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The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their... See more...
Aliases for BMPR1A Gene
Aliases for BMPR1A Gene
External Ids for BMPR1A Gene
- HGNC: 1076
- Entrez Gene: 657
- Ensembl: ENSG00000107779
- OMIM: 601299
- UniProtKB: P36894
Previous HGNC Symbols for BMPR1A Gene
- ACVRLK3
Previous GeneCards Identifiers for BMPR1A Gene
- GC10P087398
- GC10P087738
- GC10P088647
- GC10P088180
- GC10P088506
- GC10P082370
Summaries for BMPR1A Gene
-
The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. [provided by RefSeq, Jul 2008]
GeneCards Summary for BMPR1A Gene
BMPR1A (Bone Morphogenetic Protein Receptor Type 1A) is a Protein Coding gene. Diseases associated with BMPR1A include Polyposis Syndrome, Hereditary Mixed, 2 and Juvenile Polyposis Syndrome. Among its related pathways are Signaling by GPCR and Heart Development. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is BMPR1B.
UniProtKB/Swiss-Prot Summary for BMPR1A Gene
-
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6.
Additional gene information for BMPR1A Gene
- HGNC(1076)
- Entrez Gene(657)
- Ensembl(ENSG00000107779)
- OMIM(601299)
- UniProtKB(P36894)
- Open Targets Platform(ENSG00000107779)
- Monarch Initiative
- Search for BMPR1A at DataMed
- Search for BMPR1A at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BMPR1A Gene
Genomics for BMPR1A Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for BMPR1A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around BMPR1A on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for BMPR1A
- Top Transcription factor binding sites by QIAGEN in the BMPR1A gene promoter:
-
- NF-1
- NF-1/L
- Nkx2-5
Genomic Locations for BMPR1A Gene
Genomic Locations for BMPR1A Gene
- chr10:86,755,786-86,932,825
- (GRCh38/hg38)
- Size:
- 177,040 bases
- Orientation:
- Plus strand
- chr10:88,516,396-88,692,595
- (GRCh37/hg19)
- Size:
- 176,200 bases
- Orientation:
- Plus strand
Genomic View for BMPR1A Gene
Genes around BMPR1A on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10q23.2 by HGNC
- 10q23.2 by Entrez Gene
- 10q23.2 by Ensembl
BMPR1A Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for BMPR1A Gene
Proteins for BMPR1A Gene
-
Protein details for BMPR1A Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P36894-BMR1A_HUMAN
- Recommended name:
- Bone morphogenetic protein receptor type-1A
- Protein Accession:
- P36894
- A8K6U9
- Q8NEN8
Protein attributes for BMPR1A Gene
- Size:
- 532 amino acids
- Molecular mass:
- 60198 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Cofactor:
- Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
- Quaternary structure:
-
- Interacts with BMP2 (PubMed:10881198, PubMed:18937504). Interacts with low affinity with GDF5; positively regulates chondrocyte differentiation (PubMed:24098149).
Protein Expression for BMPR1A Gene
Selected DME Specific Peptides for BMPR1A Gene
- P36894:
-
- LITDYHE
- RHENILGFIAAD
- RVGTKRYM
- GESLKDLI
- KPAIAHRD
- IADLGLA
- PLLVQRTIA
- ECWAHNPASRLTALR
- SGSGSGLP
- RYMAPEVL
- YMAPEVL
- CCIADLGLA
Post-translational modifications for BMPR1A Gene
- Glycosylated.
-
Glycosylation at Asn73
- NX_P36894 (NX_P36894-1)
- Modification sites at PhosphoSitePlus
Other Protein References for BMPR1A Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ BMPR1A Antibody
- NSJ Bioreagents BMPR1A Antibody (ALK3)
- HUABIO BMPR1A Antibody (R1510-1)
-
Custom Antibody ServicesOriGene Antibodies for BMPR1A
- Novus Biologicals Antibodies for BMPR1A
-
Abcam antibodies for BMPR1A
- Invitrogen Antibodies for BMPR1A (AFLGC-BMPR1A)
- antibodies-online: Show 65 available BMPR1A Antibodies ranked by validation data
- Compare Top BMPR1A Antibodies
-
Recommended
- 191 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 5 IHC (p) Antibodies (anti-human)
- 3 FACS Antibodies (anti-human)
- 1 IHC Antibody (anti-human)
- 58 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 1 FACS Antibody (anti-mouse)
- 21 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 1 FACS Antibody (anti-rat)
-
Santa Cruz Biotechnology (SCBT) Antibodies for BMPR1A
- Sino Biological Antibodies for BMPR1A
Protein Products
- G Biosciences Human ALK-3/BMPR1A/BMPR-IA, Lyophilized
- Search Origene for MassSpec and Protein Over-expression Lysates for BMPR1A
- Origene Custom Protein Services for BMPR1A
- Novus Biologicals proteins for BMPR1A
- Sino Biological Recombinant Proteins for BMPR1A
- Sino Biological Cell Lysates for BMPR1A
- ProSpec Recombinant Proteins for BMPR1A
-
Abcam proteins for BMPR1A
Assay Products
- RayBiotech Custom Human BMPR-IA ELISA
- Novus Biologicals ELISA Kits for BMPR1A
- antibodies-online: Show 64 available BMPR1A Elisa Kits ranked by validation data
- Compare Top BMPR1A Elisa Kits
-
Quality Products:
- ABIN365788
- ABIN1028254
- ABIN1113794
- ABIN5519987
- ABIN5591708
- ABIN511253
- ABIN6384285
- ABIN4881978
- ABIN4967545
- ABIN2945736
- ABIN424018
- ABIN366324
- ABIN1568667
- ABIN1113796
- ABIN772857
- ABIN5652297
- ABIN4967544
- ABIN2542153
- ABIN6202040
- ABIN2542099
- ABIN1113795
- ABIN431354
- ABIN368119
- ABIN1568668
- ABIN5519988
- ABIN771535
- ABIN5591709
- ABIN5652298
- ABIN2542154
- ABIN2945732
Domains & Families for BMPR1A Gene
Gene Families for BMPR1A Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- CD markers
- Disease related genes
- Enzymes
- FDA approved drug targets
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for BMPR1A Gene
- InterPro:
- Blocks:
-
- Domain in TGF-beta receptor/activin receptor, type I/II
- ProtoNet:
Suggested Antigen Peptide Sequences for BMPR1A Gene
- GenScript: Design optimal peptide antigens:
-
- Bone morphogenetic protein receptor type IA (B5BUG9_HUMAN)
- Serine/threonine-protein kinase receptor R5 (BMR1A_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P36894UniProtKB/Swiss-Prot:
BMR1A_HUMAN :- Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
- Family:
-
- Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
Function for BMPR1A Gene
Molecular function for BMPR1A Gene
- UniProtKB/Swiss-Prot Function:
- On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=[receptor-protein]-L-threonine + ATP = [receptor-protein]-O-phospho-L-threonine + ADP + H(+); Xref=Rhea:RHEA:44880, Rhea:RHEA-COMP:11024, Rhea:RHEA-COMP:11025, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.30;.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=[receptor-protein]-L-serine + ATP = [receptor-protein]-O-phospho-L-serine + ADP + H(+); Xref=Rhea:RHEA:18673, Rhea:RHEA-COMP:11022, Rhea:RHEA-COMP:11023, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.30;.
- GENATLAS Biochemistry:
- bone morphogenetic protein receptor,type 1A,expressed almost exclusively in skeletal muscle,regulator of chondrocyte differentiation,down stream mediator of Indian Hedgehog,TGFBR superfamily
Enzyme Numbers (IUBMB) for BMPR1A Gene
Phenotypes From GWAS Catalog for BMPR1A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | IEA | -- |
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0004674 | protein serine/threonine kinase activity | IDA | 12065756 |
| GO:0004675 | transmembrane receptor protein serine/threonine kinase activity | TAS | -- |
Phenotypes for BMPR1A Gene
- MGI mutant phenotypes for BMPR1A:
-
inferred from 4 alleles
- nervous system phenotype
- immune system phenotype
- respiratory system phenotype
- normal phenotype
- cardiovascular system phenotype
- cellular phenotype
- behavior/neurological phenotype
- mortality/aging
- muscle phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- neoplasm
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- vision/eye phenotype
- limbs/digits/tail phenotype
- hearing/vestibular/ear phenotype
- skeleton phenotype
- hematopoietic system phenotype
- integument phenotype
- embryo phenotype
- pigmentation phenotype
- craniofacial phenotype
- GenomeRNAi human phenotypes for BMPR1A:
-
- Decreased hepcidin::fluc mRNA expression
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- no effect
- shRNA abundance <= 50%
- Decreased viability
- Synthetic lethal with Ras
- Increased shRNA abundance (Z-score > 2)
- Increased NF-kappaB reporter expression
- Increased viability
- Decreased shRNA abundance (Z-score < -2)
- Decreased viability in ovarian lineage
- Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435)
- Increased G2M DNA content, increased 8N DNA content
- Decreased substrate adherent cell growth
- Increased cell viability after pRB stimulation
- Decreased human cytomegalovirus (HCMV) strain AD169 replication
- Increased mitotic index
- Transferrin accumulation in the perinuclear area
- Decreased cell viability after pRB stimulation
- Polylobed nuclei, many micronuclei (grape), dynamic nuclei (hole, folded or small irregular)
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, decreased FA abundance, increased peripheral FA formation, decreased cell spreading
Animal Models for BMPR1A Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for BMPR1A - Select products 50% OFF >
- * BMPR1A CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for BMPR1A
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BMPR1A
-
Santa Cruz Biotechnology (SCBT) CRISPR for BMPR1A
miRNA for BMPR1A Gene
- miRTarBase miRNAs that target BMPR1A
-
- mmu-miR-324-3p (MIRT010975)
- mmu-miR-26a-5p (MIRT011420)
- mmu-miR-15a-5p (MIRT011975)
- mmu-let-7b-5p (MIRT012229)
- mmu-miR-122-5p (MIRT013536)
- hsa-miR-124-3p (MIRT022438)
- hsa-miR-455-3p (MIRT037861)
- mmu-miR-27a-3p (MIRT054438)
- hsa-miR-656-3p (MIRT054590)
- hsa-miR-580-3p (MIRT178213)
- hsa-miR-548l (MIRT230556)
- hsa-miR-510-3p (MIRT445779)
- hsa-miR-431-5p (MIRT445780)
- hsa-miR-3140-3p (MIRT445781)
- hsa-miR-203a-3p (MIRT445782)
- hsa-miR-302f (MIRT445783)
- hsa-miR-3616-5p (MIRT449624)
- hsa-miR-573 (MIRT449625)
- hsa-miR-34a-3p (MIRT449626)
- hsa-miR-1264 (MIRT449627)
- hsa-miR-574-5p (MIRT538935)
- hsa-miR-1277-5p (MIRT538936)
- hsa-miR-190a-3p (MIRT538937)
- hsa-miR-6867-5p (MIRT538938)
- hsa-miR-223-5p (MIRT538939)
- hsa-miR-5585-3p (MIRT541912)
- hsa-miR-5011-5p (MIRT541913)
- hsa-miR-511-3p (MIRT541914)
- hsa-miR-1273e (MIRT559185)
- hsa-miR-765 (MIRT559186)
- hsa-miR-766-5p (MIRT559187)
- hsa-miR-4459 (MIRT559188)
- hsa-miR-92b-3p (MIRT559189)
- hsa-miR-92a-3p (MIRT559190)
- hsa-miR-367-3p (MIRT559191)
- hsa-miR-363-3p (MIRT559192)
- hsa-miR-32-5p (MIRT559193)
- hsa-miR-25-3p (MIRT559194)
- hsa-miR-4521 (MIRT624546)
- hsa-miR-34c-3p (MIRT624547)
- hsa-miR-1197 (MIRT624548)
- hsa-miR-499b-3p (MIRT624549)
- hsa-miR-499a-3p (MIRT624550)
- hsa-miR-8485 (MIRT624551)
- hsa-miR-6816-3p (MIRT624552)
- hsa-miR-8080 (MIRT624553)
- hsa-miR-139-3p (MIRT628413)
- hsa-miR-8055 (MIRT660190)
- hsa-miR-6739-5p (MIRT660191)
- hsa-miR-6733-5p (MIRT660192)
- hsa-miR-3153 (MIRT660193)
- hsa-miR-6770-5p (MIRT660194)
- hsa-miR-1253 (MIRT660195)
- hsa-miR-9500 (MIRT660196)
- hsa-miR-6822-5p (MIRT660197)
- hsa-miR-6750-5p (MIRT660198)
- hsa-miR-5584-5p (MIRT660199)
- hsa-miR-6783-3p (MIRT660200)
- hsa-miR-1343-3p (MIRT660201)
- hsa-miR-4465 (MIRT660202)
- hsa-miR-26b-5p (MIRT660203)
- hsa-miR-26a-5p (MIRT660204)
- hsa-miR-1297 (MIRT660205)
- hsa-miR-23b-5p (MIRT660206)
- hsa-miR-23a-5p (MIRT660207)
- hsa-miR-6829-3p (MIRT660208)
- hsa-miR-6791-3p (MIRT660209)
- hsa-miR-4695-3p (MIRT660210)
- hsa-miR-4772-3p (MIRT660211)
- hsa-miR-1281 (MIRT660212)
- hsa-miR-6742-3p (MIRT660213)
- hsa-miR-6852-5p (MIRT660214)
- hsa-miR-660-3p (MIRT660215)
- hsa-miR-4485-5p (MIRT660216)
- hsa-miR-6736-3p (MIRT660217)
- hsa-miR-6890-3p (MIRT660218)
- hsa-miR-6513-3p (MIRT660219)
- hsa-miR-8062 (MIRT660220)
- hsa-miR-4755-5p (MIRT660221)
- hsa-miR-5006-3p (MIRT660222)
- hsa-miR-6832-3p (MIRT660223)
- hsa-miR-623 (MIRT660224)
- hsa-miR-5692a (MIRT660225)
- hsa-miR-548t-5p (MIRT660226)
- hsa-miR-548az-5p (MIRT660227)
- hsa-miR-548n (MIRT660228)
- hsa-miR-211-5p (MIRT660229)
- hsa-miR-204-5p (MIRT660230)
- hsa-miR-4762-3p (MIRT669341)
- hsa-miR-3192-3p (MIRT669342)
- hsa-miR-29a-5p (MIRT669343)
- hsa-miR-3920 (MIRT669344)
- hsa-miR-6787-3p (MIRT669345)
- hsa-miR-1304-3p (MIRT669346)
- hsa-miR-1237-3p (MIRT669347)
- hsa-miR-885-3p (MIRT733414)
- mmu-miR-503-5p (MIRT735434)
- hsa-miR-1247-3p (MIRT761518)
- hsa-miR-1976 (MIRT763543)
- hsa-miR-3653-5p (MIRT766340)
- hsa-miR-3689d (MIRT767051)
- hsa-miR-377-5p (MIRT767360)
- hsa-miR-4279 (MIRT768288)
- hsa-miR-450b-3p (MIRT769876)
- hsa-miR-4713-3p (MIRT771398)
- hsa-miR-4722-3p (MIRT771456)
- hsa-miR-6086 (MIRT775491)
- hsa-miR-6134 (MIRT775927)
- hsa-miR-619-5p (MIRT776048)
- hsa-miR-638 (MIRT776150)
- hsa-miR-6506-5p (MIRT776597)
- hsa-miR-6727-3p (MIRT777858)
- hsa-miR-6747-3p (MIRT778247)
- hsa-miR-6802-3p (MIRT779500)
- hsa-miR-6851-5p (MIRT780389)
- hsa-miR-6880-5p (MIRT780815)
- hsa-miR-769-3p (MIRT781954)
- hsa-miR-7847-3p (MIRT782133)
miRNA Products
Inhibitory RNA Products
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Clone Products
- Applied Biological Materials (abm): Clones for BMPR1A - Select products 50% OFF >
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- Sino Biological Human cDNA Clone for BMPR1A
- Addgene plasmids for BMPR1A
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BMPR1A
Cell Line Products
-
Horizon Cell Lines for BMPR1A
No data available for Transcription Factor Targets and HOMER Transcription for BMPR1A Gene
Localization for BMPR1A Gene
Subcellular locations from UniProtKB/Swiss-Prot for BMPR1A Gene
- Cell membrane. Single-pass type I membrane protein. Cell surface.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 3 |
| cytosol | 3 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| nucleus | 2 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Cytosol (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | IDA,TAS | -- |
| GO:0005901 | colocalizes_with caveola | IMP | 15657086 |
| GO:0009897 | external side of plasma membrane | IDA | 24904118 |
| GO:0009986 | cell surface | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for BMPR1A Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Apoptosis Pathway |
.39
|
|
| 2 | Akt Signaling |
Akt Signaling
.60
p38 Signaling
.60
|
Tec Kinases Signaling
.55
|
| 3 | PEDF Induced Signaling |
STAT3 Pathway
.47
|
|
| 4 | nNOS Signaling in Skeletal Muscle |
BMP Pathway
.44
|
TOB in Osteoblast Signaling
.01
|
| 5 | Human Embryonic Stem Cell Pluripotency |
Factors Promoting Cardiogenesis in Vertebrates
.50
|
Human Embryonic Stem Cell Pluripotency
.50
|
Pathways by source for BMPR1A Gene
8 BioSystems pathways for BMPR1A Gene
2 Reactome pathways for BMPR1A Gene
5 KEGG pathways for BMPR1A Gene
1 R&D Systems pathway for BMPR1A Gene
4 Tocris pathways for BMPR1A Gene
11 Qiagen pathways for BMPR1A Gene
- Akt Signaling
- Antioxidant Action of Vitamin-C
- BMP Pathway
- Cardiomyocyte Differentiation through BMP Receptors
- Factors Promoting Cardiogenesis in Vertebrates
1 GeneTex pathway for BMPR1A Gene
Interacting Proteins for BMPR1A Gene
Selected Interacting proteins:
P36894-BMR1A_HUMAN
ENSP00000361107
for BMPR1A Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for BMPR1A
SIGNOR curated interactions for BMPR1A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001701 | in utero embryonic development | IEA | -- |
| GO:0001707 | mesoderm formation | IEA | -- |
| GO:0001756 | somitogenesis | IEA | -- |
| GO:0001880 | Mullerian duct regression | IEA | -- |
| GO:0002053 | positive regulation of mesenchymal cell proliferation | IEA | -- |
Drugs & Compounds for BMPR1A Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Dibotermin alfa | Approved, Investigational | Pharma | Target, ligand | 0 | ||
| Magnesium | Approved, Experimental, Investigational | Pharma | 0 | |||
| Manganese | Approved | Nutra | 56 | |||
| ATP | Investigational | Nutra | Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation | 0 | ||
| DMH-1 | Pharma | Selective BMP ALK2 receptor, Selective ALK2 inhibitor | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist | 58-64-0 |
|
(4) ApexBio Compounds for BMPR1A Gene
| Compound | Action | Cas Number |
|---|---|---|
| DMH-1 | Selective BMP ALK2 receptor | 1206711-16-1 |
| LDN-193189 | ALK inhibitor,potent and selective | 1062368-24-4 |
| LDN-212854 | BMP receptor inhibitor,potent and selective | 1432597-26-6 |
| ML347 | BMP receptor inhibitor,potent and selective | 1062368-49-3 |
Transcripts for BMPR1A Gene
mRNA/cDNA for BMPR1A Gene
- 1 REFSEQ mRNAs :
- 6 NCBI additional mRNA sequence :
- 5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000638429 5632 nts (view in UCSC)
- ENST00000372037 6417 nts (view in UCSC)
- ENST00000636056 3233 nts (view in UCSC)
- ENST00000635816 3238 nts (view in UCSC)
- ENST00000480152 421 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for BMPR1A - Select products 50% OFF >
- * BMPR1A CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for BMPR1A
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BMPR1A
-
Santa Cruz Biotechnology (SCBT) CRISPR for BMPR1A
miRNA Products
Inhibitory RNA Products
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Clone Products
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- Sino Biological Human cDNA Clone for BMPR1A
- Addgene plasmids for BMPR1A
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BMPR1A
Relevant External Links for BMPR1A Gene
- GeneLoc Exon Structure for
- BMPR1A
Expression for BMPR1A Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Hair (Integumentary System)
- Fetal Inner Root Sheath Cells Inner Root Sheath
- Dermal Condensate Cells Dermal Papilla
- Zigzag Dermal Papilla Cells Dermal Papilla
- Fetal Hair Placode Cells Hair Follicle
- Fetal Hair Shaft Cuticle Cells Hair Shaft
-
Bone (Muscoskeletal System)
- Mesenchymal Condensate Cells Autopod
- Endochondral Preosteoblasts Stylopod Perichondrium
- Endochondral Osteoblasts Rostral Endochondral Facial Bones
- Endochondral Preosteoblasts Zeugopod Perichondrium
- Endochondral Preosteoblasts Rib
-
Epithelial Cells
- Fetal Inner Root Sheath Cells Inner Root Sheath
- Mature Choroid Plexus Cells Choroid Plexus
- Fetal Hair Placode Cells Hair Follicle
- Fetal Hair Shaft Cuticle Cells Hair Shaft
- Fetal Medulla Cells Hair Shaft
-
Brain (Nervous System)
- Mature Choroid Plexus Cells Choroid Plexus
- Choroid Plexus Progenitor Cells Choroid Plexus
- Hypothalamus
- Cerebellum
- Medulla Oblongata
- Neural Tube (Nervous System)
-
Limb (Muscoskeletal System)
- Mesenchymal Condensate Cells Autopod
- Bone Marrow Stromal Cells Pelvic Girdle
- Mesenchymal Condensate Cells Stylopod
- Mesenchymal Condensate Cells Zeugopod
-
Cartilage (Muscoskeletal System)
- Mesenchymal Condensate Cells Autopod
- Mesenchymal Condensate Cells Stylopod
- Mesenchymal Condensate Cells Zeugopod
- Blood (Hematopoietic System)
-
Dermis (Integumentary System)
- Dermal Condensate Cells Dermal Papilla
- Zigzag Dermal Papilla Cells Dermal Papilla
- Guard Dermal Papilla Cells Dermal Papilla
-
Adipose (Muscoskeletal System)
- Common Preadipocyte Lateral Plate Mesoderm
- Visceral White Preadipocytes Visceral White Adipose
- Subcutaneous White Preadipocytes Body Subcutaneous White Adipose
-
Kidney (Urinary System)
- Ureteric Bud Cells Ureteric Bud
- Metanephros
-
Head Mesenchyme (Muscoskeletal System)
- Smooth Muscle Cells Prechordal Mesenchyme
- Paraxial Mesoderm Cells Branchial Arch 1
- Mesenchymal Stem Cells
-
Lateral Plate Mesoderm (Gastrulation Derivatives)
- Common Preadipocyte Lateral Plate Mesoderm
-
Smooth Muscle (Muscoskeletal System)
- Smooth Muscle Cells Prechordal Mesenchyme
-
Ovary (Reproductive System)
- Ovarian Mesenchymal Stroma Cells Ovary Interstitium
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
-
Skeletal Muscle (Muscoskeletal System)
- Paraxial Mesoderm Cells Branchial Arch 1
-
Liver (Hepatobiliary System)
- Hepatocytes Liver Lobule
-
Epidermis (Integumentary System)
- Basal Keratinocytes Embryonic Epidermis
- Thyroid (Endocrine System)
- Gut Tube (Gastrointestinal Tract)
- Intestine (Gastrointestinal Tract)
- Tooth (Integumentary System)
- Umbilical Cord (Extraembryonic Tissues)
- NULL (Uncategorized)
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for BMPR1A Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for BMPR1A
SOURCE GeneReport for Unigene cluster for BMPR1A Gene:
Hs.524477mRNA Expression by UniProt/SwissProt for BMPR1A Gene:
P36894-BMR1A_HUMAN
Tissue specificity:
Highly expressed in skeletal muscle.
Evidence on tissue expression from TISSUES for BMPR1A Gene
- Heart(3)
- Intestine(3)
- Muscle(2.9)
- Nervous system(2.9)
- Kidney(2.7)
- Liver(2.5)
- Lung(2.5)
- Skin(2.5)
- Thyroid gland(2.4)
- Bone(2.4)
- Pancreas(2.4)
- Stomach(2.3)
- Bone marrow(2.1)
- Blood(2.1)
Phenotype-based relationships between genes and organs from Gene ORGANizer for BMPR1A Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- endocrine
- integumentary
- nervous
- reproductive
- skeletal muscle
- urinary
Regions:
Head and neck:
- ear
Thorax:
- heart
Abdomen:
- biliary tract
- gallbladder
- intestine
- kidney
- large intestine
- liver
- pancreas
- small intestine
- stomach
Pelvis:
- anus
- ovary
- rectum
- uterus
General:
- blood
- blood vessel
- peripheral nerve
- peripheral nervous system
- red blood cell
- skin
Primer Products
-
OriGene qPCR primer pairs for BMPR1A
-
OriGene qPCR primer pairs and template standards for BMPR1A
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Protein tissue co-expression partners for BMPR1A Gene
Orthologs for BMPR1A Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | BMPR1A 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | BMPR-IA 31 |
|
OneToOne | |
| BMPR1A 30 |
|
||||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | BMPR1A 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | BMPR1A 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Bmpr1a 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | BMPR1A 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Bmpr1a 30 |
|
||
| Chicken (Gallus gallus) |
Aves | BMPR1A 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | BMPR1A 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | bmpr1a 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | bmpr1aa 31 |
|
OneToMany | |
| bmpr1ab 31 |
|
OneToMany | |||
| bmpr1a 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | babo 32 |
|
|
|
| tkv 31 32 |
|
OneToMany | |||
| Worm (Caenorhabditis elegans) |
Secernentea | daf-1 32 |
|
|
|
| sma-6 32 |
|
|
- Species where no ortholog for BMPR1A was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for BMPR1A Gene
- ENSEMBL:
- Gene Tree for BMPR1A (if available)
- TreeFam:
- Gene Tree for BMPR1A (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for BMPR1A: view image
Paralogs for BMPR1A Gene
Paralogs for BMPR1A Gene
(8) SIMAP similar genes for BMPR1A Gene using alignment to 2 proteins:
- BMR1A_HUMAN
- B5BUG9_HUMAN
Pseudogenes.org Pseudogenes for BMPR1A Gene
Variants for BMPR1A Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for BMPR1A Gene
| SNP ID | Clinical significance and condition | Chr 10 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 640281 | Uncertain Significance: Juvenile polyposis syndrome; Hereditary cancer-predisposing syndrome | 86,890,162(+) | G/C | MISSENSE_VARIANT | |
| 640551 | Uncertain Significance: Juvenile polyposis syndrome | 86,900,059(+) | G/T | MISSENSE_VARIANT | |
| 640801 | Uncertain Significance: Juvenile polyposis syndrome | 86,890,086(+) | A/C | MISSENSE_VARIANT | |
| 640806 | Uncertain Significance: Juvenile polyposis syndrome | 86,919,421(+) | A/G | MISSENSE_VARIANT | |
| 640914 | Uncertain Significance: Juvenile polyposis syndrome | 86,923,486(+) | A/C | MISSENSE_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv267e212 | CNV | loss | 25503493 |
| dgv491n106 | CNV | deletion | 24896259 |
| esv1482533 | CNV | insertion | 17803354 |
| esv2249804 | CNV | deletion | 18987734 |
| esv22608 | CNV | loss | 19812545 |
| esv2566276 | CNV | deletion | 19546169 |
| esv2759774 | CNV | gain+loss | 17122850 |
| esv2811 | CNV | loss | 18987735 |
| esv33714 | CNV | loss | 17666407 |
| esv3391392 | CNV | insertion | 20981092 |
| esv3546621 | CNV | deletion | 23714750 |
| esv3546624 | CNV | deletion | 23714750 |
| esv3579036 | CNV | loss | 25503493 |
| esv3579037 | CNV | loss | 25503493 |
| esv9067 | CNV | loss | 19470904 |
| nsv1141879 | OTHER | inversion | 24896259 |
| nsv428236 | CNV | loss | 18775914 |
| nsv478432 | CNV | novel sequence insertion | 20440878 |
| nsv517487 | CNV | gain+loss | 19592680 |
| nsv551795 | CNV | gain | 21841781 |
| nsv7481 | CNV | deletion | 18451855 |
| nsv7482 | CNV | insertion | 18451855 |
| nsv958319 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
17.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
11.38;
92.72% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for BMPR1A Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BMPR1A Gene
Disorders for BMPR1A Gene
(35) MalaCards diseases for BMPR1A Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| polyposis syndrome, hereditary mixed, 2 |
|
|
| juvenile polyposis syndrome |
|
|
| generalized juvenile polyposis/juvenile polyposis coli |
|
|
| juvenile polyposis of infancy |
|
|
| hereditary mixed polyposis syndrome |
|
|
Search BMPR1A in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
BMR1A_HUMAN- Juvenile polyposis syndrome (JPS) [MIM:174900]: Autosomal dominant gastrointestinal hamartomatous polyposis syndrome in which patients are at risk for developing gastrointestinal cancers. The lesions are typified by a smooth histological appearance, predominant stroma, cystic spaces and lack of a smooth muscle core. Multiple juvenile polyps usually occur in a number of Mendelian disorders. Sometimes, these polyps occur without associated features as in JPS; here, polyps tend to occur in the large bowel and are associated with an increased risk of colon and other gastrointestinal cancers. {ECO:0000269 PubMed:11536076, ECO:0000269 PubMed:12136244, ECO:0000269 PubMed:12417513, ECO:0000269 PubMed:12630959}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Polyposis syndrome, mixed hereditary 2 (HMPS2) [MIM:610069]: A disease is characterized by atypical juvenile polyps, colonic adenomas, and colorectal carcinomas. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Note=A microdeletion of chromosome 10q23 involving BMPR1A and PTEN is a cause of chromosome 10q23 deletion syndrome, which shows overlapping features of the following three disorders: Bannayan-Zonana syndrome, Cowden disease and juvenile polyposis syndrome. {ECO:0000269 PubMed:11381269, ECO:0000269 PubMed:16525031}.
Additional Disease Information for BMPR1A
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for Genatlas for BMPR1A Gene
Publications for BMPR1A Gene
- Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity. (PMID: 8397373) ten Dijke P … Miyazono K (Oncogene 1993) 2 3 4 23
- The rate of germline mutations and large deletions of SMAD4 and BMPR1A in juvenile polyposis. (PMID: 18823382) Calva-Cerqueira D … Howe JR (Clinical genetics 2009) 3 23 41
- High proportion of large genomic deletions and a genotype phenotype update in 80 unrelated families with juvenile polyposis syndrome. (PMID: 17873119) Aretz S … Friedl W (Journal of medical genetics 2007) 3 23 41
- The prevalence of MADH4 and BMPR1A mutations in juvenile polyposis and absence of BMPR2, BMPR1B, and ACVR1 mutations. (PMID: 15235019) Howe JR … Lynch HT (Journal of medical genetics 2004) 3 23 41
- Identification of a novel BMPR1A germline mutation in a Korean juvenile polyposis patient without SMAD4 mutation. (PMID: 12630959) Kim IJ … Park JG (Clinical genetics 2003) 3 4 23
ExternalLinks
Products for BMPR1A Gene
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- View all 2 R&D Systems BMPR1A (BMPR-IA/ALK-3) Proteins and Enzymes
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- Custom Antibody ServicesOriGene Antibodies for BMPR1A
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- OriGene qPCR primer pairs for BMPR1A
- OriGene qPCR primer pairs and template standards for BMPR1A
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Novus Biologicals Antibodies for BMPR1A
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- Browse Antibodies
- Browse Peptides and Proteins
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- Abcam antibodies for BMPR1A
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- Browse Primary Antibodies
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- ApexBio compounds for BMPR1A
- VectorBuilder Custom and pre-made DNA vectors for BMPR1A (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for BMPR1A (ie. lentivirus, AAV, adenovirus)
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- VectorBuilder Virus packaging for BMPR1A CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for BMPR1A
- Addgene plasmids for BMPR1A
- antibodies-online: Show 65 available BMPR1A Antibodies ranked by validation data
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- 191 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 5 IHC (p) Antibodies (anti-human)
- 3 FACS Antibodies (anti-human)
- 1 IHC Antibody (anti-human)
- 58 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 1 FACS Antibody (anti-mouse)
- 21 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 1 FACS Antibody (anti-rat)
- antibodies-online: Show 64 available BMPR1A Elisa Kits ranked by validation data
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- ABIN365788
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- antibodies-online: Show 44 available BMPR1A Proteins ranked by validation data
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Sources for BMPR1A Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB