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Aliases for BNIPL Gene

Aliases for BNIPL Gene

  • BCL2 Interacting Protein Like 2 3 5
  • BCL2/Adenovirus E1B 19kD Interacting Protein Like 2 3
  • Bcl-2/Adenovirus E1B 19 KDa-Interacting Protein 2-Like Protein 3
  • BNIP-2 Similar 3
  • BNIP-Salpha 3
  • BNIP-Sbeta 3
  • BNIPL-1 3
  • BNIPL-2 3
  • BNIP-S 3
  • BNIPL1 3
  • BNIPL2 3
  • BNIPS 3
  • PP753 3

External Ids for BNIPL Gene

Previous GeneCards Identifiers for BNIPL Gene

  • GC00U991195
  • GC01P148225
  • GC01P148188
  • GC01P147822
  • GC01P149275
  • GC01P122386

Summaries for BNIPL Gene

Entrez Gene Summary for BNIPL Gene

  • The protein encoded by this gene interacts with several other proteins, such as BCL2, ARHGAP1, MIF and GFER. It may function as a bridge molecule between BCL2 and ARHGAP1/CDC42 in promoting cell death. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for BNIPL Gene

BNIPL (BCL2 Interacting Protein Like) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include identical protein binding. An important paralog of this gene is BNIP2.

UniProtKB/Swiss-Prot for BNIPL Gene

  • May be a bridge molecule between BCL2 and ARHGAP1/CDC42 in promoting cell death.

Gene Wiki entry for BNIPL Gene

Additional gene information for BNIPL Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BNIPL Gene

Genomics for BNIPL Gene

GeneHancer (GH) Regulatory Elements for BNIPL Gene

Promoters and enhancers for BNIPL Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J151036 Promoter/Enhancer 1.1 EPDnew ENCODE 650.7 +0.0 7 0.2 SMARCE1 MAZ NEUROD1 SIN3A GATAD2B DPF2 MNT KLF4 ZNF217 CTBP1 BNIPL C1orf56
GH01J151142 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 32.3 +108.7 108656 6.1 HDGF PKNOX1 ATF1 FOXA2 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF48 SEMA6C BNIPL GABPB2 PIP5K1A PRPF3 PI4KB SETDB1 ZNF687 POGZ UBE2D3P3
GH01J151054 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 24.4 +22.5 22451 9.9 CLOCK YBX1 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 MLLT11 CDC42SE1 SETDB1 PRPF3 ARNT PIP5K1A PI4KB ZNF687 GABPB2 UBE2D3P3
GH01J151068 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 23.8 +33.9 33933 3.3 CLOCK FEZF1 IRF4 YY1 ZNF213 E2F8 ZNF416 ZNF143 ZNF548 SP3 GABPB2 CDC42SE1 SETDB1 PRPF3 PI4KB PIP5K1A MRPL9 UBE2D3P3 ARNT ZNF687
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BNIPL on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the BNIPL gene promoter:
  • SEF-1 (1)
  • NF-1/L
  • NF-1
  • STAT1beta
  • STAT1alpha
  • STAT1
  • AML1a
  • CP2
  • Pax-4a
  • AREB6

Genomic Locations for BNIPL Gene

Genomic Locations for BNIPL Gene
11,048 bases
Plus strand
11,048 bases
Plus strand

Genomic View for BNIPL Gene

Genes around BNIPL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BNIPL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BNIPL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BNIPL Gene

Proteins for BNIPL Gene

  • Protein details for BNIPL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein
    Protein Accession:
    Secondary Accessions:
    • Q6DK43
    • Q8TCY7
    • Q8WYG2

    Protein attributes for BNIPL Gene

    357 amino acids
    Molecular mass:
    39713 Da
    Quaternary structure:
    • Homodimer. Interacts with BCL2, ARHGAP1, MIF and GFER.

    Alternative splice isoforms for BNIPL Gene


neXtProt entry for BNIPL Gene

Post-translational modifications for BNIPL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for BNIPL Gene

Domains & Families for BNIPL Gene

Gene Families for BNIPL Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for BNIPL Gene

Suggested Antigen Peptide Sequences for BNIPL Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with BNIPL: view

No data available for UniProtKB/Swiss-Prot for BNIPL Gene

Function for BNIPL Gene

Molecular function for BNIPL Gene

UniProtKB/Swiss-Prot Function:
May be a bridge molecule between BCL2 and ARHGAP1/CDC42 in promoting cell death.

Phenotypes From GWAS Catalog for BNIPL Gene

Gene Ontology (GO) - Molecular Function for BNIPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004309 exopolyphosphatase activity IBA --
GO:0005515 protein binding IPI 12681488
GO:0042802 identical protein binding IPI 12901880
genes like me logo Genes that share ontologies with BNIPL: view
genes like me logo Genes that share phenotypes with BNIPL: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BNIPL Gene

Localization for BNIPL Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BNIPL gene
Compartment Confidence
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for BNIPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 11741952
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol IDA 11741952
genes like me logo Genes that share ontologies with BNIPL: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for BNIPL Gene

Pathways & Interactions for BNIPL Gene

SuperPathways for BNIPL Gene

No Data Available

Gene Ontology (GO) - Biological Process for BNIPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006798 polyphosphate catabolic process IBA --
GO:0006915 apoptotic process IDA 11741952
GO:0008285 negative regulation of cell proliferation IDA 12681488
GO:0040009 regulation of growth rate IDA 12681488
genes like me logo Genes that share ontologies with BNIPL: view

No data available for Pathways by source and SIGNOR curated interactions for BNIPL Gene

Drugs & Compounds for BNIPL Gene

No Compound Related Data Available

Transcripts for BNIPL Gene

Unigene Clusters for BNIPL Gene

BCL2/adenovirus E1B 19kD interacting protein like:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for BNIPL Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b
SP1: -
SP2: - -
SP3: - - -
SP4: - - - - -

Relevant External Links for BNIPL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BNIPL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BNIPL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BNIPL Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x12.6), Skin - Not Sun Exposed (Suprapubic) (x12.1), Esophagus - Mucosa (x11.2), and Vagina (x5.5).

Protein differential expression in normal tissues from HIPED for BNIPL Gene

This gene is overexpressed in Urine (34.0) and Cervix (29.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BNIPL Gene

Protein tissue co-expression partners for BNIPL Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of BNIPL Gene:


SOURCE GeneReport for Unigene cluster for BNIPL Gene:


mRNA Expression by UniProt/SwissProt for BNIPL Gene:

Tissue specificity: Isoform 2 is expressed in placenta and lung.

Evidence on tissue expression from TISSUES for BNIPL Gene

  • Skin(2.1)
genes like me logo Genes that share expression patterns with BNIPL: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for BNIPL Gene

Orthologs for BNIPL Gene

This gene was present in the common ancestor of animals.

Orthologs for BNIPL Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BNIPL 34 33
  • 99.63 (n)
(Bos Taurus)
Mammalia BNIPL 34 33
  • 88.64 (n)
(Canis familiaris)
Mammalia BNIPL 34 33
  • 87.89 (n)
(Rattus norvegicus)
Mammalia Bnipl 33
  • 84.32 (n)
(Mus musculus)
Mammalia Bnipl 16 34 33
  • 84.23 (n)
(Ornithorhynchus anatinus)
Mammalia BNIPL 34
  • 79 (a)
(Anolis carolinensis)
Reptilia BNIPL 34
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia bnipl 33
  • 59.04 (n)
(Danio rerio)
Actinopterygii bnipl 34 33
  • 55.62 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG11593 34
  • 22 (a)
Species where no ortholog for BNIPL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BNIPL Gene

Gene Tree for BNIPL (if available)
Gene Tree for BNIPL (if available)
Evolutionary constrained regions (ECRs) for BNIPL: view image

Paralogs for BNIPL Gene

Paralogs for BNIPL Gene

(4) SIMAP similar genes for BNIPL Gene using alignment to 3 proteins:

  • A2A492_HUMAN
  • F8W685_HUMAN
genes like me logo Genes that share paralogs with BNIPL: view

Variants for BNIPL Gene

Sequence variations from dbSNP and Humsavar for BNIPL Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000158756 -- 151,042,241(+) T/G intron_variant
rs1000185357 -- 151,036,047(+) C/T upstream_transcript_variant
rs1000528754 -- 151,040,441(+) A/T intron_variant
rs1000588042 -- 151,047,699(+) G/A downstream_transcript_variant
rs1000992955 -- 151,037,244(+) T/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for BNIPL Gene

Variant ID Type Subtype PubMed ID
esv1745722 CNV insertion 17803354
nsv1145369 CNV deletion 24896259
nsv522840 CNV gain 19592680

Variation tolerance for BNIPL Gene

Residual Variation Intolerance Score: 87.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.27; 76.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BNIPL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BNIPL Gene

Disorders for BNIPL Gene

Additional Disease Information for BNIPL

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for BNIPL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BNIPL Gene

Publications for BNIPL Gene

  1. The apoptosis-associated protein BNIPL interacts with two cell proliferation-related proteins, MIF and GFER. (PMID: 12681488) Shen L … Gu J (FEBS letters 2003) 2 3 4 22 58
  2. The BNIP-2 and Cdc42GAP homology/Sec14p-like domain of BNIP-Salpha is a novel apoptosis-inducing sequence. (PMID: 11741952) Zhou YT … Low BC (The Journal of biological chemistry 2002) 2 3 4 22 58
  3. BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis. (PMID: 12901880) Qin W … Gu J (Biochemical and biophysical research communications 2003) 3 4 22 58
  4. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F … Nebel A (Mutation research 2010) 3 44 58
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58

Products for BNIPL Gene

Sources for BNIPL Gene

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