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Aliases for BRIX1 Gene

Aliases for BRIX1 Gene

  • BRX1, Biogenesis Of Ribosomes 2 3 5
  • Brix Domain-Containing Protein 2 3 4
  • Brix Domain Containing 2 2 3
  • BXDC2 3 4
  • BRIX 3 4
  • BRX1, Biogenesis Of Ribosomes, Homolog (S. Cerevisiae) 2
  • Ribosome Biogenesis Protein BRX1 Homolog 3
  • BRX1, Biogenesis Of Ribosomes, Homolog 3

External Ids for BRIX1 Gene

Previous HGNC Symbols for BRIX1 Gene

  • BXDC2

Previous GeneCards Identifiers for BRIX1 Gene

  • GC05P034953

Summaries for BRIX1 Gene

GeneCards Summary for BRIX1 Gene

BRIX1 (BRX1, Biogenesis Of Ribosomes) is a Protein Coding gene. Among its related pathways are Gastric Cancer Network 2.

UniProtKB/Swiss-Prot for BRIX1 Gene

  • Required for biogenesis of the 60S ribosomal subunit.

Gene Wiki entry for BRIX1 Gene

Additional gene information for BRIX1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BRIX1 Gene

Genomics for BRIX1 Gene

GeneHancer (GH) Regulatory Elements for BRIX1 Gene

Promoters and enhancers for BRIX1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J034913 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 662.1 +0.5 504 4.4 CLOCK FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC SSRP1 BRIX1 RAD1 DNAJC21 TTC23L GC05P034888
GH05J035616 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 53.9 +702.6 702599 2.2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 ZNF213 ZNF143 ZNF548 SPEF2 BRIX1 NADK2-AS1 RAI14 RNU7-130P GC05P035369
GH05J034654 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 24.4 -256.8 -256826 7.8 PKNOX1 SIN3A YY1 FOS SP3 SP5 MXD4 REST ZNF592 SREBF1 RAI14 ENSG00000250234 BRIX1 LOC643373 LOC105374723 GC05P034707
GH05J034682 Enhancer 1.4 Ensembl ENCODE dbSUPER 21.7 -229.5 -229514 7.2 PKNOX1 FOXA2 ARNT SIN3A FEZF1 ZNF2 YY1 ZNF213 FOS SP3 BRIX1 LOC643373 RAI14 ENSG00000250234 TTC23L GC05P034707
GH05J034006 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.8 -906.7 -906720 4.5 FOXA2 SMAD1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 POLR2B AMACR ENSG00000249572 BRIX1 TTC23L LOC643373 DNAJC21 C1QTNF3 C1QTNF3-AMACR
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BRIX1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for BRIX1 Gene

Genomic Locations for BRIX1 Gene
chr5:34,915,376-34,925,996
(GRCh38/hg38)
Size:
10,621 bases
Orientation:
Plus strand
chr5:34,915,481-34,926,101
(GRCh37/hg19)
Size:
10,621 bases
Orientation:
Plus strand

Genomic View for BRIX1 Gene

Genes around BRIX1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BRIX1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BRIX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BRIX1 Gene

Proteins for BRIX1 Gene

  • Protein details for BRIX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TDN6-BRX1_HUMAN
    Recommended name:
    Ribosome biogenesis protein BRX1 homolog
    Protein Accession:
    Q8TDN6
    Secondary Accessions:
    • A8K0P5
    • Q3ZTT4
    • Q8N453
    • Q96DH1

    Protein attributes for BRIX1 Gene

    Size:
    353 amino acids
    Molecular mass:
    41401 Da
    Quaternary structure:
    No Data Available

neXtProt entry for BRIX1 Gene

Post-translational modifications for BRIX1 Gene

  • Ubiquitination at Lys276
  • Modification sites at PhosphoSitePlus

Other Protein References for BRIX1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Boster Bio Antibodies for BRIX1
  • Santa Cruz Biotechnology (SCBT) Antibodies for BRIX1

No data available for DME Specific Peptides for BRIX1 Gene

Domains & Families for BRIX1 Gene

Gene Families for BRIX1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for BRIX1 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for BRIX1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TDN6

UniProtKB/Swiss-Prot:

BRX1_HUMAN :
  • Belongs to the BRX1 family.
Family:
  • Belongs to the BRX1 family.
genes like me logo Genes that share domains with BRIX1: view

Function for BRIX1 Gene

Molecular function for BRIX1 Gene

UniProtKB/Swiss-Prot Function:
Required for biogenesis of the 60S ribosomal subunit.

Phenotypes From GWAS Catalog for BRIX1 Gene

Gene Ontology (GO) - Molecular Function for BRIX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IBA --
genes like me logo Genes that share ontologies with BRIX1: view
genes like me logo Genes that share phenotypes with BRIX1: view

Animal Model Products

CRISPR Products

miRNA for BRIX1 Gene

miRTarBase miRNAs that target BRIX1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BRIX1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BRIX1 Gene

Localization for BRIX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BRIX1 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BRIX1 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for BRIX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IBA,IDA --
genes like me logo Genes that share ontologies with BRIX1: view

Pathways & Interactions for BRIX1 Gene

SuperPathways for BRIX1 Gene

SuperPathway Contained pathways
1 Gastric Cancer Network 2
genes like me logo Genes that share pathways with BRIX1: view

Pathways by source for BRIX1 Gene

1 BioSystems pathway for BRIX1 Gene

Gene Ontology (GO) - Biological Process for BRIX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000027 ribosomal large subunit assembly IBA --
GO:0042254 ribosome biogenesis IEA --
genes like me logo Genes that share ontologies with BRIX1: view

No data available for SIGNOR curated interactions for BRIX1 Gene

Drugs & Compounds for BRIX1 Gene

No Compound Related Data Available

Transcripts for BRIX1 Gene

mRNA/cDNA for BRIX1 Gene

Unigene Clusters for BRIX1 Gene

BRX1, biogenesis of ribosomes, homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BRIX1

Alternative Splicing Database (ASD) splice patterns (SP) for BRIX1 Gene

No ASD Table

Relevant External Links for BRIX1 Gene

GeneLoc Exon Structure for
BRIX1
ECgene alternative splicing isoforms for
BRIX1

Expression for BRIX1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BRIX1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for BRIX1 Gene

This gene is overexpressed in Adrenal (28.9) and Fetal testis (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for BRIX1 Gene



Protein tissue co-expression partners for BRIX1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of BRIX1 Gene:

BRIX1

SOURCE GeneReport for Unigene cluster for BRIX1 Gene:

Hs.718510

Evidence on tissue expression from TISSUES for BRIX1 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with BRIX1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for BRIX1 Gene

Orthologs for BRIX1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for BRIX1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BRIX1 34 33
  • 97.95 (n)
OneToOne
cow
(Bos Taurus)
Mammalia BRIX1 34 33
  • 92.07 (n)
OneToOne
dog
(Canis familiaris)
Mammalia BRIX1 34 33
  • 90.06 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 89 (a)
OneToMany
-- 34
  • 84 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Brix1 16 34 33
  • 88.01 (n)
rat
(Rattus norvegicus)
Mammalia Brix1 33
  • 87.03 (n)
oppossum
(Monodelphis domestica)
Mammalia BRIX1 34
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves BRIX1 34 33
  • 73.26 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BRIX1 34
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia brix1 33
  • 69.44 (n)
zebrafish
(Danio rerio)
Actinopterygii bxdc2 34 33
  • 63.8 (n)
OneToOne
Dr.9734 33
fruit fly
(Drosophila melanogaster)
Insecta CG11583 34 33
  • 58.91 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005365 33
  • 53.75 (n)
worm
(Caenorhabditis elegans)
Secernentea K12H4.3 34
  • 38 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BRX1 36 34 33
  • 57.56 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E17799g 33
  • 56.89 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER020W 33
  • 53.55 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G15460 33
  • 55.83 (n)
rice
(Oryza sativa)
Liliopsida Os02g0591800 33
  • 52.8 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes brx1 33
  • 55.33 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU01524 33
  • 52.03 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6852 34
  • 51 (a)
OneToOne
Species where no ortholog for BRIX1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BRIX1 Gene

ENSEMBL:
Gene Tree for BRIX1 (if available)
TreeFam:
Gene Tree for BRIX1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for BRIX1: view image

Paralogs for BRIX1 Gene

(1) SIMAP similar genes for BRIX1 Gene using alignment to 1 proteins:

  • BRX1_HUMAN

Pseudogenes.org Pseudogenes for BRIX1 Gene

genes like me logo Genes that share paralogs with BRIX1: view

No data available for Paralogs for BRIX1 Gene

Variants for BRIX1 Gene

Sequence variations from dbSNP and Humsavar for BRIX1 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000154959 -- 34,916,318(+) G/A intron_variant
rs1000450483 -- 34,916,667(+) A/C intron_variant
rs1000994229 -- 34,921,861(+) C/G/T intron_variant
rs1001205374 -- 34,920,461(+) C/T intron_variant
rs1001336712 -- 34,922,155(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for BRIX1 Gene

Variant ID Type Subtype PubMed ID
dgv5629n100 CNV gain 25217958
esv3604679 CNV gain 21293372
esv3604690 CNV gain 21293372
nsv4789 CNV deletion 18451855
nsv597809 CNV gain 21841781

Variation tolerance for BRIX1 Gene

Residual Variation Intolerance Score: 67.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.17; 80.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BRIX1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BRIX1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BRIX1 Gene

Disorders for BRIX1 Gene

Additional Disease Information for BRIX1

No disorders were found for BRIX1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BRIX1 Gene

Publications for BRIX1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. Brix from xenopus laevis and brx1p from yeast define a new family of proteins involved in the biogenesis of large ribosomal subunits. (PMID: 11843177) Kaser A … Kreil G (Biological chemistry 2001) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for BRIX1 Gene

Sources for BRIX1 Gene

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