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This gene encodes a lipopolysaccharide binding protein. It is associated with human neutrophil granules and has antimicrobial activity against gram-negative organisms. [provided by RefSeq, Nov 2014] See more...
Aliases for BPI Gene
Aliases for BPI Gene
External Ids for BPI Gene
- HGNC: 1095
- Entrez Gene: 671
- Ensembl: ENSG00000101425
- OMIM: 109195
- UniProtKB: P17213
Previous GeneCards Identifiers for BPI Gene
- GC20P036661
- GC20P037571
- GC20P037618
- GC20P036365
- GC20P036888
- GC20P038261
Summaries for BPI Gene
-
This gene encodes a lipopolysaccharide binding protein. It is associated with human neutrophil granules and has antimicrobial activity against gram-negative organisms. [provided by RefSeq, Nov 2014]
GeneCards Summary for BPI Gene
BPI (Bactericidal Permeability Increasing Protein) is a Protein Coding gene. Diseases associated with BPI include Meningococcemia and Vasculitis. Among its related pathways are Activated TLR4 signalling and Innate Immune System. Gene Ontology (GO) annotations related to this gene include lipid binding and lipopolysaccharide binding. An important paralog of this gene is LBP.
UniProtKB/Swiss-Prot Summary for BPI Gene
-
The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa.
Additional gene information for BPI Gene
- HGNC(1095)
- Entrez Gene(671)
- Ensembl(ENSG00000101425)
- OMIM(109195)
- UniProtKB(P17213)
- Open Targets Platform(ENSG00000101425)
- Monarch Initiative
- Search for BPI at DataMed
- Search for BPI at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BPI Gene
Genomics for BPI Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for BPI Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around BPI on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for BPI
- Top Transcription factor binding sites by QIAGEN in the BPI gene promoter:
-
- AP-1
- ATF-2
- c-Fos
- c-Jun
- C/EBPbeta
- Sp1
Genomic Locations for BPI Gene
Genomic Locations for BPI Gene
- chr20:38,304,150-38,337,505
- (GRCh38/hg38)
- Size:
- 33,356 bases
- Orientation:
- Plus strand
- chr20:36,888,551-36,965,907
- (GRCh37/hg19)
- Size:
- 77,357 bases
- Orientation:
- Plus strand
Genomic View for BPI Gene
Genes around BPI on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 20q11.23 by HGNC
- 20q11.23 by Entrez Gene
- 20q11.23 by Ensembl
BPI Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for BPI Gene
Proteins for BPI Gene
-
Protein details for BPI Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P17213-BPI_HUMAN
- Recommended name:
- Bactericidal permeability-increasing protein
- Protein Accession:
- P17213
- B2RCY2
- Q1ZZU8
- Q5JRW0
- Q8IW58
- Q9BYZ9
- Q9H1L2
- Q9H1M8
- Q9H203
- Q9UCT4
- Q9UD65
Protein attributes for BPI Gene
- Size:
- 487 amino acids
- Molecular mass:
- 53900 Da
- Quaternary structure:
-
- Monomer. Homodimer; disulfide-linked.
Protein Expression for BPI Gene
Post-translational modifications for BPI Gene
Other Protein References for BPI Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences BPI Antibody
- G Biosciences Immunotag™ BPI Antibody
-
Custom Antibody ServicesOriGene Antibodies for BPI
- Novus Biologicals Antibodies for BPI
-
Abcam antibodies for BPI
- Invitrogen Antibodies for BPI (AFLGC-BPI)
-
Santa Cruz Biotechnology (SCBT) Antibodies for BPI
- Sino Biological Antibodies for BPI
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for BPI
- Origene Custom Protein Services for BPI
- Sino Biological Recombinant Proteins for BPI
- Sino Biological Cell Lysates for BPI
- ProSpec Recombinant Proteins for BPI
- antibodies-online: Show 20 available BPI Proteins ranked by validation data
- Compare Top BPI Proteins
-
ProSci Proteins for BPI
-
Abcam proteins for BPI
No data available for DME Specific Peptides for BPI Gene
Domains & Families for BPI Gene
Gene Families for BPI Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted secreted proteins
- Transporters
Protein Domains for BPI Gene
- InterPro:
- Blocks:
-
- Lipid-binding serum glycoprotein
- ProtoNet:
Suggested Antigen Peptide Sequences for BPI Gene
- GenScript: Design optimal peptide antigens:
-
- Bactericidal/permeability-increasing protein (B1APZ9_HUMAN)
- CAP 57 (BPI_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P17213UniProtKB/Swiss-Prot:
BPI_HUMAN :- The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.
- Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
- Domain:
-
- The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.
- The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues.
- Family:
-
- Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
Function for BPI Gene
Molecular function for BPI Gene
- UniProtKB/Swiss-Prot Function:
- The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa.
- GENATLAS Biochemistry:
- bactericidal permeability increasing protein,55kDa,released from azurophilic granules of neutrophiles,oxygen independent phagocytosis of Gram- bacteria
Phenotypes From GWAS Catalog for BPI Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001530 | lipopolysaccharide binding | IBA,IDA | 8409400 |
| GO:0008289 | lipid binding | IEA | -- |
Phenotypes for BPI Gene
- MGI mutant phenotypes for BPI:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for BPI:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for BPI - Select products 50% OFF >
- * BPI CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for BPI
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BPI
-
Santa Cruz Biotechnology (SCBT) CRISPR for BPI
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BPI
- Browse OriGene Inhibitory RNA Products For BPI
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BPI
Clone Products
- Applied Biological Materials (abm): Clones for BPI - Select products 50% OFF >
- * BPI as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for BPI
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BPI
Cell Line Products
-
Horizon Cell Lines for BPI
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BPI Gene
Localization for BPI Gene
Subcellular locations from UniProtKB/Swiss-Prot for BPI Gene
- Secreted. Cytoplasmic granule membrane. Note=Membrane-associated in polymorphonuclear Leukocytes (PMN) granules. {ECO:0000269 PubMed:2722846}.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| lysosome | 4 |
| plasma membrane | 2 |
| nucleus | 2 |
| cytosol | 2 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | IBA | 21873635 |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0035578 | azurophil granule lumen | TAS | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for BPI Gene
Pathways & Interactions for BPI Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Innate Immune System |
.61
|
|
| 2 | Activated TLR4 signalling | ||
| 3 | Defensins | ||
Pathways by source for BPI Gene
6 Reactome pathways for BPI Gene
Interacting Proteins for BPI Gene
GPS-Prot Interaction Network for BPI
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006955 | immune response | IEA | -- |
| GO:0019730 | antimicrobial humoral response | TAS | -- |
| GO:0031663 | lipopolysaccharide-mediated signaling pathway | IBA | 21873635 |
| GO:0032715 | negative regulation of interleukin-6 production | IBA,IDA | 8409400 |
| GO:0032717 | negative regulation of interleukin-8 production | IBA,IDA | 8409400 |
No data available for SIGNOR curated interactions for BPI Gene
Transcripts for BPI Gene
mRNA/cDNA for BPI Gene
- 1 REFSEQ mRNAs :
- 12 NCBI additional mRNA sequence :
- 6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000642449 1841 nts (view in UCSC)
- ENST00000417318 1082 nts (view in UCSC)
- ENST00000489102 794 nts (view in UCSC)
- ENST00000489039 515 nts (view in UCSC)
- ENST00000490381 318 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for BPI - Select products 50% OFF >
- * BPI CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for BPI
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BPI
-
Santa Cruz Biotechnology (SCBT) CRISPR for BPI
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BPI
- Browse OriGene Inhibitory RNA Products For BPI
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BPI
Clone Products
- Applied Biological Materials (abm): Clones for BPI - Select products 50% OFF >
- * BPI as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for BPI
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BPI
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15a | · | 15b | ^ | 16a | · | 16b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP6: |
Relevant External Links for BPI Gene
- GeneLoc Exon Structure for
- BPI
Expression for BPI Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
- Bone (Muscoskeletal System)
-
Testis (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for BPI Gene
This gene is overexpressed in Whole Blood (x39.4) and Testis (x4.6).
This gene is overexpressed in Neutrophil (26.8) and Nasal epithelium (19.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BPI Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for BPI
SOURCE GeneReport for Unigene cluster for BPI Gene:
Hs.529019mRNA Expression by UniProt/SwissProt for BPI Gene:
P17213-BPI_HUMAN
Tissue specificity:
Restricted to cells of the myeloid series.
Evidence on tissue expression from TISSUES for BPI Gene
- Blood(4.9)
- Heart(4.4)
- Bone marrow(3.3)
- Lung(2.5)
- Intestine(2.3)
- Liver(2.2)
- Kidney(2.1)
Primer Products
-
OriGene qPCR primer pairs for BPI
-
OriGene qPCR primer pairs and template standards for BPI
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for BPI Gene
Orthologs for BPI Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | BPI 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | BPI 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | BPI 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Bpi 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Bpi 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | BPI 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | BPI 30 |
|
||
| -- 31 |
|
OneToMany | |||
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
| Zebrafish (Danio rerio) |
Actinopterygii | bpifcl 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for BPI was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for BPI Gene
- ENSEMBL:
- Gene Tree for BPI (if available)
- TreeFam:
- Gene Tree for BPI (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for BPI: view image
Paralogs for BPI Gene
Variants for BPI Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for BPI Gene
| SNP ID | Clinical significance and condition | Chr 20 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 708034 | Likely Benign: not provided | 38,326,268(+) | G/A | MISSENSE_VARIANT | |
| 710655 | Benign: not provided | 38,318,483(+) | G/T | INTRON_VARIANT | |
| 727484 | Likely Benign: not provided | 38,335,600(+) | A/G | MISSENSE_VARIANT | |
| 764933 | Likely Benign: not provided | 38,310,569(+) | G/A | SYNONYMOUS_VARIANT | |
| 764934 | Likely Benign: not provided | 38,326,345(+) | C/T | SYNONYMOUS_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv4309n100 | CNV | loss | 25217958 |
| esv2722392 | CNV | deletion | 23290073 |
| esv2722393 | CNV | deletion | 23290073 |
| esv2722394 | CNV | deletion | 23290073 |
| esv2758794 | CNV | gain | 17122850 |
| esv35121 | CNV | gain | 17911159 |
| esv3645775 | CNV | loss | 21293372 |
| esv3645778 | CNV | loss | 21293372 |
| nsv1058457 | CNV | loss | 25217958 |
| nsv1063495 | CNV | gain | 25217958 |
| nsv1071695 | CNV | deletion | 25765185 |
| nsv1077911 | CNV | duplication | 25765185 |
| nsv1142308 | CNV | tandem duplication | 24896259 |
| nsv585964 | CNV | loss | 21841781 |
| nsv817893 | CNV | gain | 17921354 |
| nsv954034 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
96.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
11.32;
92.63% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for BPI Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BPI Gene
Disorders for BPI Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| meningococcemia |
|
|
| vasculitis |
|
|
| reactive arthritis |
|
|
| crescentic glomerulonephritis |
|
|
| bronchiectasis |
|
Search BPI in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for BPI
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for BPI Gene
Publications for BPI Gene
- Polymorphisms in the lipopolysaccharide-binding protein and bactericidal/permeability-increasing protein in patients with myocardial infarction. (PMID: 12521224) Hubacek JA … Poledne R (Clinical chemistry and laboratory medicine 2002) 3 23 41
- Gene variants of the bactericidal/permeability increasing protein and lipopolysaccharide binding protein in sepsis patients: gender-specific genetic predisposition to sepsis. (PMID: 11373419) Hubacek JA … Schmitz G (Critical care medicine 2001) 3 23 41
- Crystal structure of human BPI and two bound phospholipids at 2.4 angstrom resolution. (PMID: 9188532) Beamer LJ … Eisenberg D (Science (New York, N.Y.) 1997) 3 4 23
- Bactericidal/permeability-increasing protein and lipopolysaccharide (LPS)-binding protein. LPS binding properties and effects on LPS-mediated cell activation. (PMID: 7517398) Wilde CG … Scott RW (The Journal of biological chemistry 1994) 3 4 23
- The genes for the lipopolysaccharide binding protein (LBP) and the bactericidal permeability increasing protein (BPI) are encoded in the same region of human chromosome 20. (PMID: 8432532) Gray PW … Shows TB (Genomics 1993) 2 3 23
ExternalLinks
Products for BPI Gene
- View all 11 R&D Systems BPI (BPI) Products
- View all R&D Systems BPI (BPI) Proteins and Enzymes
- View all 9 R&D Systems BPI (BPI) Primary Antibodies
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- Learn more about R&D Systems custom BPI antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for BPI
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for BPI
- Origene Custom Protein Services for BPI
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BPI
- Browse OriGene Inhibitory RNA Products For BPI
- OriGene qPCR primer pairs for BPI
- OriGene qPCR primer pairs and template standards for BPI
- OriGene CRISPR knockouts for BPI
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For BPI
- Sino Biological Human cDNA Clone for BPI
- Sino Biological Recombinant Proteins for BPI
- Sino Biological Cell Lysates for BPI
- Sino Biological Antibodies for BPI
- Browse Sino Biological Assays
- Browse Recombinant Proteins
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for BPI
- Novus Biologicals proteins and lysates for BPI
- Novus Biologicals ELISA Kits for BPI
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for BPI
- Abcam proteins for BPI
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- VectorBuilder Custom and pre-made DNA vectors for BPI (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for BPI (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for BPI (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for BPI CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for BPI
- antibodies-online: Show 103 available BPI Antibodies ranked by validation data
- Compare Top BPI Antibodies
- antibodies-online: Show 37 available BPI Elisa Kits ranked by validation data
- Compare Top BPI Elisa Kits
- antibodies-online: Show 20 available BPI Proteins ranked by validation data
- Compare Top BPI Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for BPI
- Search Santa Cruz Biotechnology (SCBT) for BPI siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for BPI
- Horizon Cell Lines for BPI
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BPI
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BPI
- Search GeneCopoeia for miRNA 3'UTR Target clone products for BPI
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BPI
Sources for BPI Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
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