Aliases for BRPF1 Gene
External Ids for BRPF1 Gene
Previous GeneCards Identifiers for BRPF1 Gene
This gene encodes a bromodomain, PHD finger and chromo/Tudor-related Pro-Trp-Trp-Pro (PWWP) domain containing protein. The encoded protein is a component of the MOZ/MORF histone acetyltransferase complexes which function as a transcriptional regulators. This protein binds to the catalytic MYST domains of the MOZ and MORF proteins and may play a role in stimulating acetyltransferase and transcriptional activity of the complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
GeneCards Summary for BRPF1 Gene
BRPF1 (Bromodomain And PHD Finger Containing 1) is a Protein Coding gene. Diseases associated with BRPF1 include Intellectual Developmental Disorder With Dysmorphic Facies And Ptosis and Cerebellar Atrophy, Developmental Delay, And Seizures. Among its related pathways are Regulation of TP53 Activity and Regulation of TP53 Activity through Acetylation. An important paralog of this gene is BRPF3.
UniProtKB/Swiss-Prot for BRPF1 Gene
Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (PubMed:16387653, PubMed:27939640). Preferentially mediates histone H3-K23 acetylation (PubMed:27939640). Positively regulates the transcription of RUNX1 and RUNX2 (PubMed:18794358).
Bromodomains (BRDs) are epigenetic reader domains that selectively recognize acetylated lysine residues on the tails of histone proteins, and are the only known protein modules that can target acetylated lysine residues.