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Aliases for BPIFB2 Gene

Aliases for BPIFB2 Gene

  • BPI Fold Containing Family B Member 2 2 3 5
  • Bactericidal/Permeability-Increasing Protein-Like 1 2 3 4
  • Long Palate, Lung And Nasal Epithelium Carcinoma-Associated Protein 2 3 4
  • BPI-Like 1 3 4
  • C20orf184 3 4
  • LPLUNC2 3 4
  • BPIL1 3 4
  • RYSR 3 4
  • BPI Fold-Containing Family B Member 2 3
  • DJ726C3.2 3

External Ids for BPIFB2 Gene

Previous HGNC Symbols for BPIFB2 Gene

  • C20orf184
  • BPIL1

Previous GeneCards Identifiers for BPIFB2 Gene

  • GC20P031596

Summaries for BPIFB2 Gene

Entrez Gene Summary for BPIFB2 Gene

  • This gene encodes a member of the lipid transfer/lipopolysaccharide binding protein (LT/LBP) gene family. It is highly expressed in hypertrophic tonsils. This gene and three other members of the LT/LBP gene family form a cluster on the long arm of chromosome 20. [provided by RefSeq, Jul 2008]

GeneCards Summary for BPIFB2 Gene

BPIFB2 (BPI Fold Containing Family B Member 2) is a Protein Coding gene. Among its related pathways are Defensins and Innate Immune System. Gene Ontology (GO) annotations related to this gene include lipid binding. An important paralog of this gene is BPIFB3.

Gene Wiki entry for BPIFB2 Gene

Additional gene information for BPIFB2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BPIFB2 Gene

Genomics for BPIFB2 Gene

GeneHancer (GH) Regulatory Elements for BPIFB2 Gene

Promoters and enhancers for BPIFB2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J033007 Promoter/Enhancer 1.4 EPDnew dbSUPER 650.7 +0.1 107 0.1 FOXA2 MLX ARID4B DMAP1 ZNF48 ETS1 NFKBIZ RXRA SP5 NFYC BPIFB2 BPIFB6
GH20J033009 Enhancer 1.2 FANTOM5 dbSUPER 5.3 +2.0 2035 0.6 FOXA2 MLX ZFP64 ARID4B DMAP1 ZNF48 SLC30A9 NFKBIZ SP5 ZHX2 BPIFB2 BPIFB6
GH20J033285 Enhancer 0.3 FANTOM5 5.3 +277.6 277584 0.2 ZFP3 BPIFB1 BPIFA1 ENSG00000224876 BPIFA3 BPIFB2 PIR39691
GH20J033005 Enhancer 0.5 ENCODE 0.7 -2.3 -2318 0.1 CTCF XRCC5 FOXA2 ZNF143 ZNF24 RAD21 SUN5 BPIFB2
GH20J033004 Promoter 0.5 EPDnew 0.7 -3.1 -3125 0.1 SUN5 BPIFB2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BPIFB2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for BPIFB2 Gene

Genomic Locations for BPIFB2 Gene
16,132 bases
Plus strand
16,110 bases
Plus strand

Genomic View for BPIFB2 Gene

Genes around BPIFB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BPIFB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BPIFB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BPIFB2 Gene

Proteins for BPIFB2 Gene

  • Protein details for BPIFB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    BPI fold-containing family B member 2
    Protein Accession:
    Secondary Accessions:
    • Q6UWN3
    • Q6ZME0
    • Q8NFQ7

    Protein attributes for BPIFB2 Gene

    458 amino acids
    Molecular mass:
    49172 Da
    Quaternary structure:
    No Data Available

neXtProt entry for BPIFB2 Gene

Post-translational modifications for BPIFB2 Gene

  • Glycosylation at posLast=332332, Asn293, posLast=151151, and posLast=9696
  • Modification sites at PhosphoSitePlus

Other Protein References for BPIFB2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BPIFB2 Gene

Domains & Families for BPIFB2 Gene

Gene Families for BPIFB2 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins
  • Transporters

Suggested Antigen Peptide Sequences for BPIFB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
  • Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
genes like me logo Genes that share domains with BPIFB2: view

Function for BPIFB2 Gene

Gene Ontology (GO) - Molecular Function for BPIFB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with BPIFB2: view
genes like me logo Genes that share phenotypes with BPIFB2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for BPIFB2

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BPIFB2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BPIFB2 Gene

Localization for BPIFB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BPIFB2 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BPIFB2 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 5
plasma membrane 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for BPIFB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with BPIFB2: view

Pathways & Interactions for BPIFB2 Gene

genes like me logo Genes that share pathways with BPIFB2: view

Pathways by source for BPIFB2 Gene

3 Reactome pathways for BPIFB2 Gene

Interacting Proteins for BPIFB2 Gene

Selected Interacting proteins: Q8N4F0-BPIB2_HUMAN for BPIFB2 Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for BPIFB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019730 antimicrobial humoral response TAS --
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with BPIFB2: view

No data available for SIGNOR curated interactions for BPIFB2 Gene

Drugs & Compounds for BPIFB2 Gene

No Compound Related Data Available

Transcripts for BPIFB2 Gene

mRNA/cDNA for BPIFB2 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(18) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for BPIFB2 Gene

BPI fold containing family B, member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BPIFB2

Alternative Splicing Database (ASD) splice patterns (SP) for BPIFB2 Gene

No ASD Table

Relevant External Links for BPIFB2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BPIFB2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BPIFB2 Gene

mRNA differential expression in normal tissues according to GTEx for BPIFB2 Gene

This gene is overexpressed in Minor Salivary Gland (x48.8).

Protein differential expression in normal tissues from HIPED for BPIFB2 Gene

This gene is overexpressed in Saliva (32.6), Oral epithelium (22.9), and Salivary gland (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BPIFB2 Gene

Protein tissue co-expression partners for BPIFB2 Gene

NURSA nuclear receptor signaling pathways regulating expression of BPIFB2 Gene:


SOURCE GeneReport for Unigene cluster for BPIFB2 Gene:


mRNA Expression by UniProt/SwissProt for BPIFB2 Gene:

Tissue specificity: Highly expressed in tonsils, especially in hypertrophic tonsils. Detected at very low levels in fetal liver.

Evidence on tissue expression from TISSUES for BPIFB2 Gene

  • Lung(4.2)
  • Saliva(4.2)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with BPIFB2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for BPIFB2 Gene

Orthologs for BPIFB2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BPIFB2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BPIFB2 34 33
  • 99.49 (n)
(Canis familiaris)
Mammalia BPIFB2 33
  • 83.15 (n)
BPIL1 34
  • 78 (a)
(Bos Taurus)
Mammalia BPIFB2 34 33
  • 81.37 (n)
(Mus musculus)
Mammalia Bpifb2 16 34 33
  • 77.85 (n)
(Rattus norvegicus)
Mammalia Bpifb2 33
  • 77.83 (n)
(Monodelphis domestica)
Mammalia BPIFB2 34
  • 43 (a)
(Gallus gallus)
Aves BPIFB8 34
  • 17 (a)
(Anolis carolinensis)
Reptilia BPIFB2 34
  • 35 (a)
Species where no ortholog for BPIFB2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BPIFB2 Gene

Gene Tree for BPIFB2 (if available)
Gene Tree for BPIFB2 (if available)
Evolutionary constrained regions (ECRs) for BPIFB2: view image

Paralogs for BPIFB2 Gene

Paralogs for BPIFB2 Gene

genes like me logo Genes that share paralogs with BPIFB2: view

Variants for BPIFB2 Gene

Sequence variations from dbSNP and Humsavar for BPIFB2 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
VAR_036550 A colorectal cancer sample p.Ala20Val
rs1000318524 -- 33,013,012(+) C/T intron_variant
rs1000445001 -- 33,007,662(+) C/T 5_prime_UTR_variant
rs1000540211 -- 33,011,985(+) A/C intron_variant
rs1000640810 -- 33,006,382(+) A/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for BPIFB2 Gene

Variant ID Type Subtype PubMed ID
esv2758792 CNV loss 17122850
nsv1056411 CNV loss 25217958
nsv3351 CNV insertion 18451855
nsv3352 CNV deletion 18451855

Variation tolerance for BPIFB2 Gene

Residual Variation Intolerance Score: 69.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.62; 72.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BPIFB2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BPIFB2 Gene

Disorders for BPIFB2 Gene

Additional Disease Information for BPIFB2

No disorders were found for BPIFB2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BPIFB2 Gene

Publications for BPIFB2 Gene

  1. Three new human members of the lipid transfer/lipopolysaccharide binding protein family (LT/LBP). (PMID: 12185532) Mulero JJ … Rupp F (Immunogenetics 2002) 2 3 4 58
  2. Systematic nomenclature for the PLUNC/PSP/BSP30/SMGB proteins as a subfamily of the BPI fold-containing superfamily. (PMID: 21787333) Bingle CD … Craven CJ (Biochemical Society transactions 2011) 2 3 58
  3. Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. (PMID: 16740002) Ramachandran P … Loo JA (Journal of proteome research 2006) 3 4 58
  4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z … Henzel WJ (Protein science : a publication of the Protein Society 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for BPIFB2 Gene

Sources for BPIFB2 Gene

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