Aliases for BRICD5 Gene

Aliases for BRICD5 Gene

  • BRICHOS Domain Containing 5 2 3 5
  • BRICHOS Domain-Containing Protein 5 3 4
  • C16orf79 3 4
  • BRICHOS Domain-Containing Protein C16orf79 3
  • Chromosome 16 Open Reading Frame 79 2

External Ids for BRICD5 Gene

Previous HGNC Symbols for BRICD5 Gene

  • C16orf79

Previous GeneCards Identifiers for BRICD5 Gene

  • GC16M002260
  • GC16M002262
  • GC16M002263
  • GC16M002223
  • GC16M002226
  • GC16M002232

Summaries for BRICD5 Gene

GeneCards Summary for BRICD5 Gene

BRICD5 (BRICHOS Domain Containing 5) is a Protein Coding gene. An important paralog of this gene is GKN2.

Additional gene information for BRICD5 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BRICD5 Gene

Genomics for BRICD5 Gene

GeneHancer (GH) Regulatory Elements for BRICD5 Gene

Promoters and enhancers for BRICD5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BRICD5 on UCSC Golden Path with GeneCards custom track

Genomic Locations for BRICD5 Gene

Genomic Locations for BRICD5 Gene
chr16:2,209,253-2,213,540
(GRCh38/hg38)
Size:
4,288 bases
Orientation:
Minus strand
chr16:2,259,254-2,261,951
(GRCh37/hg19)
Size:
2,698 bases
Orientation:
Minus strand

Genomic View for BRICD5 Gene

Genes around BRICD5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BRICD5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BRICD5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BRICD5 Gene

Proteins for BRICD5 Gene

  • Protein details for BRICD5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PL45-BRID5_HUMAN
    Recommended name:
    BRICHOS domain-containing protein 5
    Protein Accession:
    Q6PL45
    Secondary Accessions:
    • C9J7K2
    • Q8IXU9

    Protein attributes for BRICD5 Gene

    Size:
    260 amino acids
    Molecular mass:
    28486 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for BRICD5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BRICD5 Gene

Post-translational modifications for BRICD5 Gene

  • Glycosylation at Asn79
  • Modification sites at PhosphoSitePlus

Other Protein References for BRICD5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BRICD5 Gene

Domains & Families for BRICD5 Gene

Gene Families for BRICD5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for BRICD5 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for BRICD5 Gene

GenScript: Design optimal peptide antigens:
  • BRICHOS domain-containing protein C16orf79 (CP079_HUMAN)
genes like me logo Genes that share domains with BRICD5: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for BRICD5 Gene

Function for BRICD5 Gene

Phenotypes From GWAS Catalog for BRICD5 Gene

Gene Ontology (GO) - Molecular Function for BRICD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with BRICD5: view
genes like me logo Genes that share phenotypes with BRICD5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BRICD5

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BRICD5 Gene

Localization for BRICD5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BRICD5 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BRICD5 gene
Compartment Confidence
plasma membrane 3
extracellular 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for BRICD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with BRICD5: view

Pathways & Interactions for BRICD5 Gene

PathCards logo

SuperPathways for BRICD5 Gene

No Data Available

Interacting Proteins for BRICD5 Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: Q6PL45-BRID5_HUMAN ENSP00000332389 for BRICD5 Gene via UniProtKB STRING IID

Gene Ontology (GO) - Biological Process for BRICD5 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for BRICD5 Gene

Drugs & Compounds for BRICD5 Gene

No Compound Related Data Available

Transcripts for BRICD5 Gene

mRNA/cDNA for BRICD5 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BRICD5

Alternative Splicing Database (ASD) splice patterns (SP) for BRICD5 Gene

No ASD Table

Relevant External Links for BRICD5 Gene

GeneLoc Exon Structure for
BRICD5
ECgene alternative splicing isoforms for
BRICD5

Expression for BRICD5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BRICD5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BRICD5 Gene

This gene is overexpressed in Brain - Cerebellum (x6.9) and Brain - Cerebellar Hemisphere (x6.1).

NURSA nuclear receptor signaling pathways regulating expression of BRICD5 Gene:

BRICD5

SOURCE GeneReport for Unigene cluster for BRICD5 Gene:

Hs.647399

Evidence on tissue expression from TISSUES for BRICD5 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with BRICD5: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for BRICD5 Gene

Orthologs for BRICD5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BRICD5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BRICD5 33
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bricd5 17 33 32
  • 79.41 (n)
cow
(Bos Taurus)
Mammalia BRICD5 33 32
  • 78.15 (n)
OneToOne
dog
(Canis familiaris)
Mammalia BRICD5 33 32
  • 76.74 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BRICD5 33
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves BRICD5 33
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BRICD5 33
  • 35 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bricd5 32
  • 54.89 (n)
zebrafish
(Danio rerio)
Actinopterygii bricd5 33 32
  • 53.92 (n)
OneToOne
Species where no ortholog for BRICD5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BRICD5 Gene

ENSEMBL:
Gene Tree for BRICD5 (if available)
TreeFam:
Gene Tree for BRICD5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for BRICD5: view image

Paralogs for BRICD5 Gene

Paralogs for BRICD5 Gene

genes like me logo Genes that share paralogs with BRICD5: view

Variants for BRICD5 Gene

Sequence variations from dbSNP and Humsavar for BRICD5 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1002731996 -- 2,211,153(-) G/A/T upstream_transcript_variant
rs1003215184 -- 2,211,320(-) C/G upstream_transcript_variant
rs1003242181 -- 2,209,034(-) C/T downstream_transcript_variant
rs1003275110 -- 2,209,174(-) C/T downstream_transcript_variant
rs1003813865 -- 2,212,202(-) C/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for BRICD5 Gene

Variant ID Type Subtype PubMed ID
dgv4859n54 CNV loss 21841781
dgv4861n54 CNV loss 21841781
dgv4863n54 CNV loss 21841781
esv2422427 CNV duplication 17116639
nsv1052260 CNV gain 25217958
nsv1711 CNV insertion 18451855
nsv457351 CNV loss 19166990
nsv471072 CNV loss 18288195
nsv571200 CNV loss 21841781
nsv952902 CNV deletion 24416366

Variation tolerance for BRICD5 Gene

Residual Variation Intolerance Score: 92.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.42; 54.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BRICD5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BRICD5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BRICD5 Gene

Disorders for BRICD5 Gene

Additional Disease Information for BRICD5

No disorders were found for BRICD5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BRICD5 Gene

Publications for BRICD5 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 56
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 56
  3. Systematic identification of pathological lamin A interactors. (PMID: 24623722) Dittmer TA … Misteli T (Molecular biology of the cell 2014) 3 56
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 56
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P … Vidal M (Genomics 2007) 3 56

Products for BRICD5 Gene

Sources for BRICD5 Gene