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Aliases for BOD1 Gene

Aliases for BOD1 Gene

  • Biorientation Of Chromosomes In Cell Division 1 2 3 5
  • Family With Sequence Similarity 44, Member B 2 3
  • Biorientation Defective 1 2 3
  • FAM44B 3 4
  • Biorientation Of Chromosomes In Cell Division Protein 1 3
  • Biorientation Defective Protein 1 4
  • Protein FAM44B 4

External Ids for BOD1 Gene

Previous HGNC Symbols for BOD1 Gene

  • FAM44B

Previous GeneCards Identifiers for BOD1 Gene

  • GC05M172968
  • GC05M168131

Summaries for BOD1 Gene

GeneCards Summary for BOD1 Gene

BOD1 (Biorientation Of Chromosomes In Cell Division 1) is a Protein Coding gene. An important paralog of this gene is BOD1L2.

UniProtKB/Swiss-Prot for BOD1 Gene

  • Required for proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles.

Additional gene information for BOD1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BOD1 Gene

Genomics for BOD1 Gene

GeneHancer (GH) Regulatory Elements for BOD1 Gene

Promoters and enhancers for BOD1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I173614 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 556.5 +0.9 934 2.9 HDGF PKNOX1 CLOCK ARNT ARID4B SIN3A FEZF1 DMAP1 IRF4 YY1 BOD1 LOC285593 LOC105377735
GH05I172763 Promoter/Enhancer 3.1 VISTA EPDnew FANTOM5 Ensembl ENCODE dbSUPER 23.2 +844.9 844878 16.8 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 ZNF143 SP3 DUSP1 CREBRF BOD1 ERGIC1 SH3PXD2B LOC100268168 LOC100130394 LOC401218 UBTD2 LOC105377730
GH05I173322 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 22.1 +289.5 289473 9.6 CLOCK MLX FEZF1 DMAP1 IRF4 SLC30A9 ZNF213 ZNF143 ZNF263 SP3 STC2 SH3PXD2B BOD1 LOC100268168 RNU6-500P LOC285593 BNIP1 CREBRF GC05M173296 GC05P173099
GH05I172787 Enhancer 1.9 FANTOM5 Ensembl ENCODE dbSUPER 22.1 +821.3 821335 16.6 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B YBX1 ZBTB7B IRF4 YY1 CREBRF ERGIC1 BOD1 SH3PXD2B DUSP1 FBXW11 LOC401218 LOC105377730 CDC42P5 LOC100130394
GH05I173757 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 22.5 -146.1 -146095 10.6 CLOCK MLX DMAP1 YY1 SLC30A9 MEF2D GLIS1 RCOR2 NBN NR2C1 BOD1 C5orf47 CPEB4 ATP6V0E1 LINC01484 LINC01485
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around BOD1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the BOD1 gene promoter:

Genomic Locations for BOD1 Gene

Genomic Locations for BOD1 Gene
chr5:173,607,145-173,617,077
(GRCh38/hg38)
Size:
9,933 bases
Orientation:
Minus strand
chr5:173,034,148-173,043,666
(GRCh37/hg19)

Genomic View for BOD1 Gene

Genes around BOD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BOD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BOD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BOD1 Gene

Proteins for BOD1 Gene

  • Protein details for BOD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96IK1-BOD1_HUMAN
    Recommended name:
    Biorientation of chromosomes in cell division protein 1
    Protein Accession:
    Q96IK1
    Secondary Accessions:
    • B4DXH8
    • Q9BTW1

    Protein attributes for BOD1 Gene

    Size:
    185 amino acids
    Molecular mass:
    19196 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for BOD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BOD1 Gene

Post-translational modifications for BOD1 Gene

  • Ubiquitination at posLast=140140
  • Modification sites at PhosphoSitePlus

Other Protein References for BOD1 Gene

No data available for DME Specific Peptides for BOD1 Gene

Domains & Families for BOD1 Gene

Gene Families for BOD1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for BOD1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for BOD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96IK1

UniProtKB/Swiss-Prot:

BOD1_HUMAN :
  • Belongs to the BOD1 family.
Family:
  • Belongs to the BOD1 family.
genes like me logo Genes that share domains with BOD1: view

Function for BOD1 Gene

Molecular function for BOD1 Gene

UniProtKB/Swiss-Prot Function:
Required for proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles.

Phenotypes From GWAS Catalog for BOD1 Gene

Gene Ontology (GO) - Molecular Function for BOD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004864 protein phosphatase inhibitor activity IDA 24157919
GO:0051721 protein phosphatase 2A binding IPI 24157919
genes like me logo Genes that share ontologies with BOD1: view

Phenotypes for BOD1 Gene

genes like me logo Genes that share phenotypes with BOD1: view

Animal Model Products

Clone Products

  • Addgene plasmids for BOD1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BOD1 Gene

Localization for BOD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BOD1 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Note=Localizes at the centrosomes throughout the cell cycle, only dissociating during cytokinesis. Localizes at the kinetochore from prometaphase until anaphase.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BOD1 gene
Compartment Confidence
cytoskeleton 5
cytosol 2
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for BOD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore IEA --
GO:0000777 condensed chromosome kinetochore IEA --
GO:0000922 spindle pole IDA 17938248
GO:0000940 condensed chromosome outer kinetochore IDA 17938248
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with BOD1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for BOD1 Gene

Pathways & Interactions for BOD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for BOD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0007080 mitotic metaphase plate congression IMP 17938248
GO:0032515 negative regulation of phosphoprotein phosphatase activity IDA 24157919
GO:0051301 cell division IEA --
GO:0071459 protein localization to chromosome, centromeric region IMP 17938248
genes like me logo Genes that share ontologies with BOD1: view

No data available for Pathways by source and SIGNOR curated interactions for BOD1 Gene

Drugs & Compounds for BOD1 Gene

No Compound Related Data Available

Transcripts for BOD1 Gene

Unigene Clusters for BOD1 Gene

Biorientation of chromosomes in cell division 1:
Representative Sequences:

Clone Products

  • Addgene plasmids for BOD1

Alternative Splicing Database (ASD) splice patterns (SP) for BOD1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e · 5f
SP1: - - -
SP2: - - - -
SP3: - -
SP4: - - - - -
SP5: - - -
SP6: - - - - - -
SP7:
SP8:

Relevant External Links for BOD1 Gene

GeneLoc Exon Structure for
BOD1
ECgene alternative splicing isoforms for
BOD1

Expression for BOD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BOD1 Gene

Protein differential expression in normal tissues from HIPED for BOD1 Gene

This gene is overexpressed in Plasma (36.1), Fetal Brain (15.7), and Fetal ovary (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for BOD1 Gene



Protein tissue co-expression partners for BOD1 Gene

NURSA nuclear receptor signaling pathways regulating expression of BOD1 Gene:

BOD1

SOURCE GeneReport for Unigene cluster for BOD1 Gene:

Hs.425091

Evidence on tissue expression from TISSUES for BOD1 Gene

  • Muscle(4.4)
  • Lung(4.3)
  • Blood(3.5)
  • Nervous system(2.8)
genes like me logo Genes that share expression patterns with BOD1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for BOD1 Gene

Orthologs for BOD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for BOD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BOD1 33 34
  • 99.82 (n)
dog
(Canis familiaris)
Mammalia BOD1 33 34
  • 94.37 (n)
cow
(Bos Taurus)
Mammalia BOD1 33 34
  • 93.92 (n)
rat
(Rattus norvegicus)
Mammalia Bod1 33
  • 89.57 (n)
mouse
(Mus musculus)
Mammalia Bod1 33 16 34
  • 89.19 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 63 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 61 (a)
OneToMany
chicken
(Gallus gallus)
Aves BOD1 33
  • 84.25 (n)
-- 34
  • 79 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 73 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia bod1 33
  • 72.83 (n)
Str.4589 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.3658 33
zebrafish
(Danio rerio)
Actinopterygii bod1 33 34
  • 72.63 (n)
wufb24f11 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8879 33
fruit fly
(Drosophila melanogaster)
Insecta CG5514 34
  • 5 (a)
OneToMany
Species where no ortholog for BOD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BOD1 Gene

ENSEMBL:
Gene Tree for BOD1 (if available)
TreeFam:
Gene Tree for BOD1 (if available)

Paralogs for BOD1 Gene

Paralogs for BOD1 Gene

(2) SIMAP similar genes for BOD1 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for BOD1 Gene

genes like me logo Genes that share paralogs with BOD1: view

Variants for BOD1 Gene

Sequence variations from dbSNP and Humsavar for BOD1 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000887395 -- 173,611,486(-) T/A intron_variant
rs1001315661 -- 173,615,673(-) C/T intron_variant
rs1001491903 -- 173,615,752(-) G/A intron_variant
rs1001819665 -- 173,616,041(-) G/C intron_variant
rs1001920017 -- 173,610,567(-) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for BOD1 Gene

Variant ID Type Subtype PubMed ID
dgv3219n106 CNV deletion 24896259
esv2145234 CNV deletion 18987734
esv2184384 CNV deletion 18987734
esv2731116 CNV deletion 23290073
esv34083 CNV loss 18971310
nsv600298 CNV gain 21841781

Variation tolerance for BOD1 Gene

Residual Variation Intolerance Score: 52.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.59; 12.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BOD1 Gene

Human Gene Mutation Database (HGMD)
BOD1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
BOD1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BOD1 Gene

Disorders for BOD1 Gene

Additional Disease Information for BOD1

No disorders were found for BOD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BOD1 Gene

Publications for BOD1 Gene

  1. Bod1, a novel kinetochore protein required for chromosome biorientation. (PMID: 17938248) Porter IM … Swedlow JR (The Journal of cell biology 2007) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. BOD1 Is Required for Cognitive Function in Humans and Drosophila. (PMID: 27166630) Esmaeeli-Nieh S … Kuss AW (PLoS genetics 2016) 3 58
  5. Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci. (PMID: 25429064) He M … Qi L (Human molecular genetics 2015) 3 58

Products for BOD1 Gene

  • Addgene plasmids for BOD1

Sources for BOD1 Gene

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