Aliases for BOK Gene
Aliases for BOK Gene
External Ids for BOK Gene
- HGNC: 1087
- Entrez Gene: 666
- Ensembl: ENSG00000176720
- OMIM: 605404
- UniProtKB: Q9UMX3
Previous GeneCards Identifiers for BOK Gene
- GC02U990010
- GC02M239779
- GC02P242517
- GC02P242818
- GC02P242218
- GC02P242146
- GC02P234252
- GC02P242498
Summaries for BOK Gene
-
The protein encoded by this gene belongs to the BCL2 family, members of which form homo- or heterodimers, and act as anti- or proapoptotic regulators that are involved in a wide variety of cellular processes. Studies in rat show that this protein has restricted expression in reproductive tissues, interacts strongly with some antiapoptotic BCL2 proteins, not at all with proapoptotic BCL2 proteins, and induces apoptosis in transfected cells. Thus, this protein represents a proapoptotic member of the BCL2 family. [provided by RefSeq, Sep 2011]
GeneCards Summary for BOK Gene
BOK (BOK, BCL2 Family Apoptosis Regulator) is a Protein Coding gene. Among its related pathways are Apoptosis and Autophagy and Apoptosis Modulation and Signaling. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein dimerization activity.
UniProtKB/Swiss-Prot for BOK Gene
-
Isoform 1: Apoptosis regulator that functions through different apoptotic signaling pathways (PubMed:27076518, PubMed:15102863, PubMed:20673843). Plays a roles as pro-apoptotic protein that positively regulates intrinsic apoptotic process in a BAX- and BAK1-dependent manner or in a BAX- and BAK1-independent manner (PubMed:27076518, PubMed:15102863). In response to endoplasmic reticulum stress promotes mitochondrial apoptosis through downstream BAX/BAK1 activation and positive regulation of PERK-mediated unfolded protein response (By similarity). Activates apoptosis independently of heterodimerization with survival-promoting BCL2 and BCL2L1 through induction of mitochondrial outer membrane permeabilization, in a BAX- and BAK1-independent manner, in response to inhibition of ERAD-proteasome degradation system, resulting in cytochrome c release (PubMed:27076518). In response to DNA damage, mediates intrinsic apoptotic process in a TP53-dependent manner (PubMed:15102863). Plays a role in granulosa cell apoptosis by CASP3 activation (PubMed:20673843). Plays a roles as anti-apoptotic protein during neuronal apoptotic process, by negatively regulating poly ADP-ribose polymerase-dependent cell death through regulation of neuronal calcium homeostasis and mitochondrial bioenergetics in response to NMDA excitation (By similarity). In addition to its role in apoptosis, may regulate trophoblast cell proliferation during the early stages of placental development, by acting on G1/S transition through regulation of CCNE1 expression (PubMed:19942931). May also play a role as an inducer of autophagy by disrupting interaction between MCL1 and BECN1 (PubMed:24113155).
-
Isoform 2: Pro-apoptotic molecule exerting its function through the mitochondrial pathway.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BOK Gene
Genomics for BOK Gene
GeneHancer (GH) Regulatory Elements for BOK Gene
Promoters and enhancers for BOK Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around BOK on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the BOK gene promoter:
Regulatory Element Products
Genomic Locations for BOK Gene
Genomic Locations for BOK Gene
- chr2:241,551,424-241,574,138
- (GRCh38/hg38)
- Size:
- 22,715 bases
- Orientation:
- Plus strand
- chr2:242,498,136-242,513,553
- (GRCh37/hg19)
Genomic View for BOK Gene
Genes around BOK on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q37.3 by Entrez Gene
- 2q37.3 by HGNC
- 2q37.3 by Ensembl
BOK Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for BOK Gene
Proteins for BOK Gene
-
Protein details for BOK Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UMX3-BOK_HUMAN
- Recommended name:
- Bcl-2-related ovarian killer protein
- Protein Accession:
- Q9UMX3
Protein attributes for BOK Gene
- Size:
- 212 amino acids
- Molecular mass:
- 23280 Da
- Quaternary structure:
-
- Monomer; positively regulates apoptotic process. Homodimer (By similarity). Heterodimer (By similarity). Oligomer; promoted by apoptotic stimuli and BH3-only proteins; mediates constitutive activation (PubMed:15868100). Interacts (via BH4 domain) with ITPR1; enhances BOK expression and stabilization; limits apoptosis and prevents ubiquitination and then degradation; protects ITPR1 from proteolysis by CASP3 during apoptosis (PubMed:23884412). Interacts with ITPR2 AND ITPR3; binds most strongly to ITPR2, and barely to ITPR3; regulates their expression (By similarity). Interacts with XPO1; translocates to the cytoplasm (PubMed:16302269). Interacts with BNIP3; promotes oligomerization (PubMed:15868100).
Protein Expression for BOK Gene
Post-translational modifications for BOK Gene
- Ubiquitinated by AMFR/gp78 E3 ubiquitin ligase complex; mediates degradation by ubiquitin-proteasome pathway in a VCP/p97-dependent manner; prevents from pro-apoptotic activity; promotes degradation of newly synthesized proteins that are not ITPR1 associated.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for BOK Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for BOK (BOK)
-
Custom Antibody ServicesOriGene Antibodies for BOK
- Novus Biologicals Antibodies for BOK
- Invitrogen Antibodies for BOK
- GeneTex BOK Antibody for BOK
-
Custom Antibody ServicesProSci Antibodies for BOK
Protein Products
-
OriGene Purified Proteins for BOK
- Search Origene for MassSpec and Protein Over-expression Lysates for BOK
- Origene Custom Protein Services for BOK
- Novus Biologicals lysates for BOK
- Search GeneTex for Proteins for BOK
Assay Products
No data available for DME Specific Peptides for BOK Gene
Domains & Families for BOK Gene
Gene Families for BOK Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted membrane proteins
Protein Domains for BOK Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for BOK Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9UMX3UniProtKB/Swiss-Prot:
BOK_HUMAN :- BH4 domain mediates interaction with ITPR1.
- Belongs to the Bcl-2 family.
- Domain:
-
- BH4 domain mediates interaction with ITPR1.
- Family:
-
- Belongs to the Bcl-2 family.
Function for BOK Gene
Molecular function for BOK Gene
- UniProtKB/Swiss-Prot Function:
- Isoform 1: Apoptosis regulator that functions through different apoptotic signaling pathways (PubMed:27076518, PubMed:15102863, PubMed:20673843). Plays a roles as pro-apoptotic protein that positively regulates intrinsic apoptotic process in a BAX- and BAK1-dependent manner or in a BAX- and BAK1-independent manner (PubMed:27076518, PubMed:15102863). In response to endoplasmic reticulum stress promotes mitochondrial apoptosis through downstream BAX/BAK1 activation and positive regulation of PERK-mediated unfolded protein response (By similarity). Activates apoptosis independently of heterodimerization with survival-promoting BCL2 and BCL2L1 through induction of mitochondrial outer membrane permeabilization, in a BAX- and BAK1-independent manner, in response to inhibition of ERAD-proteasome degradation system, resulting in cytochrome c release (PubMed:27076518). In response to DNA damage, mediates intrinsic apoptotic process in a TP53-dependent manner (PubMed:15102863). Plays a role in granulosa cell apoptosis by CASP3 activation (PubMed:20673843). Plays a roles as anti-apoptotic protein during neuronal apoptotic process, by negatively regulating poly ADP-ribose polymerase-dependent cell death through regulation of neuronal calcium homeostasis and mitochondrial bioenergetics in response to NMDA excitation (By similarity). In addition to its role in apoptosis, may regulate trophoblast cell proliferation during the early stages of placental development, by acting on G1/S transition through regulation of CCNE1 expression (PubMed:19942931). May also play a role as an inducer of autophagy by disrupting interaction between MCL1 and BECN1 (PubMed:24113155).
- UniProtKB/Swiss-Prot Function:
- Isoform 2: Pro-apoptotic molecule exerting its function through the mitochondrial pathway.
- UniProtKB/Swiss-Prot Induction:
- Up-regulated by DNA damage.
Phenotypes From GWAS Catalog for BOK Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005102 | signaling receptor binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 15868100 |
| GO:0031625 | ubiquitin protein ligase binding | IEA | -- |
| GO:0042803 | protein homodimerization activity | IBA,ISS | -- |
| GO:0046982 | protein heterodimerization activity | IBA,ISS | -- |
Phenotypes for BOK Gene
- MGI mutant phenotypes for BOK:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for BOK:
-
- Increased shRNA abundance (Z-score > 2)
- Increased G1 DNA content
- Decreased shRNA abundance (Z-score < -2)
- Negative genetic interaction between PTEN-/- and PTEN+/+
- Reduced mammosphere formation
- Decreased viability
- no effect
- shRNA abundance <= 50%
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Increased viability with MLN4924 (a NAE inhibitor)
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for BOK
-
CRISPR Products
-
OriGene CRISPR knockouts for BOK
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BOK
- genomics-online: gRNA clones - Search results for 104 available BOK gene related products
- Overview of 104 available BOK gene related products
- Applied Biological Materials CRISPR for BOK
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for BOK
- GenScript: Design CRISPR guide RNA sequences for BOK
miRNA for BOK Gene
- miRTarBase miRNAs that target BOK
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BOK
- Browse OriGene Inhibitory RNA Products For BOK
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BOK
- genomics-online: shRNA clones - Search results for 104 available BOK gene related products
- Overview of 104 available BOK gene related products
Clone Products
- Sino Biological Human cDNA Clone for BOK
- VectorBuilder custom plasmid, inducible vectors for BOK
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for BOK
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BOK
- Applied Biological Materials Clones for BOK
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for BOK
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BOK Gene
Localization for BOK Gene
Subcellular locations from UniProtKB/Swiss-Prot for BOK Gene
- Isoform 1: Mitochondrion membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion inner membrane. Cytoplasm. Nucleus. Mitochondrion. Endoplasmic reticulum. Mitochondrion outer membrane. Early endosome membrane. Recycling endosome membrane. Nucleus outer membrane. Golgi apparatus, cis-Golgi network membrane. Golgi apparatus, trans-Golgi network membrane. Membrane. Note=Nuclear and cytoplasmic compartments in the early stages of apoptosis and during apoptosis it associates with mitochondria (PubMed:19942931). In healthy cells, associates loosely with the membrane in a hit-and-run mode. The insertion and accumulation on membranes is enhanced through the activity of death signals, resulting in the integration of the membrane-bound protein into the membrane (PubMed:15868100). The transmembrane domain controls subcellular localization; constitutes a tail-anchor. Localizes in early and late endosome upon blocking of apoptosis. Must localize to the mitochondria to induce mitochondrial outer membrane permeabilization and apoptosis (By similarity). {ECO:0000250 UniProtKB:O35425, ECO:0000269 PubMed:15868100, ECO:0000269 PubMed:19942931}.
- Isoform 2: Membrane. Cytoplasm.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| nucleus | 5 |
| endoplasmic reticulum | 5 |
| golgi apparatus | 5 |
| endosome | 4 |
| extracellular | 2 |
| cytosol | 2 |
| peroxisome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA,IEA | 16302269 |
| GO:0005640 | nuclear outer membrane | IEA | -- |
| GO:0005737 | cytoplasm | IDA,IEA | 15868100 |
| GO:0005739 | mitochondrion | IEA,IDA | 15102863 |
| GO:0005741 | mitochondrial outer membrane | IBA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for BOK Gene
Pathways & Interactions for BOK Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Apoptosis Modulation and Signaling |
.41
|
|
| 2 | Nanomaterial induced apoptosis | ||
| 3 | Apoptosis and Autophagy | ||
| 4 | Regulation of Apoptosis by Parathyroid Hormone-related Protein | ||
| 5 | TP53 Network | ||
Pathways by source for BOK Gene
4 BioSystems pathways for BOK Gene
1 KEGG pathway for BOK Gene
1 Cell Signaling Technology pathway for BOK Gene
Interacting Proteins for BOK Gene
GPS-Prot Interaction Network for BOK
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001836 | release of cytochrome c from mitochondria | IDA | 27505430 |
| GO:0006915 | apoptotic process | IEA,IDA | 15102863 |
| GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process | IMP | 20673843 |
| GO:0006921 | cellular component disassembly involved in execution phase of apoptosis | ISS | -- |
| GO:0007420 | brain development | IEA | -- |
No data available for SIGNOR curated interactions for BOK Gene
Drugs & Compounds for BOK Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| AT-101 | Approved, Investigational | Pharma | BH3-mimetic,gossypol enantiomer, BCL-2 inhibitors | 62 | ||
| Gossypol | Investigational | Pharma | PAF inhibitor;anti-fertility and anti-cancer | 24 | ||
| Bax inhibitor peptide P5 | Pharma | Bax inhibitor | 0 | |||
| Bax inhibitor peptide V5 | Pharma | Bax inhibitor | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(4) ApexBio Compounds for BOK Gene
| Compound | Action | Cas Number |
|---|---|---|
| AT-101 | BH3-mimetic,gossypol enantiomer | 90141-22-3 |
| Bax inhibitor peptide P5 | Bax inhibitor | 579492-83-4 |
| Bax inhibitor peptide V5 | Bax inhibitor | 579492-81-2 |
| Gossypol | PAF inhibitor;anti-fertility and anti-cancer | 303-45-7 |
Transcripts for BOK Gene
mRNA/cDNA for BOK Gene
- (181) Selected AceView cDNA sequences:
- (2) Additional mRNA sequences :
- (5) REFSEQ mRNAs :
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000318407 2657 bps (uc002wbq.4)
- ENST00000641230 183 bps
Unigene Clusters for BOK Gene
CRISPR Products
-
OriGene CRISPR knockouts for BOK
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BOK
- genomics-online: gRNA clones - Search results for 104 available BOK gene related products
- Overview of 104 available BOK gene related products
- Applied Biological Materials CRISPR for BOK
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for BOK
- GenScript: Design CRISPR guide RNA sequences for BOK
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BOK
- Browse OriGene Inhibitory RNA Products For BOK
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BOK
- genomics-online: shRNA clones - Search results for 104 available BOK gene related products
- Overview of 104 available BOK gene related products
Clone Products
- Sino Biological Human cDNA Clone for BOK
- VectorBuilder custom plasmid, inducible vectors for BOK
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for BOK
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BOK
- Applied Biological Materials Clones for BOK
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||
| SP4: | - | - | - | - | |||||||||||||||||||||||
| SP5: | - | - | - |
Expression for BOK Gene
mRNA differential expression in normal tissues according to GTEx for BOK Gene
This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.7) and Liver (x4.2).
This gene is overexpressed in Liver (11.6), Urinary Bladder (10.0), Rectum (9.5), Prostate (9.2), and Fetal gut (8.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BOK Gene
NURSA nuclear receptor signaling pathways regulating expression of BOK Gene:
BOKSOURCE GeneReport for Unigene cluster for BOK Gene:
Hs.293753mRNA Expression by UniProt/SwissProt for BOK Gene:
Q9UMX3-BOK_HUMAN
Tissue specificity:
Expressed mainly in oocytes; weak expression in granulosa cells of the developing follicles. In adult human ovaries, expressed in granulosa cells at all follicular stages, but expression in primordial/primary follicles granulosa cell is stronger than in secondary and antral follicles.
Evidence on tissue expression from TISSUES for BOK Gene
- Muscle(4.2)
- Nervous system(3.8)
- Liver(2.1)
Primer Products
-
OriGene qPCR primer pairs and template standards for BOK
-
OriGene qPCR primer pairs for BOK
- genomics-online: primer clones - Search results for 104 available BOK gene related products
- Overview of 104 available BOK gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for BOK Gene
Orthologs for BOK Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | BOK 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | BOK 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | BOK 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Bok 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Bok 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | BOK 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | BOK 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | BOK 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | BOK 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | bok 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | boka 34 33 |
|
OneToMany | |
| bokb 34 |
|
OneToMany | |||
| zgc64041 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | Buffy 34 33 |
|
OneToMany | |
| debcl 34 |
|
OneToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.2249 34 |
|
OneToOne |
- Species where no ortholog for BOK was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for BOK Gene
- ENSEMBL:
- Gene Tree for BOK (if available)
- TreeFam:
- Gene Tree for BOK (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for BOK: view image
Paralogs for BOK Gene
No data available for Paralogs for BOK Gene
Variants for BOK Gene
| SNP ID | Clin | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000052399 | -- | 241,562,743(+) | C/T | intron_variant | |
| rs1000510401 | -- | 241,557,852(+) | T/A | upstream_transcript_variant | |
| rs1000510541 | -- | 241,565,109(+) | C/T | intron_variant | |
| rs1000905832 | -- | 241,565,812(+) | G/A | intron_variant | |
| rs1000929515 | -- | 241,571,188(+) | A/G | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv7390n54 | CNV | loss | 21841781 |
| dgv7391n54 | CNV | loss | 21841781 |
| dgv7392n54 | CNV | loss | 21841781 |
| dgv7393n54 | CNV | loss | 21841781 |
| dgv7394n54 | CNV | loss | 21841781 |
| esv2233361 | CNV | deletion | 18987734 |
| esv2634239 | CNV | deletion | 19546169 |
| esv2668476 | CNV | deletion | 23128226 |
| esv27015 | CNV | gain | 19812545 |
| esv2722008 | CNV | deletion | 23290073 |
| esv2722009 | CNV | deletion | 23290073 |
| esv2722010 | CNV | deletion | 23290073 |
| esv2759120 | CNV | loss | 17122850 |
| esv27771 | CNV | loss | 19812545 |
| esv3561311 | CNV | deletion | 23714750 |
| esv3594835 | CNV | loss | 21293372 |
| esv3594836 | CNV | loss | 21293372 |
| esv9037 | CNV | loss | 19470904 |
| nsv1153946 | CNV | deletion | 26484159 |
| nsv584960 | CNV | loss | 21841781 |
| nsv584966 | CNV | loss | 21841781 |
| nsv584970 | CNV | loss | 21841781 |
| nsv584971 | CNV | gain | 21841781 |
| nsv834588 | CNV | loss | 17160897 |
| nsv955299 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
53.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.23;
40.20% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for BOK Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- BOK
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BOK Gene
Disorders for BOK Gene
Additional Disease Information for BOK
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for BOK Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BOK Gene
Publications for BOK Gene
- BOK and NOXA are essential mediators of p53-dependent apoptosis. (PMID: 15102863) Yakovlev AG … Faden AI (The Journal of biological chemistry 2004) 2 3 4 58
- Evolutionarily conserved Bok proteins in the Bcl-2 family. (PMID: 11034351) Zhang H … De Geyter C (FEBS letters 2000) 2 3 4 58
- Bok is a genuine multi-BH-domain protein that triggers apoptosis in the absence of Bax and Bak. (PMID: 27076518) Einsele-Scholz S … Essmann F (Journal of cell science 2016) 3 4 58
- The Bcl-2 protein family member Bok binds to the coupling domain of inositol 1,4,5-trisphosphate receptors and protects them from proteolytic cleavage. (PMID: 23884412) Schulman JJ … Wojcikiewicz RJ (The Journal of biological chemistry 2013) 3 4 58
- Placental autophagy regulation by the BOK-MCL1 rheostat. (PMID: 24113155) Kalkat M … Caniggia I (Autophagy 2013) 3 4 58
Products for BOK Gene
- R&D Systems Antibodies for BOK (BOK)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for BOK
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for BOK
- Search Origene for MassSpec and Protein Over-expression Lysates for BOK
- Origene Custom Protein Services for BOK
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BOK
- Browse OriGene Inhibitory RNA Products For BOK
- OriGene qPCR primer pairs and template standards for BOK
- OriGene qPCR primer pairs for BOK
- OriGene CRISPR knockouts for BOK
- OriGene ORF clones in human for BOK
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For BOK
- GenScript: Next-day shipping of latest version cDNA ORF clones for BOK in any vector
- GenScript Custom Purified and Recombinant Proteins Services for BOK
- GenScript Custom Assay Services for BOK
- GenScript Custom overexpressing Cell Line Services for BOK
- GenScript: Design CRISPR guide RNA sequences for BOK
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for BOK
- Sino Biological Human cDNA Clone for BOK
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for BOK
- Novus Biologicals lysates for BOK
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Invitrogen Antibodies for BOK
- ApexBio compounds for BOK
- Cyagen custom Knockout/knockin (KOKI) mouse models for BOK
- VectorBuilder custom plasmid, inducible vectors for BOK
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for BOK
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 66 available BOK Antibodies ranked by validation data
- Compare Top BOK Antibodies
- antibodies-online: Search results for 5 available BOK Elisa Kits ranked by validation data
- Compare Top BOK Elisa Kits
- antibodies-online: Search results for 6 available BOK Proteins ranked by validation data
- Compare Top BOK Proteins
- GeneTex BOK Antibody for BOK
- Search GeneTex for Proteins for BOK
- Custom Antibody ServicesProSci Antibodies for BOK
- Search for BOK Proteins at ProSci
- Horizon Cell Lines for BOK
- genomics-online: cdna clones - Search results for 104 available BOK gene related products
- Overview of 104 available BOK gene related products
- orf clones - Search results for 104 available BOK gene related products
- Overview of 104 available BOK gene related products
- genomics-online: gRNA clones - Search results for 104 available BOK gene related products
- Overview of 104 available BOK gene related products
- genomics-online: primer clones - Search results for 104 available BOK gene related products
- Overview of 104 available BOK gene related products
- genomics-online: shRNA clones - Search results for 104 available BOK gene related products
- Overview of 104 available BOK gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BOK
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BOK
- GeneCopoeia miRNA 3'UTR Target clone products for BOK
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BOK
Sources for BOK Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio