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This gene was identified based on its homology to the gene encoding the RING3 protein, a serine/threonine kinase. The gene localizes to 9q34, a region which contains several major histocompatibility complex (MHC) genes. The function of the encoded protein is not known. [provided by RefSeq, Jul 2008]
BRD3 (Bromodomain Containing 3) is a Protein Coding gene. Diseases associated with BRD3 include Foodborne Botulism and Salivary Gland Carcinoma. Gene Ontology (GO) annotations related to this gene include chromatin binding and lysine-acetylated histone binding. An important paralog of this gene is BRD2.
Bromodomains (BRDs) are epigenetic reader domains that selectively recognize acetylated lysine residues on the tails of histone proteins, and are the only known protein modules that can target acetylated lysine residues.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003682 | chromatin binding | IDA | 18406326 |
GO:0005515 | protein binding | IEA,IPI | 20195357 |
GO:0070577 | lysine-acetylated histone binding | IDA | 22464331 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006325 | chromatin organization | IEA | -- |
GO:0006357 | regulation of transcription by RNA polymerase II | IDA | 18406326 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
I-BET-762 | Pharma | BET inhibitor,highly potent | 0 | |||
Pharmaceutical Solutions | Pharma | 11855 | ||||
BAZ2-ICR | Pharma | 0 | ||||
Bromosporine | Pharma | Bromodomain inhibitor,non-selective, Broad spectrum bromodomain inhibitor | 0 | |||
CPI-203 | Pharma | BET bromodomain inhibitor | 0 |
Compound | Action | Cas Number |
---|---|---|
BAZ2-ICR | ||
Bromosporine | Bromodomain inhibitor,non-selective | 1619994-69-2 |
CPI-203 | BET bromodomain inhibitor | 1446144-04-2 |
GSK 525768A | inactive stereoisomer of I-BET-762 | 1260530-25-3 |
GSK 5959 | 901245-65-6 | |
GSK1324726A | BET proteins inhibitor | 1300031-52-0 |
I-BET 151 hydrochloride | ||
I-BET151 (GSK1210151A) | Selective BET inhibitor | 1300031-49-5 |
I-BET-762 | BET inhibitor,highly potent | 1260907-17-2 |
Ischemin sodium salt | ||
MS436 | BRD4 inhibitor | 1395084-25-9 |
OF-1 | BRPF1B and BRPF2 bromodomain inhibitor | 919973-83-4 |
OTX-015 | BRD inhibitor | 202590-98-5 |
OXF BD 02 | 1429129-68-9 | |
PFI-1 (PF-6405761) | BET inhibitor | 1403764-72-6 |
RVX-208 | Potent BET bromodomain inhibitor | 1044870-39-4 |
UNC1215 | Chemical probe for the methyllysine (Kme) | 1415800-43-9 |
UNC669 | L3MBTL antagonist,potent and selective | 1314241-44-5 |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | BRD3 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | BRD3 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | BRD3 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | BRD3 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | BRD3 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Brd3 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Brd3 30 17 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | BRD3 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | BRD3 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | brd3 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | brd3a 30 31 |
|
OneToOne | |
wufc56a11 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | fs(1)h 31 32 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany | |
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.2782 30 |
|
SNP ID | Clinical significance and condition | Chr 09 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
744481 | Benign: not provided | 134,048,266(-) | G/A | SYNONYMOUS_VARIANT | |
769759 | Benign: not provided | 134,053,433(-) | G/T | SYNONYMOUS_VARIANT | |
788425 | Benign: not provided | 134,034,697(-) | G/GT | INTRON_VARIANT | |
VAR_041913 | A renal clear cell carcinoma sample | p.Thr36Asn | |||
VAR_041914 | A gastric adenocarcinoma sample | p.Ala161Thr |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv12966n54 | CNV | gain | 21841781 |
dgv12967n54 | CNV | gain | 21841781 |
dgv12968n54 | CNV | gain+loss | 21841781 |
dgv12969n54 | CNV | loss | 21841781 |
esv25492 | CNV | loss | 19812545 |
esv2739138 | CNV | deletion | 23290073 |
esv3621951 | CNV | loss | 21293372 |
nsv1075279 | CNV | deletion | 25765185 |
nsv1125319 | OTHER | inversion | 24896259 |
nsv1133746 | CNV | deletion | 24896259 |
nsv428226 | CNV | loss | 18775914 |
nsv466627 | CNV | loss | 19166990 |
nsv466629 | CNV | loss | 19166990 |
nsv615774 | CNV | loss | 21841781 |
nsv615779 | CNV | loss | 21841781 |
nsv615780 | CNV | loss | 21841781 |
nsv615781 | CNV | gain | 21841781 |
nsv615784 | CNV | loss | 21841781 |
nsv825148 | CNV | gain | 20364138 |
nsv825149 | CNV | gain | 20364138 |
nsv831748 | CNV | loss | 17160897 |
nsv831749 | CNV | loss | 17160897 |
nsv951805 | CNV | deletion | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
foodborne botulism |
|
|
salivary gland carcinoma |
|
|
wound botulism |
|
|
nut midline carcinoma |
|
|
infant botulism |
|
|