Aliases for BPIFB6 Gene

Aliases for BPIFB6 Gene

  • BPI Fold Containing Family B Member 6 2 3 5
  • Bactericidal/Permeability-Increasing Protein-Like 3 2 3 4
  • BPI Fold-Containing Family B Member 6 3 4
  • BPIL3 3 4
  • LPLUNC6 3

External Ids for BPIFB6 Gene

Previous HGNC Symbols for BPIFB6 Gene

  • BPIL3

Previous GeneCards Identifiers for BPIFB6 Gene

  • GC20P031620

Summaries for BPIFB6 Gene

GeneCards Summary for BPIFB6 Gene

BPIFB6 (BPI Fold Containing Family B Member 6) is a Protein Coding gene. Among its related pathways are Defensins and Innate Immune System. Gene Ontology (GO) annotations related to this gene include lipid binding. An important paralog of this gene is BPIFB4.

Additional gene information for BPIFB6 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BPIFB6 Gene

Genomics for BPIFB6 Gene

GeneHancer (GH) Regulatory Elements for BPIFB6 Gene

Promoters and enhancers for BPIFB6 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J032626 Enhancer 1.3 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 1.6 -402.8 -402814 2.7 ZNF121 NFIB CREM MTA1 GMEB1 IKZF1 PKNOX1 ZIC2 PHF21A IKZF2 NOL4L ENSG00000233293 COMMD7 BAK1P1 BPIFB6 AB372778-018 lnc-DNMT3B-6
GH20J033009 Enhancer 1.5 FANTOM5 Ensembl CraniofacialAtlas dbSUPER 0.3 -21.3 -21327 0.7 MLX RBPJ NR2F1 NR2F6 MIXL1 ZNF652 MNT ELF3 POLR2A AHR BPIFB2 BPIFB6 L13712-019
GH20J033007 Promoter/Enhancer 1.2 EPDnew dbSUPER 0.3 -23.3 -23292 0.1 MLX RBPJ NR2F1 NR2F6 NFYC MNT POLR2A SP1 TFE3 CEBPG BPIFB2 CDK5RAP1 TM9SF4 ASXL1 CBFA2T2 BPIFB6 L13712-019
GH20J033021 Enhancer 0.5 Ensembl 0.4 -8.9 -8876 1.4 PPARG POLR2A NFIL3 PAF1 SSRP1 CDK5RAP1 BPIFB4 BPIFB6 BPIFB2 L13712-019
GH20J033014 Enhancer 0.4 Ensembl 0.4 -16.3 -16276 0.6 MAX POLR2A SMAD4 BPIFB2 BPIFB6 L13712-019
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BPIFB6 on UCSC Golden Path with GeneCards custom track

Genomic Locations for BPIFB6 Gene

Genomic Locations for BPIFB6 Gene
13,071 bases
Plus strand
12,400 bases
Plus strand

Genomic View for BPIFB6 Gene

Genes around BPIFB6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BPIFB6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BPIFB6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BPIFB6 Gene

Proteins for BPIFB6 Gene

  • Protein details for BPIFB6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    BPI fold-containing family B member 6
    Protein Accession:

    Protein attributes for BPIFB6 Gene

    453 amino acids
    Molecular mass:
    49717 Da
    Quaternary structure:
    No Data Available

neXtProt entry for BPIFB6 Gene

Post-translational modifications for BPIFB6 Gene

  • Glycosylation at Asn114 and Asn190
  • Modification sites at PhosphoSitePlus

Other Protein References for BPIFB6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BPIFB6 Gene

Domains & Families for BPIFB6 Gene

Gene Families for BPIFB6 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for BPIFB6 Gene

GenScript: Design optimal peptide antigens:
  • Bactericidal/permeability-increasing protein-like 3 (BPIL3_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
  • Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
genes like me logo Genes that share domains with BPIFB6: view

Function for BPIFB6 Gene

Phenotypes From GWAS Catalog for BPIFB6 Gene

Gene Ontology (GO) - Molecular Function for BPIFB6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with BPIFB6: view
genes like me logo Genes that share phenotypes with BPIFB6: view

Animal Model Products

  • Taconic Biosciences Mouse Models for BPIFB6

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BPIFB6 Gene

Localization for BPIFB6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BPIFB6 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BPIFB6 gene
Compartment Confidence
extracellular 4
endoplasmic reticulum 2
golgi apparatus 1
plasma membrane 0
mitochondrion 0
cytosol 0

Gene Ontology (GO) - Cellular Components for BPIFB6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with BPIFB6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for BPIFB6 Gene

Pathways & Interactions for BPIFB6 Gene

PathCards logo

SuperPathways for BPIFB6 Gene

genes like me logo Genes that share pathways with BPIFB6: view

Pathways by source for BPIFB6 Gene

3 Reactome pathways for BPIFB6 Gene

Interacting Proteins for BPIFB6 Gene

Gene Ontology (GO) - Biological Process for BPIFB6 Gene


No data available for SIGNOR curated interactions for BPIFB6 Gene

Drugs & Compounds for BPIFB6 Gene

No Compound Related Data Available

Transcripts for BPIFB6 Gene

mRNA/cDNA for BPIFB6 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for BPIFB6 Gene

No ASD Table

Relevant External Links for BPIFB6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BPIFB6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BPIFB6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BPIFB6 Gene

This gene is overexpressed in Minor Salivary Gland (x43.1) and Esophagus - Mucosa (x4.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BPIFB6 Gene

Protein tissue co-expression partners for BPIFB6 Gene

NURSA nuclear receptor signaling pathways regulating expression of BPIFB6 Gene:


SOURCE GeneReport for Unigene cluster for BPIFB6 Gene:


mRNA Expression by UniProt/SwissProt for BPIFB6 Gene:

Tissue specificity: Detected at very low levels in normal tonsils, and at higher levels in hypertrophic tonsils.
genes like me logo Genes that share expression patterns with BPIFB6: view

No data available for Protein differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for BPIFB6 Gene

Orthologs for BPIFB6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BPIFB6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BPIFB6 33 32
  • 98.62 (n)
(Bos Taurus)
Mammalia BPIFB6 33 32
  • 86.92 (n)
(Canis familiaris)
Mammalia BPIFB6 33 32
  • 85.01 (n)
(Mus musculus)
Mammalia Bpifb6 17 33 32
  • 79.22 (n)
(Rattus norvegicus)
Mammalia Bpifb6 32
  • 77.08 (n)
(Monodelphis domestica)
Mammalia BPIFB6 33
  • 60 (a)
(Ornithorhynchus anatinus)
Mammalia BPIFB6 33
  • 45 (a)
(Gallus gallus)
Aves BPIFB6 33
  • 37 (a)
(Anolis carolinensis)
Reptilia -- 33
  • 20 (a)
-- 33
  • 20 (a)
-- 33
  • 20 (a)
-- 33
  • 20 (a)
Species where no ortholog for BPIFB6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BPIFB6 Gene

Gene Tree for BPIFB6 (if available)
Gene Tree for BPIFB6 (if available)
Evolutionary constrained regions (ECRs) for BPIFB6: view image

Paralogs for BPIFB6 Gene

Paralogs for BPIFB6 Gene

(1) SIMAP similar genes for BPIFB6 Gene using alignment to 2 proteins:

  • F5H8I3_HUMAN
genes like me logo Genes that share paralogs with BPIFB6: view

Variants for BPIFB6 Gene

Sequence variations from dbSNP and Humsavar for BPIFB6 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000032714 -- 33,030,392(+) A/G upstream_transcript_variant
rs1000071650 -- 33,038,001(+) C/T intron_variant
rs1000319663 -- 33,035,270(+) T/C intron_variant
rs1000650197 -- 33,034,175(+) T/G intron_variant
rs1000711242 -- 33,042,599(+) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for BPIFB6 Gene

Variant ID Type Subtype PubMed ID
dgv4301n100 CNV gain 25217958
esv2758792 CNV loss 17122850
esv3567952 CNV loss 25503493
nsv1056411 CNV loss 25217958
nsv1062857 CNV gain 25217958
nsv3351 CNV insertion 18451855
nsv3352 CNV deletion 18451855

Variation tolerance for BPIFB6 Gene

Residual Variation Intolerance Score: 83% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.16; 75.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BPIFB6 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BPIFB6 Gene

Disorders for BPIFB6 Gene

Additional Disease Information for BPIFB6

No disorders were found for BPIFB6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BPIFB6 Gene

Publications for BPIFB6 Gene

  1. Three new human members of the lipid transfer/lipopolysaccharide binding protein family (LT/LBP). (PMID: 12185532) Mulero JJ … Rupp F (Immunogenetics 2002) 2 3 4 56
  2. Systematic nomenclature for the PLUNC/PSP/BSP30/SMGB proteins as a subfamily of the BPI fold-containing superfamily. (PMID: 21787333) Bingle CD … Craven CJ (Biochemical Society transactions 2011) 2 3 56
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 56
  4. BPIFB6 Regulates Secretory Pathway Trafficking and Enterovirus Replication. (PMID: 26962226) Morosky S … Coyne CB (Journal of virology 2016) 3 56
  5. New genetic associations detected in a host response study to hepatitis B vaccine. (PMID: 20237496) Davila S … Seielstad M (Genes and immunity 2010) 3 56

Products for BPIFB6 Gene

Sources for BPIFB6 Gene