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This gene was identified based on its homology to the gene encoding the RING3 protein, a serine/threonine kinase. The gene localizes to 9q34, a region which contains several major histocompatibility complex (MHC) genes. The function of the encoded protein is not known. [provided by RefSeq, Jul 2008] See more...
Aliases for BRD3 Gene
Aliases for BRD3 Gene
External Ids for BRD3 Gene
- HGNC: 1104
- Entrez Gene: 8019
- Ensembl: ENSG00000169925
- OMIM: 601541
- UniProtKB: Q15059
Previous GeneCards Identifiers for BRD3 Gene
- GC09M127972
- GC09M128566
- GC09M130323
- GC09M132239
- GC09M133927
- GC09M135886
- GC09M136897
- GC09M106393
Summaries for BRD3 Gene
-
This gene was identified based on its homology to the gene encoding the RING3 protein, a serine/threonine kinase. The gene localizes to 9q34, a region which contains several major histocompatibility complex (MHC) genes. The function of the encoded protein is not known. [provided by RefSeq, Jul 2008]
GeneCards Summary for BRD3 Gene
BRD3 (Bromodomain Containing 3) is a Protein Coding gene. Diseases associated with BRD3 include Foodborne Botulism and Salivary Gland Carcinoma. Gene Ontology (GO) annotations related to this gene include chromatin binding and lysine-acetylated histone binding. An important paralog of this gene is BRD2.
UniProtKB/Swiss-Prot Summary for BRD3 Gene
-
Chromatin reader that recognizes and binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors (PubMed:18406326, PubMed:27105114). Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity).
-
Bromodomains (BRDs) are epigenetic reader domains that selectively recognize acetylated lysine residues on the tails of histone proteins, and are the only known protein modules that can target acetylated lysine residues.
Additional gene information for BRD3 Gene
- HGNC(1104)
- Entrez Gene(8019)
- Ensembl(ENSG00000169925)
- OMIM(601541)
- UniProtKB(Q15059)
- Open Targets Platform(ENSG00000169925)
- Search for BRD3 at DataMed
- Search for BRD3 at HumanCyc
No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BRD3 Gene
Genomics for BRD3 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for BRD3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around BRD3 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for BRD3
- Top Transcription factor binding sites by QIAGEN in the BRD3 gene promoter:
-
- AhR
- AML1a
- c-Myb
- c-Myc
- Cdc5
- Evi-1
- Max
- Pax-5
- RelA
Genomic Locations for BRD3 Gene
Genomic Locations for BRD3 Gene
- chr9:134,030,305-134,068,535
- (GRCh38/hg38)
- Size:
- 38,231 bases
- Orientation:
- Minus strand
- chr9:136,895,427-136,933,657
- (GRCh37/hg19)
- Size:
- 38,231 bases
- Orientation:
- Minus strand
Genomic View for BRD3 Gene
Genes around BRD3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 9q34.2 by HGNC
- 9q34.2 by Entrez Gene
- 9q34.2 by Ensembl
BRD3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for BRD3 Gene
Proteins for BRD3 Gene
-
Protein details for BRD3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q15059-BRD3_HUMAN
- Recommended name:
- Bromodomain-containing protein 3
- Protein Accession:
- Q15059
- B1APD9
- Q4G5Y3
- Q5T1R7
- Q8N5M3
- Q92645
Protein attributes for BRD3 Gene
- Size:
- 726 amino acids
- Molecular mass:
- 79542 Da
- Quaternary structure:
-
- Interacts (via bromo domain 1) with GATA1 acetylated at 'Lys-312' and 'Lys-315'. Interacts (via bromo domain 1) with GATA2 acetylated on lysine residues (By similarity). Interacts (via bromo domains) with acetylated lysine residues on the N-terminus of histone H2A, H2B, H3 and H4 (in vitro).
- SequenceCaution:
-
- Sequence=BAA05393.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for BRD3 Gene
Protein Expression for BRD3 Gene
Post-translational modifications for BRD3 Gene
Other Protein References for BRD3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences BRD3 Antibody
- G Biosciences Immunotag™ BRD3 Antibody
- GeneTex Anti-BRD3 antibody
-
Custom Antibody ServicesOriGene Antibodies for BRD3
- Novus Biologicals Antibodies for BRD3
-
Abcam antibodies for BRD3
- Invitrogen Antibodies for BRD3 (AFLGC-BRD3)
- antibodies-online: Show 39 available BRD3 Antibodies ranked by validation data
- Compare Top BRD3 Antibodies
-
Recommended
- 89 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 3 IHC (p) Antibodies (anti-human)
- 2 IHC Antibodies (anti-human)
- 2 IP Antibodies (anti-human)
- 47 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 1 IP Antibody (anti-mouse)
- 25 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
- 1 IP Antibody (anti-rat)
-
Santa Cruz Biotechnology (SCBT) Antibodies for BRD3
- Sino Biological Antibodies for BRD3
Protein Products
-
OriGene Purified Proteins for BRD3
- Search Origene for MassSpec and Protein Over-expression Lysates for BRD3
- Origene Custom Protein Services for BRD3
- ProSpec Recombinant Proteins for BRD3
-
Abcam proteins for BRD3
Assay Products
- antibodies-online: Show 3 available BRD3 Elisa Kits ranked by validation data
- Compare Top BRD3 Elisa Kits
-
Quality Products:
-
Boster Bio ELISA Kits for BRD3
No data available for DME Specific Peptides for BRD3 Gene
Domains & Families for BRD3 Gene
Gene Families for BRD3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Predicted intracellular proteins
Protein Domains for BRD3 Gene
- InterPro:
- Blocks:
-
- Bromodomain signature
- ProtoNet:
Suggested Antigen Peptide Sequences for BRD3 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ61365, highly similar to Bromodomain-containing protein 3 (B4DS09_HUMAN)
- RING3-like protein (BRD3_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q15059UniProtKB/Swiss-Prot:
BRD3_HUMAN :- The Bromo domains specifically recognize and bind acetylated histones.
- Domain:
-
- The Bromo domains specifically recognize and bind acetylated histones.
Function for BRD3 Gene
Molecular function for BRD3 Gene
- UniProtKB/Swiss-Prot Function:
- Chromatin reader that recognizes and binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors (PubMed:18406326, PubMed:27105114). Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity).
Phenotypes From GWAS Catalog for BRD3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003682 | chromatin binding | IDA | 18406326 |
| GO:0005515 | protein binding | IEA,IPI | 20195357 |
| GO:0070577 | lysine-acetylated histone binding | IDA | 22464331 |
Phenotypes for BRD3 Gene
- GenomeRNAi human phenotypes for BRD3:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Increased cell death HMECs cells
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
- Decreased viability
- Increased hepcidin::fluc mRNA expression
- Increased viability with MLN4924 (a NAE inhibitor)
- Decreased vesicular stomatitis virus (VSV) infection
- Decreased substrate adherent cell growth
- (Transferrin accumulation in enlarged cytoplasmic structures)
Animal Model Products
-
Taconic Biosciences Mouse Models for BRD3
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for BRD3 - Select products 50% OFF >
- * BRD3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for BRD3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BRD3
-
Santa Cruz Biotechnology (SCBT) CRISPR for BRD3
miRNA for BRD3 Gene
- miRTarBase miRNAs that target BRD3
-
- hsa-miR-141-3p (MIRT003279)
- hsa-miR-192-5p (MIRT004162)
- hsa-miR-26b-5p (MIRT029195)
- hsa-miR-3658 (MIRT503103)
- hsa-miR-183-3p (MIRT503104)
- hsa-miR-3653-3p (MIRT503105)
- hsa-miR-8064 (MIRT503106)
- hsa-miR-144-5p (MIRT503107)
- hsa-miR-4680-3p (MIRT503108)
- hsa-miR-487a-3p (MIRT503109)
- hsa-miR-154-3p (MIRT503110)
- hsa-miR-200a-3p (MIRT503111)
- hsa-miR-4659b-3p (MIRT615868)
- hsa-miR-4659a-3p (MIRT615869)
- hsa-miR-6875-3p (MIRT615870)
- hsa-miR-627-3p (MIRT615871)
- hsa-miR-4778-3p (MIRT615872)
- hsa-miR-129-5p (MIRT783453)
- hsa-miR-3140-3p (MIRT784636)
- hsa-miR-4795-3p (MIRT786812)
- hsa-miR-6885-3p (MIRT789307)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BRD3
- Browse OriGene Inhibitory RNA Products For BRD3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BRD3
Clone Products
- Applied Biological Materials (abm): Clones for BRD3 - Select products 50% OFF >
- * BRD3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG210310
- MG223345
- MG224008
- MR210310
- MR210310L3
- MR210310L4
- MR223345
- MR223345L3
- MR223345L4
- MR224008
- MR224008L3
- MR224008L4
- RC217616
- RC217616L3
- RC217616L4
- RG217616
- RR204633
- RR204633L3
- RR204633L4
- MR210310L3V
- MR210310L4V
- MR223345L3V
- MR223345L4V
- MR224008L3V
- MR224008L4V
- RC217616L3V
- RC217616L4V
- RR204633L3V
- RR204633L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for BRD3
- Addgene plasmids for BRD3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BRD3
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BRD3 Gene
Localization for BRD3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for BRD3 Gene
- Nucleus. Note=Detected on chromatin. {ECO:0000250 UniProtKB:Q8K2F0}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
| golgi apparatus | 1 |
- Nuclear bodies (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
Pathways & Interactions for BRD3 Gene
Interacting Proteins for BRD3 Gene
Selected Interacting proteins:
Q15059-BRD3_HUMAN
ENSP00000305918
for BRD3 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for BRD3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006325 | chromatin organization | IEA | -- |
| GO:0006357 | regulation of transcription by RNA polymerase II | IDA | 18406326 |
No data available for Pathways by source for BRD3 Gene
Drugs & Compounds for BRD3 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| I-BET-762 | Pharma | BET inhibitor,highly potent | 0 | |||
| Pharmaceutical Solutions | Pharma | 11855 | ||||
| BAZ2-ICR | Pharma | 0 | ||||
| Bromosporine | Pharma | Bromodomain inhibitor,non-selective, Broad spectrum bromodomain inhibitor | 0 | |||
| CPI-203 | Pharma | BET bromodomain inhibitor | 0 |
(18) ApexBio Compounds for BRD3 Gene
| Compound | Action | Cas Number |
|---|---|---|
| BAZ2-ICR | ||
| Bromosporine | Bromodomain inhibitor,non-selective | 1619994-69-2 |
| CPI-203 | BET bromodomain inhibitor | 1446144-04-2 |
| GSK 525768A | inactive stereoisomer of I-BET-762 | 1260530-25-3 |
| GSK 5959 | 901245-65-6 | |
| GSK1324726A | BET proteins inhibitor | 1300031-52-0 |
| I-BET 151 hydrochloride | ||
| I-BET151 (GSK1210151A) | Selective BET inhibitor | 1300031-49-5 |
| I-BET-762 | BET inhibitor,highly potent | 1260907-17-2 |
| Ischemin sodium salt | ||
| MS436 | BRD4 inhibitor | 1395084-25-9 |
| OF-1 | BRPF1B and BRPF2 bromodomain inhibitor | 919973-83-4 |
| OTX-015 | BRD inhibitor | 202590-98-5 |
| OXF BD 02 | 1429129-68-9 | |
| PFI-1 (PF-6405761) | BET inhibitor | 1403764-72-6 |
| RVX-208 | Potent BET bromodomain inhibitor | 1044870-39-4 |
| UNC1215 | Chemical probe for the methyllysine (Kme) | 1415800-43-9 |
| UNC669 | L3MBTL antagonist,potent and selective | 1314241-44-5 |
Transcripts for BRD3 Gene
mRNA/cDNA for BRD3 Gene
- 1 REFSEQ mRNAs :
- 14 NCBI additional mRNA sequence :
- 6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000303407 5661 nts (view in UCSC)
- ENST00000473349 761 nts (view in UCSC)
- ENST00000371834 2529 nts (view in UCSC)
- ENST00000494743 507 nts (view in UCSC)
- ENST00000371842 574 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for BRD3 - Select products 50% OFF >
- * BRD3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for BRD3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BRD3
-
Santa Cruz Biotechnology (SCBT) CRISPR for BRD3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BRD3
- Browse OriGene Inhibitory RNA Products For BRD3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BRD3
Clone Products
- Applied Biological Materials (abm): Clones for BRD3 - Select products 50% OFF >
- * BRD3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG210310
- MG223345
- MG224008
- MR210310
- MR210310L3
- MR210310L4
- MR223345
- MR223345L3
- MR223345L4
- MR224008
- MR224008L3
- MR224008L4
- RC217616
- RC217616L3
- RC217616L4
- RG217616
- RR204633
- RR204633L3
- RR204633L4
- MR210310L3V
- MR210310L4V
- MR223345L3V
- MR223345L4V
- MR224008L3V
- MR224008L4V
- RC217616L3V
- RC217616L4V
- RR204633L3V
- RR204633L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for BRD3
- Addgene plasmids for BRD3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BRD3
Relevant External Links for BRD3 Gene
- GeneLoc Exon Structure for
- BRD3
Expression for BRD3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Gonad (Reproductive System)
- Testis Somatic Cells Primitive Gonad
-
Testis (Reproductive System)
- Testis Somatic Cells Primitive Gonad
This gene is overexpressed in Vitreous humor (15.1), Synovial fluid (10.8), and Lymph node (6.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for BRD3 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for BRD3
SOURCE GeneReport for Unigene cluster for BRD3 Gene:
Hs.522472mRNA Expression by UniProt/SwissProt for BRD3 Gene:
Q15059-BRD3_HUMAN
Tissue specificity:
Ubiquitous.
Evidence on tissue expression from TISSUES for BRD3 Gene
- Nervous system(4.6)
- Intestine(4.5)
- Liver(4.5)
- Bone marrow(4.4)
- Eye(3.5)
- Lung(3.2)
- Skin(2.8)
- Pancreas(2.8)
- Blood(2.6)
- Kidney(2.5)
- Muscle(2.4)
- Heart(2.3)
Primer Products
-
OriGene qPCR primer pairs for BRD3
-
OriGene qPCR primer pairs and template standards for BRD3
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for BRD3 Gene
Orthologs for BRD3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | BRD3 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | BRD3 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | BRD3 30 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | BRD3 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | BRD3 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Brd3 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Brd3 30 17 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | BRD3 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | BRD3 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | brd3 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | brd3a 30 31 |
|
OneToOne | |
| wufc56a11 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | fs(1)h 31 32 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany | |
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.2782 30 |
|
- Species where no ortholog for BRD3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for BRD3 Gene
- ENSEMBL:
- Gene Tree for BRD3 (if available)
- TreeFam:
- Gene Tree for BRD3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for BRD3: view image
Paralogs for BRD3 Gene
Paralogs for BRD3 Gene
(5) SIMAP similar genes for BRD3 Gene using alignment to 4 proteins:
- BRD3_HUMAN
- A9J571_HUMAN
- A9J575_HUMAN
- L8E9I5_HUMAN
Variants for BRD3 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for BRD3 Gene
| SNP ID | Clinical significance and condition | Chr 09 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 744481 | Benign: not provided | 134,048,266(-) | G/A | SYNONYMOUS_VARIANT | |
| 769759 | Benign: not provided | 134,053,433(-) | G/T | SYNONYMOUS_VARIANT | |
| 788425 | Benign: not provided | 134,034,697(-) | G/GT | INTRON_VARIANT | |
| VAR_041913 | A renal clear cell carcinoma sample | p.Thr36Asn | |||
| VAR_041914 | A gastric adenocarcinoma sample | p.Ala161Thr |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv12966n54 | CNV | gain | 21841781 |
| dgv12967n54 | CNV | gain | 21841781 |
| dgv12968n54 | CNV | gain+loss | 21841781 |
| dgv12969n54 | CNV | loss | 21841781 |
| esv25492 | CNV | loss | 19812545 |
| esv2739138 | CNV | deletion | 23290073 |
| esv3621951 | CNV | loss | 21293372 |
| nsv1075279 | CNV | deletion | 25765185 |
| nsv1125319 | OTHER | inversion | 24896259 |
| nsv1133746 | CNV | deletion | 24896259 |
| nsv428226 | CNV | loss | 18775914 |
| nsv466627 | CNV | loss | 19166990 |
| nsv466629 | CNV | loss | 19166990 |
| nsv615774 | CNV | loss | 21841781 |
| nsv615779 | CNV | loss | 21841781 |
| nsv615780 | CNV | loss | 21841781 |
| nsv615781 | CNV | gain | 21841781 |
| nsv615784 | CNV | loss | 21841781 |
| nsv825148 | CNV | gain | 20364138 |
| nsv825149 | CNV | gain | 20364138 |
| nsv831748 | CNV | loss | 17160897 |
| nsv831749 | CNV | loss | 17160897 |
| nsv951805 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
6.84% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.79;
47.40% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for BRD3 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BRD3 Gene
Disorders for BRD3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| foodborne botulism |
|
|
| salivary gland carcinoma |
|
|
| wound botulism |
|
|
| nut midline carcinoma |
|
|
| infant botulism |
|
|
Search BRD3 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
BRD3_HUMAN- Note=A chromosomal aberration involving BRD3 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;9)(q14;q34) with NUTM1 which produces a BRD3-NUTM1 fusion protein. {ECO:0000269 PubMed:17934517}.
Additional Disease Information for BRD3
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for Genatlas for BRD3 Gene
Publications for BRD3 Gene
- Chromosomal localization, gene structure and transcription pattern of the ORFX gene, a homologue of the MHC-linked RING3 gene. (PMID: 9373153) Thorpe KL … Beck S (Gene 1997) 3 4 23
- Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 7584044) Nomura N … Tabata S (DNA research : an international journal for rapid publication of reports on genes and genomes 1994) 2 3 4
- Molecular Coupling of Histone Crotonylation and Active Transcription by AF9 YEATS Domain. (PMID: 27105114) Li Y … Li H (Molecular cell 2016) 3 4
- Histone recognition and large-scale structural analysis of the human bromodomain family. (PMID: 22464331) Filippakopoulos P … Knapp S (Cell 2012) 3 4
- New gene functions in megakaryopoiesis and platelet formation. (PMID: 22139419) Gieger C … Soranzo N (Nature 2011) 3 41
ExternalLinks
Products for BRD3 Gene
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