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This gene encodes a protein that belongs to the pro-apoptotic subfamily within the Bcl-2 family of proteins. The encoded protein binds to Bcl-2 and possesses the BH3 domain. The protein directly targets mitochondria and causes apoptotic changes, including loss of membrane potential and the release of cytochrome c. [provided by RefSeq, Feb 2015] See more...
Aliases for BNIP3L Gene
Aliases for BNIP3L Gene
External Ids for BNIP3L Gene
- HGNC: 1085
- NCBI Entrez Gene: 665
- Ensembl: ENSG00000104765
- OMIM®: 605368
- UniProtKB/Swiss-Prot: O60238
Previous GeneCards Identifiers for BNIP3L Gene
- GC08P026013
- GC08P026594
- GC08P026262
- GC08P024785
- GC08P026240
Summaries for BNIP3L Gene
-
This gene encodes a protein that belongs to the pro-apoptotic subfamily within the Bcl-2 family of proteins. The encoded protein binds to Bcl-2 and possesses the BH3 domain. The protein directly targets mitochondria and causes apoptotic changes, including loss of membrane potential and the release of cytochrome c. [provided by RefSeq, Feb 2015]
GeneCards Summary for BNIP3L Gene
BNIP3L (BCL2 Interacting Protein 3 Like) is a Protein Coding gene. Diseases associated with BNIP3L include Pediculus Humanus Capitis Infestation and Asbestos-Related Lung Carcinoma. Among its related pathways are TP53 Regulates Transcription of Cell Death Genes and Apoptosis Modulation and Signaling. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein heterodimerization activity. An important paralog of this gene is BNIP3.
UniProtKB/Swiss-Prot Summary for BNIP3L Gene
-
Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor.
Additional gene information for BNIP3L Gene
- HGNC (1085)
- NCBI Entrez Gene (665)
- Ensembl (ENSG00000104765)
- OMIM® (605368)
- UniProtKB/Swiss-Prot (O60238)
- Open Targets Platform(ENSG00000104765)
- Monarch Initiative
- Search for BNIP3L at DataMed
- Search for BNIP3L at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BNIP3L Gene
Genomics for BNIP3L Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for BNIP3L Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around BNIP3L on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for BNIP3L
- Top Transcription factor binding sites by QIAGEN in the BNIP3L gene promoter:
-
- AP-1
- ATF-2
- c-Jun
- PPAR-gamma1
- PPAR-gamma2
- Sp1
Genomic Locations for BNIP3L Gene
Latest Assembly
- chr8:26,383,054-26,505,636
- (GRCh38/hg38)
- Size:
- 122,583 bases
- Orientation:
- Plus strand
Previous Assembly
- chr8:26,240,570-26,270,643
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 30,074 bases
- Orientation:
- Plus strand
- chr8:26,240,414-26,363,152
- (GRCh37/hg19 by Ensembl)
- Size:
- 122,739 bases
- Orientation:
- Plus strand
Genomic View for BNIP3L Gene
Genes around BNIP3L on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 8p21.2 by HGNC
- 8p21.2 by Entrez Gene
- 8p21.2 by Ensembl
BNIP3L Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for BNIP3L Gene
Proteins for BNIP3L Gene
-
Protein details for BNIP3L Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O60238-BNI3L_HUMAN
- Recommended name:
- BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like
- Protein Accession:
- O60238
- B0AZS9
- Q5JW63
- Q8NF87
Protein attributes for BNIP3L Gene
- Size:
- 219 amino acids
- Molecular mass:
- 23930 Da
- Quaternary structure:
-
- Self-associates. Interacts with BNIP3 and STEAP3. Interacts (via BH3 domain) with SPATA18 (via coiled-coil domains).
- (Microbial infection) Interacts with human adenovirus-2 E1B 19 kDa protein.
- SequenceCaution:
-
- Sequence=CAI46217.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
Protein Expression for BNIP3L Gene
Post-translational modifications for BNIP3L Gene
- Undergoes progressive proteolysis to an 11 kDa C-terminal fragment, which is blocked by the proteasome inhibitor lactacystin.
-
Ubiquitination at Lys154
- NX_O60238 (NX_O60238-1)
- Modification sites at PhosphoSitePlus
Other Protein References for BNIP3L Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences NIX / BNIP3L Antibody
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- GeneTex Anti-BNIP3L antibody
-
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-
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Protein products for research
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- Browse Sino Biological Cell Lysates
- antibodies-online: Show 4 available BNIP3L Proteins ranked by validation data
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-
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Abcam proteins for BNIP3L
Assay products for research
No data available for DME Specific Peptides for BNIP3L Gene
Domains & Families for BNIP3L Gene
Gene Families for BNIP3L Gene
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted membrane proteins
- Transporters
Suggested Antigen Peptide Sequences for BNIP3L Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA, FLJ79519, highly similar to BCL2/adenovirus E1B 19 kDaprotein-interacting protein 3 (B0AZS9_HUMAN)
- NIP3-like protein X (BNI3L_HUMAN)
- cDNA FLJ75547, highly similar to Homo sapiens BCL2/adenovirus E1B 19kDa interacting protein 3-like (BNIP3L), mRNA (Q6IBV1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O60238- Family:
-
- Belongs to the NIP3 family.
Function for BNIP3L Gene
Molecular function for BNIP3L Gene
- UniProtKB/Swiss-Prot Function:
- Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor.
- GENATLAS Biochemistry:
- BCL2/adenovirus E1B,interacting 3-like,proapoptotic,inhibiting growth of cancer cells,widely expressed (see TSG8A) and expressed in target of the mitochondria,when inducing apoptosis
Phenotypes From GWAS Catalog for BNIP3L Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 9973195 |
| GO:0005521 | lamin binding | IPI | 10381623 |
| GO:0042802 | identical protein binding | IPI | 10381623 |
| GO:0042803 | protein homodimerization activity | IDA | 10381623 |
Phenotypes for BNIP3L Gene
- MGI mutant phenotypes for BNIP3L:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for BNIP3L:
Animal Models for BNIP3L Gene
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for BNIP3L - Starting at $85 >
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- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
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-
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miRNA for BNIP3L Gene
- miRTarBase miRNAs that target BNIP3L
-
- hsa-miR-221-3p (MIRT003359)
- mmu-miR-758-3p (MIRT007712)
- hsa-let-7b-5p (MIRT052099)
- hsa-let-7a-5p (MIRT052472)
- hsa-miR-137 (MIRT054568)
- hsa-miR-30d-5p (MIRT438872)
- hsa-miR-6781-3p (MIRT660165)
- hsa-miR-2682-3p (MIRT660166)
- hsa-miR-4778-3p (MIRT660167)
- hsa-miR-877-3p (MIRT660168)
- hsa-miR-6877-3p (MIRT660169)
- hsa-miR-7109-3p (MIRT660170)
- hsa-miR-6819-3p (MIRT660171)
- hsa-miR-30a-5p (MIRT734912)
- rno-miR-30e-5p (MIRT735146)
miRNA products for research
Inhibitory RNAs for research
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Clone products for research
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Cell Lines for research
-
Horizon Cell Lines for BNIP3L
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BNIP3L Gene
Localization for BNIP3L Gene
Subcellular locations from UniProtKB/Swiss-Prot for BNIP3L Gene
- Nucleus envelope. Endoplasmic reticulum. Mitochondrion outer membrane. Membrane. Single-pass membrane protein. Note=Colocalizes with SPATA18 at the mitochondrion outer membrane.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| nucleus | 5 |
| endoplasmic reticulum | 5 |
| cytosol | 4 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| peroxisome | 2 |
| endosome | 2 |
| lysosome | 2 |
| golgi apparatus | 1 |
- Mitochondria (4)
- Nuclear speckles (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA | 21873635 |
| GO:0005635 | nuclear envelope | IBA,IDA | 10381623 |
| GO:0005739 | mitochondrion | IEA,IDA | 9973195 |
| GO:0005740 | mitochondrial envelope | IEA | -- |
| GO:0005741 | mitochondrial outer membrane | TAS | -- |
Pathways & Interactions for BNIP3L Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Gene Expression |
.48
|
|
| 2 | TP53 Regulates Transcription of Cell Death Genes | ||
| 3 | Apoptosis and Autophagy | ||
| 4 | Mitophagy - animal | ||
| 5 | Regulation of TP53 Activity | ||
Pathways by source for BNIP3L Gene
3 BioSystems pathways for BNIP3L Gene
1 KEGG pathway for BNIP3L Gene
1 Cell Signaling Technology pathway for BNIP3L Gene
Interacting Proteins for BNIP3L Gene
Selected Interacting proteins:
O60238-BNI3L_HUMAN
ENSP00000370003
for BNIP3L Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for BNIP3L
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006915 | apoptotic process | IEA | -- |
| GO:0010917 | negative regulation of mitochondrial membrane potential | IEA | -- |
| GO:0016032 | viral process | IEA | -- |
| GO:0016239 | positive regulation of macroautophagy | IGI | 19273585 |
| GO:0035694 | mitochondrial protein catabolic process | IMP | 21264228 |
No data available for SIGNOR curated interactions for BNIP3L Gene
Transcripts for BNIP3L Gene
mRNA/cDNA for BNIP3L Gene
- 2 REFSEQ mRNAs :
- 24 NCBI additional mRNA sequence :
- 7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000380629 3452 nts (view in UCSC)
- ENST00000518611 1352 nts (view in UCSC)
- ENST00000520077 922 nts (view in UCSC)
- ENST00000520409 739 nts (view in UCSC)
- ENST00000521254 502 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for BNIP3L - Starting at $85 >
- * BNIP3L CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for BNIP3L
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-
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miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BNIP3L
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Clone products for research
- Applied Biological Materials (abm): Clones for BNIP3L - Starting at $45 >
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Relevant External Links for BNIP3L Gene
- GeneLoc Exon Structure for
- BNIP3L
Expression for BNIP3L Gene
This gene is overexpressed in Adrenal (27.6) and Nasal epithelium (25.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BNIP3L Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for BNIP3L
SOURCE GeneReport for Unigene cluster for BNIP3L Gene:
Hs.131226Evidence on tissue expression from TISSUES for BNIP3L Gene
- Nervous system(5)
- Blood(4.7)
- Liver(4.6)
- Kidney(4.6)
- Skin(4.5)
- Bone marrow(4.5)
- Heart(2.9)
- Muscle(2.8)
- Eye(2.8)
- Lung(2.7)
- Intestine(2.6)
- Pancreas(2.5)
- Spleen(2.5)
- Lymph node(2.3)
- Stomach(2.2)
- Adrenal gland(2.2)
Primer products for research
-
OriGene qPCR primer pairs for BNIP3L
-
OriGene qPCR primer pairs and template standards for BNIP3L
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for BNIP3L Gene
Orthologs for BNIP3L Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | BNIP3L 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | -- 31 |
|
OneToMany | |
| BNIP3L 30 |
|
||||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| Cow (Bos Taurus) |
Mammalia | BNIP3L 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Bnip3l 30 17 31 |
|
OneToOne | |
| Bnip3l-ps 17 |
|
|
|||
| Rat (Rattus norvegicus) |
Mammalia | Bnip3l 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | BNIP3L 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | BNIP3L 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | BNIP3L 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | BNIP3L 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | bnip3l 30 |
|
||
| Str.1479 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.19770 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | bnip3la 30 31 |
|
OneToMany | |
| bnip3lb 31 |
|
OneToMany | |||
| wufb52b03 30 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.1851 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.3722 31 |
|
OneToMany |
- Species where no ortholog for BNIP3L was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for BNIP3L Gene
- ENSEMBL:
- Gene Tree for BNIP3L (if available)
- TreeFam:
- Gene Tree for BNIP3L (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for BNIP3L: view image
Paralogs for BNIP3L Gene
(1) SIMAP similar genes for BNIP3L Gene using alignment to 5 proteins:
- BNI3L_HUMAN
- B0AZS9_HUMAN
- E5RFE9_HUMAN
- H0YBC7_HUMAN
- Q6IBV1_HUMAN
Pseudogenes.org Pseudogenes for BNIP3L Gene
Variants for BNIP3L Gene
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3572648 | CNV | loss | 25503493 |
| esv3616666 | OTHER | inversion | 21293372 |
| nsv824580 | CNV | gain | 20364138 |
| nsv831273 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
29.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.49;
10.65% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for BNIP3L Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- BNIP3L
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for BNIP3L Gene
Disorders for BNIP3L Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| pediculus humanus capitis infestation |
|
|
| asbestos-related lung carcinoma |
|
|
| optic atrophy 1 |
|
|
| neuronal ceroid lipofuscinosis |
|
|
Search BNIP3L in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for BNIP3L
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for BNIP3L Gene
Publications for BNIP3L Gene
- Isolation, mapping, and functional analysis of a novel human cDNA (BNIP3L) encoding a protein homologous to human NIP3. (PMID: 9523198) Matsushima M … Nakamura Y (Genes, chromosomes & cancer 1998) 2 3 4 23
- The proapoptotic factor Nix is coexpressed with Bcl-xL during terminal erythroid differentiation. (PMID: 12663450) Aerbajinai W … Miller JL (Blood 2003) 3 4 23
- Nix and Nip3 form a subfamily of pro-apoptotic mitochondrial proteins. (PMID: 9867803) Chen G … Greenberg A (The Journal of biological chemistry 1999) 3 4 23
- Mieap, a p53-inducible protein, controls mitochondrial quality by repairing or eliminating unhealthy mitochondria. (PMID: 21264228) Kitamura N … Arakawa H (PloS one 2011) 3 4
- MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PMID: 20819778) Zhang X … Wu X (Carcinogenesis 2010) 3 41
ExternalLinks
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- Search Santa Cruz Biotechnology (SCBT) for BNIP3L siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for BNIP3L
- Custom Antibody ServicesProSci Antibodies for BNIP3L
- Search for BNIP3L Proteins at ProSci
- Horizon Cell Lines for BNIP3L
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BNIP3L
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BNIP3L
- Search GeneCopoeia for miRNA 3'UTR Target clone products for BNIP3L
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BNIP3L
Sources for BNIP3L Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB