Aliases for BROX Gene

Aliases for BROX Gene

  • BRO1 Domain And CAAX Motif Containing 2 3 5
  • BRO1 Domain-Containing Protein BROX 3 4
  • C1orf58 3 4
  • BRO1 Domain- And CAAX Motif-Containing Protein 4
  • Chromosome 1 Open Reading Frame 58 2
  • BRO1 Domain Containing Protein 2
  • FLJ32421 2
  • BROFTI 4
  • BROX 5

External Ids for BROX Gene

Previous HGNC Symbols for BROX Gene

  • C1orf58

Previous GeneCards Identifiers for BROX Gene

  • GC01P222886

Summaries for BROX Gene

GeneCards Summary for BROX Gene

BROX (BRO1 Domain And CAAX Motif Containing) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BROX Gene

Genomics for BROX Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for BROX Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BROX on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for BROX

Genomic Locations for BROX Gene

Latest Assembly
chr1:222,712,553-222,735,196
(GRCh38/hg38)
Size:
22,644 bases
Orientation:
Plus strand

Previous Assembly
chr1:222,885,906-222,908,529
(GRCh37/hg19 by Entrez Gene)
Size:
22,624 bases
Orientation:
Plus strand

chr1:222,885,895-222,908,538
(GRCh37/hg19 by Ensembl)
Size:
22,644 bases
Orientation:
Plus strand

Genomic View for BROX Gene

Genes around BROX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BROX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BROX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BROX Gene

Proteins for BROX Gene

  • Protein details for BROX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VW32-BROX_HUMAN
    Recommended name:
    BRO1 domain-containing protein BROX
    Protein Accession:
    Q5VW32
    Secondary Accessions:
    • B7Z9G5
    • Q96MG1

    Protein attributes for BROX Gene

    Size:
    411 amino acids
    Molecular mass:
    46476 Da
    Quaternary structure:
    • Interacts with CHMP4B.

    Three dimensional structures from OCA and Proteopedia for BROX Gene

    Alternative splice isoforms for BROX Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BROX Gene

Post-translational modifications for BROX Gene

  • Ubiquitination at Lys155 and Lys334
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for BROX Gene

Domains & Families for BROX Gene

Gene Families for BROX Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for BROX Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for BROX Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ78829 (B7Z9G5_HUMAN)
  • BRO1 domain- and CAAX motif-containing protein (BROX_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5VW32

UniProtKB/Swiss-Prot:

BROX_HUMAN :
  • Belongs to the BROX family.
Family:
  • Belongs to the BROX family.
genes like me logo Genes that share domains with BROX: view

Function for BROX Gene

Gene Ontology (GO) - Molecular Function for BROX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22484091
genes like me logo Genes that share ontologies with BROX: view
genes like me logo Genes that share phenotypes with BROX: view

miRNA for BROX Gene

miRTarBase miRNAs that target BROX

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BROX

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BROX Gene

Localization for BROX Gene

Subcellular locations from UniProtKB/Swiss-Prot for BROX Gene

Membrane. Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BROX gene
Compartment Confidence
extracellular 4
nucleus 2
endosome 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
cytosol 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for BROX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with BROX: view

Pathways & Interactions for BROX Gene

PathCards logo

SuperPathways for BROX Gene

No Data Available

Gene Ontology (GO) - Biological Process for BROX Gene

None

No data available for Pathways by source and SIGNOR curated interactions for BROX Gene

Drugs & Compounds for BROX Gene

No Compound Related Data Available

Transcripts for BROX Gene

mRNA/cDNA for BROX Gene

6 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BROX

Alternative Splicing Database (ASD) splice patterns (SP) for BROX Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1: - -
SP2:
SP3:

Relevant External Links for BROX Gene

GeneLoc Exon Structure for
BROX

Expression for BROX Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for BROX Gene

Protein differential expression in normal tissues from HIPED for BROX Gene

This gene is overexpressed in Urine (9.3) and Heart (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for BROX Gene



Protein tissue co-expression partners for BROX Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for BROX

SOURCE GeneReport for Unigene cluster for BROX Gene:

Hs.552608

Evidence on tissue expression from TISSUES for BROX Gene

  • Nervous system(4.4)
  • Muscle(4.3)
genes like me logo Genes that share expression patterns with BROX: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for BROX Gene

Orthologs for BROX Gene

This gene was present in the common ancestor of animals.

Orthologs for BROX Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia BROX 30 31
  • 99.43 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia BROX 30 31
  • 93.67 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia BROX 30 31
  • 92.62 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia BROX 31
  • 90 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia BROX 31
  • 89 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Brox 30
  • 85.89 (n)
Mouse
(Mus musculus)
Mammalia Brox 30 17 31
  • 85.81 (n)
OneToOne
Chicken
(Gallus gallus)
Aves BROX 30 31
  • 79.56 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia BROX 31
  • 86 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia brox 30
  • 73.64 (n)
Zebrafish
(Danio rerio)
Actinopterygii brox 30 31
  • 67.32 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea B0507.2 30 31
  • 51.82 (n)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.6818 31
  • 46 (a)
OneToOne
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.4626 30
Species where no ortholog for BROX was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for BROX Gene

ENSEMBL:
Gene Tree for BROX (if available)
TreeFam:
Gene Tree for BROX (if available)
Aminode:
Evolutionary constrained regions (ECRs) for BROX: view image

Paralogs for BROX Gene

No data available for Paralogs for BROX Gene

Variants for BROX Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for BROX Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs17163847 Benign: not provided 222,725,482(+) G/A
NM_144695.4(BROX):c.507G>A (p.Ala169=)
SYNONYMOUS
rs73124896 Benign: not provided 222,718,983(+) C/A
NM_144695.4(BROX):c.160C>A (p.Pro54Thr)
MISSENSE_VARIANT,FIVE_PRIME_UTR

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for BROX Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for BROX Gene

Variant ID Type Subtype PubMed ID
esv2668629 CNV deletion 23128226
esv3588948 CNV loss 21293372

Variation tolerance for BROX Gene

Residual Variation Intolerance Score: 13.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.15; 38.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BROX Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BROX

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BROX Gene

Disorders for BROX Gene

Additional Disease Information for BROX

No disorders were found for BROX Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BROX Gene

Publications for BROX Gene

  1. Brox, a novel farnesylated Bro1 domain-containing protein that associates with charged multivesicular body protein 4 (CHMP4). (PMID: 18190528) Ichioka F … Maki M (The FEBS journal 2008) 2 3 4
  2. Towards complete sets of farnesylated and geranylgeranylated proteins. (PMID: 17411337) Maurer-Stroh S … Eisenhaber F (PLoS computational biology 2007) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer. (PMID: 32416067) Shu S … Polyak K (Molecular cell 2020) 3
  5. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. (PMID: 30021884) Fasci D … Heck AJR (Molecular & cellular proteomics : MCP 2018) 3

Products for BROX Gene

Sources for BROX Gene