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Aliases for BMP7 Gene

Aliases for BMP7 Gene

  • Bone Morphogenetic Protein 7 2 3 4 5
  • Osteogenic Protein 1 2 3 4
  • OP-1 3 4
  • Eptotermin Alfa 4
  • BMP-7 4
  • OP1 4

External Ids for BMP7 Gene

Previous GeneCards Identifiers for BMP7 Gene

  • GC20M055473
  • GC20M056382
  • GC20M056430
  • GC20M055178
  • GC20M055743
  • GC20M052525

Summaries for BMP7 Gene

Entrez Gene Summary for BMP7 Gene

  • This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone, kidney and brown adipose tissue development. Additionally, this protein induces ectopic bone formation and may promote fracture healing in human patients. [provided by RefSeq, Jul 2016]

GeneCards Summary for BMP7 Gene

BMP7 (Bone Morphogenetic Protein 7) is a Protein Coding gene. Diseases associated with BMP7 include Renal Fibrosis and Spondylolisthesis. Among its related pathways are PEDF Induced Signaling and Apoptotic Pathways in Synovial Fibroblasts. Gene Ontology (GO) annotations related to this gene include cytokine activity and heparin binding. An important paralog of this gene is BMP5.

UniProtKB/Swiss-Prot for BMP7 Gene

  • Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.

Gene Wiki entry for BMP7 Gene

Additional gene information for BMP7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BMP7 Gene

Genomics for BMP7 Gene

GeneHancer (GH) Regulatory Elements for BMP7 Gene

Promoters and enhancers for BMP7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J057261 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 1017 +2.8 2817 6.7 RERE ZBTB7A YY1 SP7 KLF14 SP5 EGR1 GLIS2 HMG20B ZIC2 BMP7 RBM38 ENSG00000226308 PIR47382
GH20J057322 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 28.9 -61.3 -61329 15.6 MYC NCOA6 SP7 CEBPG PRDM1 HDGF CREB1 GMEB1 ZIC2 NFRKB RPL39P39 SPO11 BMP7 ENSG00000280387 CSTF1 PPP4R1L ENSG00000226308 RBM38 MIR4325 LOC105372687
GH20J057291 Enhancer 0.6 ENCODE 28.3 -24.6 -24579 0.1 CTCF CTBP1 ZNF512B ZNF207 MAZ ZNF143 XRCC5 RAD21 BMP7 ENSG00000226308 GC20M057284 PIR49257 GC20P057313 LOC105372687
GH20J057388 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 5.9 -128.7 -128725 13.2 MNT SP1 ZFX ZNF652 SIX5 GTF2F1 ZNF687 POLR2A ZNF148 AHR RBM38 ZBP1 PPP4R1L ENSG00000280387 LOC100291105 BMP7 CASS4 PMEPA1 MTRNR2L3 PIR61563
GH20J057349 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 5.9 -84.8 -84785 3 ZFX ELF3 GTF2F1 ZNF687 POLR2A SP1 CEBPG ZNF148 AHR MLLT1 LOC105372687 RAE1 RBM38 LOC100291105 AURKA BMP7 MTND1P9
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BMP7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the BMP7 gene promoter:
  • AP-1
  • ATF
  • ATF-2
  • c-Jun
  • CRE-BP1
  • MyoD

Genomic Locations for BMP7 Gene

Genomic Locations for BMP7 Gene
chr20:57,168,748-57,266,651
(GRCh38/hg38)
Size:
97,904 bases
Orientation:
Minus strand
chr20:55,743,804-55,841,707
(GRCh37/hg19)
Size:
97,904 bases
Orientation:
Minus strand

Genomic View for BMP7 Gene

Genes around BMP7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BMP7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BMP7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BMP7 Gene

Proteins for BMP7 Gene

  • Protein details for BMP7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P18075-BMP7_HUMAN
    Recommended name:
    Bone morphogenetic protein 7
    Protein Accession:
    P18075
    Secondary Accessions:
    • Q9H512
    • Q9NTQ7

    Protein attributes for BMP7 Gene

    Size:
    431 amino acids
    Molecular mass:
    49313 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with TWSG1 (By similarity). Interacts with FBN1 (via N-terminal domain) and FBN2 (PubMed:18339631).

    Three dimensional structures from OCA and Proteopedia for BMP7 Gene

neXtProt entry for BMP7 Gene

Post-translational modifications for BMP7 Gene

  • Several N-termini starting at positions 293, 300, 315 and 316 have been identified by direct sequencing resulting in secretion of different mature forms.
  • Glycosylation at Asn372, posLast=321321, Asn302, and posLast=187187
  • Modification sites at PhosphoSitePlus

Other Protein References for BMP7 Gene

No data available for DME Specific Peptides for BMP7 Gene

Domains & Families for BMP7 Gene

Gene Families for BMP7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for BMP7 Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ92758, Homo sapiens bone morphogenetic protein 7 (osteogenic protein 1)(BMP7), mRNA (A8K571_HUMAN)
  • Bone morphogenetic protein 7 (Osteogenic protein 1) (B1AL01_HUMAN)
  • Osteogenic protein 1 (BMP7_HUMAN)
  • Bone morphogenetic protein 7 (Q9H2W7_HUMAN)
  • Bone morphogenetic protein 7 (Q9NQQ8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P18075

UniProtKB/Swiss-Prot:

BMP7_HUMAN :
  • Belongs to the TGF-beta family.
Family:
  • Belongs to the TGF-beta family.
genes like me logo Genes that share domains with BMP7: view

Function for BMP7 Gene

Molecular function for BMP7 Gene

UniProtKB/Swiss-Prot Function:
Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.
GENATLAS Biochemistry:
bone morphogenetic protein 7 (Drosophila decapentaplegic-Vg-related,DVR family;TGFB superfamily)

LifeMap Function Summary for BMP7 Gene

During embryonic development, BMP7 as signaling molecule is secreted from the following cells
It affects the following cells:
BMP7 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:

Phenotypes From GWAS Catalog for BMP7 Gene

Gene Ontology (GO) - Molecular Function for BMP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA 21873635
GO:0005160 transforming growth factor beta receptor binding IBA 21873635
GO:0005515 protein binding IPI 9872992
GO:0008083 growth factor activity IEA --
GO:0008201 heparin binding IEA --
genes like me logo Genes that share ontologies with BMP7: view
genes like me logo Genes that share phenotypes with BMP7: view

Animal Models for BMP7 Gene

MGI Knock Outs for BMP7:
  • Bmp7 Bmp7<tm1Kry>
  • Bmp7 Bmp7<tm1.2Dgra>
  • Bmp7 Bmp7<tm1Rob>
  • Bmp7 Bmp7<tm2Rob>
  • Bmp7 Bmp7<tm1a(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for BMP7 - Now 50% OFF >
  • * BMP7 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * BMP7 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BMP7 Gene

Localization for BMP7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BMP7 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BMP7 gene
Compartment Confidence
extracellular 5
plasma membrane 2
cytoskeleton 2
mitochondrion 2
nucleus 2
golgi apparatus 2
peroxisome 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for BMP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IBA,IDA 17977014
GO:0031982 vesicle IEA --
GO:0062023 collagen-containing extracellular matrix IEA --
genes like me logo Genes that share ontologies with BMP7: view

Pathways & Interactions for BMP7 Gene

genes like me logo Genes that share pathways with BMP7: view

SIGNOR curated interactions for BMP7 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for BMP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development TAS 2357959
GO:0001503 ossification IEA --
GO:0001654 eye development IEA --
GO:0001656 metanephros development IEP 18437684
GO:0001657 ureteric bud development ISS --
genes like me logo Genes that share ontologies with BMP7: view

Drugs & Compounds for BMP7 Gene

(32) Drugs for BMP7 Gene - From: PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dexamethasone Approved, Investigational, Vet_approved Pharma Agonist Anti-inflammatory glucocorticoid 2588
Calcium Approved Nutra 7539
Cyclophosphamide Approved, Investigational Pharma Nitrogen mustard alkylating agent and prodrug. 3386
Cytarabine Approved, Experimental, Investigational Pharma 1258
Daunorubicin Approved Pharma DNA topoisomerase II inhibitor 331

(18) Additional Compounds for BMP7 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with BMP7: view

Transcripts for BMP7 Gene

mRNA/cDNA for BMP7 Gene

Unigene Clusters for BMP7 Gene

Bone morphogenetic protein 7:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for BMP7 - Now 50% OFF >
  • * BMP7 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * BMP7 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for BMP7 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c · 11d ^ 12a · 12b
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - - -
SP4: - -
SP5: - - - -
SP6: - - -
SP7:
SP8: -

Relevant External Links for BMP7 Gene

GeneLoc Exon Structure for
BMP7
ECgene alternative splicing isoforms for
BMP7

Expression for BMP7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BMP7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for BMP7 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for BMP7 Gene



Protein tissue co-expression partners for BMP7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of BMP7 Gene:

BMP7

SOURCE GeneReport for Unigene cluster for BMP7 Gene:

Hs.473163

mRNA Expression by UniProt/SwissProt for BMP7 Gene:

P18075-BMP7_HUMAN
Tissue specificity: Expressed in the kidney and bladder. Lower levels seen in the brain.

Evidence on tissue expression from TISSUES for BMP7 Gene

  • Nervous system(4.7)
  • Bone(3)
  • Kidney(2.6)
  • Muscle(2.3)
  • Eye(2.2)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with BMP7: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for BMP7 Gene

Orthologs for BMP7 Gene

This gene was present in the common ancestor of animals.

Orthologs for BMP7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BMP7 35 34
  • 99.77 (n)
OneToOne
cow
(Bos Taurus)
Mammalia BMP7 35 34
  • 92.73 (n)
OneToOne
dog
(Canis familiaris)
Mammalia BMP7 35 34
  • 92.5 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BMP7 35
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BMP7 35
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bmp7 17 35 34
  • 90.31 (n)
rat
(Rattus norvegicus)
Mammalia Bmp7 34
  • 89.84 (n)
chicken
(Gallus gallus)
Aves BMP7 35 34
  • 81.72 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BMP7 35
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bmp7.1 34
  • 76.11 (n)
MGC76016 34
African clawed frog
(Xenopus laevis)
Amphibia bmp7-prov 34
zebrafish
(Danio rerio)
Actinopterygii bmp7b 35 34
  • 77.45 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta gbb 36 34
  • 54.7 (n)
scw 36
  • 29 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000824 34
  • 50.86 (n)
worm
(Caenorhabditis elegans)
Secernentea dbl-1 36
  • 32 (a)
Species where no ortholog for BMP7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BMP7 Gene

ENSEMBL:
Gene Tree for BMP7 (if available)
TreeFam:
Gene Tree for BMP7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for BMP7: view image

Paralogs for BMP7 Gene

(10) SIMAP similar genes for BMP7 Gene using alignment to 7 proteins:

  • BMP7_HUMAN
  • A8K571_HUMAN
  • B1AKZ9_HUMAN
  • B1AL00_HUMAN
  • H0Y4B5_HUMAN
  • Q9H2W7_HUMAN
  • Q9NQQ8_HUMAN
genes like me logo Genes that share paralogs with BMP7: view

Variants for BMP7 Gene

Sequence variations from dbSNP and Humsavar for BMP7 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs112344257 uncertain-significance, Congenital anomalies of kidney and urinary tract 57,202,483(-) G/A coding_sequence_variant, missense_variant
rs1186663823 uncertain-significance, Inborn genetic diseases 57,265,966(-) C/G/T coding_sequence_variant, missense_variant
rs1555815731 pathogenic, Inborn genetic diseases 57,228,383(-) GG/G coding_sequence_variant, frameshift
rs540533068 uncertain-significance, Congenital anomalies of kidney and urinary tract 57,183,780(-) G/C/T coding_sequence_variant, missense_variant
rs755895161 uncertain-significance, Congenital anomalies of kidney and urinary tract 57,265,789(-) T/C coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for BMP7 Gene

Variant ID Type Subtype PubMed ID
esv1010828 CNV deletion 20482838
esv1062572 CNV deletion 17803354
esv24660 CNV loss 19812545
esv2668178 CNV deletion 23128226
esv2673209 CNV deletion 23128226
esv2722598 CNV deletion 23290073
esv2722599 CNV deletion 23290073
esv2722600 CNV deletion 23290073
esv3646209 CNV loss 21293372
esv3646210 CNV loss 21293372
nsv1055983 CNV gain 25217958
nsv1072123 CNV deletion 25765185
nsv523091 CNV loss 19592680

Variation tolerance for BMP7 Gene

Residual Variation Intolerance Score: 35% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.95; 19.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BMP7 Gene

Human Gene Mutation Database (HGMD)
BMP7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
BMP7

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BMP7 Gene

Disorders for BMP7 Gene

MalaCards: The human disease database

(21) MalaCards diseases for BMP7 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search BMP7 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for BMP7

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with BMP7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BMP7 Gene

Publications for BMP7 Gene

  1. Expression and characterization of a human BMP-7 variant with improved biochemical properties. (PMID: 17977014) Swencki-Underwood B … Amegadzie B (Protein expression and purification 2008) 3 4 23 58
  2. Bone morphogenetic protein 7 (BMP-7) increases the expression of follicle-stimulating hormone (FSH) receptor in human granulosa cells. (PMID: 19108831) Shi J … Taketani Y (Fertility and sterility 2010) 3 23 58
  3. The role of BMP-7 in chondrogenic and osteogenic differentiation of human bone marrow multipotent mesenchymal stromal cells in vitro. (PMID: 19950204) Shen B … Diwan AD (Journal of cellular biochemistry 2010) 3 23 58
  4. Bone morphogenetic protein-7 inhibits proximal tubular epithelial cell Smad3 signaling via increased SnoN expression. (PMID: 20093492) Luo DD … Fraser D (The American journal of pathology 2010) 3 23 58
  5. Bone morphogenetic protein 7 is expressed in prostate cancer metastases and its effects on prostate tumor cells depend on cell phenotype and the tumor microenvironment. (PMID: 20126477) Morrissey C … Corey E (Neoplasia (New York, N.Y.) 2010) 3 23 58

Products for BMP7 Gene