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Aliases for BORCS7 Gene

Aliases for BORCS7 Gene

  • BLOC-1 Related Complex Subunit 7 2 3 5
  • Diaskedin 2 3 4
  • C10orf32 3 4
  • Chromosome 10 Open Reading Frame 32 2
  • BLOC-1-Related Complex Subunit 7 3
  • UPF0693 Protein C10orf32 3

External Ids for BORCS7 Gene

Previous HGNC Symbols for BORCS7 Gene

  • C10orf32

Summaries for BORCS7 Gene

GeneCards Summary for BORCS7 Gene

BORCS7 (BLOC-1 Related Complex Subunit 7) is a Protein Coding gene. An important paralog of this gene is BORCS7-ASMT.

UniProtKB/Swiss-Prot for BORCS7 Gene

  • As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor.

Additional gene information for BORCS7 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BORCS7 Gene

Genomics for BORCS7 Gene

GeneHancer (GH) Regulatory Elements for BORCS7 Gene

Promoters and enhancers for BORCS7 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10I102853 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +0.2 244 1.5 HDGF FOXA2 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 BORCS7 BORCS7-ASMT ENSG00000282772 GBF1 NOLC1 PDCD11 RPEL1 TAF5 SFXN2 WBP1L
GH10I102855 Enhancer 1 ENCODE 550.8 +1.8 1809 1.5 FOXA2 FEZF1 GLI4 ZNF2 ZNF48 GLIS2 ZNF213 KLF7 FOS SP3 BORCS7 BORCS7-ASMT ENSG00000282772 AS3MT TAF5 PDCD11 GC10P102871
GH10I103237 Enhancer 1.5 FANTOM5 Ensembl ENCODE 20 +386.2 386158 5 PKNOX1 CLOCK ARID4B NEUROD1 SIN3A BRCA1 ZNF48 ZNF121 ZNF143 ATF7 BORCS7 NT5C2 AS3MT INA CNNM2 PFN1P11 PTGES3P4 CYP17A1 RNU11-3P ARL3
GH10I102772 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.5 -75.5 -75524 11.8 PKNOX1 FOXA2 SIN3A YY1 ZNF121 GLIS2 FOS RUNX3 RXRA REST WBP1L SFXN2 AS3MT ARL3 PPRC1 NFKB2 LDB1 PDCD11 BORCS7 CYP17A1
GH10I103190 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 8.1 +338.1 338130 4.5 ARNT ARID4B SIN3A DMAP1 IRF4 YY1 ZNF207 ZNF143 SP3 NFYC NT5C2 GC10P103194 AS3MT MARCKSL1P1 BORCS7 SFXN2 WBP1L GC10P103176
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around BORCS7 on UCSC Golden Path with GeneCards custom track

Genomic Locations for BORCS7 Gene

Genomic Locations for BORCS7 Gene
10,752 bases
Plus strand

Genomic View for BORCS7 Gene

Genes around BORCS7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BORCS7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BORCS7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BORCS7 Gene

Proteins for BORCS7 Gene

  • Protein details for BORCS7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    BLOC-1-related complex subunit 7
    Protein Accession:
    Secondary Accessions:
    • B2R488
    • B3KUW4
    • C9K0X3

    Protein attributes for BORCS7 Gene

    105 amino acids
    Molecular mass:
    11564 Da
    Quaternary structure:
    • Component of the BLOC-one-related complex (BORC) which is composed of BLOC1S1, BLOC1S2, BORCS5, BORCS6, BORCS7, BORCS8, KXD1 and SNAPIN.
    • Diaskedin is from the ancient Greek diaskedazo, meaning to disperse.

neXtProt entry for BORCS7 Gene

Post-translational modifications for BORCS7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BORCS7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BORCS7 Gene

Domains & Families for BORCS7 Gene

Gene Families for BORCS7 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for BORCS7 Gene


Suggested Antigen Peptide Sequences for BORCS7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the BORCS7 family.
  • Belongs to the BORCS7 family.
genes like me logo Genes that share domains with BORCS7: view

Function for BORCS7 Gene

Molecular function for BORCS7 Gene

UniProtKB/Swiss-Prot Function:
As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor.

Phenotypes From GWAS Catalog for BORCS7 Gene

Gene Ontology (GO) - Molecular Function for BORCS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25898167
genes like me logo Genes that share ontologies with BORCS7: view
genes like me logo Genes that share phenotypes with BORCS7: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BORCS7 Gene

Localization for BORCS7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BORCS7 Gene

Lysosome membrane.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BORCS7 gene
Compartment Confidence
cytosol 5
nucleus 3
lysosome 3
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for BORCS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IEA --
GO:0005765 lysosomal membrane IEA --
GO:0016020 membrane IEA --
GO:0099078 BORC complex IDA 25898167
genes like me logo Genes that share ontologies with BORCS7: view

Pathways & Interactions for BORCS7 Gene

SuperPathways for BORCS7 Gene

No Data Available

Interacting Proteins for BORCS7 Gene

Selected Interacting proteins: Q96B45-BORC7_HUMAN for BORCS7 Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for BORCS7 Gene


No data available for Pathways by source and SIGNOR curated interactions for BORCS7 Gene

Drugs & Compounds for BORCS7 Gene

No Compound Related Data Available

Transcripts for BORCS7 Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for BORCS7 Gene

No ASD Table

Relevant External Links for BORCS7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BORCS7 Gene

NURSA nuclear receptor signaling pathways regulating expression of BORCS7 Gene:


Evidence on tissue expression from TISSUES for BORCS7 Gene

  • Adrenal gland(4.3)
  • Nervous system(3)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for BORCS7 Gene

Orthologs for BORCS7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BORCS7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C10H10orf32 33
  • 100 (n)
C10ORF32 34
  • 100 (a)
(Bos Taurus)
Mammalia -- 34
  • 96 (a)
C26H10orf32 33
  • 91.75 (n)
(Canis familiaris)
Mammalia C28H10orf32 33
  • 92.45 (n)
-- 34
  • 82 (a)
(Mus musculus)
Mammalia 2010012O05Rik 33 34
  • 90.16 (n)
Borcs7 16
(Monodelphis domestica)
Mammalia -- 34
  • 90 (a)
(Rattus norvegicus)
Mammalia RGD1311783 33
  • 88.36 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 88 (a)
(Gallus gallus)
Aves C6H10ORF32 33 34
  • 79.56 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 83 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia c10orf32 33
  • 77.02 (n)
Str.2187 33
(Danio rerio)
Actinopterygii C13H10orf32 34
  • 79 (a)
zgc:114169 33
  • 68.95 (n)
Dr.16036 33
Species where no ortholog for BORCS7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BORCS7 Gene

Gene Tree for BORCS7 (if available)
Gene Tree for BORCS7 (if available)

Paralogs for BORCS7 Gene

Paralogs for BORCS7 Gene

genes like me logo Genes that share paralogs with BORCS7: view

Variants for BORCS7 Gene

Sequence variations from dbSNP and Humsavar for BORCS7 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000351567 -- 102,859,130(+) CTCCT/CT intron_variant
rs1000390019 -- 102,862,471(+) G/A intron_variant
rs1000471832 -- 102,853,544(+) C/T upstream_transcript_variant
rs1000955352 -- 102,857,236(+) C/T intron_variant
rs1001252651 -- 102,856,628(+) A/T intron_variant

Variation tolerance for BORCS7 Gene

Residual Variation Intolerance Score: 48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.15; 3.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BORCS7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for BORCS7 Gene

Disorders for BORCS7 Gene

No disorders were found for BORCS7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BORCS7 Gene

Publications for BORCS7 Gene

  1. BORC, a multisubunit complex that regulates lysosome positioning. (PMID: 25898167) Pu J … Bonifacino JS (Developmental cell 2015) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for BORCS7 Gene

Sources for BORCS7 Gene

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