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The protein encoded by this gene shows sequence similarity to the human breast carcinoma metastasis suppressor (BRMS1) protein and the mammalian Sds3 (suppressor of defective silencing 3) proteins. This protein is a component of the mSin3a family of histone deacetylase complexes (HDAC). [provided by RefSeq, Jul 2008]
BRMS1L (BRMS1 Like Transcriptional Repressor) is a Protein Coding gene. Diseases associated with BRMS1L include Breast Cancer. Gene Ontology (GO) annotations related to this gene include histone deacetylase binding and histone deacetylase activity. An important paralog of this gene is BRMS1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004407 | contributes_to histone deacetylase activity | IBA | 21873635 |
GO:0005515 | protein binding | IPI | 25416956 |
GO:0042826 | histone deacetylase binding | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA | -- |
GO:0070822 | Sin3-type complex | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | IBA | 21873635 |
GO:0016575 | histone deacetylation | IBA | 21873635 |
GO:0040008 | regulation of growth | IEA | -- |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Dog (Canis familiaris) |
Mammalia | BRMS1L 31 |
|
OneToOne | |
LOC480292 30 |
|
||||
Chimpanzee (Pan troglodytes) |
Mammalia | BRMS1L 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | BRMS1L 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | BRMS1L 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | BRMS1L 30 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Rat (Rattus norvegicus) |
Mammalia | LOC100910898 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Brms1l 30 17 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | BRMS1L 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | BRMS1L 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | brms1l 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.21343 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | brms1lb 31 |
|
OneToMany | |
brms1la 30 31 |
|
OneToMany | |||
-- 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.443 30 |
|
||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP002712 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG4400 30 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.8326 31 |
|
OneToMany |
Disorder | Aliases | PubMed IDs |
---|---|---|
breast cancer |
|
|