Aliases for BPI Gene
External Ids for BPI Gene
Previous GeneCards Identifiers for BPI Gene
This gene encodes a lipopolysaccharide binding protein. It is associated with human neutrophil granules and has antimicrobial activity against gram-negative organisms. [provided by RefSeq, Nov 2014]
GeneCards Summary for BPI Gene
BPI (Bactericidal Permeability Increasing Protein) is a Protein Coding gene. Diseases associated with BPI include Meningococcemia and Reactive Arthritis. Among its related pathways are Activated TLR4 signalling and Innate Immune System. Gene Ontology (GO) annotations related to this gene include lipid binding and lipopolysaccharide binding. An important paralog of this gene is LBP.
UniProtKB/Swiss-Prot for BPI Gene
The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa.