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Aliases for BPIFB3 Gene

Aliases for BPIFB3 Gene

  • BPI Fold Containing Family B Member 3 2 3 5
  • Long Palate, Lung And Nasal Epithelium Carcinoma-Associated Protein 3 3 4
  • Ligand-Binding Protein RYA3 3 4
  • C20orf185 3 4
  • LPLUNC3 3 4
  • BPI Fold-Containing Family B Member 3 3
  • Chromosome 20 Open Reading Frame 185 2
  • RYA3 3

External Ids for BPIFB3 Gene

Previous HGNC Symbols for BPIFB3 Gene

  • C20orf185

Previous GeneCards Identifiers for BPIFB3 Gene

  • GC20P031645

Summaries for BPIFB3 Gene

GeneCards Summary for BPIFB3 Gene

BPIFB3 (BPI Fold Containing Family B Member 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include lipid binding. An important paralog of this gene is BPIFB4.

UniProtKB/Swiss-Prot for BPIFB3 Gene

  • May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received (By similarity).

Additional gene information for BPIFB3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BPIFB3 Gene

Genomics for BPIFB3 Gene

GeneHancer (GH) Regulatory Elements for BPIFB3 Gene

Promoters and enhancers for BPIFB3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20I032760 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 2.3 -292.3 -292252 4.7 HDGF PKNOX1 FOXA2 ARNT SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF143 DNMT3B BAK1P1 MAPRE1 ASXL1 TM9SF4 PLAGL2 ENSG00000260257 ZNF341 C20orf203 BPIFB3
GH20I032680 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 2.9 -373.7 -373702 2.7 HDGF PKNOX1 ARNT SLC30A9 ZNF766 CBX5 FOS MXD4 REST ZNF592 COMMD7 PLAGL2 ENSG00000260257 C20orf203 BPIFB3 BAK1P1
GH20I033411 Enhancer 0.5 FANTOM5 2.8 +355.8 355827 0.2 ZNF664 ZFHX2 POLR2A EGR2 SNTA1 CBFA2T2 ACTL10 NECAB3 C20orf144 BPIFB3 CDK5RAP1 PIR51053
GH20I033206 Enhancer 0.2 FANTOM5 6.1 +151.2 151180 0.1 BPIFA1 BPIFB3 DNMT3B BPIFA4P ENSG00000224876
GH20I032785 Enhancer 0.2 FANTOM5 5.4 -269.7 -269674 0.3 COMMD7 BPIFB3 DNMT3B GC20P032809
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around BPIFB3 on UCSC Golden Path with GeneCards custom track

Genomic Locations for BPIFB3 Gene

Genomic Locations for BPIFB3 Gene
chr20:33,055,331-33,073,637
(GRCh38/hg38)
Size:
18,307 bases
Orientation:
Plus strand
chr20:31,643,230-31,661,434
(GRCh37/hg19)

Genomic View for BPIFB3 Gene

Genes around BPIFB3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BPIFB3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BPIFB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BPIFB3 Gene

Proteins for BPIFB3 Gene

  • Protein details for BPIFB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P59826-BPIB3_HUMAN
    Recommended name:
    BPI fold-containing family B member 3
    Protein Accession:
    P59826
    Secondary Accessions:
    • Q5TDX7

    Protein attributes for BPIFB3 Gene

    Size:
    476 amino acids
    Molecular mass:
    50342 Da
    Quaternary structure:
    No Data Available

neXtProt entry for BPIFB3 Gene

Post-translational modifications for BPIFB3 Gene

  • Glycosylation at Asn142, Asn288, and posLast=457457
  • Modification sites at PhosphoSitePlus

Other Protein References for BPIFB3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BPIFB3 Gene

Domains & Families for BPIFB3 Gene

Gene Families for BPIFB3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for BPIFB3 Gene

Graphical View of Domain Structure for InterPro Entry

P59826

UniProtKB/Swiss-Prot:

BPIB3_HUMAN :
  • Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
Family:
  • Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
genes like me logo Genes that share domains with BPIFB3: view

Function for BPIFB3 Gene

Molecular function for BPIFB3 Gene

UniProtKB/Swiss-Prot Function:
May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received (By similarity).

Phenotypes From GWAS Catalog for BPIFB3 Gene

Gene Ontology (GO) - Molecular Function for BPIFB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with BPIFB3: view
genes like me logo Genes that share phenotypes with BPIFB3: view

Animal Models for BPIFB3 Gene

MGI Knock Outs for BPIFB3:

Animal Model Products

  • Taconic Biosciences Mouse Models for BPIFB3

miRNA for BPIFB3 Gene

miRTarBase miRNAs that target BPIFB3

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BPIFB3 Gene

Localization for BPIFB3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BPIFB3 Gene

Secreted. Cytoplasm. Note=According to PubMed:12837268, it is cytoplasmic.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BPIFB3 gene
Compartment Confidence
extracellular 4
plasma membrane 3
endoplasmic reticulum 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for BPIFB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IDA,IEA 12837268
genes like me logo Genes that share ontologies with BPIFB3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for BPIFB3 Gene

Pathways & Interactions for BPIFB3 Gene

SuperPathways for BPIFB3 Gene

No Data Available

Interacting Proteins for BPIFB3 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000364643%0d%0a9606.ENSP00000354394%0d%0a9606.ENSP00000385026%0d%0a
Selected Interacting proteins: P59826-BPIB3_HUMAN ENSP00000364643 for BPIFB3 Gene via IID STRING

Gene Ontology (GO) - Biological Process for BPIFB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045087 innate immune response NAS 11971875
genes like me logo Genes that share ontologies with BPIFB3: view

No data available for Pathways by source and SIGNOR curated interactions for BPIFB3 Gene

Drugs & Compounds for BPIFB3 Gene

No Compound Related Data Available

Transcripts for BPIFB3 Gene

mRNA/cDNA for BPIFB3 Gene

(1) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for BPIFB3 Gene

No ASD Table

Relevant External Links for BPIFB3 Gene

GeneLoc Exon Structure for
BPIFB3
ECgene alternative splicing isoforms for
BPIFB3

Expression for BPIFB3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BPIFB3 Gene

mRNA differential expression in normal tissues according to GTEx for BPIFB3 Gene

This gene is overexpressed in Pituitary (x27.5) and Testis (x24.8).

Protein differential expression in normal tissues from HIPED for BPIFB3 Gene

This gene is overexpressed in Bone (48.8), Plasma (10.0), and Tlymphocyte (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BPIFB3 Gene



NURSA nuclear receptor signaling pathways regulating expression of BPIFB3 Gene:

BPIFB3

SOURCE GeneReport for Unigene cluster for BPIFB3 Gene:

Hs.472442

mRNA Expression by UniProt/SwissProt for BPIFB3 Gene:

P59826-BPIB3_HUMAN
Tissue specificity: Detected in nasal septal epithelium.

Evidence on tissue expression from TISSUES for BPIFB3 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with BPIFB3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for BPIFB3 Gene

Orthologs for BPIFB3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BPIFB3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BPIFB3 34 33
  • 98.95 (n)
OneToOne
cow
(Bos Taurus)
Mammalia BPIFB3 33 34
  • 84.82 (n)
dog
(Canis familiaris)
Mammalia BPIFB3 33 34
  • 84.64 (n)
mouse
(Mus musculus)
Mammalia Bpifb3 33 16 34
  • 81.19 (n)
rat
(Rattus norvegicus)
Mammalia Bpifb3 33
  • 79.91 (n)
oppossum
(Monodelphis domestica)
Mammalia BPIFB3 34
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves BPIL3 33
  • 53.16 (n)
BPIFB3 34
  • 36 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BPIFB3 34
  • 30 (a)
OneToOne
Species where no ortholog for BPIFB3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BPIFB3 Gene

ENSEMBL:
Gene Tree for BPIFB3 (if available)
TreeFam:
Gene Tree for BPIFB3 (if available)

Paralogs for BPIFB3 Gene

Paralogs for BPIFB3 Gene

(2) SIMAP similar genes for BPIFB3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with BPIFB3: view

Variants for BPIFB3 Gene

Sequence variations from dbSNP and Humsavar for BPIFB3 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000021762 -- 33,069,449(+) C/T intron_variant
rs1000096673 -- 33,065,241(+) A/T intron_variant
rs1000611793 -- 33,054,346(+) C/T upstream_transcript_variant
rs1000912701 -- 33,063,516(+) A/G intron_variant
rs1001049521 -- 33,069,660(+) A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for BPIFB3 Gene

Variant ID Type Subtype PubMed ID
esv2668356 CNV deletion 23128226
esv2758792 CNV loss 17122850
esv3645675 CNV loss 21293372
nsv1056411 CNV loss 25217958
nsv1062857 CNV gain 25217958
nsv3352 CNV deletion 18451855

Variation tolerance for BPIFB3 Gene

Residual Variation Intolerance Score: 94.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 20.36; 99.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BPIFB3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BPIFB3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BPIFB3 Gene

Disorders for BPIFB3 Gene

Additional Disease Information for BPIFB3

No disorders were found for BPIFB3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BPIFB3 Gene

Publications for BPIFB3 Gene

  1. PLUNC: a novel family of candidate host defence proteins expressed in the upper airways and nasopharynx. (PMID: 11971875) Bingle CD … Craven CJ (Human molecular genetics 2002) 2 3 4 58
  2. Systematic nomenclature for the PLUNC/PSP/BSP30/SMGB proteins as a subfamily of the BPI fold-containing superfamily. (PMID: 21787333) Bingle CD … Craven CJ (Biochemical Society transactions 2011) 2 3 58
  3. Expansion of the BPI family by duplication on human chromosome 20: characterization of the RY gene cluster in 20q11.21 encoding olfactory transporters/antimicrobial-like peptides. (PMID: 12837268) Andrault JB … Rouquier S (Genomics 2003) 3 4 58
  4. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for BPIFB3 Gene

Sources for BPIFB3 Gene

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