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This gene encodes a protein that belongs to the pro-apoptotic subfamily within the Bcl-2 family of proteins. The encoded protein binds to Bcl-2 and possesses the BH3 domain. The protein directly targets mitochondria and causes apoptotic changes, including loss of membrane potential and the release of cytochrome c. [provided by RefSeq, Feb 2015]
BNIP3L (BCL2 Interacting Protein 3 Like) is a Protein Coding gene. Diseases associated with BNIP3L include Pediculus Humanus Capitis Infestation and Asbestos-Related Lung Carcinoma. Among its related pathways are Apoptosis Modulation and Signaling and TP53 Regulates Transcription of Cell Death Genes. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein heterodimerization activity. An important paralog of this gene is BNIP3.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 9973195 |
GO:0005521 | lamin binding | IPI | 10381623 |
GO:0042802 | identical protein binding | IPI | 10381623 |
GO:0042803 | protein homodimerization activity | IDA | 10381623 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA,IBA | 21873635 |
GO:0005635 | nuclear envelope | IEA,IDA | 10381623 |
GO:0005739 | mitochondrion | IEA,IDA | 9973195 |
GO:0005740 | mitochondrial envelope | IEA | -- |
GO:0005741 | mitochondrial outer membrane | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Gene Expression |
.48
|
|
2 | TP53 Regulates Transcription of Cell Death Genes | ||
3 | Apoptosis and Autophagy | ||
4 | Mitophagy - animal | ||
5 | Regulation of TP53 Activity |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006915 | apoptotic process | IEA | -- |
GO:0010917 | negative regulation of mitochondrial membrane potential | IEA | -- |
GO:0016032 | viral process | IEA | -- |
GO:0016239 | positive regulation of macroautophagy | IGI | 19273585 |
GO:0035694 | mitochondrial protein catabolic process | IMP | 21264228 |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | BNIP3L 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | -- 31 |
|
OneToMany | |
BNIP3L 30 |
|
||||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
Cow (Bos Taurus) |
Mammalia | BNIP3L 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Bnip3l 30 17 31 |
|
OneToOne | |
Bnip3l-ps 17 |
|
|
|||
Rat (Rattus norvegicus) |
Mammalia | Bnip3l 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | BNIP3L 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | BNIP3L 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | BNIP3L 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | BNIP3L 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | bnip3l 30 |
|
||
Str.1479 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.19770 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | bnip3la 30 31 |
|
OneToMany | |
bnip3lb 31 |
|
OneToMany | |||
wufb52b03 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.1851 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.3722 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3572648 | CNV | loss | 25503493 |
esv3616666 | OTHER | inversion | 21293372 |
nsv824580 | CNV | gain | 20364138 |
nsv831273 | CNV | loss | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
pediculus humanus capitis infestation |
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|
asbestos-related lung carcinoma |
|
|
optic atrophy 1 |
|
|
neuronal ceroid lipofuscinosis |
|
|
visual epilepsy |
|
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