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Aliases for BOLA2B Gene

Aliases for BOLA2B Gene

  • BolA Family Member 2B 2 3 5
  • BolA-Like Protein 2 Member B 3
  • BolA Homolog 2B (E. Coli) 2
  • BolA-Like 2B (E. Coli) 2
  • BolA-Like Protein 2B 3
  • BolA-Like Protein 2 3
  • BolA Homolog 2B 3
  • BOLA2 BOLA2B 4
  • BOLA2A 4
  • BOLA2 3

External Ids for BOLA2B Gene

Previous GeneCards Identifiers for BOLA2B Gene

  • GC16U900518
  • GC16M030112

Summaries for BOLA2B Gene

Entrez Gene Summary for BOLA2B Gene

  • This gene is located within a region of a segmental duplication on chromosome 16 and is identical to BOLA2 (bolA family member 2). The product of this gene belongs to a family of proteins that are widely conserved and may be involved in iron maturation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

GeneCards Summary for BOLA2B Gene

BOLA2B (BolA Family Member 2B) is a Protein Coding gene. An important paralog of this gene is BOLA2.

UniProtKB/Swiss-Prot for BOLA2B Gene

  • Acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (PubMed:26613676, PubMed:27519415). Acts together with the monothiol glutaredoxin GLRX3 (PubMed:26613676, PubMed:27519415).

Additional gene information for BOLA2B Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BOLA2B Gene

Genomics for BOLA2B Gene

GeneHancer (GH) Regulatory Elements for BOLA2B Gene

Promoters and enhancers for BOLA2B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I030193 Promoter/Enhancer 1.2 EPDnew Ensembl dbSUPER 550.8 +0.4 405 1.8 BOLA2B SLX1A-SULT1A3 SLX1A GC16P030195
GH16I030195 Enhancer 0.2 dbSUPER 550.8 -1.7 -1732 0.7 BOLA2B GC16P030195 SULT1A3 SLX1A-SULT1A3 SLX1A
GH16I030192 Enhancer 0.2 dbSUPER 550.8 +2.0 1982 0.3 BOLA2B SLX1A SLX1A-SULT1A3 ENSG00000261416
GH16I030200 Enhancer 0.2 dbSUPER 550.8 -1.0 -966 0.3 BOLA2B SLX1A-SULT1A3 SLX1A GC16P030195 SULT1A3
GH16I030119 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 12.6 +72.1 72135 5.8 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 POLR2B ZNF766 ZNF207 MAPK3 YPEL3 SETD1A NPIPB13 NPIPB12 SRCAP ZNF747 INO80E CORO1A SLX1A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around BOLA2B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the BOLA2B gene promoter:

Genomic Locations for BOLA2B Gene

Genomic Locations for BOLA2B Gene
1,373 bases
Minus strand

Genomic View for BOLA2B Gene

Genes around BOLA2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BOLA2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BOLA2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BOLA2B Gene

Proteins for BOLA2B Gene

  • Protein details for BOLA2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    BolA-like protein 2
    Protein Accession:
    Secondary Accessions:
    • A1L454
    • A7YDY3

    Protein attributes for BOLA2B Gene

    86 amino acids
    Molecular mass:
    10117 Da
    Quaternary structure:
    • Interacts with GLRX3; forms a heterotrimeric complex composed by two BOLA2 molecules and one GLRX3 molecule; linked by [2Fe-2S] clusters (PubMed:22309771, PubMed:26613676, PubMed:27519415).
    • Interacts with GLRX3; forms a heterotrimeric complex composed by two BOLA2 molecules and one GLRX3 molecule; linked by [2Fe-2S] clusters (PubMed:22309771, PubMed:26613676, PubMed:27519415).
    • Sequence=AAH22832.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI30402.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI30404.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI37533.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI37535.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI44689.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for BOLA2B Gene


neXtProt entry for BOLA2B Gene

Post-translational modifications for BOLA2B Gene

  • Ubiquitination at posLast=4343 and posLast=7373
  • Modification sites at PhosphoSitePlus

Other Protein References for BOLA2B Gene

No data available for DME Specific Peptides for BOLA2B Gene

Domains & Families for BOLA2B Gene

Gene Families for BOLA2B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for BOLA2B Gene


Suggested Antigen Peptide Sequences for BOLA2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the BolA/IbaG family.
  • Belongs to the BolA/IbaG family.
genes like me logo Genes that share domains with BOLA2B: view

Function for BOLA2B Gene

Molecular function for BOLA2B Gene

UniProtKB/Swiss-Prot Function:
Acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (PubMed:26613676, PubMed:27519415). Acts together with the monothiol glutaredoxin GLRX3 (PubMed:26613676, PubMed:27519415).

Gene Ontology (GO) - Molecular Function for BOLA2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 27519415
genes like me logo Genes that share ontologies with BOLA2B: view

Phenotypes for BOLA2B Gene

GenomeRNAi human phenotypes for BOLA2B:
genes like me logo Genes that share phenotypes with BOLA2B: view

miRNA for BOLA2B Gene

miRTarBase miRNAs that target BOLA2B

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BOLA2B Gene

Localization for BOLA2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for BOLA2B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BOLA2B gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for BOLA2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 22746225
GO:0005737 cytoplasm IEA,IDA 22746225
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA,HDA 23376485
genes like me logo Genes that share ontologies with BOLA2B: view

Pathways & Interactions for BOLA2B Gene

SuperPathways for BOLA2B Gene

No Data Available

Gene Ontology (GO) - Biological Process for BOLA2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035722 interleukin-12-mediated signaling pathway TAS --
GO:0044571 [2Fe-2S] cluster assembly IDA 27519415
GO:0097428 protein maturation by iron-sulfur cluster transfer IDA 27519415
genes like me logo Genes that share ontologies with BOLA2B: view

No data available for Pathways by source and SIGNOR curated interactions for BOLA2B Gene

Drugs & Compounds for BOLA2B Gene

No Compound Related Data Available

Transcripts for BOLA2B Gene

mRNA/cDNA for BOLA2B Gene

(2) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for BOLA2B Gene

No ASD Table

Relevant External Links for BOLA2B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BOLA2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BOLA2B Gene

Protein differential expression in normal tissues from HIPED for BOLA2B Gene

This gene is overexpressed in Lavage (18.1) and Peripheral blood mononuclear cells (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for BOLA2B Gene

Protein tissue co-expression partners for BOLA2B Gene

NURSA nuclear receptor signaling pathways regulating expression of BOLA2B Gene:


SOURCE GeneReport for Unigene cluster for BOLA2B Gene:


Evidence on tissue expression from TISSUES for BOLA2B Gene

  • Blood(4.1)
  • Eye(4.1)
  • Kidney(4.1)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with BOLA2B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for BOLA2B Gene

Orthologs for BOLA2B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for BOLA2B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 34
  • 97 (a)
(Bos Taurus)
Mammalia -- 34
  • 90 (a)
(Mus musculus)
Mammalia Bola2 34
  • 87 (a)
(Rattus norvegicus)
Mammalia LOC100363408 33
  • 85.27 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 84 (a)
(Danio rerio)
Actinopterygii BOLA2B 34
  • 58 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG33672 34
  • 47 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BOL2 36
Species where no ortholog for BOLA2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BOLA2B Gene

Gene Tree for BOLA2B (if available)
Gene Tree for BOLA2B (if available)

Paralogs for BOLA2B Gene

Paralogs for BOLA2B Gene

(1) SIMAP similar genes for BOLA2B Gene using alignment to 3 proteins: Pseudogenes for BOLA2B Gene

genes like me logo Genes that share paralogs with BOLA2B: view

Variants for BOLA2B Gene

Sequence variations from dbSNP and Humsavar for BOLA2B Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1003660683 -- 30,194,786(-) C/T upstream_transcript_variant
rs1012919487 -- 30,194,823(-) G/A/T upstream_transcript_variant
rs1015002392 -- 30,194,881(-) C/A/T upstream_transcript_variant
rs1027624502 -- 30,194,827(-) G/A upstream_transcript_variant
rs142135049 -- 30,195,486(-) TTTTTTTTTTTTTTTTTTTT/TTTTTTTTTTTTTTTTTTTTT upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for BOLA2B Gene

Variant ID Type Subtype PubMed ID
dgv1515e59 CNV duplication 20981092
esv22245 CNV gain 19812545
esv2714183 CNV deletion 23290073
esv2758641 CNV gain 17122850
esv2758642 CNV gain 17122850
esv29892 CNV gain 19812545
esv3333204 CNV duplication 20981092
esv3388213 CNV duplication 20981092
nsv1056249 CNV gain 25217958
nsv1078392 CNV duplication 25765185
nsv1078393 CNV duplication 25765185
nsv1139652 CNV duplication 24896259
nsv1141284 CNV duplication 24896259
nsv1146152 CNV duplication 26484159
nsv1150245 CNV duplication 26484159
nsv471387 CNV gain 19718026
nsv471388 CNV gain 19718026
nsv498862 CNV loss 21111241
nsv571809 CNV loss 21841781
nsv571810 CNV loss 21841781
nsv571819 CNV gain 21841781
nsv820959 CNV duplication 20802225
nsv821543 CNV duplication 20802225
nsv9426 CNV gain 18304495
nsv9431 CNV gain+loss 18304495
nsv960011 CNV duplication 23825009
nsv978130 CNV duplication 23825009

Additional Variant Information for BOLA2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for BOLA2B Gene

Disorders for BOLA2B Gene

Additional Disease Information for BOLA2B

No disorders were found for BOLA2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BOLA2B Gene

Publications for BOLA2B Gene

  1. A Glutaredoxin·BolA Complex Serves as an Iron-Sulfur Cluster Chaperone for the Cytosolic Cluster Assembly Machinery. (PMID: 27519415) Frey AG … Philpott CC (The Journal of biological chemistry 2016) 3 4 58
  2. Elucidating the Molecular Function of Human BOLA2 in GRX3-Dependent Anamorsin Maturation Pathway. (PMID: 26613676) Banci L … Muzzioli R (Journal of the American Chemical Society 2015) 3 4 58
  3. BOLA1 is an aerobic protein that prevents mitochondrial morphology changes induced by glutathione depletion. (PMID: 22746225) Willems P … Huynen MA (Antioxidants & redox signaling 2013) 3 4 58
  4. Human glutaredoxin 3 forms [2Fe-2S]-bridged complexes with human BolA2. (PMID: 22309771) Li H … Outten CE (Biochemistry 2012) 3 4 58
  5. Solution structure of a BolA-like protein from Mus musculus. (PMID: 14718656) Kasai T … Yokoyama S (Protein science : a publication of the Protein Society 2004) 2 3 58

Products for BOLA2B Gene

Sources for BOLA2B Gene

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