Aliases for BRAT1 Gene
External Ids for BRAT1 Gene
Previous HGNC Symbols for BRAT1 Gene
Previous GeneCards Identifiers for BRAT1 Gene
The protein encoded by this ubiquitously expressed gene interacts with the tumor suppressing BRCA1 (breast cancer 1) protein and and the ATM (ataxia telangiectasia mutated) protein. ATM is thought to be a master controller of cell cycle checkpoint signalling pathways that are required for cellular responses to DNA damage such as double-strand breaks that are induced by ionizing radiation and complexes with BRCA1 in the multi-protein complex BASC (BRAC1-associated genome surveillance complex). The protein encoded by this gene is thought to play a role in the DNA damage pathway regulated by BRCA1 and ATM. [provided by RefSeq, Mar 2012]
GeneCards Summary for BRAT1 Gene
BRAT1 (BRCA1 Associated ATM Activator 1) is a Protein Coding gene. Diseases associated with BRAT1 include Rigidity And Multifocal Seizure Syndrome, Lethal Neonatal and Neurodevelopmental Disorder With Cerebellar Atrophy And With Or Without Seizures. Gene Ontology (GO) annotations related to this gene include binding.
UniProtKB/Swiss-Prot Summary for BRAT1 Gene
Involved in DNA damage response; activates kinases ATM, SMC1A and PRKDC by modulating their phosphorylation status following ionizing radiation (IR) stress (PubMed:16452482, PubMed:22977523). Plays a role in regulating mitochondrial function and cell proliferation (PubMed:25070371). Required for protein stability of MTOR and MTOR-related proteins, and cell cycle progress by growth factors (PubMed:25657994).