Aliases for BRIP1 Gene
External Ids for BRIP1 Gene
Previous GeneCards Identifiers for BRIP1 Gene
The protein encoded by this gene is a member of the RecQ DEAH helicase family and interacts with the BRCT repeats of breast cancer, type 1 (BRCA1). The bound complex is important in the normal double-strand break repair function of breast cancer, type 1 (BRCA1). This gene may be a target of germline cancer-inducing mutations. [provided by RefSeq, Jul 2008]
GeneCards Summary for BRIP1 Gene
BRIP1 (BRCA1 Interacting Protein C-Terminal Helicase 1) is a Protein Coding gene. Diseases associated with BRIP1 include Fanconi Anemia, Complementation Group J and Breast Cancer. Among its related pathways are DNA Double-Strand Break Repair and Regulation of TP53 Activity. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and 4 iron, 4 sulfur cluster binding. An important paralog of this gene is RTEL1.
UniProtKB/Swiss-Prot Summary for BRIP1 Gene
DNA-dependent ATPase and 5' to 3' DNA helicase required for the maintenance of chromosomal stability. Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination. Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1.