Aliases for BPHL Gene
External Ids for BPHL Gene
Previous HGNC Symbols for BPHL Gene
Previous GeneCards Identifiers for BPHL Gene
This gene encodes a member of the serine protease family of hydrolytic enzymes which contain a serine in their active site. The encoded protein may play a role in activation of the antiviral prodrug valacyclovir. Alternatively spliced transcript variants have been described.[provided by RefSeq, Jan 2009]
GeneCards Summary for BPHL Gene
BPHL (Biphenyl Hydrolase Like) is a Protein Coding gene. Diseases associated with BPHL include Zika Fever and Cardiomyopathy, Dilated, 1M. Among its related pathways are Cytochrome P450 - arranged by substrate type and Metabolism. Gene Ontology (GO) annotations related to this gene include hydrolase activity. An important paralog of this gene is EPHX3.
UniProtKB/Swiss-Prot Summary for BPHL Gene
Serine hydrolase that catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir. Activates valacyclovir to acyclovir. May play a role in detoxification processes. It is a specific alpha-amino acid ester hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol.