Aliases for BNIP5 Gene

Aliases for BNIP5 Gene

  • BCL2 Interacting Protein 5 2 3 5
  • Protein BNIP5 3 4
  • C6orf222 3 4
  • Chromosome 6 Open Reading Frame 222 2
  • Uncharacterized Protein C6orf222 3
  • DKFZp779B1540 2
  • BNIP5 5

External Ids for BNIP5 Gene

Previous HGNC Symbols for BNIP5 Gene

  • C6orf222

Previous GeneCards Identifiers for BNIP5 Gene

  • GC06M039804
  • GC06M039989
  • GC06M041372

Summaries for BNIP5 Gene

GeneCards Summary for BNIP5 Gene

BNIP5 (BCL2 Interacting Protein 5) is a Protein Coding gene.

Additional gene information for BNIP5 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BNIP5 Gene

Genomics for BNIP5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for BNIP5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J036333 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 600.7 +1.5 1450 4.2 ATF7 TEAD4 ZNF629 TFE3 RFX1 IKZF1 ZNF692 RCOR2 JUND FOXA1 BNIP5 lnc-C6orf222-2 PNPLA1
GH06J036422 Promoter/Enhancer 1.8 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 10.8 -86.5 -86515 2 ZNF221 GATAD2A CTCF TEAD4 PRDM10 REST ZNF629 TFE3 IKZF1 NFKBIZ ETV7 MAPK13 KCTD20 ETV7-AS1 BNIP5 STK38 PI16 PXT1 SRSF3 CDKN1A
GH06J036289 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 11.9 +45.7 45663 3 CEBPG ATF7 PRDM10 RFX1 IKZF1 JUND PKNOX1 BRD9 DPF2 HDAC1 PNPLA1 BNIP5 CLPS BRPF3 MAPK13 lnc-C6orf222-2 piR-50437-565
GH06J036357 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 13.3 -21.5 -21513 1.4 SP1 PRDM10 ZNF512 BACH1 LARP7 STAT3 RELA TCF12 IKZF2 RCOR1 BNIP5 ETV7 ETV7-AS1 FGD2 MAPK13 KCTD20 PXT1 PNPLA1 CPNE5 piR-33422-364
GH06J036386 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 11.2 -50.2 -50201 2.8 CTCF EZH2 EED RUNX3 GATAD2B CBX2 NFIC IKZF1 NR2F1 IRF2 ETV7 ETV7-AS1 KCTD20 BNIP5 MAPK13 PNPLA1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BNIP5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for BNIP5

Genomic Locations for BNIP5 Gene

Genomic Locations for BNIP5 Gene
chr6:36,315,757-36,337,015
(GRCh38/hg38)
Size:
21,259 bases
Orientation:
Minus strand
chr6:36,283,534-36,304,662
(GRCh37/hg19)
Size:
21,129 bases
Orientation:
Minus strand

Genomic View for BNIP5 Gene

Genes around BNIP5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BNIP5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BNIP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BNIP5 Gene

Proteins for BNIP5 Gene

  • Protein details for BNIP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C671-BNIP5_HUMAN
    Recommended name:
    Protein BNIP5
    Protein Accession:
    P0C671
    Secondary Accessions:
    • B2RTY8

    Protein attributes for BNIP5 Gene

    Size:
    652 amino acids
    Molecular mass:
    71930 Da
    Quaternary structure:
    No Data Available

neXtProt entry for BNIP5 Gene

Post-translational modifications for BNIP5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BNIP5 Gene

No data available for DME Specific Peptides for BNIP5 Gene

Domains & Families for BNIP5 Gene

Gene Families for BNIP5 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for BNIP5 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with BNIP5: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for BNIP5 Gene

Function for BNIP5 Gene

Phenotypes From GWAS Catalog for BNIP5 Gene

Phenotypes for BNIP5 Gene

genes like me logo Genes that share phenotypes with BNIP5: view

Animal Model Products

CRISPR Products

miRNA for BNIP5 Gene

miRTarBase miRNAs that target BNIP5

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BNIP5

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BNIP5 Gene

Localization for BNIP5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BNIP5 gene
Compartment Confidence
nucleus 2
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for BNIP5 Gene

Pathways & Interactions for BNIP5 Gene

PathCards logo

SuperPathways for BNIP5 Gene

No Data Available

Interacting Proteins for BNIP5 Gene

Gene Ontology (GO) - Biological Process for BNIP5 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for BNIP5 Gene

Drugs & Compounds for BNIP5 Gene

No Compound Related Data Available

Transcripts for BNIP5 Gene

mRNA/cDNA for BNIP5 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BNIP5

Alternative Splicing Database (ASD) splice patterns (SP) for BNIP5 Gene

No ASD Table

Relevant External Links for BNIP5 Gene

GeneLoc Exon Structure for
BNIP5

Expression for BNIP5 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for BNIP5

SOURCE GeneReport for Unigene cluster for BNIP5 Gene:

Hs.162104
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for BNIP5 Gene

Orthologs for BNIP5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for BNIP5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia C6H6orf222 30
  • 99.13 (n)
C6orf222 31
  • 98 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia C12H6orf222 30
  • 76.38 (n)
C6orf222 31
  • 59 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia C23H6orf222 30
  • 76.25 (n)
C6orf222 31
  • 59 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia 4930539E08Rik 30 31
  • 66.61 (n)
OneToOne
Bnip5 17
Rat
(Rattus norvegicus)
Mammalia LOC689561 30
  • 65.29 (n)
Species where no ortholog for BNIP5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for BNIP5 Gene

ENSEMBL:
Gene Tree for BNIP5 (if available)
TreeFam:
Gene Tree for BNIP5 (if available)

Paralogs for BNIP5 Gene

No data available for Paralogs for BNIP5 Gene

Variants for BNIP5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for BNIP5 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs193920980 Uncertain Significance: Malignant tumor of prostate 36,323,317(-) G/A MISSENSE_VARIANT
rs743852 - p.Leu582Val

Additional dbSNP identifiers (rs#s) for BNIP5 Gene

Variation tolerance for BNIP5 Gene

Residual Variation Intolerance Score: 93.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.50; 91.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BNIP5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BNIP5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for BNIP5 Gene

Disorders for BNIP5 Gene

No disorders were found for BNIP5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BNIP5 Gene

Publications for BNIP5 Gene

  1. Genome-wide prediction and validation of peptides that bind human prosurvival Bcl-2 proteins. (PMID: 24967846) DeBartolo J … Keating AE (PLoS computational biology 2014) 2 3
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. Uncovering global SUMOylation signaling networks in a site-specific manner. (PMID: 25218447) Hendriks IA … Vertegaal AC (Nature structural & molecular biology 2014) 4
  5. A quantitative atlas of mitotic phosphorylation. (PMID: 18669648) Dephoure N … Gygi SP (Proceedings of the National Academy of Sciences of the United States of America 2008) 4

No data available for Mastermind for BNIP5 Gene

Products for BNIP5 Gene

Sources for BNIP5 Gene