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Aliases for BRI3 Gene

Aliases for BRI3 Gene

  • Brain Protein I3 2 3 5
  • PRGR2 3 4
  • I3 3

External Ids for BRI3 Gene

Previous GeneCards Identifiers for BRI3 Gene

  • GC07P096445
  • GC07P097479
  • GC07P097522
  • GC07P097555
  • GC07P097748
  • GC07P097910
  • GC07P092511

Summaries for BRI3 Gene

GeneCards Summary for BRI3 Gene

BRI3 (Brain Protein I3) is a Protein Coding gene. Among its related pathways are Innate Immune System. Gene Ontology (GO) annotations related to this gene include identical protein binding.

UniProtKB/Swiss-Prot for BRI3 Gene

  • Participates in tumor necrosis factor-alpha (TNF)-induced cell death (PubMed:14592447). May be a target of Wnt/beta-catenin signaling in the liver (PubMed:20538055).

Additional gene information for BRI3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BRI3 Gene

Genomics for BRI3 Gene

GeneHancer (GH) Regulatory Elements for BRI3 Gene

Promoters and enhancers for BRI3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I098280 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 573.3 +32.1 32134 8.3 PKNOX1 ARID4B SIN3A FEZF1 ZNF48 YY1 ZNF121 GLIS2 FOS DEK BRI3 ENSG00000272950 BAIAP2L1 LMTK2
GH07I098248 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 550.8 -1.6 -1645 4.7 PKNOX1 CLOCK ARID4B SIN3A DMAP1 ZNF2 ZBTB7B E2F8 ZNF143 FOS BRI3 TECPR1 ENSG00000272950 BHLHA15 BAIAP2L1 LOC100419643 TRRAP PIR62558
GH07I098398 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 20.2 +147.6 147566 3.6 PKNOX1 SIN3A ZNF2 ZBTB7B ZNF207 ZNF143 KLF13 ZNF263 SP3 SP5 BAIAP2L1 BRI3 TRRAP ENSG00000272950 LOC101927550 LOC100419643 RPS3AP26 SMURF1 GC07M098389
GH07I098350 Enhancer 1.4 Ensembl ENCODE dbSUPER 19.4 +105.4 105372 14.1 CLOCK FOXA2 ARID4B NEUROD1 SIN3A YY1 FOS REST SMARCB1 KAT8 ENSG00000272950 BRI3 BAIAP2L1 TRRAP RPS3AP26
GH07I098293 Enhancer 1 ENCODE dbSUPER 21.4 +42.5 42471 3 HDGF RB1 ARID4B KLF17 SIN3A GLI4 ZNF2 RAD21 GLIS2 ARID2 ENSG00000272950 BRI3 TECPR1 BHLHA15 BAIAP2L1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around BRI3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the BRI3 gene promoter:

Genomic Locations for BRI3 Gene

Genomic Locations for BRI3 Gene
71,052 bases
Plus strand

Genomic View for BRI3 Gene

Genes around BRI3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BRI3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BRI3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BRI3 Gene

Proteins for BRI3 Gene

  • Protein details for BRI3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Brain protein I3
    Protein Accession:
    Secondary Accessions:
    • D6W5R8
    • Q8WV52
    • Q9UIC6

    Protein attributes for BRI3 Gene

    125 amino acids
    Molecular mass:
    13645 Da
    Quaternary structure:
    • Interacts with BRI3BP.

neXtProt entry for BRI3 Gene

Post-translational modifications for BRI3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for BRI3 Gene

Domains & Families for BRI3 Gene

Gene Families for BRI3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for BRI3 Gene


Suggested Antigen Peptide Sequences for BRI3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the BRI3 family.
  • Belongs to the BRI3 family.
genes like me logo Genes that share domains with BRI3: view

Function for BRI3 Gene

Molecular function for BRI3 Gene

UniProtKB/Swiss-Prot Function:
Participates in tumor necrosis factor-alpha (TNF)-induced cell death (PubMed:14592447). May be a target of Wnt/beta-catenin signaling in the liver (PubMed:20538055).
UniProtKB/Swiss-Prot Induction:
Up-regulated during TNF-mediated inflammation and immunity (By similarity). Up-regulated by beta-catenin and TCF4 (PubMed:20538055).

Phenotypes From GWAS Catalog for BRI3 Gene

Gene Ontology (GO) - Molecular Function for BRI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042802 identical protein binding IDA 15606899
genes like me logo Genes that share ontologies with BRI3: view
genes like me logo Genes that share phenotypes with BRI3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for BRI3

miRNA for BRI3 Gene

miRTarBase miRNAs that target BRI3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BRI3 Gene

Localization for BRI3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BRI3 Gene

Lysosome membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BRI3 gene
Compartment Confidence
plasma membrane 5
lysosome 4

Gene Ontology (GO) - Cellular Components for BRI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0035577 azurophil granule membrane TAS --
genes like me logo Genes that share ontologies with BRI3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for BRI3 Gene

Pathways & Interactions for BRI3 Gene

genes like me logo Genes that share pathways with BRI3: view

Pathways by source for BRI3 Gene

3 Reactome pathways for BRI3 Gene

Interacting Proteins for BRI3 Gene

Gene Ontology (GO) - Biological Process for BRI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with BRI3: view

No data available for SIGNOR curated interactions for BRI3 Gene

Drugs & Compounds for BRI3 Gene

No Compound Related Data Available

Transcripts for BRI3 Gene

Unigene Clusters for BRI3 Gene

Brain protein I3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for BRI3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c
SP1: -
SP2: - -

Relevant External Links for BRI3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BRI3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BRI3 Gene

mRNA differential expression in normal tissues according to GTEx for BRI3 Gene

This gene is overexpressed in Whole Blood (x5.4).

Protein differential expression in normal tissues from HIPED for BRI3 Gene

This gene is overexpressed in Gallbladder (18.2), Testis (15.1), Monocytes (12.1), Frontal cortex (9.6), and Islet of Langerhans (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for BRI3 Gene

Protein tissue co-expression partners for BRI3 Gene

NURSA nuclear receptor signaling pathways regulating expression of BRI3 Gene:


SOURCE GeneReport for Unigene cluster for BRI3 Gene:


Evidence on tissue expression from TISSUES for BRI3 Gene

  • Lung(4.9)
  • Nervous system(4.9)
  • Eye(4.3)
  • Intestine(3.1)
  • Kidney(2.8)
  • Muscle(2.4)
  • Stomach(2.4)
  • Skin(2.2)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with BRI3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for BRI3 Gene

Orthologs for BRI3 Gene

This gene was present in the common ancestor of animals.

Orthologs for BRI3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BRI3 33 34
  • 99.2 (n)
(Canis familiaris)
Mammalia BRI3 33 34
  • 92.27 (n)
(Bos Taurus)
Mammalia BRI3 33 34
  • 90.05 (n)
(Mus musculus)
Mammalia Bri3 33 16 34
  • 89.6 (n)
(Rattus norvegicus)
Mammalia Bri3 33
  • 87.47 (n)
(Monodelphis domestica)
Mammalia BRI3 34
  • 55 (a)
(Anolis carolinensis)
Reptilia BRI3 34
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia bri3 33
  • 62.53 (n)
(Danio rerio)
Actinopterygii bri3 33 34
  • 61.26 (n)
wufc63g12 33
fruit fly
(Drosophila melanogaster)
Insecta CG12012 34
  • 32 (a)
Species where no ortholog for BRI3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BRI3 Gene

Gene Tree for BRI3 (if available)
Gene Tree for BRI3 (if available)

Paralogs for BRI3 Gene Pseudogenes for BRI3 Gene

genes like me logo Genes that share paralogs with BRI3: view

No data available for Paralogs for BRI3 Gene

Variants for BRI3 Gene

Sequence variations from dbSNP and Humsavar for BRI3 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs201588264 benign, not specified 98,315,622(+) /T/TAAT genic_downstream_transcript_variant, intron_variant
rs372695844 benign, not specified 98,315,626(+) /T/TAAT/TAATAAT genic_downstream_transcript_variant, intron_variant
rs1000003091 -- 98,288,366(+) G/A intron_variant
rs1000013887 -- 98,300,929(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000079497 -- 98,306,360(+) A/G genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for BRI3 Gene

Variant ID Type Subtype PubMed ID
dgv3623n106 CNV deletion 24896259
nsv1076933 CNV deletion 25765185
nsv831067 CNV loss 17160897

Variation tolerance for BRI3 Gene

Residual Variation Intolerance Score: 52.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.19; 4.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BRI3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BRI3 Gene

Disorders for BRI3 Gene

Additional Disease Information for BRI3

No disorders were found for BRI3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BRI3 Gene

Publications for BRI3 Gene

  1. bri3, a novel gene, participates in tumor necrosis factor-alpha-induced cell death. (PMID: 14592447) Wu H … Zhao S (Biochemical and biophysical research communications 2003) 2 3 4 58
  2. Analysis of the Wnt/B-catenin/TCF4 pathway using SAGE, genome-wide microarray and promoter analysis: Identification of BRI3 and HSF2 as novel targets. (PMID: 20538055) Kavak E … Koman A (Cellular signalling 2010) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Cloning, tissue expression pattern, and chromosome location of a novel human gene BRI3BP. (PMID: 11860200) Lin L … Zhao S (Biochemical genetics 2001) 3 4 58
  5. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie AG … Butte NF (PloS one 2012) 3 58

Products for BRI3 Gene

Sources for BRI3 Gene

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