Aliases for BOD1 Gene
Aliases for BOD1 Gene
External Ids for BOD1 Gene
- HGNC: 25114
- Entrez Gene: 91272
- Ensembl: ENSG00000145919
- OMIM: 616745
- UniProtKB: Q96IK1
Previous HGNC Symbols for BOD1 Gene
- FAM44B
Previous GeneCards Identifiers for BOD1 Gene
- GC05M172968
- GC05M168131
Summaries for BOD1 Gene
GeneCards Summary for BOD1 Gene
BOD1 (Biorientation Of Chromosomes In Cell Division 1) is a Protein Coding gene. Diseases associated with BOD1 include Myoma. An important paralog of this gene is BOD1L2.
UniProtKB/Swiss-Prot for BOD1 Gene
-
Required for proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BOD1 Gene
Genomics for BOD1 Gene
GeneHancer (GH) Regulatory Elements for BOD1 Gene
Promoters and enhancers for BOD1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around BOD1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the BOD1 gene promoter:
-
- HTF
- Pax-5
- CUTL1
- Roaz
- AML1a
- FOXO3
- FOXO3a
- FOXO3b
- HSF2
Regulatory Element Products
Genomic Locations for BOD1 Gene
Genomic Locations for BOD1 Gene
- chr5:173,607,145-173,617,077
- (GRCh38/hg38)
- Size:
- 9,933 bases
- Orientation:
- Minus strand
- chr5:173,034,148-173,043,666
- (GRCh37/hg19)
- Size:
- 9,519 bases
- Orientation:
- Minus strand
Genomic View for BOD1 Gene
Genes around BOD1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q35.2 by Entrez Gene
- 5q35.2 by HGNC
- 5q35.2 by Ensembl
BOD1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for BOD1 Gene
Proteins for BOD1 Gene
-
Protein details for BOD1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96IK1-BOD1_HUMAN
- Recommended name:
- Biorientation of chromosomes in cell division protein 1
- Protein Accession:
- Q96IK1
- B4DXH8
- Q9BTW1
Protein attributes for BOD1 Gene
- Size:
- 185 amino acids
- Molecular mass:
- 19196 Da
- Quaternary structure:
- No Data Available
Protein Expression for BOD1 Gene
Post-translational modifications for BOD1 Gene
Other Protein References for BOD1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for BOD1
- Novus Biologicals Antibodies for BOD1
-
Abcam antibodies for BOD1
- Invitrogen Antibodies for BOD1 (AFLGC-BOD1)
- GeneTex BOD1 Antibody for BOD1
Protein Products
-
OriGene Purified Proteins for BOD1
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- antibodies-online: Search results for 3 available BOD1 Proteins ranked by validation data
- Compare Top BOD1 Proteins
-
Quality Products:
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-
Abcam proteins for BOD1
Assay Products
- antibodies-online: Search results for 3 available BOD1 Elisa Kits ranked by validation data
- Compare Top BOD1 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for BOD1 Gene
Domains & Families for BOD1 Gene
Gene Families for BOD1 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted secreted proteins
Protein Domains for BOD1 Gene
- ProtoNet:
Suggested Antigen Peptide Sequences for BOD1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q96IK1- Family:
-
- Belongs to the BOD1 family.
Function for BOD1 Gene
Molecular function for BOD1 Gene
- UniProtKB/Swiss-Prot Function:
- Required for proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles.
Phenotypes From GWAS Catalog for BOD1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004864 | protein phosphatase inhibitor activity | IDA | 24157919 |
| GO:0051721 | protein phosphatase 2A binding | IPI | 24157919 |
Phenotypes for BOD1 Gene
Animal Model Products
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-
CRISPR Products
-
OriGene CRISPR knockouts for BOD1
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- Overview of 133 available BOD1 gene related products
- Applied Biological Materials CRISPR for BOD1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for BOD1
- GenScript: Design CRISPR guide RNA sequences for BOD1
miRNA for BOD1 Gene
- miRTarBase miRNAs that target BOD1
miRNA Products
Inhibitory RNA Products
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- Overview of 133 available BOD1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for BOD1
- Addgene plasmids for BOD1
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- Applied Biological Materials Clones for BOD1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for BOD1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BOD1 Gene
Localization for BOD1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for BOD1 Gene
- Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Note=Localizes at the centrosomes throughout the cell cycle, only dissociating during cytokinesis. Localizes at the kinetochore from prometaphase until anaphase.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| cytosol | 2 |
| extracellular | 1 |
| nucleus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000776 | kinetochore | IEA | -- |
| GO:0000777 | condensed chromosome kinetochore | IEA | -- |
| GO:0000922 | spindle pole | IDA | 17938248 |
| GO:0000940 | condensed chromosome outer kinetochore | IDA | 17938248 |
| GO:0005694 | chromosome | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for BOD1 Gene
Pathways & Interactions for BOD1 Gene
No Data Available
Interacting Proteins for BOD1 Gene
GPS-Prot Interaction Network for BOD1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007049 | cell cycle | IEA | -- |
| GO:0007080 | mitotic metaphase plate congression | IMP | 17938248 |
| GO:0032515 | negative regulation of phosphoprotein phosphatase activity | IDA | 24157919 |
| GO:0051301 | cell division | IEA | -- |
| GO:0071459 | protein localization to chromosome, centromeric region | IMP | 17938248 |
No data available for Pathways by source and SIGNOR curated interactions for BOD1 Gene
Transcripts for BOD1 Gene
mRNA/cDNA for BOD1 Gene
- (3) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (277) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000311086 1562 bps (uc003mcq.3)
- ENST00000285908 1286 bps (uc003mcr.3)
- ENST00000477985 850 bps (uc063jtl.1)
- ENST00000480951 814 bps (uc063jtm.1)
- ENST00000518658 736 bps (uc063jtn.1)
Unigene Clusters for BOD1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for BOD1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BOD1
- genomics-online: gRNA clones - Search results for 133 available BOD1 gene related products
- Overview of 133 available BOD1 gene related products
- Applied Biological Materials CRISPR for BOD1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for BOD1
- GenScript: Design CRISPR guide RNA sequences for BOD1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BOD1
- Browse OriGene Inhibitory RNA Products For BOD1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BOD1
- genomics-online: shRNA clones - Search results for 133 available BOD1 gene related products
- Overview of 133 available BOD1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for BOD1
- Addgene plasmids for BOD1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BOD1
- Applied Biological Materials Clones for BOD1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e | · | 5f |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||
| SP4: | - | - | - | - | - | ||||||||||||||||||||||
| SP5: | - | - | - | ||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | |||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||
| SP8: |
Expression for BOD1 Gene
This gene is overexpressed in Plasma (36.1), Fetal Brain (15.7), and Fetal ovary (10.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for BOD1 Gene
NURSA nuclear receptor signaling pathways regulating expression of BOD1 Gene:
BOD1SOURCE GeneReport for Unigene cluster for BOD1 Gene:
Hs.425091Evidence on tissue expression from TISSUES for BOD1 Gene
- Muscle(4.4)
- Lung(4.3)
- Blood(3.5)
- Nervous system(2.8)
Primer Products
-
OriGene qPCR primer pairs for BOD1
-
OriGene qPCR primer pairs and template standards for BOD1
- genomics-online: primer clones - Search results for 133 available BOD1 gene related products
- Overview of 133 available BOD1 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for BOD1 Gene
Orthologs for BOD1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | BOD1 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | BOD1 34 33 |
|
OneToMany | |
| cow (Bos Taurus) |
Mammalia | BOD1 34 33 |
|
OneToMany | |
| rat (Rattus norvegicus) |
Mammalia | Bod1 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Bod1 16 34 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | BOD1 33 |
|
||
| -- 34 |
|
OneToMany | |||
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | bod1 33 |
|
||
| Str.4589 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.3658 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | bod1 34 33 |
|
OneToMany | |
| wufb24f11 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.8879 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG5514 34 |
|
OneToMany |
- Species where no ortholog for BOD1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for BOD1 Gene
- ENSEMBL:
- Gene Tree for BOD1 (if available)
- TreeFam:
- Gene Tree for BOD1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for BOD1: view image
Paralogs for BOD1 Gene
(2) SIMAP similar genes for BOD1 Gene using alignment to 4 proteins:
- BOD1_HUMAN
- C9J8U9_HUMAN
- C9JNZ5_HUMAN
- H7C5I4_HUMAN
Pseudogenes.org Pseudogenes for BOD1 Gene
Variants for BOD1 Gene
| SNP ID | Clin | Chr 05 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000887395 | -- | 173,611,486(-) | T/A | intron_variant | |
| rs1001315661 | -- | 173,615,673(-) | C/T | intron_variant | |
| rs1001491903 | -- | 173,615,752(-) | G/A | intron_variant | |
| rs1001819665 | -- | 173,616,041(-) | G/C | intron_variant | |
| rs1001920017 | -- | 173,610,567(-) | C/G | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv3219n106 | CNV | deletion | 24896259 |
| esv2145234 | CNV | deletion | 18987734 |
| esv2184384 | CNV | deletion | 18987734 |
| esv2731116 | CNV | deletion | 23290073 |
| esv34083 | CNV | loss | 18971310 |
| nsv600298 | CNV | gain | 21841781 |
Residual Variation Intolerance Score:
52.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.59;
12.79% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for BOD1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BOD1 Gene
Disorders for BOD1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| myoma |
|
|
Search BOD1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for BOD1
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for BOD1 Gene
Publications for BOD1 Gene
- Bod1, a novel kinetochore protein required for chromosome biorientation. (PMID: 17938248) Porter IM … Swedlow JR (The Journal of cell biology 2007) 2 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
- Radiation induces premature chromatid separation via the miR-142-3p/Bod1 pathway in carcinoma cells. (PMID: 27527863) Pan D … Hu B (Oncotarget 2016) 3 58
- BOD1 Is Required for Cognitive Function in Humans and Drosophila. (PMID: 27166630) Esmaeeli-Nieh S … Kuss AW (PLoS genetics 2016) 3 58
Products for BOD1 Gene
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- Quality Products:
- GeneTex BOD1 Antibody for BOD1
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- Overview of 133 available BOD1 gene related products
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- genomics-online: gRNA clones - Search results for 133 available BOD1 gene related products
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Sources for BOD1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
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- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
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- (86) RefSeq
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- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
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- (114) diseasecard
- (115) NIH Rare Diseases
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- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt