Aliases for BRD3 Gene
External Ids for BRD3 Gene
Previous GeneCards Identifiers for BRD3 Gene
This gene was identified based on its homology to the gene encoding the RING3 protein, a serine/threonine kinase. The gene localizes to 9q34, a region which contains several major histocompatibility complex (MHC) genes. The function of the encoded protein is not known. [provided by RefSeq, Jul 2008]
GeneCards Summary for BRD3 Gene
BRD3 (Bromodomain Containing 3) is a Protein Coding gene. Diseases associated with BRD3 include Foodborne Botulism and Salivary Gland Carcinoma. Gene Ontology (GO) annotations related to this gene include chromatin binding and lysine-acetylated histone binding. An important paralog of this gene is BRD2.
UniProtKB/Swiss-Prot Summary for BRD3 Gene
Chromatin reader that recognizes and binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors (PubMed:18406326, PubMed:27105114). Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity).
Bromodomains (BRDs) are epigenetic reader domains that selectively recognize acetylated lysine residues on the tails of histone proteins, and are the only known protein modules that can target acetylated lysine residues.