Aliases for BRINP2 Gene

Aliases for BRINP2 Gene

  • BMP/Retinoic Acid Inducible Neural Specific 2 2 3 5
  • Bone Morphogenetic Protein/Retinoic Acid Inducible Neural-Specific 2 2 3
  • BMP/Retinoic Acid-Inducible Neural-Specific Protein 2 3 4
  • Family With Sequence Similarity 5, Member B 2 3
  • DBCCR1-Like Protein 2 3 4
  • DBCCR1L2 3 4
  • FAM5B 3 4
  • Bone Morphogenic Protein/Retinoic Acid Inducible Neural-Specific 2 3
  • Protein FAM5B 3
  • DBCCR1-Like2 3
  • KIAA1747 4

External Ids for BRINP2 Gene

Previous HGNC Symbols for BRINP2 Gene

  • FAM5B

Previous GeneCards Identifiers for BRINP2 Gene

  • GC01P177141

Summaries for BRINP2 Gene

GeneCards Summary for BRINP2 Gene

BRINP2 (BMP/Retinoic Acid Inducible Neural Specific 2) is a Protein Coding gene. An important paralog of this gene is BRINP3.

UniProtKB/Swiss-Prot Summary for BRINP2 Gene

  • Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition.

Additional gene information for BRINP2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BRINP2 Gene

Genomics for BRINP2 Gene

GeneHancer (GH) Regulatory Elements for BRINP2 Gene

Promoters and enhancers for BRINP2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J177170 Promoter 1.2 EPDnew Ensembl 750.6 +0.2 179 1.8 POU5F1 SP1 GLIS2 ZIC2 PRDM10 CTBP1 ZSCAN4 POLR2A SP2 DDX20 BRINP2 LOC105371625
GH01J177173 Enhancer 0.2 Ensembl 750.6 +1.4 1379 0.2 BRINP2 LOC105371625
GH01J178092 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.9 +923.9 923902 5.6 SIN3A CTCF ZBTB6 POLR2A USF2 HCFC1 MIXL1 MYC NFYC L3MBTL2 RASAL2-AS1 RASAL2 ASTN1 BRINP2 ANGPTL1 PTPN2P1 lnc-SEC16B-6
GH01J177206 Enhancer 1.2 FANTOM5 Ensembl ENCODE 16.3 +37.9 37879 3.6 FOXA1 SP1 MAFK SP7 ZSCAN21 PKNOX1 ZIC2 RXRA ZBTB8A PRDM10 BRINP2 ASTN1 LOC105371625
GH01J177142 Enhancer 0.6 Ensembl 11.4 -27.9 -27921 0.8 PKNOX1 TCF7L2 PRDM10 ZNF501 ZNF561 OSR2 ZBTB17 ZNF580 PRDM4 FEZF1 piR-45035-014 ASTN1 BRINP2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BRINP2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for BRINP2 Gene

Genomic Locations for BRINP2 Gene
111,501 bases
Plus strand
110,926 bases
Plus strand

Genomic View for BRINP2 Gene

Genes around BRINP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BRINP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BRINP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BRINP2 Gene

Proteins for BRINP2 Gene

  • Protein details for BRINP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    BMP/retinoic acid-inducible neural-specific protein 2
    Protein Accession:
    Secondary Accessions:
    • O95560
    • Q6ZWC1
    • Q7LCZ9
    • Q8N360

    Protein attributes for BRINP2 Gene

    783 amino acids
    Molecular mass:
    89005 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB21838.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for BRINP2 Gene


neXtProt entry for BRINP2 Gene

Post-translational modifications for BRINP2 Gene

  • Glycosylation at Asn185, Asn354, Asn473, Asn579, Asn626, and Asn658
  • Modification sites at PhosphoSitePlus

Other Protein References for BRINP2 Gene

No data available for DME Specific Peptides for BRINP2 Gene

Domains & Families for BRINP2 Gene

Gene Families for BRINP2 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins
  • Transporters

Protein Domains for BRINP2 Gene


Suggested Antigen Peptide Sequences for BRINP2 Gene

GenScript: Design optimal peptide antigens:
  • DBCCR1-like protein 2 (FAM5B_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the BRINP family.
  • Belongs to the BRINP family.
genes like me logo Genes that share domains with BRINP2: view

Function for BRINP2 Gene

Molecular function for BRINP2 Gene

UniProtKB/Swiss-Prot Function:
Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition.

Phenotypes From GWAS Catalog for BRINP2 Gene

genes like me logo Genes that share phenotypes with BRINP2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for BRINP2

CRISPR Products

miRNA for BRINP2 Gene

miRTarBase miRNAs that target BRINP2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BRINP2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BRINP2 Gene

Localization for BRINP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BRINP2 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BRINP2 gene
Compartment Confidence
extracellular 4
endoplasmic reticulum 3
mitochondrion 1
cytosol 1
golgi apparatus 1
plasma membrane 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for BRINP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005783 endoplasmic reticulum IBA 21873635
GO:0030425 dendrite IBA 21873635
GO:0043025 neuronal cell body IBA 21873635
genes like me logo Genes that share ontologies with BRINP2: view

Pathways & Interactions for BRINP2 Gene

PathCards logo

SuperPathways for BRINP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for BRINP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0007050 cell cycle arrest IEA --
GO:0045666 positive regulation of neuron differentiation IBA 21873635
GO:0045930 negative regulation of mitotic cell cycle IBA 21873635
GO:0071300 cellular response to retinoic acid IEA,IBA 21873635
genes like me logo Genes that share ontologies with BRINP2: view

No data available for Pathways by source and SIGNOR curated interactions for BRINP2 Gene

Drugs & Compounds for BRINP2 Gene

No Compound Related Data Available

Transcripts for BRINP2 Gene

mRNA/cDNA for BRINP2 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(51) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BRINP2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for BRINP2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10 ^ 11
SP1: - - - - - - -
SP4: - -
SP5: - - - -
SP6: -
SP7: -

Relevant External Links for BRINP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BRINP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BRINP2 Gene

mRNA differential expression in normal tissues according to GTEx for BRINP2 Gene

This gene is overexpressed in Brain - Cortex (x9.3), Brain - Frontal Cortex (BA9) (x7.3), Brain - Anterior cingulate cortex (BA24) (x6.2), and Brain - Amygdala (x5.7).

NURSA nuclear receptor signaling pathways regulating expression of BRINP2 Gene:


Evidence on tissue expression from TISSUES for BRINP2 Gene

  • Nervous system(4.9)
genes like me logo Genes that share expression patterns with BRINP2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for BRINP2 Gene

Orthologs for BRINP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BRINP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BRINP2 33
  • 100 (a)
FAM5B 32
  • 99.66 (n)
(Canis familiaris)
Mammalia BRINP2 33
  • 96 (a)
FAM5B 32
  • 90.72 (n)
(Bos Taurus)
Mammalia FAM5B 32
  • 90.71 (n)
  • 90 (a)
(Rattus norvegicus)
Mammalia Brinp2 32
  • 90.42 (n)
(Mus musculus)
Mammalia Brinp2 17 33 32
  • 90.08 (n)
(Monodelphis domestica)
Mammalia BRINP2 33
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia BRINP2 33
  • 83 (a)
(Gallus gallus)
Aves BRINP2 33
  • 82 (a)
FAM5B 32
  • 77.94 (n)
(Anolis carolinensis)
Reptilia BRINP2 33
  • 80 (a)
(Danio rerio)
Actinopterygii brinp3a 32
  • 65.8 (n)
brinp2 33
  • 62 (a)
Species where no ortholog for BRINP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BRINP2 Gene

Gene Tree for BRINP2 (if available)
Gene Tree for BRINP2 (if available)
Evolutionary constrained regions (ECRs) for BRINP2: view image

Paralogs for BRINP2 Gene

Paralogs for BRINP2 Gene

(2) SIMAP similar genes for BRINP2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with BRINP2: view

Variants for BRINP2 Gene

Sequence variations from dbSNP and Humsavar for BRINP2 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000006275 -- 177,261,915(+) C/G intron_variant
rs1000012976 -- 177,187,101(+) T/G genic_upstream_transcript_variant, intron_variant
rs1000104675 -- 177,232,642(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000137075 -- 177,277,305(+) T/C intron_variant
rs1000140217 -- 177,189,442(+) A/G genic_upstream_transcript_variant, intron_variant

Variation tolerance for BRINP2 Gene

Residual Variation Intolerance Score: 58% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.93; 83.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BRINP2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for BRINP2 Gene

Disorders for BRINP2 Gene

Additional Disease Information for BRINP2

No disorders were found for BRINP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BRINP2 Gene

Publications for BRINP2 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 56
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  4. Identification and characterization of novel developmentally regulated neural-specific proteins, BRINP family. (PMID: 15193423) Kawano H … Matsuoka I (Brain research. Molecular brain research 2004) 2 3 56
  5. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 3 4 56

Products for BRINP2 Gene

Sources for BRINP2 Gene