Aliases for BPIFA2 Gene
External Ids for BPIFA2 Gene
Previous HGNC Symbols for BPIFA2 Gene
Previous GeneCards Identifiers for BPIFA2 Gene
This gene encodes a member of the palate, lung and nasal epithelium clone (Plunc) family of proteins. Members of this family have been proposed to play a role in the local antibacterial response in nose, mouth and upper respiratory pathways. The encoded soluble salivary protein binds bacterial lipopolysaccharide (LPS) and inhibits bacterial growth. This gene is present in a gene cluster on chromosome 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
GeneCards Summary for BPIFA2 Gene
BPIFA2 (BPI Fold Containing Family A Member 2) is a Protein Coding gene. Diseases associated with BPIFA2 include Xerophthalmia and Filamentary Keratitis. Among its related pathways are Innate Immune System and Defensins. Gene Ontology (GO) annotations related to this gene include lipid binding and lipopolysaccharide binding. An important paralog of this gene is BPIFA1.
UniProtKB/Swiss-Prot Summary for BPIFA2 Gene
Has strong antibacterial activity against P. aeruginosa.