BRD4 Gene (Protein Coding)

Bromodomain Containing 4

GC19M015236
GIFtS:
44
The protein encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. This gene has been implicated as the chromosome 19 target of translocatio... See more...

Aliases for BRD4 Gene

Aliases for BRD4 Gene

  • Bromodomain Containing 4 2 3 5
  • HUNK1 2 3 4
  • Mitotic Chromosome-Associated Protein 2 3
  • Bromodomain-Containing Protein 4 3 4
  • Chromosome-Associated Protein 2 3
  • HUNKI 2 3
  • MCAP 2 3
  • CAP 2 3
  • Bromodomain-Containing 4 2
  • Protein HUNK1 4
  • BRD4 5

External Ids for BRD4 Gene

Previous GeneCards Identifiers for BRD4 Gene

  • GC19M015727
  • GC19M015193
  • GC19M015209
  • GC19M015348
  • GC19M014916

Summaries for BRD4 Gene

Entrez Gene Summary for BRD4 Gene

  • The protein encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. This gene has been implicated as the chromosome 19 target of translocation t(15;19)(q13;p13.1), which defines an upper respiratory tract carcinoma in young people. Two alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]

CIViC Summary for BRD4 Gene

GeneCards Summary for BRD4 Gene

BRD4 (Bromodomain Containing 4) is a Protein Coding gene. Diseases associated with BRD4 include Nut Midline Carcinoma and Exophthalmic Ophthalmoplegia. Among its related pathways are Chromatin Regulation / Acetylation. Gene Ontology (GO) annotations related to this gene include chromatin binding and lysine-acetylated histone binding. An important paralog of this gene is BRD2.

UniProtKB/Swiss-Prot Summary for BRD4 Gene

  • Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation. Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 gene transcription by preserving acetylated chromatin status and maintaining high-order chromatin structure (PubMed:23589332, PubMed:23317504, PubMed:22334664). During interphase, plays a key role in regulating the transcription of signal-inducible genes by associating with the P-TEFb complex and recruiting it to promoters. Also recruits P-TEFb complex to distal enhancers, so called anti-pause enhancers in collaboration with JMJD6. BRD4 and JMJD6 are required to form the transcriptionally active P-TEFb complex by displacing negative regulators such as HEXIM1 and 7SKsnRNA complex from P-TEFb, thereby transforming it into an active form that can then phosphorylate the C-terminal domain (CTD) of RNA polymerase II (PubMed:23589332, PubMed:19596240, PubMed:16109377, PubMed:16109376, PubMed:24360279). Promotes phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II (PubMed:23086925). According to a report, directly acts as an atypical protein kinase and mediates phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II; these data however need additional evidences in vivo (PubMed:22509028). In addition to acetylated histones, also recognizes and binds acetylated RELA, leading to further recruitment of the P-TEFb complex and subsequent activation of NF-kappa-B (PubMed:19103749). Also acts as a regulator of p53/TP53-mediated transcription: following phosphorylation by CK2, recruited to p53/TP53 specific target promoters (PubMed:23317504).
  • [Isoform B]: Acts as a chromatin insulator in the DNA damage response pathway. Inhibits DNA damage response signaling by recruiting the condensin-2 complex to acetylated histones, leading to chromatin structure remodeling, insulating the region from DNA damage response by limiting spreading of histone H2AX/H2A.x phosphorylation.

Tocris Summary for BRD4 Gene

  • Bromodomains (BRDs) are epigenetic reader domains that selectively recognize acetylated lysine residues on the tails of histone proteins, and are the only known protein modules that can target acetylated lysine residues.

Gene Wiki entry for BRD4 Gene

Additional gene information for BRD4 Gene

No data available for PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BRD4 Gene

Genomics for BRD4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for BRD4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BRD4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for BRD4

Top Transcription factor binding sites by QIAGEN in the BRD4 gene promoter:
  • AP-1
  • FOXO3
  • FOXO3a
  • FOXO3b
  • NF-1
  • p53
  • RFX1

Genomic Locations for BRD4 Gene

Genomic Locations for BRD4 Gene
chr19:15,235,519-15,332,545
(GRCh38/hg38)
Size:
97,027 bases
Orientation:
Minus strand
chr19:15,347,647-15,443,356
(GRCh37/hg19)
Size:
95,710 bases
Orientation:
Minus strand

Genomic View for BRD4 Gene

Genes around BRD4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BRD4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BRD4 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for BRD4 Gene

Proteins for BRD4 Gene

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  • Protein details for BRD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60885-BRD4_HUMAN
    Recommended name:
    Bromodomain-containing protein 4
    Protein Accession:
    O60885
    Secondary Accessions:
    • O60433
    • Q4G0X8
    • Q86YS8
    • Q96PD3

    Protein attributes for BRD4 Gene

    Size:
    1362 amino acids
    Molecular mass:
    152219 Da
    Quaternary structure:
    • Binds acetylated histone H4 (PubMed:29176719). Interacts with p53/TP53; the interaction is direct (PubMed:23317504). Interacts (via CTD region) with CDK9 and CCNT1, acting as an associated component of P-TEFb complex (PubMed:16109376, PubMed:16109377, PubMed:23317504, PubMed:24360279). Interacts with RELA (when acetylated at 'Lys-310')(PubMed:19103749). Interacts (via NET domain) with NSD3, CHD4, BICRA and ATAD5 (PubMed:21555454,PubMed:29176719). The interaction with BICRA bridges BRD4 to the GBAF complex (PubMed:29374058, PubMed:16109376, PubMed:16109377, PubMed:19103749, PubMed:21555454, PubMed:23317504). Interacts (via NET domain) with JMJD6 (via JmjC and N-terminal domains); the interaction is stronger in presence of ssRNA and recruits JMJD6 on distal enhancers (PubMed:24360279, PubMed:21555454, PubMed:29176719). Interacts with NSD3 (PubMed:29176719). Isoform B: interacts with NCAPD3 and SMC2 (PubMed:23728299).
    • (Microbial infection) Interacts with bovine papillomavirus type 1 regulatory protein E2. This interactions may serve for the tethering of viral genomes to host mitotic chromosomes allowing successful partitioning of the viral genome during cell division.
    • (Microbial infection) Interacts with Epstein-Barr virus (EBV) protein EBNA1; this interaction facilitates transcriptional activation by EBNA1.
    • (Microbial infection) Interacts with human herpes virus-8 (HHV-8) protein LANA.
    SequenceCaution:
    • Sequence=AAC27978.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
    Miscellaneous:
    • Some specific inhibitors of BRD4 that prevent binding to acetylated histones by binding Asn-140 and Asn-433 are promising therapeutic molecules for the treatment of leukemias. JQ1, a thieno-triazolo-1,4-diazepine derivative, and I-BET, a benzodiazepine derivative, have been tested on tumors with success (PubMed:20871596, PubMed:21068722, PubMed:21964340). Treatment with GSK1210151A (I-BET151, a I-BET derivative) has strong effets on mixed lineage leukemia and promotes myeloid differentiation and leukemia stem-cell depletion (PubMed:21964340).
    • [Isoform B]: Does not contain the C-terminal (CTD) region required to recruit the P-TEFb complex.

    Three dimensional structures from OCA and Proteopedia for BRD4 Gene

    Alternative splice isoforms for BRD4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BRD4 Gene

Protein Expression for BRD4 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for BRD4 Gene

  • Phosphorylation by CK2 disrupt the intramolecular binding between the bromo domain 2 and the NPS region and promotes binding between the NPS and the BID regions, leading to activate the protein and promote binding to acetylated histones. In absence of phosphorylation, BRD4 does not localize to p53/TP53 target gene promoters, phosphorylation promoting recruitment to p53/TP53 target promoters.
  • Ubiquitination at Lys99
  • Modification sites at PhosphoSitePlus

Other Protein References for BRD4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BRD4 Gene

Domains & Families for BRD4 Gene

Gene Families for BRD4 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for BRD4 Gene

InterPro:
Blocks:
  • Bromodomain signature
ProtoNet:

Suggested Antigen Peptide Sequences for BRD4 Gene

GenScript: Design optimal peptide antigens:
  • Protein HUNK1 (BRD4_HUMAN)
  • BRD4 protein (Q05BM2_HUMAN)
  • BRD4 protein (Q5BJ26_HUMAN)
  • BRD4 protein (Q6NXE4_HUMAN)
  • BRD4 protein (Q6PIS5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O60885

UniProtKB/Swiss-Prot:

BRD4_HUMAN :
  • The NET domain mediates interaction with a number of chromatin proteins involved in transcription regulation (NSD3, JMJD6, CHD4, GLTSCR1 and ATAD5).
Domain:
  • The NET domain mediates interaction with a number of chromatin proteins involved in transcription regulation (NSD3, JMJD6, CHD4, GLTSCR1 and ATAD5).
  • The C-terminal (CTD) region mediates interaction and recruitment of CDK9 and CCNT1 subunits of the P-TEFb complex (PubMed:16109376, PubMed:16109377). It is also required for maintenance of higher-order chromatin structure (PubMed:22334664).
  • The 2 bromo domains mediate specific binding to acetylated histones via Asn-140 and Asn-433, respectively (PubMed:20871596). The exact combination of modified histone tails required to recruit BRD4 to target genes is still unclear. The first bromo domain has high affinity for acetylated histone H4 tail, whereas the second bromo domain recognizes multiply acetylated marks in histone H3 (PubMed:22464331). A number of specific inhibitors bind competitively to acetyl-lysine-binding residues Asn-140 and Asn-433, promoting removal from acetylated histones. Many of these inhibitors are benzodiazepine derivatives (PubMed:22137933, PubMed:22136404, PubMed:23517011, PubMed:23530754).
genes like me logo Genes that share domains with BRD4: view

Function for BRD4 Gene

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Molecular function for BRD4 Gene

UniProtKB/Swiss-Prot Function:
Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation. Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 gene transcription by preserving acetylated chromatin status and maintaining high-order chromatin structure (PubMed:23589332, PubMed:23317504, PubMed:22334664). During interphase, plays a key role in regulating the transcription of signal-inducible genes by associating with the P-TEFb complex and recruiting it to promoters. Also recruits P-TEFb complex to distal enhancers, so called anti-pause enhancers in collaboration with JMJD6. BRD4 and JMJD6 are required to form the transcriptionally active P-TEFb complex by displacing negative regulators such as HEXIM1 and 7SKsnRNA complex from P-TEFb, thereby transforming it into an active form that can then phosphorylate the C-terminal domain (CTD) of RNA polymerase II (PubMed:23589332, PubMed:19596240, PubMed:16109377, PubMed:16109376, PubMed:24360279). Promotes phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II (PubMed:23086925). According to a report, directly acts as an atypical protein kinase and mediates phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II; these data however need additional evidences in vivo (PubMed:22509028). In addition to acetylated histones, also recognizes and binds acetylated RELA, leading to further recruitment of the P-TEFb complex and subsequent activation of NF-kappa-B (PubMed:19103749). Also acts as a regulator of p53/TP53-mediated transcription: following phosphorylation by CK2, recruited to p53/TP53 specific target promoters (PubMed:23317504).
UniProtKB/Swiss-Prot Function:
[Isoform B]: Acts as a chromatin insulator in the DNA damage response pathway. Inhibits DNA damage response signaling by recruiting the condensin-2 complex to acetylated histones, leading to chromatin structure remodeling, insulating the region from DNA damage response by limiting spreading of histone H2AX/H2A.x phosphorylation.

Phenotypes From GWAS Catalog for BRD4 Gene

Gene Ontology (GO) - Molecular Function for BRD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002039 p53 binding IDA 23317504
GO:0003682 chromatin binding IDA 20871596
GO:0003712 transcription coregulator activity IMP 24360279
GO:0005515 protein binding IEA,IPI 17023018
GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity IMP 22509028
genes like me logo Genes that share ontologies with BRD4: view
genes like me logo Genes that share phenotypes with BRD4: view

Human Phenotype Ontology for BRD4 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

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No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for BRD4 Gene

Localization for BRD4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BRD4 Gene

Nucleus. Chromosome. Note=Associates with acetylated chromatin (PubMed:21890894, PubMed:16109376). Released from chromatin upon deacetylation of histones that can be triggered by different signals such as activation of the JNK pathway or nocodazole treatment (PubMed:21890894, PubMed:16109376). Preferentially localizes to mitotic chromosomes, while it does not localizes to meiotic chromosomes (PubMed:21890894, PubMed:16109376). {ECO:0000269 PubMed:16109376, ECO:0000269 PubMed:21890894}.
[Isoform B]: Chromosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BRD4 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for BRD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000794 condensed nuclear chromosome IDA 10938129
GO:0005634 nucleus IEA,IDA 20871596
GO:0005654 nucleoplasm IDA --
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with BRD4: view

Pathways & Interactions for BRD4 Gene

PathCards logo

SuperPathways for BRD4 Gene

genes like me logo Genes that share pathways with BRD4: view

Pathways by source for BRD4 Gene

1 Cell Signaling Technology pathway for BRD4 Gene
1 GeneTex pathway for BRD4 Gene

SIGNOR curated interactions for BRD4 Gene

Activates:

Gene Ontology (GO) - Biological Process for BRD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle IMP 18039861
GO:0006325 chromatin organization IEA --
GO:0006468 protein phosphorylation IEA --
GO:0006974 cellular response to DNA damage stimulus IEA --
GO:0010971 positive regulation of G2/M transition of mitotic cell cycle IMP 10938129
genes like me logo Genes that share ontologies with BRD4: view

Drugs & Compounds for BRD4 Gene

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  1. Drug

(52) Drugs for BRD4 Gene - From: ClinicalTrials, ApexBio, DGIdb, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Olaparib Approved Pharma PARP inhibitor, PARP Inhibitors, Other, Poly(ADPRIBOSE) polymerase (PARP) inhibitors 277
rituximab Approved Pharma Therapeutic Antibodies 2024
Fedratinib Approved, Investigational Pharma 0
CPI-203 Pharma BET bromodomain inhibitor 0
I-BET-762 Pharma BET inhibitor,highly potent 0

(2) Additional Compounds for BRD4 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
I-BET 151 dihydrochloride
1883545-47-8
PFI 1
1403764-72-6

(5) Tocris Compounds for BRD4 Gene

Compound Action Cas Number
(+)-JQ1 Potent, selective BET bromodomain inhibitor; cell permeable 1268524-70-4
Bromosporine Broad spectrum bromodomain inhibitor
I-BET 151 dihydrochloride BET bromodomain inhibitor; also promotes differentiation of hiPSCs into megakaryocytes 1883545-47-8
Ischemin sodium salt CBP inhibitor; cell permeable
PFI 1 BET bromodomain inhibitor 1403764-72-6

(21) ApexBio Compounds for BRD4 Gene

Compound Action Cas Number
(-)-JQ1 BET bromodomain inhibitor 1268524-71-5
BAZ2-ICR
BET bromodomain inhibitor Potent and selective inhibitor for BRD4 1380087-89-7
Bromodomain Inhibitor, (+)-JQ1 BET bromodomain inhibitor 1268524-70-4
Bromosporine Bromodomain inhibitor,non-selective 1619994-69-2
CPI-203 BET bromodomain inhibitor 1446144-04-2
GSK 525768A inactive stereoisomer of I-BET-762 1260530-25-3
GSK 5959 901245-65-6
GSK1324726A BET proteins inhibitor 1300031-52-0
I-BET 151 hydrochloride
I-BET151 (GSK1210151A) Selective BET inhibitor 1300031-49-5
I-BET-762 BET inhibitor,highly potent 1260907-17-2
Ischemin sodium salt
MS436 BRD4 inhibitor 1395084-25-9
OF-1 BRPF1B and BRPF2 bromodomain inhibitor 919973-83-4
OTX-015 BRD inhibitor 202590-98-5
OXF BD 02 1429129-68-9
PFI-1 (PF-6405761) BET inhibitor 1403764-72-6
RVX-208 Potent BET bromodomain inhibitor 1044870-39-4
UNC1215 Chemical probe for the methyllysine (Kme) 1415800-43-9
UNC669 L3MBTL antagonist,potent and selective 1314241-44-5
genes like me logo Genes that share compounds with BRD4: view

Drug Products

Transcripts for BRD4 Gene

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mRNA/cDNA for BRD4 Gene

5 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BRD4

Alternative Splicing Database (ASD) splice patterns (SP) for BRD4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a ·
SP1: -
SP2:
SP3:
SP4:
SP5: -
SP6: - -
SP7: - -
SP8: -
SP9:
SP10: -
SP11:
SP12:
SP13:

ExUns: 24b ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for BRD4 Gene

GeneLoc Exon Structure for
BRD4

Expression for BRD4 Gene

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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for BRD4 Gene

mRNA expression in normal human tissues for BRD4 Gene
mRNA expression by BioGPS for BRD4 GenemRNA expression by GTEx for BRD4 Gene

Protein differential expression in normal tissues from HIPED for BRD4 Gene

This gene is overexpressed in Adrenal (13.6), Peripheral blood mononuclear cells (10.0), and Lymph node (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for BRD4 Gene



Protein tissue co-expression partners for BRD4 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for BRD4

SOURCE GeneReport for Unigene cluster for BRD4 Gene:

Hs.187763

mRNA Expression by UniProt/SwissProt for BRD4 Gene:

O60885-BRD4_HUMAN
Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for BRD4 Gene

  • Liver(4.7)
  • Nervous system(4.2)
  • Blood(3.4)
  • Lung(3.4)
  • Muscle(3.3)
  • Kidney(3.3)
  • Intestine(3.2)
  • Skin(3.2)
  • Heart(3)
  • Spleen(2.7)
  • Pancreas(2.7)
  • Bone marrow(2.6)
  • Lymph node(2.6)
  • Thyroid gland(2.5)
  • Stomach(2.4)
  • Urine(2.4)
  • Adrenal gland(2.4)
  • Eye(2.2)
  • Bone(2)
genes like me logo Genes that share expression patterns with BRD4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for BRD4 Gene

Orthologs for BRD4 Gene

This gene was present in the common ancestor of animals.

Orthologs for BRD4 Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
 Mammalia BRD4 31
  • 97 (a)
 OneToOne
Chimpanzee
(Pan troglodytes)
 Mammalia BRD4 30 31
  • 96.88 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia BRD4 31
  • 96 (a)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Brd4 31
  • 93 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia BRD4 31
  • 88 (a)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia BRD4 31
  • 85 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves BRD4 31
  • 79 (a)
 OneToOne
LOC100859056 30
  • 77.15 (n)
Lizard
(Anolis carolinensis)
 Reptilia BRD4 31
  • 81 (a)
 OneToOne
Zebrafish
(Danio rerio)
 Actinopterygii brd4 31
  • 55 (a)
 OneToOne
Fruit Fly
(Drosophila melanogaster)
 Insecta fs(1)h 31 32
  • 24 (a)
 OneToMany
Species where no ortholog for BRD4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for BRD4 Gene

ENSEMBL:
Gene Tree for BRD4 (if available)
TreeFam:
Gene Tree for BRD4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for BRD4: view image

Paralogs for BRD4 Gene

Paralogs for BRD4 Gene

(8) SIMAP similar genes for BRD4 Gene using alignment to 8 proteins:

  • BRD4_HUMAN
  • M0QYW0_HUMAN
  • M0QZD9_HUMAN
  • M0R0H4_HUMAN
  • Q05BM2_HUMAN
  • Q5BJ26_HUMAN
  • Q6NXE4_HUMAN
  • Q6PIS5_HUMAN
genes like me logo Genes that share paralogs with BRD4: view

Variants for BRD4 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for BRD4 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
710756 Benign: not provided 15,238,836(-) G/A SYNONYMOUS_VARIANT
710757 Benign: not provided 15,239,479(-) C/T SYNONYMOUS_VARIANT
710758 Benign: not provided 15,244,571(-) C/T SYNONYMOUS_VARIANT
718290 Benign: not provided 15,238,785(-) C/A MISSENSE_VARIANT
718319 Benign: not provided 15,239,151(-) G/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for BRD4 Gene

Structural Variations from Database of Genomic Variants (DGV) for BRD4 Gene

Variant ID Type Subtype PubMed ID
dgv3442n100 CNV loss 25217958
esv3382180 CNV insertion 20981092
esv34154 CNV loss 18971310
nsv1078911 CNV insertion 25765185
nsv474976 CNV novel sequence insertion 20440878
nsv578717 CNV loss 21841781
nsv953983 CNV deletion 24416366

Variation tolerance for BRD4 Gene

Residual Variation Intolerance Score: 1.79% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.96; 49.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BRD4 Gene

Human Gene Mutation Database (HGMD)
BRD4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
BRD4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BRD4 Gene

Disorders for BRD4 Gene

MalaCards: The human disease database

(21) MalaCards diseases for BRD4 Gene - From: Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
nut midline carcinoma
  • nuclear protein in testis midline carcinoma
exophthalmic ophthalmoplegia
hyperglobulinemic purpura
  • purpura, hyperglobulinemic
dermatitis, atopic, 7
  • atod7
ureteral obstruction
- elite association - COSMIC cancer census association via MalaCards
Search BRD4 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

BRD4_HUMAN
  • Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUTM1 which produces a BRD4-NUTM1 fusion protein. {ECO:0000269 PubMed:11733348, ECO:0000269 PubMed:12543779}.

Additional Disease Information for BRD4

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with BRD4: view

No data available for Genatlas for BRD4 Gene

Publications for BRD4 Gene

  1. BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma. (PMID: 12543779) French CA … Fletcher JA (Cancer research 2003) 3 4 23
  2. BRD4 bromodomain gene rearrangement in aggressive carcinoma with translocation t(15;19). (PMID: 11733348) French CA … Fletcher JA (The American journal of pathology 2001) 3 4 23
  3. A bromodomain protein, MCAP, associates with mitotic chromosomes and affects G(2)-to-M transition. (PMID: 10938129) Dey A … Ozato K (Molecular and cellular biology 2000) 2 3 23
  4. Glioma tumor suppressor candidate region gene 1 (GLTSCR1) and its paralog GLTSCR1-like form SWI/SNF chromatin remodeling subcomplexes. (PMID: 29374058) Alpsoy A … Dykhuizen EC (The Journal of biological chemistry 2018) 3 4
  5. Structural Mechanism of the Oxygenase JMJD6 Recognition by the Extraterminal (ET) Domain of BRD4. (PMID: 29176719) Konuma T … Zeng L (Scientific reports 2017) 3 4

ExternalLinks

View latest publications for BRD4 gene in Mastermind

Products for BRD4 Gene

  • Addgene plasmids for BRD4

Sources for BRD4 Gene