Aliases for BMP6 Gene
External Ids for BMP6 Gene
Previous HGNC Symbols for BMP6 Gene
Previous GeneCards Identifiers for BMP6 Gene
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates a wide range of biological processes including iron homeostasis, fat and bone development, and ovulation. Differential expression of this gene may be associated with progression of breast and prostate cancer. Mutations in this gene may be associated with iron overload in human patients. [provided by RefSeq, Jul 2016]
GeneCards Summary for BMP6 Gene
BMP6 (Bone Morphogenetic Protein 6) is a Protein Coding gene. Diseases associated with BMP6 include Hemochromatosis, Type 5 and Renal Fibrosis. Among its related pathways are NF-KappaB Family Pathway and Activation of cAMP-Dependent PKA. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and growth factor activity. An important paralog of this gene is BMP5.
UniProtKB/Swiss-Prot Summary for BMP6 Gene
Induces cartilage and bone formation.