Aliases for BOD1L2 Gene

Aliases for BOD1L2 Gene

  • Biorientation Of Chromosomes In Cell Division 1 Like 2 2 3 5
  • Biorientation Of Chromosomes In Cell Division Protein 1 Pseudogene 3 4
  • Biorientation Of Chromosomes In Cell Division Protein 1-Like 2 3 4
  • Biorientation Of Chromosomes In Cell Division 1 Pseudogene 2 3
  • Family With Sequence Similarity 44, Member C 2 3
  • FAM44C 3 4
  • BOD1P 3 4
  • Putative Biorientation Of Chromosomes In Cell Division Protein 1 Pseudogene 3
  • Putative Biorientation Of Chromosomes In Cell Division Protein 1-Like 2 3
  • Putative Protein FAM44C 3
  • Protein FAM44C 4
  • MGC33608 2
  • BOD1L2 5

External Ids for BOD1L2 Gene

Previous HGNC Symbols for BOD1L2 Gene

  • FAM44C
  • BOD1P

Previous GeneCards Identifiers for BOD1L2 Gene

  • GC18P054826
  • GC18P054831
  • GC18P054835
  • GC18P054840

Summaries for BOD1L2 Gene

GeneCards Summary for BOD1L2 Gene

BOD1L2 (Biorientation Of Chromosomes In Cell Division 1 Like 2) is a Protein Coding gene. An important paralog of this gene is BOD1.

UniProtKB/Swiss-Prot Summary for BOD1L2 Gene

  • May play a role in proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles.

Additional gene information for BOD1L2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BOD1L2 Gene

Genomics for BOD1L2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for BOD1L2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18J057209 Enhancer 0.7 ENCODE 11.4 +63.6 63641 2.2 JUND SP1 CEBPB FOS JUN ZBTB48 ZNF592 SMARCB1 FOSL1 EP300 BOD1L2 ST8SIA3 piR-51671-044 piR-32461-079 LINC02565
GH18J056992 Enhancer 0.6 Ensembl 10.4 -154.2 -154186 0.6 ZNF629 NFE2 FOSL1 EP300 JUND ZNF366 PRDM6 ZNF664 ATF2 SP7 BOD1L2 WDR7 WDR7-OT1 ENSG00000212539 TXNL1
GH18J057208 Enhancer 0.4 ENCODE 11 +61.1 61078 0.2 ESRRA USF2 SMAD4 TFAP4 BOD1L2 piR-51671-044 piR-32461-079 ST8SIA3 LINC02565
GH18J057207 Enhancer 0.3 ENCODE 11 +60.3 60258 0.2 TEAD4 SPI1 BOD1L2 piR-51671-044 piR-32461-079 ST8SIA3 LINC02565
GH18J057117 Enhancer 0.3 Ensembl 12 -30.2 -30186 0.2 SMARCA4 BOD1L2 ST8SIA3 ENSG00000267789 piR-32559-195 TXNL1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BOD1L2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for BOD1L2

Genomic Locations for BOD1L2 Gene

Genomic Locations for BOD1L2 Gene
chr18:57,147,087-57,150,410
(GRCh38/hg38)
Size:
3,324 bases
Orientation:
Plus strand
chr18:54,814,293-54,817,639
(GRCh37/hg19)
Size:
3,347 bases
Orientation:
Plus strand

Genomic View for BOD1L2 Gene

Genes around BOD1L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BOD1L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BOD1L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BOD1L2 Gene

Proteins for BOD1L2 Gene

  • Protein details for BOD1L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYS8-BD1L2_HUMAN
    Recommended name:
    Biorientation of chromosomes in cell division protein 1-like 2
    Protein Accession:
    Q8IYS8
    Secondary Accessions:
    • B3KXU4
    • Q8WW13

    Protein attributes for BOD1L2 Gene

    Size:
    172 amino acids
    Molecular mass:
    18075 Da
    Quaternary structure:
    No Data Available

neXtProt entry for BOD1L2 Gene

Post-translational modifications for BOD1L2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BOD1L2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BOD1L2 Gene

Domains & Families for BOD1L2 Gene

Gene Families for BOD1L2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for BOD1L2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for BOD1L2 Gene

GenScript: Design optimal peptide antigens:
  • Putative protein FAM44C (BD1L2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8IYS8

UniProtKB/Swiss-Prot:

BD1L2_HUMAN :
  • Belongs to the BOD1 family.
Family:
  • Belongs to the BOD1 family.
genes like me logo Genes that share domains with BOD1L2: view

Function for BOD1L2 Gene

Molecular function for BOD1L2 Gene

UniProtKB/Swiss-Prot Function:
May play a role in proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles.

Phenotypes From GWAS Catalog for BOD1L2 Gene

Gene Ontology (GO) - Molecular Function for BOD1L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004864 protein phosphatase inhibitor activity IBA 21873635
GO:0051721 protein phosphatase 2A binding IBA 21873635
genes like me logo Genes that share ontologies with BOD1L2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BOD1L2

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BOD1L2 Gene

Localization for BOD1L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BOD1L2 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BOD1L2 gene
Compartment Confidence
cytoskeleton 3

Gene Ontology (GO) - Cellular Components for BOD1L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IEA --
GO:0000776 kinetochore IEA --
GO:0000777 condensed chromosome kinetochore IEA --
GO:0000922 spindle pole IBA 21873635
GO:0000940 condensed chromosome outer kinetochore IBA 21873635
genes like me logo Genes that share ontologies with BOD1L2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for BOD1L2 Gene

Pathways & Interactions for BOD1L2 Gene

PathCards logo

SuperPathways for BOD1L2 Gene

No Data Available

Interacting Proteins for BOD1L2 Gene

Gene Ontology (GO) - Biological Process for BOD1L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0032515 negative regulation of phosphoprotein phosphatase activity IBA 21873635
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with BOD1L2: view

No data available for Pathways by source and SIGNOR curated interactions for BOD1L2 Gene

Drugs & Compounds for BOD1L2 Gene

No Compound Related Data Available

Transcripts for BOD1L2 Gene

mRNA/cDNA for BOD1L2 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BOD1L2

Alternative Splicing Database (ASD) splice patterns (SP) for BOD1L2 Gene

No ASD Table

Relevant External Links for BOD1L2 Gene

GeneLoc Exon Structure for
BOD1L2

Expression for BOD1L2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for BOD1L2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

mRNA differential expression in normal tissues according to GTEx for BOD1L2 Gene

This gene is overexpressed in Testis (x52.7).

Protein differential expression in normal tissues from HIPED for BOD1L2 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BOD1L2 Gene



Protein tissue co-expression partners for BOD1L2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for BOD1L2

SOURCE GeneReport for Unigene cluster for BOD1L2 Gene:

Hs.127882
genes like me logo Genes that share expression patterns with BOD1L2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for BOD1L2 Gene

Orthologs for BOD1L2 Gene

This gene was present in the common ancestor of animals.

Orthologs for BOD1L2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia BOD1L2 30 31
  • 99.79 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Bod1 31
  • 77 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia BOD1 31
  • 71 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia BOD1 31
  • 71 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 52 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 50 (a)
OneToMany
Chicken
(Gallus gallus)
Aves -- 31
  • 67 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 61 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii bod1 31
  • 42 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CG5514 31
  • 5 (a)
OneToMany
Species where no ortholog for BOD1L2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for BOD1L2 Gene

ENSEMBL:
Gene Tree for BOD1L2 (if available)
TreeFam:
Gene Tree for BOD1L2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for BOD1L2: view image

Paralogs for BOD1L2 Gene

Paralogs for BOD1L2 Gene

(2) SIMAP similar genes for BOD1L2 Gene using alignment to 1 proteins:

  • BD1L2_HUMAN

Pseudogenes.org Pseudogenes for BOD1L2 Gene

genes like me logo Genes that share paralogs with BOD1L2: view

Variants for BOD1L2 Gene

Additional dbSNP identifiers (rs#s) for BOD1L2 Gene

Variation tolerance for BOD1L2 Gene

Residual Variation Intolerance Score: 83.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.56; 55.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BOD1L2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BOD1L2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for BOD1L2 Gene

Disorders for BOD1L2 Gene

No disorders were found for BOD1L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BOD1L2 Gene

Publications for BOD1L2 Gene

  1. Bod1, a novel kinetochore protein required for chromosome biorientation. (PMID: 17938248) Porter IM … Swedlow JR (The Journal of cell biology 2007) 2 3
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3

Products for BOD1L2 Gene

Sources for BOD1L2 Gene