This gene was identified based on its homology to the gene encoding the RING3 protein, a serine/threonine kinase. The gene localizes to 9q34, a region which contains several major histocompatibility complex (MHC) genes. The function of the encoded protein is not known. [provided by RefSeq, Jul 2008] See more...

Aliases for BRD3 Gene

Aliases for BRD3 Gene

  • Bromodomain Containing 3 2 3 5
  • Bromodomain-Containing Protein 3 3 4
  • RING3-Like Protein 3 4
  • RING3L 3 4
  • Bromodomain-Containing Protein 3 Short Isoform 3
  • Bromodomain-Containing 3 2
  • RING3-Like 2
  • KIAA0043 4
  • ORFX 3

External Ids for BRD3 Gene

Previous GeneCards Identifiers for BRD3 Gene

  • GC09M127972
  • GC09M128566
  • GC09M130323
  • GC09M132239
  • GC09M133927
  • GC09M135886
  • GC09M136897
  • GC09M106393

Summaries for BRD3 Gene

Entrez Gene Summary for BRD3 Gene

  • This gene was identified based on its homology to the gene encoding the RING3 protein, a serine/threonine kinase. The gene localizes to 9q34, a region which contains several major histocompatibility complex (MHC) genes. The function of the encoded protein is not known. [provided by RefSeq, Jul 2008]

GeneCards Summary for BRD3 Gene

BRD3 (Bromodomain Containing 3) is a Protein Coding gene. Diseases associated with BRD3 include Foodborne Botulism and Salivary Gland Carcinoma. Gene Ontology (GO) annotations related to this gene include chromatin binding and lysine-acetylated histone binding. An important paralog of this gene is BRD2.

UniProtKB/Swiss-Prot Summary for BRD3 Gene

  • Chromatin reader that recognizes and binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors (PubMed:18406326, PubMed:27105114). Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity).

Tocris Summary for BRD3 Gene

  • Bromodomains (BRDs) are epigenetic reader domains that selectively recognize acetylated lysine residues on the tails of histone proteins, and are the only known protein modules that can target acetylated lysine residues.

Gene Wiki entry for BRD3 Gene

Additional gene information for BRD3 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BRD3 Gene

Genomics for BRD3 Gene

GeneHancer (GH) Regulatory Elements for BRD3 Gene

Promoters and enhancers for BRD3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J134065 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 511.3 +1.1 1131 4.8 EP300 SIN3A NRF1 POLR2G PHF8 SIX5 ZFX ZIC2 POLR2A ZBTB10 BRD3 BRD3OS ENSG00000235138 LOC100130548
GH09J134162 Promoter/Enhancer 1.9 Ensembl ENCODE CraniofacialAtlas 15.8 -96.0 -95950 3.6 EP300 FOXK2 ZBTB40 ZNF217 CTCF SIN3A TCF12 NRF1 MYC SP1 RNU6ATAC lnc-WDR5-4 WDR5 REXO4 BRD3 ENSG00000273249 MED22 SURF6 RPL7A ENSG00000235138
GH09J133333 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas 11.9 +733.2 733244 4.2 EP300 FOXK2 HNRNPK ZBTB40 ZNF217 SIN3A NRF1 MYC TCF12 USF1 SURF6 lnc-MED22-1 SURF1 WDR5 GTF3C4 BRD3 DDX31 ENSG00000235138 REXO4 MED22
GH09J134363 Promoter/Enhancer 2 VISTA FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 12.8 -297.7 -297704 5.4 EP300 ZNF217 TCF12 NCOR1 ZFX ZNF10 ZIC2 KDM6A ZBTB10 CLOCK WDR5 BRD3OS OLFM1 BRD3 RXRA lnc-BRD3-7
GH09J134640 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 9.7 -575.7 -575741 7.8 NRF1 USF1 JUND FOS CTCF ZNF10 ZIC2 ZNF423 ZNF623 ZBTB26 COL5A1 WDR5 ENSG00000235138 BRD3 C9orf116 COL5A1-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BRD3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for BRD3

Top Transcription factor binding sites by QIAGEN in the BRD3 gene promoter:
  • AhR
  • AML1a
  • c-Myb
  • c-Myc
  • Cdc5
  • Evi-1
  • Max
  • Pax-5
  • RelA

Genomic Locations for BRD3 Gene

Genomic Locations for BRD3 Gene
chr9:134,030,305-134,068,535
(GRCh38/hg38)
Size:
38,231 bases
Orientation:
Minus strand
chr9:136,895,427-136,933,657
(GRCh37/hg19)
Size:
38,231 bases
Orientation:
Minus strand

Genomic View for BRD3 Gene

Genes around BRD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BRD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BRD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BRD3 Gene

Proteins for BRD3 Gene

  • Protein details for BRD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15059-BRD3_HUMAN
    Recommended name:
    Bromodomain-containing protein 3
    Protein Accession:
    Q15059
    Secondary Accessions:
    • B1APD9
    • Q4G5Y3
    • Q5T1R7
    • Q8N5M3
    • Q92645

    Protein attributes for BRD3 Gene

    Size:
    726 amino acids
    Molecular mass:
    79542 Da
    Quaternary structure:
    • Interacts (via bromo domain 1) with GATA1 acetylated at 'Lys-312' and 'Lys-315'. Interacts (via bromo domain 1) with GATA2 acetylated on lysine residues (By similarity). Interacts (via bromo domains) with acetylated lysine residues on the N-terminus of histone H2A, H2B, H3 and H4 (in vitro).
    SequenceCaution:
    • Sequence=BAA05393.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for BRD3 Gene

    Alternative splice isoforms for BRD3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BRD3 Gene

Post-translational modifications for BRD3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for BRD3 Gene

Domains & Families for BRD3 Gene

Gene Families for BRD3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for BRD3 Gene

Blocks:
  • Bromodomain signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for BRD3 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ61365, highly similar to Bromodomain-containing protein 3 (B4DS09_HUMAN)
  • RING3-like protein (BRD3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q15059

UniProtKB/Swiss-Prot:

BRD3_HUMAN :
  • The Bromo domains specifically recognize and bind acetylated histones.
Domain:
  • The Bromo domains specifically recognize and bind acetylated histones.
genes like me logo Genes that share domains with BRD3: view

Function for BRD3 Gene

Molecular function for BRD3 Gene

UniProtKB/Swiss-Prot Function:
Chromatin reader that recognizes and binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors (PubMed:18406326, PubMed:27105114). Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity).

Phenotypes From GWAS Catalog for BRD3 Gene

Gene Ontology (GO) - Molecular Function for BRD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IDA 18406326
GO:0005515 protein binding IPI,IEA 20195357
GO:0070577 lysine-acetylated histone binding IDA 22464331
genes like me logo Genes that share ontologies with BRD3: view
genes like me logo Genes that share phenotypes with BRD3: view

Animal Model Products

CRISPR Products

Clone Products

  • Addgene plasmids for BRD3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BRD3 Gene

Localization for BRD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BRD3 Gene

Nucleus. Note=Detected on chromatin. {ECO:0000250 UniProtKB:Q8K2F0}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BRD3 gene
Compartment Confidence
nucleus 5
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
cytosol 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for BRD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with BRD3: view

Pathways & Interactions for BRD3 Gene

PathCards logo

SuperPathways for BRD3 Gene

No Data Available

SIGNOR curated interactions for BRD3 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for BRD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization IEA --
GO:0006357 regulation of transcription by RNA polymerase II IDA 18406326
genes like me logo Genes that share ontologies with BRD3: view

No data available for Pathways by source for BRD3 Gene

Drugs & Compounds for BRD3 Gene

(26) Drugs for BRD3 Gene - From: ClinicalTrials, ApexBio, and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
GW841819X Pharma BET bromodomain inhibitor 0
I-BET-762 Pharma BET inhibitor,highly potent 0
Pharmaceutical Solutions Pharma 11396
BAZ2-ICR Pharma 0
BET-BAY 002 Pharma 0

(20) ApexBio Compounds for BRD3 Gene

Compound Action Cas Number
BAZ2-ICR
BET-BAY 002 1588521-78-1
Bromosporine Bromodomain inhibitor,non-selective 1619994-69-2
CPI-203 BET bromodomain inhibitor 1446144-04-2
GSK 525768A inactive stereoisomer of I-BET-762 1260530-25-3
GSK 5959 901245-65-6
GSK1324726A BET proteins inhibitor 1300031-52-0
GW841819X BET bromodomain inhibitor
I-BET 151 hydrochloride
I-BET151 (GSK1210151A) Selective BET inhibitor 1300031-49-5
I-BET-762 BET inhibitor,highly potent 1260907-17-2
Ischemin sodium salt
MS436 BRD4 inhibitor 1395084-25-9
OF-1 BRPF1B and BRPF2 bromodomain inhibitor 919973-83-4
OTX-015 BRD inhibitor 202590-98-5
OXF BD 02 1429129-68-9
PFI-1 (PF-6405761) BET inhibitor 1403764-72-6
RVX-208 Potent BET bromodomain inhibitor 1044870-39-4
UNC1215 Chemical probe for the methyllysine (Kme) 1415800-43-9
UNC669 L3MBTL antagonist,potent and selective 1314241-44-5
genes like me logo Genes that share compounds with BRD3: view

Drug Products

Transcripts for BRD3 Gene

mRNA/cDNA for BRD3 Gene

1 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for BRD3

Alternative Splicing Database (ASD) splice patterns (SP) for BRD3 Gene

No ASD Table

Relevant External Links for BRD3 Gene

GeneLoc Exon Structure for
BRD3

Expression for BRD3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for BRD3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for BRD3 Gene

This gene is overexpressed in Vitreous humor (15.1), Synovial fluid (10.8), and Lymph node (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for BRD3 Gene



Protein tissue co-expression partners for BRD3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for BRD3

SOURCE GeneReport for Unigene cluster for BRD3 Gene:

Hs.522472

mRNA Expression by UniProt/SwissProt for BRD3 Gene:

Q15059-BRD3_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for BRD3 Gene

  • Nervous system(4.5)
  • Intestine(4.2)
  • Liver(4.2)
  • Bone marrow(4.1)
  • Eye(3.3)
  • Lung(2.8)
genes like me logo Genes that share expression patterns with BRD3: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for BRD3 Gene

Orthologs for BRD3 Gene

This gene was present in the common ancestor of animals.

Orthologs for BRD3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BRD3 31 30
  • 99.36 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BRD3 31
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BRD3 31 30
  • 89.93 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BRD3 31
  • 89 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BRD3 31 30
  • 88.68 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Brd3 30
  • 88.02 (n)
mouse
(Mus musculus)
Mammalia Brd3 17 31 30
  • 87.81 (n)
chicken
(Gallus gallus)
Aves BRD3 31 30
  • 81.17 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BRD3 31
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia brd3 30
  • 74.65 (n)
zebrafish
(Danio rerio)
Actinopterygii brd3a 31 30
  • 69.21 (n)
OneToOne
wufc56a11 30
fruit fly
(Drosophila melanogaster)
Insecta fs(1)h 31 32
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 46 (a)
OneToMany
Cin.2782 30
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2782 30
Species where no ortholog for BRD3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BRD3 Gene

ENSEMBL:
Gene Tree for BRD3 (if available)
TreeFam:
Gene Tree for BRD3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for BRD3: view image

Paralogs for BRD3 Gene

Paralogs for BRD3 Gene

(5) SIMAP similar genes for BRD3 Gene using alignment to 4 proteins:

  • BRD3_HUMAN
  • A9J571_HUMAN
  • A9J575_HUMAN
  • L8E9I5_HUMAN
genes like me logo Genes that share paralogs with BRD3: view

Variants for BRD3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for BRD3 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
744481 Benign: not provided 134,048,266(-) G/A SYNONYMOUS_VARIANT
769759 Benign: not provided 134,053,433(-) G/T SYNONYMOUS_VARIANT
788425 Benign: not provided 134,034,697(-) G/GT INTRON_VARIANT
VAR_041913 A renal clear cell carcinoma sample p.Thr36Asn
VAR_041914 A gastric adenocarcinoma sample p.Ala161Thr

Additional dbSNP identifiers (rs#s) for BRD3 Gene

Structural Variations from Database of Genomic Variants (DGV) for BRD3 Gene

Variant ID Type Subtype PubMed ID
dgv12966n54 CNV gain 21841781
dgv12967n54 CNV gain 21841781
dgv12968n54 CNV gain+loss 21841781
dgv12969n54 CNV loss 21841781
esv25492 CNV loss 19812545
esv2739138 CNV deletion 23290073
esv3621951 CNV loss 21293372
nsv1075279 CNV deletion 25765185
nsv1125319 OTHER inversion 24896259
nsv1133746 CNV deletion 24896259
nsv428226 CNV loss 18775914
nsv466627 CNV loss 19166990
nsv466629 CNV loss 19166990
nsv615774 CNV loss 21841781
nsv615779 CNV loss 21841781
nsv615780 CNV loss 21841781
nsv615781 CNV gain 21841781
nsv615784 CNV loss 21841781
nsv825148 CNV gain 20364138
nsv825149 CNV gain 20364138
nsv831748 CNV loss 17160897
nsv831749 CNV loss 17160897
nsv951805 CNV deletion 24416366

Variation tolerance for BRD3 Gene

Residual Variation Intolerance Score: 6.84% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.79; 47.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BRD3 Gene

Human Gene Mutation Database (HGMD)
BRD3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
BRD3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BRD3 Gene

Disorders for BRD3 Gene

MalaCards: The human disease database

(10) MalaCards diseases for BRD3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
foodborne botulism
  • wound botulism
salivary gland carcinoma
  • salivary gland cancer
wound botulism
  • cutaneous infectious botulism
nut midline carcinoma
  • nuclear protein in testis midline carcinoma
infant botulism
  • infant intestinal botulism
- elite association - COSMIC cancer census association via MalaCards
Search BRD3 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

BRD3_HUMAN
  • Note=A chromosomal aberration involving BRD3 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;9)(q14;q34) with NUTM1 which produces a BRD3-NUTM1 fusion protein. {ECO:0000269 PubMed:17934517}.

Additional Disease Information for BRD3

genes like me logo Genes that share disorders with BRD3: view

No data available for Genatlas for BRD3 Gene

Publications for BRD3 Gene

  1. Chromosomal localization, gene structure and transcription pattern of the ORFX gene, a homologue of the MHC-linked RING3 gene. (PMID: 9373153) Thorpe KL … Beck S (Gene 1997) 3 4 23 54
  2. Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 7584044) Nomura N … Tabata S (DNA research : an international journal for rapid publication of reports on genes and genomes 1994) 2 3 4 54
  3. Molecular Coupling of Histone Crotonylation and Active Transcription by AF9 YEATS Domain. (PMID: 27105114) Li Y … Li H (Molecular cell 2016) 3 4 54
  4. Histone recognition and large-scale structural analysis of the human bromodomain family. (PMID: 22464331) Filippakopoulos P … Knapp S (Cell 2012) 3 4 54
  5. New gene functions in megakaryopoiesis and platelet formation. (PMID: 22139419) Gieger C … Soranzo N (Nature 2011) 3 41 54

Products for BRD3 Gene

Sources for BRD3 Gene