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This gene represents naturally-occurring readthrough transcription between the upstream BOLA2 (bolA family member 2) and downstream SMG1 pseudogene 6 (SMG1P6) loci. Alternative splicing results in multiple transcript variants, some of which may encode proteins with an N-terminus similar to BOLA2 and a C-terminus related to SMG1 phosphatidylinositol 3-kinase-related kinase. [pro... See more...
Aliases for BOLA2-SMG1P6 Gene
Aliases for BOLA2-SMG1P6 Gene
External Ids for BOLA2-SMG1P6 Gene
- HGNC: 53563
- Entrez Gene: 107282092
- Ensembl: ENSG00000261740
- UniProtKB: H3BVE0
- UniProtKB: A0A0B4J295
- UniProtKB: H3BTW0
Previous GeneCards Identifiers for BOLA2-SMG1P6 Gene
- GC16M029444
- GC16M029451
- GC16M029578
- GC16U902267
Summaries for BOLA2-SMG1P6 Gene
-
This gene represents naturally-occurring readthrough transcription between the upstream BOLA2 (bolA family member 2) and downstream SMG1 pseudogene 6 (SMG1P6) loci. Alternative splicing results in multiple transcript variants, some of which may encode proteins with an N-terminus similar to BOLA2 and a C-terminus related to SMG1 phosphatidylinositol 3-kinase-related kinase. [provided by RefSeq, Feb 2016]
GeneCards Summary for BOLA2-SMG1P6 Gene
BOLA2-SMG1P6 (BOLA2-SMG1P6 Readthrough) is a Protein Coding gene.
Additional gene information for BOLA2-SMG1P6 Gene
- HGNC(53563)
- Entrez Gene(107282092)
- Ensembl(ENSG00000261740)
- UniProtKB(H3BVE0)
- UniProtKB(A0A0B4J295)
- UniProtKB(H3BTW0)
- Search for BOLA2-SMG1P6 at DataMed
- Search for BOLA2-SMG1P6 at HumanCyc
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BOLA2-SMG1P6 Gene
Genomics for BOLA2-SMG1P6 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for BOLA2-SMG1P6 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH16J029453 | Promoter/Enhancer | 0.8 | EPDnew Ensembl dbSUPER | 600.7 | +0.4 | 363 | 3.2 | BOLA2 BOLA2-SMG1P6 SLX1B SLX1B-SULT1A4 lnc-BOLA2-1 | ||
| GH16J029456 | Promoter/Enhancer | 0.5 | Ensembl dbSUPER | 600.7 | -1.5 | -1537 | 0.2 | BOLA2 BOLA2-SMG1P6 SLX1B SLX1B-SULT1A4 SULT1A4 | ||
| GH16J029457 | Promoter/Enhancer | 0.5 | EPDnew dbSUPER | 0.7 | -3.0 | -2971 | 0.1 | SULT1A4 BOLA2 BOLA2-SMG1P6 SLX1B SLX1B-SULT1A4 | ||
| GH16J029458 | Promoter/Enhancer | 0.5 | Ensembl dbSUPER | 0.7 | -2.7 | -2737 | 0.2 | BOLA2 BOLA2-SMG1P6 SULT1A4 SLX1B SLX1B-SULT1A4 | ||
| GH16J029444 | Enhancer | 0.2 | Ensembl | 0.4 | +10.2 | 10163 | 0.8 | SMG1P6 piR-59315-005 SLX1B lnc-BOLA2-1 BOLA2 BOLA2-SMG1P6 NPIPB11 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around BOLA2-SMG1P6 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for BOLA2-SMG1P6
Genomic Locations for BOLA2-SMG1P6 Gene
Genomic Locations for BOLA2-SMG1P6 Gene
- chr16:29,442,905-29,454,964
- (GRCh38/hg38)
- Size:
- 12,060 bases
- Orientation:
- Minus strand
- chr16:29,454,551-29,465,972
- (GRCh37/hg19)
- Size:
- 11,422 bases
- Orientation:
- Minus strand
Genomic View for BOLA2-SMG1P6 Gene
Genes around BOLA2-SMG1P6 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16p11.2 by HGNC
- 16p11.2 by Entrez Gene
- 16p11.2 by Ensembl
BOLA2-SMG1P6 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for BOLA2-SMG1P6 Gene
Proteins for BOLA2-SMG1P6 Gene
-
Protein details for BOLA2-SMG1P6 Gene (UniProtKB/TrEMBL)
- Protein Symbol:
- H3BVE0-H3BVE0_HUMAN
- Recommended name:
- BOLA2-SMG1P6 readthrough
- Protein Accession:
- H3BVE0
Protein attributes for BOLA2-SMG1P6 Gene
- Size:
- 249 amino acids
- Molecular mass:
- 27665 Da
- Quaternary structure:
- No Data Available
-
Protein details for BOLA2-SMG1P6 Gene (UniProtKB/TrEMBL)
- Protein Symbol:
- A0A0B4J295-A0A0B4J295_HUMAN
- Recommended name:
- BOLA2-SMG1P6 readthrough
- Protein Accession:
- A0A0B4J295
Protein attributes for BOLA2-SMG1P6 Gene
- Size:
- 124 amino acids
- Molecular mass:
- 13658 Da
- Quaternary structure:
- No Data Available
-
Protein details for BOLA2-SMG1P6 Gene (UniProtKB/TrEMBL)
- Protein Symbol:
- H3BTW0-H3BTW0_HUMAN
- Recommended name:
- BOLA2-SMG1P6 readthrough
- Protein Accession:
- H3BTW0
Protein attributes for BOLA2-SMG1P6 Gene
- Size:
- 89 amino acids
- Molecular mass:
- 9854 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for BOLA2-SMG1P6 Gene
No Post-translational modifications
Other Protein References for BOLA2-SMG1P6 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for BOLA2-SMG1P6
- Origene Custom Protein Services for BOLA2-SMG1P6
No data available for DME Specific Peptides for BOLA2-SMG1P6 Gene
Domains & Families for BOLA2-SMG1P6 Gene
Gene Families for BOLA2-SMG1P6 Gene
- Unknown:
-
- Belongs to the BolA/IbaG family.
- Belongs to the BolA/IbaG family.
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for BOLA2-SMG1P6 Gene
- InterPro:
- ProtoNet:
No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for BOLA2-SMG1P6 Gene
Function for BOLA2-SMG1P6 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
miRNA Products
Inhibitory RNA Products
Clone Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BOLA2-SMG1P6 Gene
Localization for BOLA2-SMG1P6 Gene
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for BOLA2-SMG1P6 Gene
Pathways & Interactions for BOLA2-SMG1P6 Gene
Interacting Proteins for BOLA2-SMG1P6 Gene
Selected Interacting proteins:
A0A0B4J295-A0A0B4J295_HUMAN
ENSP00000458075
for BOLA2-SMG1P6 Gene via
UniProtKB
STRING
| Symbol | External ID(s) | Details |
|---|---|---|
| CDK3 | ||
| CHD2 | ||
| ENSG00000272822 | ||
| ERCC6 | ||
| ABCF3 |
GPS-Prot Interaction Network for BOLA2-SMG1P6
No data available for Pathways by source and SIGNOR curated interactions for BOLA2-SMG1P6 Gene
Transcripts for BOLA2-SMG1P6 Gene
mRNA/cDNA for BOLA2-SMG1P6 Gene
- 6 REFSEQ mRNAs :
- 13 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000569622 937 nts (view in UCSC)
- ENST00000565417 3103 nts (view in UCSC)
- ENST00000568556 1305 nts (view in UCSC)
miRNA Products
Inhibitory RNA Products
Clone Products
Relevant External Links for BOLA2-SMG1P6 Gene
- GeneLoc Exon Structure for
- BOLA2-SMG1P6
Expression for BOLA2-SMG1P6 Gene
No Expression Related Data Available
Primer Products
Gene Expression Assay Products
No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for BOLA2-SMG1P6 Gene
Orthologs for BOLA2-SMG1P6 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToOne | |
| Zebrafish (Danio rerio) |
Actinopterygii | smg1 31 |
|
OneToMany | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | nonC 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | smg-1 31 |
|
OneToMany | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | TOR2 31 |
|
OneToMany |
- Species where no ortholog for BOLA2-SMG1P6 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- Cow (Bos Taurus)
- Dog (Canis familiaris)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Mouse (Mus musculus)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
Paralogs for BOLA2-SMG1P6 Gene
Pseudogenes.org Pseudogenes for BOLA2-SMG1P6 Gene
No data available for Paralogs for BOLA2-SMG1P6 Gene
Variants for BOLA2-SMG1P6 Gene
Additional Variant Information for BOLA2-SMG1P6 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- BOLA2-SMG1P6
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for BOLA2-SMG1P6 Gene
Disorders for BOLA2-SMG1P6 Gene
Additional Disease Information for BOLA2-SMG1P6
No disorders were found for BOLA2-SMG1P6 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BOLA2-SMG1P6 Gene
Publications for BOLA2-SMG1P6 Gene
- A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3
- The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J … Pennacchio LA (Nature 2004) 13
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3
No data available for Mastermind for BOLA2-SMG1P6 Gene
Products for BOLA2-SMG1P6 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for BOLA2-SMG1P6
- Origene Custom Protein Services for BOLA2-SMG1P6
- Browse OriGene Inhibitory RNA Products For BOLA2-SMG1P6
- Browse OriGene qPCR primer pairs and template standards
- OriGene CRISPR knockouts for BOLA2-SMG1P6
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For BOLA2-SMG1P6
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
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- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- VectorBuilder Custom and pre-made DNA vectors for BOLA2-SMG1P6 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for BOLA2-SMG1P6 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for BOLA2-SMG1P6 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for BOLA2-SMG1P6 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for BOLA2-SMG1P6
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for knockout CRISPR/Cas9 clones, lentivirus, and/or AAV products for BOLA2-SMG1P6
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles, and/or promoter clone products for BOLA2-SMG1P6
- Search GeneCopoeia for miRNA 3'UTR Target clone products for BOLA2-SMG1P6
- Search GeneCopoeia for shRNA, lentivirus, and/or AAV clone products for BOLA2-SMG1P6
Sources for BOLA2-SMG1P6 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB