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Aliases for BRI3BP Gene

Aliases for BRI3BP Gene

  • BRI3 Binding Protein 2 3 5
  • Cervical Cancer 1 Proto-Oncogene-Binding Protein KG19 3 4
  • I3-Binding Protein 3 4
  • HCCRBP-1 3 4
  • KG19 3 4
  • Cervical Cancer Oncogene Binding Protein 3
  • BRI3-Binding Protein 3
  • HCCRBP-3 3
  • HCCR-1 3
  • HCCR-2 3
  • BNAS1 3

External Ids for BRI3BP Gene

Previous GeneCards Identifiers for BRI3BP Gene

  • GC12P124206
  • GC12P125244
  • GC12P123831
  • GC12P124003
  • GC12P125478
  • GC12P122461

Summaries for BRI3BP Gene

GeneCards Summary for BRI3BP Gene

BRI3BP (BRI3 Binding Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for BRI3BP Gene

  • Involved in tumorigenesis and may function by stabilizing p53/TP53.

Additional gene information for BRI3BP Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BRI3BP Gene

Genomics for BRI3BP Gene

GeneHancer (GH) Regulatory Elements for BRI3BP Gene

Promoters and enhancers for BRI3BP Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I124992 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 550.8 +1.4 1384 5.2 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF213 ZNF207 BRI3BP PIR45759
GH12I124913 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.3 -74.5 -74465 12.7 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 UBC NCOR2 DHX37 ENSG00000270130 ENSG00000269938 ENSG00000269997 ENSG00000270061 DNAH10OS SCARB1 BRI3BP
GH12I124937 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 12.5 -54.1 -54131 5 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 GC12P124940 TRD-GTC2-10 PIR61666 TRA-TGC4-1 ENSG00000270130 NCOR2 DHX37 ENSG00000269938 ENSG00000270061 ENSG00000269997
GH12I125048 Enhancer 1.2 Ensembl ENCODE 0.2 +56.0 55953 1.6 PKNOX1 ATF1 SIN3A GLI4 ZNF2 GLIS2 KLF7 ZNF548 FOS ATF7 NCOR2 AACS GC12P125055 GC12P125029 BRI3BP
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around BRI3BP on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the BRI3BP gene promoter:

Genomic Locations for BRI3BP Gene

Genomic Locations for BRI3BP Gene
58,198 bases
Plus strand

Genomic View for BRI3BP Gene

Genes around BRI3BP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BRI3BP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BRI3BP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BRI3BP Gene

Proteins for BRI3BP Gene

  • Protein details for BRI3BP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    BRI3-binding protein
    Protein Accession:
    Secondary Accessions:
    • Q8WY23

    Protein attributes for BRI3BP Gene

    251 amino acids
    Molecular mass:
    27836 Da
    Quaternary structure:
    • Interacts with LETMD1 (PubMed:17943721). Interacts with BRI3 (PubMed:11860200).
    • Sequence=AAL33003.2; Type=Frameshift; Positions=43, 47, 59; Evidence={ECO:0000305};

neXtProt entry for BRI3BP Gene

Post-translational modifications for BRI3BP Gene

Other Protein References for BRI3BP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BRI3BP Gene

Domains & Families for BRI3BP Gene

Gene Families for BRI3BP Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for BRI3BP Gene


Suggested Antigen Peptide Sequences for BRI3BP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with BRI3BP: view

No data available for UniProtKB/Swiss-Prot for BRI3BP Gene

Function for BRI3BP Gene

Molecular function for BRI3BP Gene

UniProtKB/Swiss-Prot Function:
Involved in tumorigenesis and may function by stabilizing p53/TP53.

Phenotypes for BRI3BP Gene

GenomeRNAi human phenotypes for BRI3BP:
genes like me logo Genes that share phenotypes with BRI3BP: view

miRNA for BRI3BP Gene

miRTarBase miRNAs that target BRI3BP

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BRI3BP Gene

Localization for BRI3BP Gene

Subcellular locations from UniProtKB/Swiss-Prot for BRI3BP Gene

Mitochondrion outer membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BRI3BP gene
Compartment Confidence
mitochondrion 5
plasma membrane 3
extracellular 2
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for BRI3BP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 17943721
GO:0005741 mitochondrial outer membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with BRI3BP: view

Pathways & Interactions for BRI3BP Gene

SuperPathways for BRI3BP Gene

No Data Available

Interacting Proteins for BRI3BP Gene

Gene Ontology (GO) - Biological Process for BRI3BP Gene


No data available for Pathways by source and SIGNOR curated interactions for BRI3BP Gene

Drugs & Compounds for BRI3BP Gene

No Compound Related Data Available

Transcripts for BRI3BP Gene

mRNA/cDNA for BRI3BP Gene

Unigene Clusters for BRI3BP Gene

BRI3 binding protein:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for BRI3BP Gene

No ASD Table

Relevant External Links for BRI3BP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BRI3BP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BRI3BP Gene

Protein differential expression in normal tissues from HIPED for BRI3BP Gene

This gene is overexpressed in Nasal epithelium (19.7) and Heart (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for BRI3BP Gene

Protein tissue co-expression partners for BRI3BP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of BRI3BP Gene:


SOURCE GeneReport for Unigene cluster for BRI3BP Gene:


mRNA Expression by UniProt/SwissProt for BRI3BP Gene:

Tissue specificity: Most abundantly expressed in brain, liver and kidney (PubMed:11860200). Overexpressed in leukemia and lymphoma cell lines, as well as in various carcinomas (PubMed:17943721).

Evidence on tissue expression from TISSUES for BRI3BP Gene

  • Nervous system(2.3)
  • Intestine(2)
  • Kidney(2)
genes like me logo Genes that share expression patterns with BRI3BP: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for BRI3BP Gene

Orthologs for BRI3BP Gene

This gene was present in the common ancestor of chordates.

Orthologs for BRI3BP Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BRI3BP 34
  • 100 (a)
(Bos Taurus)
Mammalia BRI3BP 33 34
  • 88.71 (n)
(Mus musculus)
Mammalia Bri3bp 33 16 34
  • 83.54 (n)
(Canis familiaris)
Mammalia BRI3BP 34
  • 82 (a)
(Rattus norvegicus)
Mammalia Bri3bp 33
  • 81.65 (n)
(Ornithorhynchus anatinus)
Mammalia BRI3BP 34
  • 66 (a)
(Gallus gallus)
Aves BRI3BP 33 34
  • 75.21 (n)
(Anolis carolinensis)
Reptilia BRI3BP 34
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia bri3bp 33
  • 68.14 (n)
Str.11937 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.19125 33
(Danio rerio)
Actinopterygii bri3bp 33 34
  • 68.47 (n)
Species where no ortholog for BRI3BP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BRI3BP Gene

Gene Tree for BRI3BP (if available)
Gene Tree for BRI3BP (if available)

Paralogs for BRI3BP Gene Pseudogenes for BRI3BP Gene

genes like me logo Genes that share paralogs with BRI3BP: view

No data available for Paralogs for BRI3BP Gene

Variants for BRI3BP Gene

Sequence variations from dbSNP and Humsavar for BRI3BP Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000001580 -- 124,997,984(+) C/T intron_variant
rs1000024313 -- 125,009,123(+) G/A intron_variant
rs1000057568 -- 125,032,937(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000107563 -- 125,017,958(+) C/T intron_variant
rs1000108634 -- 125,003,311(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for BRI3BP Gene

Variant ID Type Subtype PubMed ID
nsv560595 CNV gain 21841781
nsv509485 CNV insertion 20534489
nsv1138181 CNV deletion 24896259
nsv1126329 CNV deletion 24896259
nsv1070561 CNV deletion 25765185
nsv1051020 CNV gain 25217958
nsv1047470 CNV loss 25217958
esv998178 CNV insertion 20482838
esv3892269 CNV gain 25118596
esv3631032 CNV gain 21293372
esv3333171 CNV duplication 20981092
dgv325e199 CNV deletion 23128226

Variation tolerance for BRI3BP Gene

Residual Variation Intolerance Score: 46.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.78; 16.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BRI3BP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BRI3BP Gene

Disorders for BRI3BP Gene

Additional Disease Information for BRI3BP

No disorders were found for BRI3BP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BRI3BP Gene

Publications for BRI3BP Gene

  1. Cloning, tissue expression pattern, and chromosome location of a novel human gene BRI3BP. (PMID: 11860200) Lin L … Zhao S (Biochemical genetics 2001) 2 3 4 22 58
  2. Augmentation of drug-induced cell death by ER protein BRI3BP. (PMID: 17765869) Yamazaki T … Takeshima H (Biochemical and biophysical research communications 2007) 2 3 22 58
  3. HCCRBP-1 directly interacting with HCCR-1 induces tumorigenesis through P53 stabilization. (PMID: 17943721) Ha SA … Kim JW (International journal of cancer 2008) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for BRI3BP Gene

Sources for BRI3BP Gene

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