways regulating expression of BRS3 Gene:
BRS3SOURCE GeneReport for Unigene cluster for BRS3 Gene:
Hs.121484mRNA Expression by UniProt/SwissProt for BRS3 Gene:
P32247-BRS3_HUMAN
Tissue specificity:
In germ cells in testis. Lung carcinoma cells.
Primer Products
-
OriGene qPCR primer pairs for BRS3
-
OriGene qPCR primer pairs and template standards for BRS3
- genomics-online: primer clones - Search results for 71 available BRS3 gene related products
- Overview of 71 available BRS3 gene related products
-
Recommended
- pCMV6-Entry
- pCMV6-XL4
- pcDNA3.1+C-(K)-DYK
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- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-C-His
- pPB-N-His
- pRFP-C-RS
- pGFP-V-RS
- pCMV6-Entry
- pCMV6-XL4
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
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- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-C-His
- pPB-N-His
- pRFP-C-RS
- pGFP-V-RS
Gene Expression Assay Products
No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for BRS3 Gene
Orthologs for BRS3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | BRS3 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | BRS3 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | BRS3 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Brs3 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Brs3 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | BRS3 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | BRS3 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | BRS3 33 |
|
||
| BRS3.5 34 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | BRS3 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100488712 33 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | GPRGRP2 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CCHa2r 34 33 |
|
ManyToMany | |
| CG30106 35 |
|
|
|||
| CCHa1r 34 |
|
ManyToMany |
- Species where no ortholog for BRS3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Evolution for BRS3 Gene
- ENSEMBL:
- Gene Tree for BRS3 (if available)
- TreeFam:
- Gene Tree for BRS3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for BRS3: view image
Paralogs for BRS3 Gene
Variants for BRS3 Gene
| SNP ID | Clin | Chr 0X pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000432052 | -- | 136,488,672(+) | G/C | intron_variant | |
| rs1001041241 | -- | 136,487,812(+) | A/G | upstream_transcript_variant | |
| rs1001536047 | -- | 136,486,857(+) | G/A | upstream_transcript_variant | |
| rs1002810040 | -- | 136,486,677(+) | C/T | upstream_transcript_variant | |
| rs1004999274 | -- | 136,486,045(+) | G/A | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3577408 | CNV | gain | 25503493 |
Residual Variation Intolerance Score:
67.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.43;
9.47% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for BRS3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- BRS3
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BRS3 Gene
Disorders for BRS3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| lung cancer |
|
|
| body mass index quantitative trait locus 11 |
|
Search BRS3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for BRS3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for BRS3 Gene
Publications for BRS3 Gene
- BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells. (PMID: 8383682) Fathi Z … Battey JF (The Journal of biological chemistry 1993) 2 3 4 22 58
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
- PPARalpha and AP-2alpha regulate bombesin receptor subtype 3 expression in ozone-stressed bronchial epithelial cells. (PMID: 17355223) Tan YR … Weber HC (The Biochemical journal 2007) 3 22 58
- BRS-3 activation transforms the effect of human bronchial epithelial cells from PGE2 mediated inhibition to TGF-beta1 dependent promotion on proliferation and collagen synthesis of lung fibroblasts. (PMID: 17714959) Wang Y … Qin X (Cell biology international 2007) 3 22 58
- Activation of bombesin receptor subtype-3 stimulates adhesion of lung cancer cells. (PMID: 16979789) Hou X … Tatamoto K (Lung cancer (Amsterdam, Netherlands) 2006) 3 22 58
Products for BRS3 Gene
- Browse R&D Systems for Antibodies
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- Taconic Biosciences Mouse Models for BRS3
- Find your next knockout model in the Taconic Knockout Repository
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- antibodies-online: Search results for 115 available BRS3 Antibodies ranked by validation data
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- GeneTex BRS3 Antibody for BRS3
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- genomics-online: cdna clones - Search results for 71 available BRS3 gene related products
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- Overview of 71 available BRS3 gene related products
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- Boster Bio Antibodies for BRS3
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Sources for BRS3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt