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Aliases for BORA Gene

Aliases for BORA Gene

  • Bora, Aurora Kinase A Activator 2 3 5
  • C13orf34 3 4
  • Chromosome 13 Open Reading Frame 34 2
  • Protein Aurora Borealis 3
  • HsBora 4

External Ids for BORA Gene

Previous HGNC Symbols for BORA Gene

  • C13orf34

Previous GeneCards Identifiers for BORA Gene

  • GC13P073302

Summaries for BORA Gene

Entrez Gene Summary for BORA Gene

  • BORA is an activator of the protein kinase Aurora A (AURKA; MIM 603072), which is required for centrosome maturation, spindle assembly, and asymmetric protein localization during mitosis (Hutterer et al., 2006 [PubMed 16890155]).[supplied by OMIM, Mar 2008]

GeneCards Summary for BORA Gene

BORA (Bora, Aurora Kinase A Activator) is a Protein Coding gene. Among its related pathways are DNA Damage and Regulation of PLK1 Activity at G2/M Transition. Gene Ontology (GO) annotations related to this gene include protein kinase binding.

UniProtKB/Swiss-Prot for BORA Gene

  • Required for the activation of AURKA at the onset of mitosis.

Additional gene information for BORA Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BORA Gene

Genomics for BORA Gene

GeneHancer (GH) Regulatory Elements for BORA Gene

Promoters and enhancers for BORA Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13I072726 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 572.2 +0.2 194 3.2 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 CBX5 BORA MZT1 DIS3 PIBF1
GH13I073054 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 20.4 +338.2 338176 23.6 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 SLC30A9 ZNF143 KLF5 DIS3 BORA RNU4-10P FABP5P1
GH13I073039 Enhancer 1 ENCODE dbSUPER 9.8 +313.0 312985 3.3 JUN TEAD4 TAL1 MAX CEBPG BRCA1 TCF12 NCOR1 RCOR1 CBFA2T2 BORA PIBF1 PSMD10P3 KLF5
GH13I072970 Enhancer 0.7 ENCODE 13.1 +243.2 243244 1.8 ZNF680 ZNF189 ZNF529 ZFP37 ZNF140 ZNF266 ZNF501 ZNF781 ZNF518A ZNF697 DIS3 PIBF1 BORA GC13M072950 PSMD10P3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around BORA on UCSC Golden Path with GeneCards custom track

Genomic Locations for BORA Gene

Genomic Locations for BORA Gene
28,450 bases
Plus strand

Genomic View for BORA Gene

Genes around BORA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BORA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BORA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BORA Gene

Proteins for BORA Gene

  • Protein details for BORA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein aurora borealis
    Protein Accession:
    Secondary Accessions:
    • B4DQ30
    • Q5W0P3
    • Q5W0P4
    • Q86YC6
    • Q96IW9
    • Q9H640

    Protein attributes for BORA Gene

    559 amino acids
    Molecular mass:
    61203 Da
    Quaternary structure:
    • Interacts with AURKA.
    • Sequence=BAB15426.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for BORA Gene


neXtProt entry for BORA Gene

Post-translational modifications for BORA Gene

Antibody Products

  • Abcam antibodies for BORA
  • Santa Cruz Biotechnology (SCBT) Antibodies for BORA

No data available for DME Specific Peptides for BORA Gene

Domains & Families for BORA Gene

Gene Families for BORA Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for BORA Gene


Suggested Antigen Peptide Sequences for BORA Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the BORA family.
  • Belongs to the BORA family.
genes like me logo Genes that share domains with BORA: view

Function for BORA Gene

Molecular function for BORA Gene

UniProtKB/Swiss-Prot Function:
Required for the activation of AURKA at the onset of mitosis.

Gene Ontology (GO) - Molecular Function for BORA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18521620
GO:0019901 protein kinase binding IPI 18521620
genes like me logo Genes that share ontologies with BORA: view

Phenotypes for BORA Gene

genes like me logo Genes that share phenotypes with BORA: view

Animal Model Products

CRISPR Products

miRNA for BORA Gene

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BORA Gene

Localization for BORA Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BORA gene
Compartment Confidence
cytosol 5
nucleus 3
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for BORA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0072687 meiotic spindle IEA --
genes like me logo Genes that share ontologies with BORA: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for BORA Gene

Pathways & Interactions for BORA Gene

genes like me logo Genes that share pathways with BORA: view

Pathways by source for BORA Gene

1 GeneTex pathway for BORA Gene
1 BioSystems pathway for BORA Gene
1 Cell Signaling Technology pathway for BORA Gene

SIGNOR curated interactions for BORA Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for BORA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0007049 cell cycle IEA --
GO:0007088 regulation of mitotic nuclear division IMP 18521620
GO:0032880 regulation of protein localization IMP 18521620
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with BORA: view

Drugs & Compounds for BORA Gene

No Compound Related Data Available

Transcripts for BORA Gene

Unigene Clusters for BORA Gene

Bora, aurora kinase A activator:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for BORA Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP3: - - -

Relevant External Links for BORA Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BORA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BORA Gene

Protein differential expression in normal tissues from HIPED for BORA Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for BORA Gene

Protein tissue co-expression partners for BORA Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of BORA Gene:


SOURCE GeneReport for Unigene cluster for BORA Gene:


Evidence on tissue expression from TISSUES for BORA Gene

  • Intestine(4.2)
genes like me logo Genes that share expression patterns with BORA: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for BORA Gene

Orthologs for BORA Gene

This gene was present in the common ancestor of chordates.

Orthologs for BORA Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BORA 33 34
  • 99.62 (n)
(Canis familiaris)
Mammalia BORA 33 34
  • 90.15 (n)
(Bos Taurus)
Mammalia BORA 33 34
  • 87.42 (n)
(Rattus norvegicus)
Mammalia Bora 33
  • 80.01 (n)
(Mus musculus)
Mammalia Bora 33 16 34
  • 77.59 (n)
(Monodelphis domestica)
Mammalia BORA 34
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia BORA 34
  • 67 (a)
(Gallus gallus)
Aves BORA 33 34
  • 68.38 (n)
(Anolis carolinensis)
Reptilia BORA 34
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia bora 33
  • 62.1 (n)
(Danio rerio)
Actinopterygii bora 33 34
  • 53.09 (n)
Species where no ortholog for BORA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BORA Gene

Gene Tree for BORA (if available)
Gene Tree for BORA (if available)

Paralogs for BORA Gene

(1) SIMAP similar genes for BORA Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with BORA: view

No data available for Paralogs for BORA Gene

Variants for BORA Gene

Sequence variations from dbSNP and Humsavar for BORA Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs1000104366 -- 72,751,810(+) T/C intron_variant
rs1000158630 -- 72,754,915(+) T/C intron_variant
rs1000368767 -- 72,729,530(+) C/T intron_variant
rs1000480381 -- 72,748,584(+) T/G intron_variant
rs1000495450 -- 72,756,482(+) C/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for BORA Gene

Variant ID Type Subtype PubMed ID
nsv1049859 CNV loss 25217958

Variation tolerance for BORA Gene

Residual Variation Intolerance Score: 50.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.20; 39.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BORA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BORA Gene

Disorders for BORA Gene

Additional Disease Information for BORA

No disorders were found for BORA Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BORA Gene

Publications for BORA Gene

  1. Mitotic activation of the kinase Aurora-A requires its binding partner Bora. (PMID: 16890155) Hutterer A … Knoblich JA (Developmental cell 2006) 2 3 4 58
  2. Aurora-A and hBora join the game of Polo. (PMID: 19487276) Macurek L … Medema RH (Cancer research 2009) 2 3 58
  3. Plk1- and beta-TrCP-dependent degradation of Bora controls mitotic progression. (PMID: 18378770) Seki A … Fang G (The Journal of cell biology 2008) 2 3 58
  4. Bora and the kinase Aurora a cooperatively activate the kinase Plk1 and control mitotic entry. (PMID: 18566290) Seki A … Fang G (Science (New York, N.Y.) 2008) 2 3 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for BORA Gene

Sources for BORA Gene

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