Aliases for BRMS1L Gene
Aliases for BRMS1L Gene
External Ids for BRMS1L Gene
- HGNC: 20512
- Entrez Gene: 84312
- Ensembl: ENSG00000100916
- UniProtKB: Q5PSV4
Previous HGNC Symbols for BRMS1L Gene
- BRMS1
Previous GeneCards Identifiers for BRMS1L Gene
- GC14P034286
- GC14P034287
- GC14P035365
- GC14P036295
- GC14P016409
Summaries for BRMS1L Gene
-
The protein encoded by this gene shows sequence similarity to the human breast carcinoma metastasis suppressor (BRMS1) protein and the mammalian Sds3 (suppressor of defective silencing 3) proteins. This protein is a component of the mSin3a family of histone deacetylase complexes (HDAC). [provided by RefSeq, Jul 2008]
GeneCards Summary for BRMS1L Gene
BRMS1L (BRMS1 Like Transcriptional Repressor) is a Protein Coding gene. Diseases associated with BRMS1L include Breast Cancer and Lacrimal Gland Adenocarcinoma. Gene Ontology (GO) annotations related to this gene include histone deacetylase binding and histone deacetylase activity. An important paralog of this gene is BRMS1.
UniProtKB/Swiss-Prot for BRMS1L Gene
-
Involved in the histone deacetylase (HDAC1)-dependent transcriptional repression activity. When overexpressed in lung cancer cell line that lacks p53/TP53 expression, inhibits cell growth.
Additional gene information for BRMS1L Gene
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BRMS1L Gene
Genomics for BRMS1L Gene
GeneHancer (GH) Regulatory Elements for BRMS1L Gene
Promoters and enhancers for BRMS1L Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH14J035825 | Promoter/Enhancer | 2.1 | EPDnew Ensembl ENCODE | 650.7 | 0.0 | -2 | 2.2 | HDGF FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 | BRMS1L ENSG00000258938 RALGAPA1 DNAJC8P1 NUTF2P2 | |
| GH14J035827 | Enhancer | 0.2 | ENCODE | 650.7 | +1.3 | 1342 | 0.2 | BRMS1L ENSG00000258938 ENSG00000257272 | ||
| GH14J035856 | Enhancer | 0.8 | ENCODE | 12.3 | +30.1 | 30131 | 0.8 | PKNOX1 STAT5A BMI1 BATF IRF4 ATF7 ETV6 BCLAF1 IKZF2 RUNX3 | RALGAPA1 BRMS1L ENSG00000257272 ENSG00000258938 | |
| GH14J035415 | Enhancer | 1.5 | FANTOM5 Ensembl ENCODE dbSUPER | 1.2 | -409.4 | -409373 | 3.9 | HDGF PKNOX1 RB1 STAT5A BMI1 BATF KLF5 IRF4 ZNF614 ZNF143 | CFL2 RNU1-27P EAPP SRP54-AS1 INSM2 RALGAPA1 NFKBIA FAM177A1 BRMS1L PPP2R3C | |
| GH14J035821 | Enhancer | 0.9 | ENCODE | 0.7 | -4.3 | -4268 | 0.2 | ATF1 MLX ARID4B GTF3C2 SLC30A9 ZNF143 SP5 MIER2 PPARG KAT8 | BRMS1L NUTF2P2 ENSG00000258938 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around BRMS1L on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for BRMS1L Gene
Genomic Locations for BRMS1L Gene
- chr14:35,826,318-35,932,325
- (GRCh38/hg38)
- Size:
- 106,008 bases
- Orientation:
- Plus strand
- chr14:36,295,524-36,401,531
- (GRCh37/hg19)
Genomic View for BRMS1L Gene
Genes around BRMS1L on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q13.2 by Entrez Gene
- 14q13.2 by HGNC
- 14q13.2 by Ensembl
BRMS1L Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for BRMS1L Gene
Proteins for BRMS1L Gene
-
Protein details for BRMS1L Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q5PSV4-BRM1L_HUMAN
- Recommended name:
- Breast cancer metastasis-suppressor 1-like protein
- Protein Accession:
- Q5PSV4
- A6NFW5
- A6NH45
- B2RD65
- Q9BRI4
Protein attributes for BRMS1L Gene
- Size:
- 323 amino acids
- Molecular mass:
- 37629 Da
- Quaternary structure:
-
- Component of the Sin3/HDAC1 corepressor complex at least composed of BRMS1, BRMS1L and ING2/ING1L. Interacts with HDAC and SIN3A.
Protein Expression for BRMS1L Gene
Post-translational modifications for BRMS1L Gene
Other Protein References for BRMS1L Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for BRMS1L
- Novus Biologicals Antibodies for BRMS1L
- Invitrogen Antibodies for BRMS1L
- GeneTex BRMS1L Antibody for BRMS1L
-
Boster Bio Antibodies for BRMS1L
Protein Products
-
OriGene Purified Proteins for BRMS1L
- Search Origene for MassSpec and Protein Over-expression Lysates for BRMS1L
- Origene Custom Protein Services for BRMS1L
- Novus Biologicals proteins for BRMS1L
- antibodies-online: Search results for 6 available BRMS1L Proteins ranked by validation data
- Compare Top BRMS1L Proteins
-
Quality Products:
- Search GeneTex for Proteins for BRMS1L
Assay Products
No data available for DME Specific Peptides for BRMS1L Gene
Domains & Families for BRMS1L Gene
Gene Families for BRMS1L Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Suggested Antigen Peptide Sequences for BRMS1L Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q5PSV4- Family:
-
- Belongs to the BRMS1 family.
Function for BRMS1L Gene
Molecular function for BRMS1L Gene
- UniProtKB/Swiss-Prot Function:
- Involved in the histone deacetylase (HDAC1)-dependent transcriptional repression activity. When overexpressed in lung cancer cell line that lacks p53/TP53 expression, inhibits cell growth.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004407 | contributes_to histone deacetylase activity | IBA | -- |
| GO:0005515 | protein binding | IPI | 25416956 |
| GO:0042826 | histone deacetylase binding | IBA | -- |
Phenotypes for BRMS1L Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for BRMS1L
-
CRISPR Products
-
OriGene CRISPR knockouts for BRMS1L
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- genomics-online: gRNA clones - Search results for 105 available BRMS1L gene related products
- Overview of 105 available BRMS1L gene related products
- Applied Biological Materials CRISPR for BRMS1L
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for BRMS1L
- GenScript: Design CRISPR guide RNA sequences for BRMS1L
miRNA for BRMS1L Gene
- miRTarBase miRNAs that target BRMS1L
-
- hsa-mir-106b-5p (MIRT020480)
- hsa-mir-142-3p (MIRT021608)
- hsa-mir-181a-5p (MIRT025127)
- hsa-mir-196a-5p (MIRT048172)
- hsa-mir-190a-3p (MIRT069886)
- hsa-mir-5011-5p (MIRT069894)
- hsa-mir-377-5p (MIRT069911)
- hsa-mir-6086 (MIRT069924)
- hsa-mir-17-5p (MIRT138109)
- hsa-mir-20a-5p (MIRT138110)
- hsa-mir-93-5p (MIRT138112)
- hsa-mir-20b-5p (MIRT138116)
- hsa-mir-519d-3p (MIRT138120)
- hsa-mir-4733-3p (MIRT138126)
- hsa-mir-32-5p (MIRT190971)
- hsa-mir-92a-3p (MIRT190972)
- hsa-mir-92b-3p (MIRT190975)
- hsa-mir-488-3p (MIRT448077)
- hsa-mir-4711-3p (MIRT448078)
- hsa-mir-431-5p (MIRT448079)
- hsa-mir-4635 (MIRT448080)
- hsa-mir-3163 (MIRT448081)
- hsa-mir-4311 (MIRT448082)
- hsa-mir-3662 (MIRT448083)
- hsa-mir-1185-2-3p (MIRT524710)
- hsa-mir-1185-1-3p (MIRT524711)
- hsa-let-7f-2-3p (MIRT524712)
- hsa-mir-4789-5p (MIRT524713)
- hsa-mir-3941 (MIRT524714)
- hsa-mir-4789-3p (MIRT524715)
- hsa-mir-603 (MIRT524716)
- hsa-mir-362-3p (MIRT524717)
- hsa-mir-329-3p (MIRT524718)
- hsa-mir-8485 (MIRT524719)
- hsa-mir-575 (MIRT638942)
- hsa-mir-4676-5p (MIRT638943)
- hsa-mir-6856-3p (MIRT638944)
- hsa-mir-6773-5p (MIRT672538)
- hsa-mir-6724-5p (MIRT672539)
- hsa-mir-7977 (MIRT672540)
- hsa-mir-6508-3p (MIRT672541)
- hsa-mir-4726-5p (MIRT672542)
- hsa-mir-4640-5p (MIRT672543)
- hsa-mir-24-3p (MIRT672544)
- hsa-mir-4284 (MIRT672545)
- hsa-mir-3934-5p (MIRT672546)
- hsa-mir-383-3p (MIRT672547)
- hsa-mir-6794-3p (MIRT672548)
- hsa-mir-6879-3p (MIRT672549)
- hsa-mir-4524a-3p (MIRT672550)
- hsa-mir-215-3p (MIRT672551)
- hsa-mir-6773-3p (MIRT672552)
- hsa-mir-1304-3p (MIRT672553)
- hsa-mir-4494 (MIRT672554)
- hsa-mir-4639-3p (MIRT672555)
- hsa-mir-1226-3p (MIRT672556)
- hsa-mir-5007-5p (MIRT672557)
- hsa-mir-4463 (MIRT672558)
- hsa-mir-3664-5p (MIRT672559)
- hsa-mir-4797-5p (MIRT672560)
- hsa-mir-4279 (MIRT679630)
- hsa-mir-3649 (MIRT679631)
- hsa-mir-6789-3p (MIRT679632)
- hsa-mir-6778-3p (MIRT679633)
- hsa-mir-4707-3p (MIRT679634)
- hsa-mir-1976 (MIRT679635)
- hsa-mir-3653-5p (MIRT679636)
- hsa-mir-6747-3p (MIRT679637)
- hsa-mir-6727-3p (MIRT679638)
- hsa-mir-4722-3p (MIRT679639)
- hsa-mir-4258 (MIRT679640)
- hsa-mir-4740-3p (MIRT679641)
- hsa-mir-140-3p (MIRT679642)
- hsa-mir-6133 (MIRT705232)
- hsa-mir-6516-5p (MIRT705233)
- hsa-mir-455-3p (MIRT705234)
- hsa-mir-765 (MIRT705235)
- hsa-mir-6499-3p (MIRT705236)
- hsa-mir-4537 (MIRT705237)
- hsa-mir-6840-3p (MIRT705238)
- hsa-mir-665 (MIRT705239)
- hsa-mir-4459 (MIRT705240)
- hsa-mir-1228-3p (MIRT705241)
- hsa-mir-1277-5p (MIRT707038)
- hsa-mir-1281 (MIRT762133)
- hsa-mir-1915-3p (MIRT763410)
- hsa-mir-4485-5p (MIRT769606)
- hsa-mir-4695-3p (MIRT771140)
- hsa-mir-4726-3p (MIRT771644)
- hsa-mir-4772-3p (MIRT772201)
- hsa-mir-498 (MIRT772815)
- hsa-mir-6736-3p (MIRT778038)
- hsa-mir-6764-5p (MIRT778499)
- hsa-mir-6787-3p (MIRT779182)
- hsa-mir-6814-5p (MIRT779783)
- hsa-mir-6890-3p (MIRT781134)
- hsa-mir-7641 (MIRT781799)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BRMS1L
- Browse OriGene Inhibitory RNA Products For BRMS1L
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BRMS1L
- genomics-online: shRNA clones - Search results for 105 available BRMS1L gene related products
- Overview of 105 available BRMS1L gene related products
Clone Products
- Sino Biological Human cDNA Clone for BRMS1L
- VectorBuilder custom plasmid, inducible vectors for BRMS1L
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for BRMS1L
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BRMS1L
- Applied Biological Materials Clones for BRMS1L
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for BRMS1L
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BRMS1L Gene
Localization for BRMS1L Gene
Subcellular locations from UniProtKB/Swiss-Prot for BRMS1L Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 3 |
| extracellular | 1 |
| cytoskeleton | 1 |
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0070822 | Sin3-type complex | IBA | -- |
Pathways & Interactions for BRMS1L Gene
No Data Available
Interacting Proteins for BRMS1L Gene
Selected Interacting proteins:
Q5PSV4-BRM1L_HUMAN
ENSP00000216807
for BRMS1L Gene via
IID
STRING
UniProtKB
GPS-Prot Interaction Network for BRMS1L
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IBA | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0016575 | histone deacetylation | IBA | -- |
| GO:0040008 | regulation of growth | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for BRMS1L Gene
Transcripts for BRMS1L Gene
mRNA/cDNA for BRMS1L Gene
- (84) Selected AceView cDNA sequences:
- (7) Additional mRNA sequences :
- (8) REFSEQ mRNAs :
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000216807 2657 bps (uc001wtl.4)
- ENST00000547420 650 bps (uc059awe.1)
- ENST00000548758 1077 bps (uc059awf.1)
- ENST00000551774 1201 bps (uc059awg.1)
- ENST00000552677 1544 bps (uc059awd.1)
Unigene Clusters for BRMS1L Gene
CRISPR Products
-
OriGene CRISPR knockouts for BRMS1L
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BRMS1L
- genomics-online: gRNA clones - Search results for 105 available BRMS1L gene related products
- Overview of 105 available BRMS1L gene related products
- Applied Biological Materials CRISPR for BRMS1L
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for BRMS1L
- GenScript: Design CRISPR guide RNA sequences for BRMS1L
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BRMS1L
- Browse OriGene Inhibitory RNA Products For BRMS1L
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BRMS1L
- genomics-online: shRNA clones - Search results for 105 available BRMS1L gene related products
- Overview of 105 available BRMS1L gene related products
Clone Products
- Sino Biological Human cDNA Clone for BRMS1L
- VectorBuilder custom plasmid, inducible vectors for BRMS1L
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for BRMS1L
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BRMS1L
- Applied Biological Materials Clones for BRMS1L
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for BRMS1L Gene
This gene is overexpressed in Placenta (15.2), Retina (12.8), Fetal testis (9.6), Pancreas (8.5), and Prostate (7.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for BRMS1L Gene
NURSA nuclear receptor signaling pathways regulating expression of BRMS1L Gene:
BRMS1LSOURCE GeneReport for Unigene cluster for BRMS1L Gene:
Hs.525299Evidence on tissue expression from TISSUES for BRMS1L Gene
- Nervous system(2.5)
Primer Products
-
OriGene qPCR primer pairs and template standards for BRMS1L
-
OriGene qPCR primer pairs for BRMS1L
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for BRMS1L Gene
Orthologs for BRMS1L Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| dog (Canis familiaris) |
Mammalia | BRMS1L 34 |
|
OneToOne | |
| LOC480292 33 |
|
||||
| chimpanzee (Pan troglodytes) |
Mammalia | BRMS1L 34 33 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | BRMS1L 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | BRMS1L 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | BRMS1L 34 33 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| rat (Rattus norvegicus) |
Mammalia | LOC100910898 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Brms1l 16 34 33 |
|
||
| chicken (Gallus gallus) |
Aves | BRMS1L 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | BRMS1L 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | brms1l 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.21343 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | brms1lb 34 |
|
OneToMany | |
| brms1la 34 33 |
|
OneToMany | |||
| -- 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.443 33 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP002712 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG4400 34 33 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.8326 34 |
|
OneToMany |
- Species where no ortholog for BRMS1L was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for BRMS1L Gene
- ENSEMBL:
- Gene Tree for BRMS1L (if available)
- TreeFam:
- Gene Tree for BRMS1L (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for BRMS1L: view image
Paralogs for BRMS1L Gene
Variants for BRMS1L Gene
| SNP ID | Clin | Chr 14 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000037687 | -- | 35,842,601(+) | C/T | genic_downstream_transcript_variant, intron_variant | |
| rs1000041286 | -- | 35,849,237(+) | A/G | genic_downstream_transcript_variant, intron_variant | |
| rs1000142094 | -- | 35,839,537(+) | C/T | genic_downstream_transcript_variant, intron_variant | |
| rs1000185414 | -- | 35,834,438(+) | G/C | genic_downstream_transcript_variant, intron_variant | |
| rs1000237064 | -- | 35,846,334(+) | T/C | genic_downstream_transcript_variant, intron_variant |
Residual Variation Intolerance Score:
47.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.79;
16.60% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for BRMS1L Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- BRMS1L
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BRMS1L Gene
Disorders for BRMS1L Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| breast cancer |
|
|
| lacrimal gland adenocarcinoma |
|
|
Search BRMS1L in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for BRMS1L
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for BRMS1L Gene
Publications for BRMS1L Gene
- Identification of a novel BRMS1-homologue protein p40 as a component of the mSin3A/p33(ING1b)/HDAC1 deacetylase complex. (PMID: 15451426) Nikolaev AY … Gu W (Biochemical and biophysical research communications 2004) 3 4 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
- Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58
- Recruitment of the Mammalian Histone-modifying EMSY Complex to Target Genes Is Regulated by ZNF131. (PMID: 26841866) Varier RA … Vermeulen M (The Journal of biological chemistry 2016) 3 58
Products for BRMS1L Gene
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- OriGene Purified Proteins for BRMS1L
- Search Origene for MassSpec and Protein Over-expression Lysates for BRMS1L
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- Origene shrna, sirna, and RNAi products in human, mouse, rat for BRMS1L
- Browse OriGene Inhibitory RNA Products For BRMS1L
- OriGene qPCR primer pairs and template standards for BRMS1L
- OriGene qPCR primer pairs for BRMS1L
- OriGene CRISPR knockouts for BRMS1L
- OriGene ORF clones in human for BRMS1L
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For BRMS1L
- GenScript: Next-day shipping of latest version cDNA ORF clones for BRMS1L in any vector
- GenScript Custom Purified and Recombinant Proteins Services for BRMS1L
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- GenScript Custom overexpressing Cell Line Services for BRMS1L
- GenScript: Design CRISPR guide RNA sequences for BRMS1L
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for BRMS1L
- Sino Biological Human cDNA Clone for BRMS1L
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Antibodies
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- Browse Sino Biological ELISA Kits
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- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for BRMS1L
- Novus Biologicals proteins for BRMS1L
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- VectorBuilder custom plasmid, inducible vectors for BRMS1L
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for BRMS1L
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 49 available BRMS1L Antibodies ranked by validation data
- Compare Top BRMS1L Antibodies
- antibodies-online: Search results for available BRMS1L related products ranked by validation data
- antibodies-online: Search results for 6 available BRMS1L Proteins ranked by validation data
- Compare Top BRMS1L Proteins
- Quality Products:
- GeneTex BRMS1L Antibody for BRMS1L
- Search GeneTex for Proteins for BRMS1L
- Horizon Cell Lines for BRMS1L
- genomics-online: cdna clones - Search results for 105 available BRMS1L gene related products
- Overview of 105 available BRMS1L gene related products
- orf clones - Search results for 105 available BRMS1L gene related products
- Overview of 105 available BRMS1L gene related products
- genomics-online: gRNA clones - Search results for 105 available BRMS1L gene related products
- Overview of 105 available BRMS1L gene related products
- genomics-online: primer clones - Search results for 105 available BRMS1L gene related products
- Overview of 105 available BRMS1L gene related products
- genomics-online: shRNA clones - Search results for 105 available BRMS1L gene related products
- Overview of 105 available BRMS1L gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BRMS1L
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BRMS1L
- GeneCopoeia miRNA 3'UTR Target clone products for BRMS1L
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BRMS1L
- Boster Bio Antibodies for BRMS1L
- Browse Boster Bio ELISA Kits
Sources for BRMS1L Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio