Aliases for BOLA2 Gene
External Ids for BOLA2 Gene
Previous GeneCards Identifiers for BOLA2 Gene
This gene is located within a region of a segmental duplication on chromosome 16 and is identical to BOLA2B (bolA family member 2B). The product of this gene belongs to a family of proteins that are widely conserved and may be involved in iron maturation. Related pseudogenes are found multiple different chromosomes. Alternative splicing results in multiple transcript variants. Transcripts initiating at this locus may extend into downstream SMG1 pseudogene 6 (SMG1P6) and encode fusion proteins with a C-terminus related to SMG1 phosphatidylinositol 3-kinase-related kinase. A readthrough locus is represented with GeneID:107282092. [provided by RefSeq, Feb 2016]
GeneCards Summary for BOLA2 Gene
BOLA2 (BolA Family Member 2) is a Protein Coding gene. Diseases associated with BOLA2 include Multiple Mitochondrial Dysfunctions Syndrome 2 With Hyperglycinemia and Multiple Mitochondrial Dysfunctions Syndrome. An important paralog of this gene is BOLA2B.
UniProtKB/Swiss-Prot Summary for BOLA2 Gene
Acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (PubMed:26613676, PubMed:27519415). Acts together with the monothiol glutaredoxin GLRX3 (PubMed:26613676, PubMed:27519415).