Aliases for BRF2 Gene
- BRF2 RNA Polymerase III Transcription Initiation Factor Subunit 2 3 5
- TFIIIB50 2 3 4
- BRFU 2 3 4
- BRF2, Subunit Of RNA Polymerase III Transcription Initiation Factor, BRF1-Like 2 3
- BRF2, RNA Polymerase III Transcription Initiation Factor 50 KDa Subunit 2 3
- Transcription Factor IIIB 50 KDa Subunit 3 4
- B-Related Factor 2 3 4
External Ids for BRF2 Gene
Previous GeneCards Identifiers for BRF2 Gene
This gene encodes one of the multiple subunits of the RNA polymerase III transcription factor complex required for transcription of genes with promoter elements upstream of the initiation site. The product of this gene, a TFIIB-like factor, is directly recruited to the TATA-box of polymerase III small nuclear RNA gene promoters through its interaction with the TATA-binding protein. [provided by RefSeq, Jul 2008]
GeneCards Summary for BRF2 Gene
BRF2 (BRF2 RNA Polymerase III Transcription Initiation Factor Subunit) is a Protein Coding gene. Diseases associated with BRF2 include Cone-Rod Dystrophy 9 and Cone-Rod Dystrophy 3. Among its related pathways are Transcription of tRNA and RNA Polymerase III Transcription Initiation. An important paralog of this gene is BRF1.
UniProtKB/Swiss-Prot Summary for BRF2 Gene
General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites (PubMed:11040218, PubMed:11121026, PubMed:11564744, PubMed:26638071). Contributes to the regulation of gene expression; functions as activator in the absence of oxidative stress (PubMed:26638071). Down-regulates expression of target genes in response to oxidative stress (PubMed:26638071). Overexpression protects cells against apoptosis in response to oxidative stress (PubMed:26638071).