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Aliases for BNIP5 Gene
Aliases for BNIP5 Gene
External Ids for BNIP5 Gene
- HGNC: 33769
- Entrez Gene: 389384
- Ensembl: ENSG00000189325
- UniProtKB: P0C671
Previous HGNC Symbols for BNIP5 Gene
- C6orf222
Previous GeneCards Identifiers for BNIP5 Gene
- GC06M039804
- GC06M039989
- GC06M041372
Summaries for BNIP5 Gene
GeneCards Summary for BNIP5 Gene
BNIP5 (BCL2 Interacting Protein 5) is a Protein Coding gene.
Additional gene information for BNIP5 Gene
- HGNC(33769)
- Entrez Gene(389384)
- Ensembl(ENSG00000189325)
- UniProtKB(P0C671)
- Open Targets Platform(ENSG00000189325)
- Search for BNIP5 at DataMed
- Search for BNIP5 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BNIP5 Gene
Genomics for BNIP5 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for BNIP5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around BNIP5 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for BNIP5
Genomic Locations for BNIP5 Gene
Genomic Locations for BNIP5 Gene
- chr6:36,315,757-36,337,015
- (GRCh38/hg38)
- Size:
- 21,259 bases
- Orientation:
- Minus strand
- chr6:36,283,534-36,304,662
- (GRCh37/hg19)
- Size:
- 21,129 bases
- Orientation:
- Minus strand
Genomic View for BNIP5 Gene
Genes around BNIP5 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p21.31 by HGNC
- 6p21.31 by Entrez Gene
- 6p21.31 by Ensembl
BNIP5 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for BNIP5 Gene
Proteins for BNIP5 Gene
-
Protein details for BNIP5 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P0C671-BNIP5_HUMAN
- Recommended name:
- Protein BNIP5
- Protein Accession:
- P0C671
- B2RTY8
Protein attributes for BNIP5 Gene
- Size:
- 652 amino acids
- Molecular mass:
- 71930 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for BNIP5 Gene
Other Protein References for BNIP5 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- HUABIO Anti-C6orf222 Antibody
- Novus Biologicals Antibodies for BNIP5
- Invitrogen Antibodies for BNIP5 (AFLGC-C6orf222)
- antibodies-online: Show 20 available C6ORF222 Antibodies ranked by validation data
-
Biorbyt antibodies for BNIP5
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for BNIP5
- Origene Custom Protein Services for BNIP5
- Novus Biologicals proteins for BNIP5
No data available for DME Specific Peptides for BNIP5 Gene
Domains & Families for BNIP5 Gene
Gene Families for BNIP5 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for BNIP5 Gene
Function for BNIP5 Gene
Phenotypes From GWAS Catalog for BNIP5 Gene
Phenotypes for BNIP5 Gene
- GenomeRNAi human phenotypes for BNIP5:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for BNIP5 - Select products 50% OFF >
- * BNIP5 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for BNIP5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BNIP5
miRNA for BNIP5 Gene
- miRTarBase miRNAs that target BNIP5
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BNIP5
- Browse OriGene Inhibitory RNA Products For BNIP5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BNIP5
Clone Products
- Applied Biological Materials (abm): Clones for BNIP5 - Select products 50% OFF >
- * BNIP5 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for BNIP5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BNIP5
Cell Line Products
-
Horizon Cell Lines for BNIP5
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BNIP5 Gene
Localization for BNIP5 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 2 |
| cytosol | 1 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for BNIP5 Gene
Pathways & Interactions for BNIP5 Gene
Interacting Proteins for BNIP5 Gene
Selected Interacting proteins:
P0C671-BNIP5_HUMAN
ENSP00000418983
for BNIP5 Gene via
UniProtKB
STRING
GPS-Prot Interaction Network for BNIP5
No data available for Pathways by source and SIGNOR curated interactions for BNIP5 Gene
Transcripts for BNIP5 Gene
mRNA/cDNA for BNIP5 Gene
- 1 REFSEQ mRNAs :
- 2 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000437635 3735 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for BNIP5 - Select products 50% OFF >
- * BNIP5 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for BNIP5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BNIP5
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BNIP5
- Browse OriGene Inhibitory RNA Products For BNIP5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BNIP5
Clone Products
- Applied Biological Materials (abm): Clones for BNIP5 - Select products 50% OFF >
- * BNIP5 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for BNIP5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BNIP5
Relevant External Links for BNIP5 Gene
- GeneLoc Exon Structure for
- BNIP5
Expression for BNIP5 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for BNIP5
SOURCE GeneReport for Unigene cluster for BNIP5 Gene:
Hs.162104
No Expression Related Data Available
Primer Products
-
OriGene qPCR primer pairs for BNIP5
No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for BNIP5 Gene
Orthologs for BNIP5 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | C6H6orf222 30 |
|
||
| C6orf222 31 |
|
OneToOne | |||
| Dog (Canis familiaris) |
Mammalia | C12H6orf222 30 |
|
||
| C6orf222 31 |
|
OneToOne | |||
| Cow (Bos Taurus) |
Mammalia | C23H6orf222 30 |
|
||
| C6orf222 31 |
|
OneToOne | |||
| Mouse (Mus musculus) |
Mammalia | 4930539E08Rik 30 31 |
|
OneToOne | |
| Bnip5 17 |
|
||||
| Rat (Rattus norvegicus) |
Mammalia | LOC689561 30 |
|
- Species where no ortholog for BNIP5 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Paralogs for BNIP5 Gene
No data available for Paralogs for BNIP5 Gene
Variants for BNIP5 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for BNIP5 Gene
| SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs193920980 | Uncertain Significance: Malignant tumor of prostate | 36,323,317(-) | G/A | MISSENSE_VARIANT | |
| rs743852 | - | p.Leu582Val |
Residual Variation Intolerance Score:
93.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
10.50;
91.08% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for BNIP5 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- BNIP5
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for BNIP5 Gene
Disorders for BNIP5 Gene
Additional Disease Information for BNIP5
No disorders were found for BNIP5 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BNIP5 Gene
Publications for BNIP5 Gene
- Genome-wide prediction and validation of peptides that bind human prosurvival Bcl-2 proteins. (PMID: 24967846) DeBartolo J … Keating AE (PLoS computational biology 2014) 2 3
- The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4
- A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
- Uncovering global SUMOylation signaling networks in a site-specific manner. (PMID: 25218447) Hendriks IA … Vertegaal AC (Nature structural & molecular biology 2014) 4
- A quantitative atlas of mitotic phosphorylation. (PMID: 18669648) Dephoure N … Gygi SP (Proceedings of the National Academy of Sciences of the United States of America 2008) 4
No data available for Mastermind for BNIP5 Gene
Products for BNIP5 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for BNIP5
- Origene Custom Protein Services for BNIP5
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BNIP5
- Browse OriGene Inhibitory RNA Products For BNIP5
- OriGene qPCR primer pairs for BNIP5
- OriGene CRISPR knockouts for BNIP5
- OriGene ORF clones in human for BNIP5
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For BNIP5
- Sino Biological Human cDNA Clone for BNIP5
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for BNIP5
- Novus Biologicals proteins for BNIP5
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Invitrogen Antibodies for BNIP5 (AFLGC-C6orf222)
- VectorBuilder Custom and pre-made DNA vectors for BNIP5 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for BNIP5 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for BNIP5 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for BNIP5 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for BNIP5
- antibodies-online: Show 20 available C6ORF222 Antibodies ranked by validation data
- antibodies-online: Search results for available C6ORF222 related products ranked by validation data
- antibodies-online: Search results for available C6ORF222 related products ranked by validation data
- Horizon Cell Lines for BNIP5
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BNIP5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BNIP5
- Search GeneCopoeia for miRNA 3'UTR Target clone products for BNIP5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BNIP5
- Biorbyt antibodies for BNIP5
Sources for BNIP5 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB