Aliases for BRAP Gene
External Ids for BRAP Gene
Previous GeneCards Identifiers for BRAP Gene
The protein encoded by this gene was identified by its ability to bind to the nuclear localization signal of BRCA1 and other proteins. It is a cytoplasmic protein which may regulate nuclear targeting by retaining proteins with a nuclear localization signal in the cytoplasm. [provided by RefSeq, Jul 2008]
GeneCards Summary for BRAP Gene
BRAP (BRCA1 Associated Protein) is a Protein Coding gene. Diseases associated with BRAP include Astereognosia and Melanoma, Uveal. Among its related pathways are Negative regulation of MAPK pathway and RET signaling. Gene Ontology (GO) annotations related to this gene include nucleotide binding and ubiquitin-protein transferase activity.
UniProtKB/Swiss-Prot Summary for BRAP Gene
Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport.