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Aliases for BRD2 Gene

Aliases for BRD2 Gene

  • Bromodomain Containing 2 2 3 5
  • Really Interesting New Gene 3 Protein 3 4
  • BRD2 Intronic Transcript 1 2 3
  • O27.1.1 3 4
  • RING3 3 4
  • Female Sterile Homeotic-Related Gene 1 3
  • Bromodomain-Containing Protein 2 3
  • Bromodomain-Containing 2 2
  • BRD2-IT1 3
  • KIAA9001 4
  • D6S113E 3
  • FSRG1 3
  • RNF3 3
  • FSH 3
  • NAT 3

External Ids for BRD2 Gene

Previous HGNC Symbols for BRD2 Gene

  • BRD2-IT1

Previous GeneCards Identifiers for BRD2 Gene

  • GC06P032938
  • GC06P032707
  • GC06P032983
  • GC06P033044
  • GC06P032678
  • GC06P032944
  • GC06P032945
  • GC06P032949

Summaries for BRD2 Gene

Entrez Gene Summary for BRD2 Gene

  • This gene encodes a transcriptional regulator that belongs to the BET (bromodomains and extra terminal domain) family of proteins. This protein associates with transcription complexes and with acetylated chromatin during mitosis, and it selectively binds to the acetylated lysine-12 residue of histone H4 via its two bromodomains. The gene maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3, but sequence comparison suggests that the protein is not involved in the immune response. This gene has been implicated in juvenile myoclonic epilepsy, a common form of epilepsy that becomes apparent in adolescence. Multiple alternatively spliced variants have been described for this gene. [provided by RefSeq, Dec 2010]

GeneCards Summary for BRD2 Gene

BRD2 (Bromodomain Containing 2) is a Protein Coding gene. Diseases associated with BRD2 include Enterocele and Prolapse Of Female Genital Organ. Among its related pathways are Wnt / Hedgehog / Notch and Regulation of retinoblastoma protein. Gene Ontology (GO) annotations related to this gene include chromatin binding and lysine-acetylated histone binding. An important paralog of this gene is BRD3.

UniProtKB/Swiss-Prot for BRD2 Gene

  • May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.

Tocris Summary for BRD2 Gene

  • Bromodomains (BRDs) are epigenetic reader domains that selectively recognize acetylated lysine residues on the tails of histone proteins, and are the only known protein modules that can target acetylated lysine residues.

Gene Wiki entry for BRD2 Gene

Additional gene information for BRD2 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BRD2 Gene

Genomics for BRD2 Gene

GeneHancer (GH) Regulatory Elements for BRD2 Gene

Promoters and enhancers for BRD2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J032965 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 904.5 +2.0 2009 10.4 ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF548 ZNF263 BRD2 HLA-DMA ENSG00000223837 LEMD2 ATF6B VPS52 RXRB DAXX WDR46 HCG25
GH06J033270 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 124 +306.5 306469 8.4 CLOCK MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 VPS52 RPS18 PIR43330 BRD2 LEMD2 DAXX RXRB WDR46 RING1 RGL2
GH06J033203 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 109.3 +237.7 237743 5.8 DMAP1 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC SSRP1 ZNF610 GLIS1 RING1 HSD17B8 MIR219A1 GC06P033209 BRD2 LEMD2 VPS52 DAXX RXRB WDR46
GH06J032184 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 72.3 -777.4 -777380 13.4 CLOCK MLX YBX1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 PBX2 NOTCH4 GPSM3 ATF6B BRD2 DDX39B LY6G5B LSM2 RPL3P2 SKIV2L
GH06J032175 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 77.8 -790.9 -790900 5.1 DMAP1 YBX1 YY1 E2F8 ZNF143 ZNF548 SP3 NFYC GLIS1 NR2C1 RNF5 AGPAT1 BRD2 DDX39B LY6G5B LSM2 ATF6B CSNK2B GPANK1 MICA
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BRD2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the BRD2 gene promoter:
  • TFIID
  • TBP
  • SRY

Genomic Locations for BRD2 Gene

Genomic Locations for BRD2 Gene
chr6:32,968,660-32,981,505
(GRCh38/hg38)
Size:
12,846 bases
Orientation:
Plus strand
chr6:32,936,437-32,949,282
(GRCh37/hg19)
Size:
12,846 bases
Orientation:
Plus strand

Genomic View for BRD2 Gene

Genes around BRD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BRD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BRD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for BRD2 Gene

  • Protein details for BRD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25440-BRD2_HUMAN
    Recommended name:
    Bromodomain-containing protein 2
    Protein Accession:
    P25440
    Secondary Accessions:
    • A2AAU0
    • B0S7P0
    • B1AZT1
    • O00699
    • O00700
    • Q15310
    • Q5STC9
    • Q63HQ9
    • Q658Y7
    • Q6P3U2
    • Q969U4

    Protein attributes for BRD2 Gene

    Size:
    801 amino acids
    Molecular mass:
    88061 Da
    Quaternary structure:
    • Homodimer. Interacts with E2F1 and with histone H4 acetylated at Lys-13.
    SequenceCaution:
    • Sequence=AAA68890.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for BRD2 Gene

    Alternative splice isoforms for BRD2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BRD2 Gene

Post-translational modifications for BRD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for BRD2 Gene

Domains & Families for BRD2 Gene

Gene Families for BRD2 Gene

Protein Domains for BRD2 Gene

Graphical View of Domain Structure for InterPro Entry

P25440

UniProtKB/Swiss-Prot:

BRD2_HUMAN :
  • One bromodomain is sufficient for a partial interaction with histone H4 acetylated at Lys-13.
Domain:
  • One bromodomain is sufficient for a partial interaction with histone H4 acetylated at Lys-13.
genes like me logo Genes that share domains with BRD2: view

Function for BRD2 Gene

Molecular function for BRD2 Gene

UniProtKB/Swiss-Prot Function:
May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.

Phenotypes From GWAS Catalog for BRD2 Gene

Gene Ontology (GO) - Molecular Function for BRD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IDA 18406326
GO:0005515 protein binding IPI 20709061
GO:0070577 lysine-acetylated histone binding IDA 18406326
genes like me logo Genes that share ontologies with BRD2: view
genes like me logo Genes that share phenotypes with BRD2: view

Animal Model Products

Clone Products

  • Addgene plasmids for BRD2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BRD2 Gene

Localization for BRD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BRD2 Gene

Nucleus. Note=Detected on chromatin and nucleosomes.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BRD2 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for BRD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0016607 nuclear speck IDA --
genes like me logo Genes that share ontologies with BRD2: view

Pathways & Interactions for BRD2 Gene

genes like me logo Genes that share pathways with BRD2: view

Pathways by source for BRD2 Gene

1 BioSystems pathway for BRD2 Gene
3 Cell Signaling Technology pathways for BRD2 Gene

Gene Ontology (GO) - Biological Process for BRD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization IEA --
GO:0006334 nucleosome assembly IMP 18406326
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IDA 18406326
genes like me logo Genes that share ontologies with BRD2: view

No data available for SIGNOR curated interactions for BRD2 Gene

Drugs & Compounds for BRD2 Gene

(36) Drugs for BRD2 Gene - From: DrugBank, DGIdb, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cisplatin Approved Pharma Enzyme, inhibitor Inhibits DNA synthesis,chemotherapy drug, Platinum, Potent pro-apoptotic anticancer agent; activates caspase-3 2906
Isoniazid Approved, Investigational Pharma Enzyme, inhibitor 164
Mesalazine Approved Pharma Target 0
Sulfamethazine Approved, Investigational, Vet_approved Pharma Enzyme, substrate 114
GW841819X Pharma BET bromodomain inhibitor 0

(3) Additional Compounds for BRD2 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
I-BET 151 dihydrochloride
1883545-47-8
PFI 1
1403764-72-6

(5) Tocris Compounds for BRD2 Gene

Compound Action Cas Number
(+)-JQ1 Potent, selective BET bromodomain inhibitor; cell permeable 1268524-70-4
Bromosporine Broad spectrum bromodomain inhibitor
I-BET 151 dihydrochloride BET bromodomain inhibitor; also promotes differentiation of hiPSCs into megakaryocytes 1883545-47-8
Ischemin sodium salt CBP inhibitor; cell permeable
PFI 1 BET bromodomain inhibitor 1403764-72-6
genes like me logo Genes that share compounds with BRD2: view

Transcripts for BRD2 Gene

Unigene Clusters for BRD2 Gene

Bromodomain containing 2:
Representative Sequences:

Clone Products

  • Addgene plasmids for BRD2

Alternative Splicing Database (ASD) splice patterns (SP) for BRD2 Gene

No ASD Table

Relevant External Links for BRD2 Gene

GeneLoc Exon Structure for
BRD2
ECgene alternative splicing isoforms for
BRD2

Expression for BRD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BRD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for BRD2 Gene

This gene is overexpressed in CD8 Tcells (18.8) and Liver, secretome (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for BRD2 Gene



Protein tissue co-expression partners for BRD2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of BRD2 Gene:

BRD2

SOURCE GeneReport for Unigene cluster for BRD2 Gene:

Hs.75243

Evidence on tissue expression from TISSUES for BRD2 Gene

  • Nervous system(5)
  • Liver(4.6)
  • Blood(4.5)
  • Lung(4.3)
  • Bone marrow(4.1)
  • Intestine(4)
  • Kidney(3.2)
  • Eye(2.9)
  • Muscle(2.8)
  • Stomach(2.8)
  • Heart(2.6)
  • Skin(2.4)
  • Spleen(2.4)
  • Pancreas(2.1)
genes like me logo Genes that share expression patterns with BRD2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for BRD2 Gene

Orthologs for BRD2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for BRD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BRD2 34 33
  • 98.02 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BRD2 34
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BRD2 34 33
  • 89.66 (n)
OneToOne
cow
(Bos Taurus)
Mammalia BRD2 34 33
  • 89.32 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Brd2 16 34 33
  • 87.72 (n)
rat
(Rattus norvegicus)
Mammalia LOC100909544 33
  • 87.51 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 35 (a)
ManyToMany
chicken
(Gallus gallus)
Aves BRD2 34 33
  • 71.54 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BRD2 34
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia brd2 33
  • 67.65 (n)
Str.10243 33
African clawed frog
(Xenopus laevis)
Amphibia brd2-A-prov 33
zebrafish
(Danio rerio)
Actinopterygii brd2a 34 33
  • 61.53 (n)
OneToMany
brd2b 34
  • 54 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.506 33
fruit fly
(Drosophila melanogaster)
Insecta fs(1)h 34 35
  • 18 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os.37125 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 47 (a)
OneToMany
Species where no ortholog for BRD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BRD2 Gene

ENSEMBL:
Gene Tree for BRD2 (if available)
TreeFam:
Gene Tree for BRD2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for BRD2: view image

Paralogs for BRD2 Gene

Paralogs for BRD2 Gene

(5) SIMAP similar genes for BRD2 Gene using alignment to 9 proteins:

  • BRD2_HUMAN
  • E9PIQ3_HUMAN
  • E9PKQ9_HUMAN
  • H0Y6K2_HUMAN
  • H0Y799_HUMAN
  • H0YDJ7_HUMAN
  • J3QR72_HUMAN
  • U3KPW0_HUMAN
  • U3KQA6_HUMAN
genes like me logo Genes that share paralogs with BRD2: view

Variants for BRD2 Gene

Sequence variations from dbSNP and Humsavar for BRD2 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
VAR_041904 A glioblastoma multiforme sample p.Gly30Glu
VAR_041909 A gastric adenocarcinoma sample p.Arg558Gly
VAR_041912 A glioblastoma multiforme sample p.Pro714Leu
rs864309591 uncertain-significance, not specified 32,974,467(+) C/T 5_prime_UTR_variant, coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000069582 -- 32,980,805(+) G/A 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for BRD2 Gene

Variant ID Type Subtype PubMed ID
esv2759417 CNV gain 17122850
nsv1073969 CNV deletion 25765185
nsv1112900 CNV deletion 24896259
nsv1119076 CNV deletion 24896259
nsv483081 CNV loss 15286789
nsv527280 CNV loss 19592680
nsv602817 CNV loss 21841781
nsv819221 CNV gain 19587683
nsv830633 CNV loss 17160897

Variation tolerance for BRD2 Gene

Residual Variation Intolerance Score: 2.78% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.26; 76.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BRD2 Gene

Human Gene Mutation Database (HGMD)
BRD2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
BRD2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BRD2 Gene

Disorders for BRD2 Gene

MalaCards: The human disease database

(6) MalaCards diseases for BRD2 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search BRD2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for BRD2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with BRD2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BRD2 Gene

Publications for BRD2 Gene

  1. Phylogeny and structure of the RING3 gene. (PMID: 8781126) Thorpe KL … Beck S (Immunogenetics 1996) 2 3 4 22 58
  2. A homologue of the Drosophila female sterile homeotic (fsh) gene in the class II region of the human MHC. (PMID: 1352711) Beck S … Trowsdale J (DNA sequence : the journal of DNA sequencing and mapping 1992) 2 3 4 22 58
  3. BRD2 and TAP-1 genes and juvenile myoclonic epilepsy. (PMID: 19953286) Layouni S … Dogui M (Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 2010) 3 22 44 58
  4. Association of BRD2 polymorphisms with photoparoxysmal response. (PMID: 16516380) Lorenz S … Stephani U (Neuroscience letters 2006) 3 22 44 58
  5. BRD2 (RING3) is a probable major susceptibility gene for common juvenile myoclonic epilepsy. (PMID: 12830434) Pal DK … Greenberg DA (American journal of human genetics 2003) 3 22 44 58

Products for BRD2 Gene