Aliases for BNC1 Gene
External Ids for BNC1 Gene
Previous HGNC Symbols for BNC1 Gene
Previous GeneCards Identifiers for BNC1 Gene
The protein encoded by this gene is a zinc finger protein present in the basal cell layer of the epidermis and in hair follicles. It is also found in abundance in the germ cells of testis and ovary. This protein is thought to play a regulatory role in keratinocyte proliferation and it may also be a regulator for rRNA transcription. Alternative splicing of this gene results in multiple transcript variants, and multiple polyadenylation sites are indicated.[provided by RefSeq, Jul 2014]
GeneCards Summary for BNC1 Gene
BNC1 (Basonuclin 1) is a Protein Coding gene. Diseases associated with BNC1 include Premature Ovarian Failure 16 and Citrullinemia, Classic. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity. An important paralog of this gene is BNC2.
UniProtKB/Swiss-Prot Summary for BNC1 Gene
Transcriptional activator (By similarity). Likely specific for squamous epithelium and for the constituent keratinocytes at a stage either prior to or at the very beginning of terminal differentiation (PubMed:8034748). Required for the maintenance of spermatogenesis (By similarity). May also play a role in the differentiation of oocytes and the early development of embryos (By similarity).