This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with E1B 19 kDa-like sequences of BCL2, another apoptotic protector. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016] See more...

Aliases for BNIP2 Gene

Aliases for BNIP2 Gene

  • BCL2 Interacting Protein 2 2 3 5
  • BCL2/Adenovirus E1B 19 KDa Protein-Interacting Protein 2 3 4
  • BCL2/Adenovirus E1B 19kDa Interacting Protein 2 2 3
  • BNIP-2 2 3
  • NIP2 3 4
  • BNIP2 5
  • Nip2 2

External Ids for BNIP2 Gene

Previous GeneCards Identifiers for BNIP2 Gene

  • GC15M055513
  • GC15M053003
  • GC15M057534
  • GC15M057671
  • GC15M057742
  • GC15M059951
  • GC15M036777

Summaries for BNIP2 Gene

Entrez Gene Summary for BNIP2 Gene

  • This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with E1B 19 kDa-like sequences of BCL2, another apoptotic protector. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

GeneCards Summary for BNIP2 Gene

BNIP2 (BCL2 Interacting Protein 2) is a Protein Coding gene. Diseases associated with BNIP2 include Cerebellar Ataxia, Cayman Type and Hemochromatosis, Type 2B. Among its related pathways are Myogenesis and Developmental Biology. Gene Ontology (GO) annotations related to this gene include calcium ion binding and GTPase activator activity. An important paralog of this gene is PRUNE2.

UniProtKB/Swiss-Prot Summary for BNIP2 Gene

  • Implicated in the suppression of cell death. Interacts with the BCL-2 and adenovirus E1B 19 kDa proteins.

Gene Wiki entry for BNIP2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BNIP2 Gene

Genomics for BNIP2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for BNIP2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BNIP2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for BNIP2

Top Transcription factor binding sites by QIAGEN in the BNIP2 gene promoter:
  • AML1a
  • c-Myc
  • Cart-1
  • CUTL1
  • HNF-3beta
  • Max1
  • POU6F1 (c2)
  • RORalpha1
  • RSRFC4
  • Sox5

Genomic Locations for BNIP2 Gene

Latest Assembly
chr15:59,659,146-59,689,534
(GRCh38/hg38)
Size:
30,389 bases
Orientation:
Minus strand

Previous Assembly
chr15:59,951,345-59,981,519
(GRCh37/hg19 by Entrez Gene)
Size:
30,175 bases
Orientation:
Minus strand

chr15:59,951,345-59,981,733
(GRCh37/hg19 by Ensembl)
Size:
30,389 bases
Orientation:
Minus strand

Genomic View for BNIP2 Gene

Genes around BNIP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BNIP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BNIP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BNIP2 Gene

Proteins for BNIP2 Gene

  • Protein details for BNIP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12982-BNIP2_HUMAN
    Recommended name:
    BCL2/adenovirus E1B 19 kDa protein-interacting protein 2
    Protein Accession:
    Q12982
    Secondary Accessions:
    • B4DS94

    Protein attributes for BNIP2 Gene

    Size:
    314 amino acids
    Molecular mass:
    36018 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for BNIP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BNIP2 Gene

Post-translational modifications for BNIP2 Gene

  • Ubiquitination at Lys219, Lys228, and Lys267
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for BNIP2 Gene

Domains & Families for BNIP2 Gene

Gene Families for BNIP2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for BNIP2 Gene

InterPro:
Blocks:
  • Cellular retinaldehyde-binding (CRAL)/Triple function domain (TRIO)

Suggested Antigen Peptide Sequences for BNIP2 Gene

GenScript: Design optimal peptide antigens:
  • BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 (BNIP2_HUMAN)
genes like me logo Genes that share domains with BNIP2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for BNIP2 Gene

Function for BNIP2 Gene

Molecular function for BNIP2 Gene

UniProtKB/Swiss-Prot Function:
Implicated in the suppression of cell death. Interacts with the BCL-2 and adenovirus E1B 19 kDa proteins.

Phenotypes From GWAS Catalog for BNIP2 Gene

Gene Ontology (GO) - Molecular Function for BNIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004309 exopolyphosphatase activity IBA 21873635
GO:0005096 GTPase activator activity TAS 10799524
GO:0005509 calcium ion binding TAS 7954800
GO:0005515 protein binding IPI 7954800
genes like me logo Genes that share ontologies with BNIP2: view
genes like me logo Genes that share phenotypes with BNIP2: view

Animal Models for BNIP2 Gene

MGI Knock Outs for BNIP2:
  • Bnip2 Bnip2<tm1b(EUCOMM)Wtsi>

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BNIP2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BNIP2 Gene

Localization for BNIP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BNIP2 Gene

Cytoplasm. Cytoplasm, perinuclear region. Note=Localizes to the nuclear envelope region and to other cytoplasmic structures.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BNIP2 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 3
golgi apparatus 2
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1

Gene Ontology (GO) - Cellular Components for BNIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005635 nuclear envelope IDA 7954800
GO:0005737 cytoplasm IDA 7954800
GO:0005829 cytosol TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with BNIP2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for BNIP2 Gene

Pathways & Interactions for BNIP2 Gene

PathCards logo

SuperPathways for BNIP2 Gene

SuperPathway Contained pathways
1 Myogenesis
1.00
2 Developmental Biology
3 G-protein signaling_Regulation of CDC42 activity
-
genes like me logo Genes that share pathways with BNIP2: view

Pathways by source for BNIP2 Gene

3 Reactome pathways for BNIP2 Gene
1 GeneGo (Thomson Reuters) pathway for BNIP2 Gene
  • G-protein signaling_Regulation of CDC42 activity

SIGNOR curated interactions for BNIP2 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for BNIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006798 polyphosphate catabolic process IBA 21873635
GO:0006915 apoptotic process IBA,IPI 7954800
GO:0043066 negative regulation of apoptotic process TAS 7954800
GO:0043547 positive regulation of GTPase activity IEA --
GO:0051149 positive regulation of muscle cell differentiation TAS --
genes like me logo Genes that share ontologies with BNIP2: view

Drugs & Compounds for BNIP2 Gene

No Compound Related Data Available

Transcripts for BNIP2 Gene

mRNA/cDNA for BNIP2 Gene

8 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BNIP2

Alternative Splicing Database (ASD) splice patterns (SP) for BNIP2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b
SP1: - - - - - -
SP2:
SP3: - - -
SP4: - - -
SP5: -
SP6: -
SP7:

Relevant External Links for BNIP2 Gene

GeneLoc Exon Structure for
BNIP2

Expression for BNIP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for BNIP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for BNIP2 Gene

This gene is overexpressed in Pancreas (22.9), Testis (19.0), Platelet (7.7), and Monocytes (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for BNIP2 Gene



Protein tissue co-expression partners for BNIP2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for BNIP2

SOURCE GeneReport for Unigene cluster for BNIP2 Gene:

Hs.646490

Evidence on tissue expression from TISSUES for BNIP2 Gene

  • Nervous system(4.8)
  • Liver(4.4)
  • Blood(4.3)
  • Eye(4.1)
  • Muscle(2.3)
  • Bone marrow(2.3)
  • Heart(2.2)
  • Kidney(2.2)
  • Lung(2.1)
  • Intestine(2.1)
  • Skin(2)
genes like me logo Genes that share expression patterns with BNIP2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for BNIP2 Gene

Orthologs for BNIP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for BNIP2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia BNIP2 29 30
  • 99.92 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia BNIP2 29 30
  • 94.48 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia BNIP2 29 30
  • 93.72 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia BNIP2 30
  • 88 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Bnip2 29
  • 87.07 (n)
Mouse
(Mus musculus)
Mammalia Bnip2 29 16 30
  • 86.52 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia BNIP2 30
  • 81 (a)
OneToOne
Chicken
(Gallus gallus)
Aves BNIP2 29 30
  • 84.14 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia BNIP2 30
  • 81 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia bnip2 29
  • 78.09 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8459 29
Zebrafish
(Danio rerio)
Actinopterygii LOC100332015 29
  • 72.45 (n)
bnip2 29 30
  • 56 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG11593 30 31
  • 25 (a)
OneToMany
Species where no ortholog for BNIP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for BNIP2 Gene

ENSEMBL:
Gene Tree for BNIP2 (if available)
TreeFam:
Gene Tree for BNIP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for BNIP2: view image
Alliance of Genome Resources:
Additional Orthologs for BNIP2

Paralogs for BNIP2 Gene

Paralogs for BNIP2 Gene

(6) SIMAP similar genes for BNIP2 Gene using alignment to 4 proteins:

  • BNIP2_HUMAN
  • H7C096_HUMAN
  • H7C142_HUMAN
  • J3KN59_HUMAN
genes like me logo Genes that share paralogs with BNIP2: view

Variants for BNIP2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for BNIP2 Gene

SNP ID Clinical significance and condition Chr 15 pos Variation AA Info Type
rs6151509 -- p.Ser24Thr

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for BNIP2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for BNIP2 Gene

Variant ID Type Subtype PubMed ID
esv3569653 CNV gain 25503493
esv3636646 CNV gain 21293372
esv3636647 CNV gain 21293372
nsv1043693 CNV loss 25217958
nsv1108960 CNV deletion 24896259
nsv523274 CNV loss 19592680
nsv527307 CNV gain 19592680
nsv569605 CNV loss 21841781
nsv7266 OTHER inversion 18451855
nsv984080 CNV duplication 23825009

Variation tolerance for BNIP2 Gene

Residual Variation Intolerance Score: 32.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.33; 94.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BNIP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BNIP2
Leiden Open Variation Database (LOVD)
BNIP2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BNIP2 Gene

Disorders for BNIP2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for BNIP2 Gene - From: COP

Disorder Aliases PubMed IDs
cerebellar ataxia, cayman type
  • atcay
hemochromatosis, type 2b
  • hfe2b
- elite association - COSMIC cancer census association via MalaCards
Search BNIP2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for BNIP2

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with BNIP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BNIP2 Gene

Publications for BNIP2 Gene

  1. Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins. (PMID: 7954800) Boyd JM … Chinnadurai G (Cell 1994) 2 3 4
  2. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M … Tokunaga K (Human genetics 2010) 3 40
  3. Germline variation in apoptosis pathway genes and risk of non-Hodgkin's lymphoma. (PMID: 20855536) Kelly JL … Cerhan JR (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 40
  4. BNIP-2 induces cell elongation and membrane protrusions by interacting with Cdc42 via a unique Cdc42-binding motif within its BNIP-2 and Cdc42GAP homology domain. (PMID: 15652341) Zhou YT … Low BC (Experimental cell research 2005) 3 22
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for BNIP2 Gene

Sources for BNIP2 Gene