This gene encodes a lipopolysaccharide binding protein. It is associated with human neutrophil granules and has antimicrobial activity against gram-negative organisms. [provided by RefSeq, Nov 2014] See more...

Aliases for BPI Gene

Aliases for BPI Gene

  • Bactericidal Permeability Increasing Protein 2 3 5
  • Bactericidal Permeability-Increasing Protein 3 4
  • BPI Fold Containing Family D, Member 1 2 3
  • BPIFD1 2 3
  • CAP 57 3 4
  • Bactericidal/Permeability-Increasing Protein 2
  • Recombinant BPI Holoprotein, RBPI 3
  • RBPI 3
  • BPI 5

External Ids for BPI Gene

Previous GeneCards Identifiers for BPI Gene

  • GC20P036661
  • GC20P037571
  • GC20P037618
  • GC20P036365
  • GC20P036888
  • GC20P038261

Summaries for BPI Gene

Entrez Gene Summary for BPI Gene

  • This gene encodes a lipopolysaccharide binding protein. It is associated with human neutrophil granules and has antimicrobial activity against gram-negative organisms. [provided by RefSeq, Nov 2014]

GeneCards Summary for BPI Gene

BPI (Bactericidal Permeability Increasing Protein) is a Protein Coding gene. Diseases associated with BPI include Meningococcemia and Vasculitis. Among its related pathways are Activated TLR4 signalling and Innate Immune System. Gene Ontology (GO) annotations related to this gene include lipid binding and lipopolysaccharide binding. An important paralog of this gene is LBP.

UniProtKB/Swiss-Prot Summary for BPI Gene

  • The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BPI Gene

Genomics for BPI Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for BPI Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J038259 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 600.3 -43.8 -43768 2 CREB1 RFX1 KDM1A RCOR2 ZIC2 ZSCAN4 SP1 EZH2 MNT RFX3 ENSG00000285144 ENSG00000285347 LOC149684 KIAA1755 BPI TGM2
GH20J038298 Promoter/Enhancer 1.4 EPDnew FANTOM5 ENCODE CraniofacialAtlas 612.3 -4.8 -4752 2.4 CREB1 SP1 ATF7 CEBPB CTBP1 USF1 ESRRA ZNF592 ZNF217 GATAD2B BPI ENSG00000206249 lnc-KIAA1755-8 ENSG00000285100 ENSG00000285144 KIAA1755
GH20J038304 Promoter 0.7 EPDnew 626 0.0 -13 0.1 NRF1 RUNX1 CTCF SPI1 VEZF1 POLR2A IKZF1 MYC MAX ESRRA BPI ENSG00000206249 lnc-KIAA1755-8 ENSG00000285100 ENSG00000285144 KIAA1755
GH20J038303 Promoter 0.7 Ensembl 624.3 -0.2 -249 0.2 NRF1 RUNX1 CTCF NR2F6 VEZF1 POLR2A MYC ESRRA BPI ENSG00000206249 lnc-KIAA1755-8 ENSG00000285100 ENSG00000285144 KIAA1755
GH20J038305 Promoter 0.4 Ensembl 610.7 +0.5 451 0.4 CTCF BPI ENSG00000206249 lnc-KIAA1755-8 LBP
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BPI on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for BPI

Top Transcription factor binding sites by QIAGEN in the BPI gene promoter:
  • AP-1
  • ATF-2
  • c-Fos
  • c-Jun
  • C/EBPbeta
  • Sp1

Genomic Locations for BPI Gene

Genomic Locations for BPI Gene
chr20:38,304,150-38,337,505
(GRCh38/hg38)
Size:
33,356 bases
Orientation:
Plus strand
chr20:36,888,551-36,965,907
(GRCh37/hg19)
Size:
77,357 bases
Orientation:
Plus strand

Genomic View for BPI Gene

Genes around BPI on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BPI Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BPI Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BPI Gene

Proteins for BPI Gene

  • Protein details for BPI Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17213-BPI_HUMAN
    Recommended name:
    Bactericidal permeability-increasing protein
    Protein Accession:
    P17213
    Secondary Accessions:
    • B2RCY2
    • Q1ZZU8
    • Q5JRW0
    • Q8IW58
    • Q9BYZ9
    • Q9H1L2
    • Q9H1M8
    • Q9H203
    • Q9UCT4
    • Q9UD65

    Protein attributes for BPI Gene

    Size:
    487 amino acids
    Molecular mass:
    53900 Da
    Quaternary structure:
    • Monomer. Homodimer; disulfide-linked.

    Three dimensional structures from OCA and Proteopedia for BPI Gene

neXtProt entry for BPI Gene

Post-translational modifications for BPI Gene

  • Glycosylation at Asn380
  • Modification sites at PhosphoSitePlus

Other Protein References for BPI Gene

No data available for DME Specific Peptides for BPI Gene

Domains & Families for BPI Gene

Gene Families for BPI Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins
  • Transporters

Protein Domains for BPI Gene

Suggested Antigen Peptide Sequences for BPI Gene

GenScript: Design optimal peptide antigens:
  • Bactericidal/permeability-increasing protein (B1APZ9_HUMAN)
  • CAP 57 (BPI_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P17213

UniProtKB/Swiss-Prot:

BPI_HUMAN :
  • The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.
  • Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
Domain:
  • The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.
  • The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues.
Family:
  • Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
genes like me logo Genes that share domains with BPI: view

Function for BPI Gene

Molecular function for BPI Gene

UniProtKB/Swiss-Prot Function:
The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa.
GENATLAS Biochemistry:
bactericidal permeability increasing protein,55kDa,released from azurophilic granules of neutrophiles,oxygen independent phagocytosis of Gram- bacteria

Phenotypes From GWAS Catalog for BPI Gene

Gene Ontology (GO) - Molecular Function for BPI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001530 lipopolysaccharide binding IBA,IDA 8409400
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with BPI: view
genes like me logo Genes that share phenotypes with BPI: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BPI

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BPI Gene

Localization for BPI Gene

Subcellular locations from UniProtKB/Swiss-Prot for BPI Gene

Secreted. Cytoplasmic granule membrane. Note=Membrane-associated in polymorphonuclear Leukocytes (PMN) granules. {ECO:0000269 PubMed:2722846}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BPI gene
Compartment Confidence
extracellular 5
lysosome 4
plasma membrane 2
nucleus 2
cytosol 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for BPI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA 21873635
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IEA --
GO:0035578 azurophil granule lumen TAS --
genes like me logo Genes that share ontologies with BPI: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for BPI Gene

Pathways & Interactions for BPI Gene

genes like me logo Genes that share pathways with BPI: view

Gene Ontology (GO) - Biological Process for BPI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response IEA --
GO:0019730 antimicrobial humoral response TAS --
GO:0031663 lipopolysaccharide-mediated signaling pathway IBA 21873635
GO:0032715 negative regulation of interleukin-6 production IBA,IDA 8409400
GO:0032717 negative regulation of interleukin-8 production IBA,IDA 8409400
genes like me logo Genes that share ontologies with BPI: view

No data available for SIGNOR curated interactions for BPI Gene

Drugs & Compounds for BPI Gene

(14) Drugs for BPI Gene - From: DrugBank, ClinicalTrials, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Di-Stearoyl-3-Sn-Phosphatidylcholine Experimental Pharma Target 0
Liver Extracts Pharma 5699

(16) Additional Compounds for BPI Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with BPI: view

Transcripts for BPI Gene

mRNA/cDNA for BPI Gene

1 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BPI

Alternative Splicing Database (ASD) splice patterns (SP) for BPI Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b
SP1: - - - -
SP2: -
SP3: - -
SP4: -
SP5: -
SP6:

Relevant External Links for BPI Gene

GeneLoc Exon Structure for
BPI

Expression for BPI Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for BPI Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BPI Gene

This gene is overexpressed in Whole Blood (x39.4) and Testis (x4.6).

Protein differential expression in normal tissues from HIPED for BPI Gene

This gene is overexpressed in Neutrophil (26.8) and Nasal epithelium (19.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BPI Gene



Protein tissue co-expression partners for BPI Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for BPI

SOURCE GeneReport for Unigene cluster for BPI Gene:

Hs.529019

mRNA Expression by UniProt/SwissProt for BPI Gene:

P17213-BPI_HUMAN
Tissue specificity: Restricted to cells of the myeloid series.

Evidence on tissue expression from TISSUES for BPI Gene

  • Blood(4.9)
  • Heart(4.4)
  • Bone marrow(3.3)
  • Lung(2.5)
  • Intestine(2.3)
  • Liver(2.2)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with BPI: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for BPI Gene

Orthologs for BPI Gene

This gene was present in the common ancestor of chordates.

Orthologs for BPI Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia BPI 30 31
  • 96.91 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia BPI 30 31
  • 77.46 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia BPI 30 31
  • 75.47 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Bpi 30
  • 68.68 (n)
Mouse
(Mus musculus)
Mammalia Bpi 30 17 31
  • 68.48 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia BPI 31
  • 37 (a)
OneToOne
Chicken
(Gallus gallus)
Aves BPI 30
  • 61.86 (n)
-- 31
  • 49 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 46 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii bpifcl 30
  • 43.61 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 24 (a)
OneToMany
Species where no ortholog for BPI was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for BPI Gene

ENSEMBL:
Gene Tree for BPI (if available)
TreeFam:
Gene Tree for BPI (if available)
Aminode:
Evolutionary constrained regions (ECRs) for BPI: view image

Paralogs for BPI Gene

(3) SIMAP similar genes for BPI Gene using alignment to 4 proteins:

  • BPI_HUMAN
  • A2A2A1_HUMAN
  • A2A2A2_HUMAN
  • H0Y738_HUMAN
genes like me logo Genes that share paralogs with BPI: view

Variants for BPI Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for BPI Gene

SNP ID Clinical significance and condition Chr 20 pos Variation AA Info Type
708034 Likely Benign: not provided 38,326,268(+) G/A MISSENSE_VARIANT
710655 Benign: not provided 38,318,483(+) G/T INTRON_VARIANT
727484 Likely Benign: not provided 38,335,600(+) A/G MISSENSE_VARIANT
764933 Likely Benign: not provided 38,310,569(+) G/A SYNONYMOUS_VARIANT
764934 Likely Benign: not provided 38,326,345(+) C/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for BPI Gene

Structural Variations from Database of Genomic Variants (DGV) for BPI Gene

Variant ID Type Subtype PubMed ID
dgv4309n100 CNV loss 25217958
esv2722392 CNV deletion 23290073
esv2722393 CNV deletion 23290073
esv2722394 CNV deletion 23290073
esv2758794 CNV gain 17122850
esv35121 CNV gain 17911159
esv3645775 CNV loss 21293372
esv3645778 CNV loss 21293372
nsv1058457 CNV loss 25217958
nsv1063495 CNV gain 25217958
nsv1071695 CNV deletion 25765185
nsv1077911 CNV duplication 25765185
nsv1142308 CNV tandem duplication 24896259
nsv585964 CNV loss 21841781
nsv817893 CNV gain 17921354
nsv954034 CNV deletion 24416366

Variation tolerance for BPI Gene

Residual Variation Intolerance Score: 96.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.32; 92.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BPI Gene

Human Gene Mutation Database (HGMD)
BPI
SNPedia medical, phenotypic, and genealogical associations of SNPs for
BPI

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BPI Gene

Disorders for BPI Gene

MalaCards: The human disease database

(18) MalaCards diseases for BPI Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
meningococcemia
vasculitis
  • autoimmune vasculitis
reactive arthritis
  • fiessinger leroy reiter syndrome
crescentic glomerulonephritis
  • idiopathic crescentic glomerulonephritis
bronchiectasis
  • polynesian bronchiectasis
- elite association - COSMIC cancer census association via MalaCards
Search BPI in MalaCards View complete list of genes associated with diseases

Additional Disease Information for BPI

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with BPI: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BPI Gene

Publications for BPI Gene

  1. Polymorphisms in the lipopolysaccharide-binding protein and bactericidal/permeability-increasing protein in patients with myocardial infarction. (PMID: 12521224) Hubacek JA … Poledne R (Clinical chemistry and laboratory medicine 2002) 3 23 41
  2. Gene variants of the bactericidal/permeability increasing protein and lipopolysaccharide binding protein in sepsis patients: gender-specific genetic predisposition to sepsis. (PMID: 11373419) Hubacek JA … Schmitz G (Critical care medicine 2001) 3 23 41
  3. Crystal structure of human BPI and two bound phospholipids at 2.4 angstrom resolution. (PMID: 9188532) Beamer LJ … Eisenberg D (Science (New York, N.Y.) 1997) 3 4 23
  4. Bactericidal/permeability-increasing protein and lipopolysaccharide (LPS)-binding protein. LPS binding properties and effects on LPS-mediated cell activation. (PMID: 7517398) Wilde CG … Scott RW (The Journal of biological chemistry 1994) 3 4 23
  5. The genes for the lipopolysaccharide binding protein (LBP) and the bactericidal permeability increasing protein (BPI) are encoded in the same region of human chromosome 20. (PMID: 8432532) Gray PW … Shows TB (Genomics 1993) 2 3 23

Products for BPI Gene

Sources for BPI Gene