Aliases for BRAP Gene
Aliases for BRAP Gene
External Ids for BRAP Gene
- HGNC: 1099
- Entrez Gene: 8315
- Ensembl: ENSG00000089234
- OMIM: 604986
- UniProtKB: Q7Z569
Previous GeneCards Identifiers for BRAP Gene
- GC12M110940
- GC12U900022
- GC12M111864
- GC12M110493
- GC12M110544
- GC12M112080
- GC12M109093
Summaries for BRAP Gene
-
The protein encoded by this gene was identified by its ability to bind to the nuclear localization signal of BRCA1 and other proteins. It is a cytoplasmic protein which may regulate nuclear targeting by retaining proteins with a nuclear localization signal in the cytoplasm. [provided by RefSeq, Jul 2008]
GeneCards Summary for BRAP Gene
BRAP (BRCA1 Associated Protein) is a Protein Coding gene. Among its related pathways are RET signaling and HIV Life Cycle. Gene Ontology (GO) annotations related to this gene include nucleotide binding and ubiquitin-protein transferase activity.
UniProtKB/Swiss-Prot for BRAP Gene
-
Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport.
Additional gene information for BRAP Gene
- Monarch Initiative
- Search for BRAP at DataMed
- Search for BRAP at HumanCyc
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BRAP Gene
Genomics for BRAP Gene
GeneHancer (GH) Regulatory Elements for BRAP Gene
Promoters and enhancers for BRAP Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around BRAP on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the BRAP gene promoter:
-
- c-Myc
- Max1
- Max
Regulatory Element Products
Genomic Locations for BRAP Gene
Genomic Locations for BRAP Gene
- chr12:111,642,146-111,685,996
- (GRCh38/hg38)
- Size:
- 43,851 bases
- Orientation:
- Minus strand
- chr12:112,079,950-112,123,790
- (GRCh37/hg19)
- Size:
- 43,841 bases
- Orientation:
- Minus strand
Genomic View for BRAP Gene
Genes around BRAP on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q24.12 by Entrez Gene
- 12q24.12 by HGNC
- 12q24.12 by Ensembl
BRAP Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for BRAP Gene
Proteins for BRAP Gene
-
Protein details for BRAP Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q7Z569-BRAP_HUMAN
- Recommended name:
- BRCA1-associated protein
- Protein Accession:
- Q7Z569
- B4DRM1
- B9EGS8
- O43238
- O75341
Protein attributes for BRAP Gene
- Size:
- 592 amino acids
- Molecular mass:
- 67305 Da
- Quaternary structure:
-
- Interacts with the nuclear localization signal of BRCA1 and with the N-terminal of KSR1. The C-terminal portion of BCRA1 interacts with DDB1.
- SequenceCaution:
-
- Sequence=AAC24200.1; Type=Frameshift; Positions=556; Evidence={ECO:0000305};
Protein Expression for BRAP Gene
Post-translational modifications for BRAP Gene
Other Protein References for BRAP Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for BRAP
- Novus Biologicals Antibodies for BRAP
-
Abcam antibodies for BRAP
- Invitrogen Antibodies for BRAP (AFLGC-BRAP)
- GeneTex BRAP Antibody for BRAP
-
Boster Bio Antibodies for BRAP
-
Santa Cruz Biotechnology (SCBT) Antibodies for BRAP
Protein Products
-
OriGene Purified Proteins for BRAP
- Search Origene for MassSpec and Protein Over-expression Lysates for BRAP
- Origene Custom Protein Services for BRAP
- antibodies-online: Search results for 7 available BRAP Proteins ranked by validation data
- Compare Top BRAP Proteins
-
Quality Products:
- Search GeneTex for Proteins for BRAP
Assay Products
- antibodies-online: Search results for 3 available BRAP Elisa Kits ranked by validation data
- Compare Top BRAP Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for BRAP Gene
Domains & Families for BRAP Gene
Gene Families for BRAP Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for BRAP Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for BRAP Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for BRAP Gene
Function for BRAP Gene
Molecular function for BRAP Gene
- UniProtKB/Swiss-Prot Function:
- Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport.
- UniProtKB/Swiss-Prot CatalyticActivity:
- S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
Enzyme Numbers (IUBMB) for BRAP Gene
Phenotypes From GWAS Catalog for BRAP Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0004842 | ubiquitin-protein transferase activity | IDA | 14724641 |
| GO:0005515 | protein binding | IPI | 9497340 |
| GO:0008139 | nuclear localization sequence binding | IDA | 9497340 |
| GO:0008270 | zinc ion binding | IEA | -- |
Phenotypes for BRAP Gene
- MGI mutant phenotypes for BRAP:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for BRAP:
Animal Models for BRAP Gene
- MGI Knock Outs for BRAP:
-
- Brap Brap<tm1.1Yfng>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for BRAP
-
CRISPR Products
-
OriGene CRISPR knockouts for BRAP
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- genomics-online: gRNA clones - Search results for 71 available BRAP gene related products
- Overview of 71 available BRAP gene related products
- Applied Biological Materials CRISPR for BRAP
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Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for BRAP
- GenScript: Design CRISPR guide RNA sequences for BRAP
miRNA for BRAP Gene
- miRTarBase miRNAs that target BRAP
-
- hsa-mir-221-3p (MIRT003364)
- hsa-mir-1296-5p (MIRT036070)
- hsa-mir-5583-3p (MIRT559169)
- hsa-mir-664b-3p (MIRT559170)
- hsa-mir-5696 (MIRT559171)
- hsa-mir-579-3p (MIRT559172)
- hsa-mir-561-5p (MIRT559173)
- hsa-mir-3115 (MIRT559174)
- hsa-mir-4477a (MIRT559175)
- hsa-mir-6853-3p (MIRT559176)
- hsa-mir-203a-5p (MIRT559177)
- hsa-mir-503-3p (MIRT559178)
- hsa-mir-4761-5p (MIRT559179)
- hsa-mir-656-3p (MIRT559180)
- hsa-mir-140-5p (MIRT559181)
- hsa-mir-196b-5p (MIRT559182)
- hsa-mir-196a-5p (MIRT559183)
- hsa-mir-4474-3p (MIRT716582)
- hsa-mir-640 (MIRT716583)
- hsa-mir-6500-3p (MIRT716584)
- hsa-mir-3614-5p (MIRT716585)
- hsa-mir-4318 (MIRT716586)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BRAP
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- genomics-online: shRNA clones - Search results for 71 available BRAP gene related products
- Overview of 71 available BRAP gene related products
Clone Products
- Sino Biological Human cDNA Clone for BRAP
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BRAP
- Applied Biological Materials Clones for BRAP
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for BRAP
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BRAP Gene
Localization for BRAP Gene
Subcellular locations from UniProtKB/Swiss-Prot for BRAP Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| peroxisome | 2 |
| mitochondrion | 1 |
- Cytosol (3)
- Nuclear membrane (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000151 | ubiquitin ligase complex | IDA | 14724641 |
| GO:0005737 | cytoplasm | IDA,IEA | 9497340 |
| GO:0005829 | cytosol | TAS,IDA | -- |
| GO:0031965 | nuclear membrane | IDA | -- |
Pathways & Interactions for BRAP Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
.92
|
| 2 | Signaling by moderate kinase activity BRAF mutants | ||
| 3 | Developmental Biology |
.51
|
|
| 4 | Cytokine Signaling in Immune system | ||
| 5 | HIV Life Cycle |
.45
|
|
Pathways by source for BRAP Gene
54 Reactome pathways for BRAP Gene
1 KEGG pathway for BRAP Gene
UniProtKB/Swiss-Prot Q7Z569-BRAP_HUMAN
- Pathway: Protein modification; protein ubiquitination.
Interacting Proteins for BRAP Gene
Selected Interacting proteins:
Q7Z569-BRAP_HUMAN
ENSP00000403524
for BRAP Gene via
UniProtKB
STRING
MINT
IID
GPS-Prot Interaction Network for BRAP
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS,IDA | -- |
| GO:0007265 | Ras protein signal transduction | IDA | 14724641 |
| GO:0009968 | negative regulation of signal transduction | IDA | 14724641 |
| GO:0016567 | protein ubiquitination | IEA,IDA | -- |
No data available for SIGNOR curated interactions for BRAP Gene
Transcripts for BRAP Gene
mRNA/cDNA for BRAP Gene
- (7) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (127) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000419234 4026 bps (uc001tsn.4)
- ENST00000327551 1947 bps (uc009zvv.4)
- ENST00000547043 1543 bps (uc058thz.1)
Unigene Clusters for BRAP Gene
CRISPR Products
-
OriGene CRISPR knockouts for BRAP
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BRAP
- genomics-online: gRNA clones - Search results for 71 available BRAP gene related products
- Overview of 71 available BRAP gene related products
- Applied Biological Materials CRISPR for BRAP
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for BRAP
- GenScript: Design CRISPR guide RNA sequences for BRAP
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BRAP
- Browse OriGene Inhibitory RNA Products For BRAP
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BRAP
- genomics-online: shRNA clones - Search results for 71 available BRAP gene related products
- Overview of 71 available BRAP gene related products
Clone Products
- Sino Biological Human cDNA Clone for BRAP
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BRAP
- Applied Biological Materials Clones for BRAP
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||
| SP2: |
Expression for BRAP Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for BRAP Gene
This gene is overexpressed in Testis (x4.2).
This gene is overexpressed in Peripheral blood mononuclear cells (26.0), Testis (25.8), and CD8 Tcells (6.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for BRAP Gene
NURSA nuclear receptor signaling pathways regulating expression of BRAP Gene:
BRAPSOURCE GeneReport for Unigene cluster for BRAP Gene:
Hs.530940mRNA Expression by UniProt/SwissProt for BRAP Gene:
Q7Z569-BRAP_HUMAN
Tissue specificity:
Expressed in breast epithelial cell lines.
Evidence on tissue expression from TISSUES for BRAP Gene
- Nervous system(4.3)
- Liver(4.2)
Primer Products
-
OriGene qPCR primer pairs for BRAP
- genomics-online: primer clones - Search results for 71 available BRAP gene related products
- Overview of 71 available BRAP gene related products
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for BRAP Gene
Orthologs for BRAP Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | BRAP 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | BRAP 34 33 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | BRAP 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | BRAP 34 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| mouse (Mus musculus) |
Mammalia | Brap 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Brap 33 |
|
||
| chicken (Gallus gallus) |
Aves | BRAP 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | BRAP 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | brap 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC68778 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | brap 34 33 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | CG5555 34 35 33 |
|
OneToOne | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP002128 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | EEED8.16 34 35 33 |
|
OneToOne | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | ETP1 36 34 33 |
|
||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AGL079C 33 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0F25740g 33 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | BRIZ2 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os02g0182900 33 |
|
||
| bread mold (Neurospora crassa) |
Ascomycetes | NCU11215 33 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPAC16E8.13 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.4818 34 |
|
OneToOne | |
| Cin.10973 33 |
|
||||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.10973 33 |
|
- Species where no ortholog for BRAP was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for BRAP Gene
- ENSEMBL:
- Gene Tree for BRAP (if available)
- TreeFam:
- Gene Tree for BRAP (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for BRAP: view image
Paralogs for BRAP Gene
(3) SIMAP similar genes for BRAP Gene using alignment to 3 proteins:
- BRAP_HUMAN
- B4DRM1_HUMAN
- J3KNN7_HUMAN
No data available for Paralogs for BRAP Gene
Variants for BRAP Gene
| SNP ID | Clin | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000008753 | -- | 111,679,679(-) | T/G | intron_variant | |
| rs1000161614 | -- | 111,656,594(-) | A/C | intron_variant | |
| rs1000183865 | -- | 111,654,667(-) | C/T | intron_variant | |
| rs1000196871 | -- | 111,653,161(-) | T/C | intron_variant | |
| rs1000375282 | -- | 111,667,124(-) | G/C | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3630761 | CNV | loss | 21293372 |
| esv3630762 | CNV | gain | 21293372 |
| esv3630763 | CNV | gain | 21293372 |
| nsv973119 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
20.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.58;
30.55% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for BRAP Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BRAP Gene
Disorders for BRAP Gene
Additional Disease Information for BRAP
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for BRAP Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BRAP Gene
Publications for BRAP Gene
- SNPs in BRAP associated with risk of myocardial infarction in Asian populations. (PMID: 19198608) Ozaki K … Tanaka T (Nature genetics 2009) 2 3 44 58
- Identification of a novel cytoplasmic protein that specifically binds to nuclear localization signal motifs. (PMID: 9497340) Li S … Lee WH (The Journal of biological chemistry 1998) 2 3 4 58
- Genome-wide association study of hematological and biochemical traits in a Japanese population. (PMID: 20139978) Kamatani Y … Kamatani N (Nature genetics 2010) 3 44 58
- Functional variants in ADH1B and ALDH2 coupled with alcohol and smoking synergistically enhance esophageal cancer risk. (PMID: 19698717) Cui R … Matsuda K (Gastroenterology 2009) 3 44 58
- Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP. (PMID: 14724641) Matheny SA … White MA (Nature 2004) 3 4 58
Products for BRAP Gene
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- antibodies-online: Search results for 42 available BRAP Antibodies ranked by validation data
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- antibodies-online: Search results for 7 available BRAP Proteins ranked by validation data
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- genomics-online: cdna clones - Search results for 71 available BRAP gene related products
- Overview of 71 available BRAP gene related products
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- Overview of 71 available BRAP gene related products
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- Overview of 71 available BRAP gene related products
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- Overview of 71 available BRAP gene related products
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- Overview of 71 available BRAP gene related products
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- Boster Bio Antibodies for BRAP
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Sources for BRAP Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
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- (74) GeneGo (Thomson Reuters)
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